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Antenatal glucocorticoid administration: effects on oxygen-hemoglobin affinity and hemoglobin levels in experimental hyaline membrane disease.

Dexamethasone or saline was administered in a randomized fashion to pregnant Macaca nemestrina for 3 days prior to preterm abdominal delivery. The steroid-treated animals demonstrated a greater hemoglobin concentration and a greater mean corpuscular hemoglobin concentration in cord blood. There was no difference between the groups in mean P50 in cord blood. The infants of steroid-treated animals had less frequent and less severe hyaline membrane disease. We conclude that antenatal steroid administration ameliorates postnatal respiratory distress without inducing changes in P50 and with only a small change induced in cord blood hemoglobin.

Animals↗

An epidemiological study of hemoglobin levels and prevalence of anemia in young children from Bas-Zaire.

A population of 183 Zairean infants and young children (0.5 to 48 months old) who lived in rural Bas-Zaire has been examined in regard to hemoglobin (Hb), hematocrit (Hct) and mean corpuscular hemoglobin concentration (MCHC). The mean Hb was 9.03 g/dL, Hct 28.4%, and MCHC 30.7 micrograms/dL. These means are below normal by WHO and/or American Academy of Pediatrics criteria. Although there was no significant sex difference in the mean hematoglobin measurements, boys more than 24 months old had a higher mean Hb (9.98 g/dL) than girls (8.59d g/L) of the same age. Approximately 80%, 76% and 56% of children had Hb < 11 g/dL, Hct < 34% and MCHC < 32 micrograms/dL respectively. The highest prevalence of anemia was between the age of 12 and 18 months. Severe anemia (Hb < 8 g/dL) was observed in 30.65% of the study population (26.6% boys and 34.8% girls). Approximately one third of children had very low Hct levels (< or = 25%). Based on MCHC, iron deficiency was likely responsible of the anemia in 61% of the children. Both Hb (p < 0.05) and Hct positively correlated with the mother's level of education. Because of the many detrimental effects of iron deficiency in infants and young children on immunity, psychomotor, behaviour and mental development routine assessment of iron status and correction of iron deficiency should become a part of the Surveillance Programme in this population.

Anemia, Hypochromic↗

A 50-year follow-up of childhood plumbism. Hypertension, renal function, and hemoglobin levels among survivors.

A group of 192 subjects with well-documented lead poisoning in 1930 to 1942 were identified in this pilot study. Thirty-five of 72 survivors traced to a Boston area address and 22 age-, sex-, race-, and neighborhood-matched controls were recruited into a clinical study. One matched subject with plumbism had grossly abnormal renal function and an elevated blood lead level of an unclear cause. Among the remaining 21 matched pairs, the risk of hypertension was significantly higher in subjects with plumbism (relative risk, 7.0; 95% confidence interval, 1.2 to 42.3). Mean adjusted creatinine clearance rates for subjects with plumbism, however, were significantly higher than those of controls and supranormal in comparison to rates predicted for sex and age. Subjects with plumbism had significantly lower hemoglobin concentrations and hematocrit readings than the controls. Blood lead and serum creatinine levels were low for both groups. These results suggest that survivors of childhood lead poisoning have an increased risk of clinically significant hypertension developing in the setting of supranormal creatinine clearance rates.

Blood Pressure↗