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At least 397 records · Page 22Linked to original sources
PubMed2004

Use of a newly designed multifunctional coil catheter for stent placement in the upper gastrointestinal tract.

PURPOSE: To evaluate the usefulness of a newly designed multifunctional coil catheter for stent placement in patients with upper gastrointestinal tract strictures. MATERIALS AND METHODS: Constructed in our research laboratory, the coil catheter was used in 202 consecutive patients with malignant (n = 191) or corrosive (n = 11) upper gastrointestinal tract strictures. The coil catheter was made of a stainless-steel coil (1.3-mm inner diameter, 1.8-mm outer diameter), a 0.4-mm nitinol wire, a polyolefin tube, and a hemostasis valve. Usefulness of the coil catheter was evaluated based on whether the coil catheter could pass the stricture over a guide wire and whether measurement of the stricture length was possible while the guide wire was in place. RESULTS: The passage of the coil catheter over a guide wire beyond the stricture was technically successful and well tolerated in 199 of 202 patients (99%). Negotiation of a guide wire or a coil catheter through the stricture of the stomach (n = 2) or duodenum (n = 1) under fluoroscopic guidance failed in three patients. In two of these three patients, it was possible to negotiate a guide wire and a coil catheter under combined endoscopic and fluoroscopic guidance; it was not possible in the third. There were no procedure-related complications. CONCLUSION: The newly designed multifunctional coil catheter is useful in stent placement in patients with upper gastrointestinal tract strictures.

Adult↗
PubMed2005

Detection of Kawasaki disease-associated antigen in inflamed gastrointestinal tract in acute Kawasaki disease.

We performed immunohistochemistry experiments using synthetic antibodies on the gastrointestinal tract and kidney from acute Kawasaki disease patients. Significant gastrointestinal tract inflammation was present in only 2/7 patients, who had antigen detected at the site of inflammation. Antigen was not detected in kidney from 6 patients. The presence of antigen may be related to gastrointestinal pathology in acute Kawasaki disease.

Acute Disease↗
PubMed1978

Lymphoid hyperplasia of the gastrointestinal tract. A study of 26 cases and review of the literature.

Based on a study of 26 cases and a review of the literature, lymphoid hyperplasia of the gastrointestinal tract can be categorized into four clinicopathologic groups: focal lymphoid hyperplasia of the stomach, focal lymphoid hyperplasia of the small intestine, focal lymphoid hyperplasia of the rectum, and nodular lymphoid hyperplasia of the gastrointestinal tract. The focal lesions are single, variably circumscribed, and produce thickening of the wall of the affected part of the viscus. While a substantial number of the gastric lesions are associated with chronic peptic ulcers, ulceration is absent or insignificant in focal lesions located in the intestine. The extent of the infiltrate may range from involvement of the mucosa and submucosa only to infiltration of the full thickness of the wall. Nodular lymphoid hyperplasia of the gastrointestinal tract produces multiple discrete mucosal nodules in a variable segment of the small intestine, large intestine, or both. Gastric involvement is rare. The lymphoid infiltrate is confined to the lamina propria and superficial submucosa. Nodular lymphoid hyperplasia is most commonly encountered incidentally during radiologic examination or at autopsy, but it also occurs in association with hypogammaglobulinemia, especially late-onset acquired hypogammaglobulinemia. Lymphoid hyperplasia of the gastrointestinal tract can be distinguished from malignant lymphoma by the polymorphic nature of the infiltrate, the absence of significant cytologic atypia, and the presence of reactive follicles within the lesion.

Adult↗
PubMed2002

Globular amyloid deposits in the wall of the gastrointestinal tract: report of six cases.

Amyloid deposition in the gastrointestinal tract basement membrane, lamina propria, and blood vessel walls has been well documented This article describes six cases that exhibited the unusual globular pattern of deposition on light microscopy, yet exhibited the classic histochemical and immunohistochemical properties of deposited amyloid This deposition pattern is a novel finding in the gastrointestinal system. Endoscopic examination of five patients revealed mild nodularity of the gastric mucosa and diffuse gastritis. In the other case, macroscopic examination of resected small intestine showed focal mucosal depressions. In all six cases, light microscopy study revealed round to oval-shaped globules in the lamina propria, with globule diameters of 3 to 40 microm. When stained with Congo red, the deposited material refracted polarised light, and immunohistochemical testing showed a positive reaction to AA antibody. The deposits did not react with antibodies to beta2 microglobulin, transthyretin, or lambda and kappa light-chain immunoglobulins. None of the laboratory or clinical findings in the six cases was compatible with monoclonal gammopathy or multiple myeloma. The literature contains a few case reports of globular amyloid deposition in the liver, but this is the first description of a globular pattern in the gastrointestinal tract. The pathogenesis and significance of this finding are not clear, and will require further study.

Adult↗
PubMed1995

Immunocytochemical localization of motilin-containing cells in the rabbit gastrointestinal tract.

Motilin-immunopositive cells (Mo cells) are known to be present in the upper small intestine of various species, including man. However, whether Mo cells are present in the rabbit gastrointestinal tract remained to be elucidated. Therefore, this study was designed to investigate the distribution of Mo cells in the rabbit gastrointestinal tract by the avidin-biotin-peroxidase complex method using a new anti-motilin serum (CPV2) raised in chickens. The results of an enzyme-linked immunosorbent assay suggested that this antiserum recognized the C-terminal region of the motilin molecule. Motilin-immunopositive cells were found in the epithelia of the crypts and villi throughout the rabbit gastrointestinal tract from the gastric antrum to the distal colon, but no immunostaining occurred in the gastric body. Morphometric analysis revealed that Mo cells were localized preferentially in the upper small intestine, as reported for other species, and the cell densities (cells/mm2, mean +/- SE) were: gastric antrum (0.41 +/- 0.16), duodenum (8.2 +/- 0.8), jejunum (1.9 +/- 0.5), ileum (0.62 +/- 0.14), cecum (0.19 +/- 0.05), proximal colon (0.13 +/- 0.03), and distal colon (0.39 +/- 0.18). Our results demonstrated conclusively that Mo cells exist in the rabbit gastrointestinal tract and showed for the first time their regional distribution. Furthermore, our new chicken antiserum would appear to be a useful tool for the determination of plasma motilin concentrations by radioimmunoassay and for the immunoneutralization of endogenous motilin in the rabbit.

Animals↗
PubMed1999

[Experimental study on pharmacological action of fukean tablet on gastrointestinal tract].

The pharmacological effects of FuKean Tablet(FKT) on gastrointestinal tract were studied. The results showed FKT cured the diarrhea induced by rhubarb or senna, prominently reduced the quantity of feces and delayed the time of excreting charcoal powder in the diarrhea induced by rhubarb or senna model NIH mice; FKT inhibited intestinal propelling-movement in diarrhea induced by senna mmodel NIH mice. FKT inhibited the automatic contraction and Ach induced spasmodic contraction of isolated rabbit intestine(decreased the frequency and intensity of contraction). The above results revealed that the pharmacological base of curing the urgent disease in gastrointestinal tract may be curing the diarrhea, inhibiting intestinal propelling-movement and inhibiting the contraction of intestine.

Animals↗
PubMed2004

[Specialized nutrition support for the patients with advanced or recurrent carcinoma of the gastrointestinal tract].

Various nutritional disorders can occur in patients with advanced or recurrent carcinoma of the gastrointestinal tract due to the disease itself or the absence of the organs after surgery. Routine parenteral nutrition for cancer patients who undergo chemotherapy results in no benefit and troublesome complications such as catheter sepsis. Consequently, it is important to provide sufficient and proper specialized nutritional support to patients who need it, taking into account the pathologic status resulting from malignant disease. Patients with advanced or recurrent carcinoma of the gastrointestinal tract are likely to be deficient in folate and/or vitamin B12 for various reasons. Neurological disorders in vitamin B12 deficiency should worsen when folate is administered without supplementation of vitamin B12. This phenomenon should be avoided when 5-fluorouracil is used with reduced folate in cancer chemotherapy. The indications for specialized nutritional support for patients with advanced or recurrent carcinoma of the gastrointestinal tract are the same as for malnourished patients without cancer. The initial dose and formula of nutrition for cancer patients with malnutrition and various metabolic disorders should be calculated to avoid overloading. The oral intake of normal food is desirable for such patients. The placement of a central venous catheter to prevent the toxicity of chemotherapy or for venous access is contraindicated. Jejunal feeding or percutaneous endoscopic gastrostomy is performed in patients who cannot eat even a liquid diet. Total parenteral nutrition should be introduced when these accesses cannot be used. If any bowel obstruction occurs in the small intestine and/or colon, it is necessary to discuss the efficacy of surgery to resolve the obstruction.

Enteral Nutrition↗
PubMed2006

Spatial and temporal expression of Lactobacillus plantarum genes in the gastrointestinal tracts of mice.

Lactobacillus plantarum is a common inhabitant of mammalian gastrointestinal tracts, and L. plantarum strain WCFS1 is a human isolate with a known genome sequence. L. plantarum WCFS1 survives intestinal passage in an active form, and its transit time and transcriptional activities were monitored in 15 BALB/c mice at 2, 4, 6, 8, and 24 h after being fed a single intragastric dose of this organism. Enumeration of viable cells isolated from fecal material revealed that the majority of the L. plantarum inoculum transited the mouse intestine within 4 h after ingestion. Three mice were sacrificed at each time point, and total RNA was isolated from the mouse intestinal compartments (stomach through colon). Quantification of L. plantarum 16S rRNA by quantitative real-time reverse-transcription-PCR revealed that L. plantarum was present at elevated levels in the stomach and small intestine for at least 4 h following ingestion and for over 8 h in the cecum and colon. We also examined the expression of 9 L. plantarum housekeeping genes and 15 L. plantarum in vivo-inducible (ivi) genes previously identified by recombination-based in vivo expression technology to be induced in the mouse gastrointestinal tract. The relative expression levels of the ivi genes increased up to 350-fold in the mouse intestine compared to levels observed for L. plantarum WCFS1 cells grown in a rich laboratory medium. Moreover, several genes displayed intestinal compartment-specific (small intestine versus colon) activities. These results confirm that L. plantarum displays specific and differential responses at various sites along the mammalian intestine.

Animals↗
PubMed2000

Miniprobe ultrasonography and gastrointestinal tract stenosis.

OBJECTIVE: Malignant and nonmalignant stenosis of the gastrointestinal tract are a significant diagnostic and therapeutic challenge. Malignant stenosis is difficult to stage because the endosonographic catheter cannot be passed through the stricture. The objective of this study was to stage tumoral stenosis using a miniprobe. METHODS: We evaluated 30 patients (20 men, 10 women, average age 65 years). There were 9 nonmalignant cases and 21 malignant cases of stenosis of the gastrointestinal tract. Of the malignant cases, two were caused by extradigestive neoformations that infiltrated the wall of the digestive tract. Twelve of the remaining 19 cases were treated by surgery (63%). Echoendoscopy was done with a miniprobe through the working channel of the videoendoscope. The TNM classification was used to diagnose extension. The pathology study was used to confirm the final diagnosis after surgery for malignant lesions. Nonmalignant stenosis was confirmed in clinical follow-up. RESULTS: Sensitivity of the miniprobe in determining stage T and stage N were 83% and 64% respectively. CONCLUSIONS: Miniprobes provide valuable additional information in the study of stenosis of the digestive tract. Sensitivity is good in classifying tumoral T stage, and acceptable for classifying N stage, and may be improved by using low-frequency miniprobes.

Aged↗
PubMed2003

Probiotic properties of human lactobacilli strains to be used in the gastrointestinal tract.

AIMS: The study of two human strains of Lactobacillus to be used as probiotics in the gastrointestinal tract. METHODS AND RESULTS: The Lactobacillus acidophilus UO 001 and Lact. gasseri UO 002, were resistant to the gastrointestinal conditions (pH 2 and 3, presence of pepsin, pancreatin or bile salts), the resistance was enhanced in the presence of skimmed milk. Additionally, adhered to Caco-2 cells through glycoproteins in Lact. gasseri and carbohydrates in the case of Lact. acidophilus. These strains are able to inhibit the growth of certain enteropathogens: Salmonella, Listeria and Campylobacter without interfering with the normal microbiota of the gastrointestinal tract, as stated by using the mixed culture and the spot agar test. Finally, strongly adherent Lact. gasseri were found to inhibit the attachment of Escherichia coli O111 to intestinal Caco-2 cells under the condition of exclusion. CONCLUSIONS: These results indicate that the two strains of Lactobacillus from human origin present important properties for survival in, and colonization of, the gastrointestinal tract, that give them potential probiotic. SIGNIFICANCE AND IMPACT OF THE STUDY: Two strains of Lactobacillus isolated from human vagina of healthy premenopausal women could be promising candidates to be used in the preparation of probiotic products and for their use as health-promoting bacteria.

Adhesins, Bacterial↗
PubMed1998

A new source of cells contributing to the developing gastrointestinal tract demonstrated in chick embryos.

BACKGROUND & AIMS: Smooth muscle cells in the walls of the gastrointestinal tract are thought to derive solely from mesoderm surrounding the primitive gut. A population of neuroepithelial cells has recently been shown to migrate from the ventral part of the neural tube in the region joined by the vagus nerve. We sought to determine if these cells contributed to the development of the stomach and intestine. METHODS: Cells of the ventral hindbrain of chick embryos were tagged by replication-deficient retroviral vectors containing the lacZ gene, providing a permanent label that is transmitted without dilution as the cells divide. Embryos were processed for detection of labeled cells. Specific markers were used to determine differentiation of progeny in the gastrointestinal tract. RESULTS: Cells labeled in the ventral neural tube migrate in association with the vagus nerve. Labeled cells are found in the intestine and stomach after time for further migration and differentiation. Using a specific marker, they were clearly identified as smooth muscle cells. CONCLUSIONS: Some of the smooth muscle cells of the gastrointestinal tract are derived from precursor cells that originate in the ventral part of the hindbrain neural tube. Their developmental importance and functional significance remain to be determined.

Animals↗
PubMed1988

Postoperative acute gastrointestinal tract hemorrhage and multiple-organ failure.

Acute upper gastrointestinal tract hemorrhage (AUGH) was evaluated postoperatively in 720 critically ill patients and correlated with multiple-organ failure (MOF). The AUGH incidence was 20.1%. Patients were divided into three groups. Group 1 (n = 77) patients were admitted without AUGH, but developed MOF and later AUGH, with renal failure as the most common previous failure. Group 2 (n = 36) patients were admitted with AUGH and other failures. Group 3 (n = 32) patients were admitted without AUGH, which appeared as the first or only failure. Means +/- SDs for MOF and mortality for groups 1, 2, and 3, respectively, were as follows: 3.2 +/- 0.8, 75.3%; 3.2 +/- 1.1, 63.9%; and 1.8 +/- 0.8, 28.1%. A control group (n = 90) with MOF but without AUGH presented 1.8 +/- 0.9 for MOF and 41.1% mortality. Mortality, sepsis, and mean MOF were higher in AUGH cases and lower in group 3 vs groups 1 and 2. Acute upper gastrointestinal tract hemorrhage is a component of MOF (Baue's syndrome) that is closely related to sepsis particularly after abdominal surgery.

Abdomen↗
PubMed2003

Tissue engineering of the gastrointestinal tract for surgical replacement: a nutrition tool of the future?

Optimal nutrition depends on the multiple complex functions performed by the gastrointestinal tract, which range from basic functions such as storage, conduit and mechanical processing to more finely regulated capabilities such as vectorial transport, immune defence and cell signalling. Surgical strategies to supply lacking gastrointestinal tract tissues have relied on either replacement by proxy (surgical substitution) or the introduction of prostheses. Tissue engineering seeks to replace missing tissues with engineered tissues that more accurately reproduce the native physiological and anatomical milieu. It is now possible to engineer several areas of the gastrointestinal tract with high fidelity, and to employ tissue-engineered bowel in replacement in animal models. These replacement models have reflected excellent anatomical and physiological recapitulation of native bowel by the tissue-engineered constructs in vivo.

Animals↗
PubMed2001

Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract.

This review describes the current state of knowledge on the hazards of exercise and the potential benefits of physical activity on the gastrointestinal tract. In particular, acute strenuous exercise may provoke gastrointestinal symptoms such as heartburn or diarrhoea. A substantial part (20-50%) of endurance athletes are hampered by these symptoms which may deter them from participation in training and competitive events. Nevertheless, these acute symptoms are transient and do not hamper the athlete's health in the long term. The only exception is repeated gastrointestinal bleeding during training and competition, which in the long term may occasionally lead to iron deficiency and anaemia. In contrast, repetitive exercise periods at a relatively low intensity may have protective effects on the gastrointestinal tract. There is strong evidence that physical activity reduces the risk of colon cancer by up to 50%. Less convincing evidence exists for cholelithiasis and constipation. Physical activity may reduce the risk of diverticulosis, gastrointestinal haemorrhage, and inflammatory bowel disease although this cannot be substantiated firmly. Up to now, underlying mechanisms are poorly understood although decreased gastrointestinal blood flow, neuro-immuno-endocrine alterations, increased gastrointestinal motility, and mechanical bouncing during exercise are postulated. Future research on exercise associated digestive processes should give more insight into the relationship between physical activity and the function of the gastrointestinal tract.

Digestive System Physiological Phenomena↗
PubMedDate not supplied

Liquid chromatographic determination of olaquindox in medicated feeds and in contents of porcine gastrointestinal tract.

A liquid chromatographic method for the determination of olaquindox in both medicated feeds and porcine gastrointestinal tract is described. Samples are extracted with water and cleaned on a disposable reverse-phase column. The eluate is chromatographed on a reverse-phase column under isocratic conditions. Olaquindox is detected by UV absorption at 260 nm. The minimum amount detected by this method was 0.075 ng. The corresponding minimum detectable concentration in a 1 g sample was 0.3 mg/kg. The detector response was linear within the interval of 0-500 ng. Mean recovery of olaquindox in spiked gastrointestinal samples was 89 +/- 5% (mean +/- standard deviation, n = 43). Concentration profiles of olaquindox in the gastrointestinal tract of pigs fed medicated feed were used to evaluate the preventive potency against Treponema hyodysenteriae. The presence of some N-O reduced metabolites of olaquindox in the gastrointestinal tract was assessed.

Animal Feed↗
PubMed2006

Proenkephalin-A mRNA is widely expressed in tissues of the human gastrointestinal tract.

BACKGROUND: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth. The expression and tissue location of proenkephalin-A mRNA in the gastrointestinal tract remains largely unknown. METHODS: In this study we have analyzed the expression of proenkephalin-A mRNA in the human esophagus, gastrointestinal tract and surrounding organs by means of reverse-transcriptase PCR (RT-PCR). RESULTS: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder. CONCLUSION: The present study demonstrates proenkephalin-A mRNA expression in regions of the human esophagus, gastrointestinal tract, pancreas, and gallbladder tissues which provides information for the future mapping of proenkephalin-A mRNA and protein expression/co-expression at the cellular level.

Aged↗
PubMed1999

Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tracts.

Because few previous studies have shown the immunohistochemical localization of tryptophan 5-hydroxylase (TPH) in the gastrointestinal tract, we developed a specific antibody against TPH purified from mouse mastocytoma P-815 and stained human and rat gastrointestinal tracts. The specificity of the antibody was examined by Western blotting and by immunohistochemistry in brain sections. Human ileum and colon specimens, rat stomach, duodenum, jejunum, ileum and colon specimens, with and without colchicine treatment were prepared for immunohistochemistry. Immunoelectron microscopic double staining of TPH and serotonin/chromogranin A and immunofluorescence double staining of TPH and serotonin were performed to identify the cell types. Epithelial enterochromaffin (EC) cells, mast cells in the lamina propria and submucosa, and varicose fibers in the submucosa and muscle layer showed positive immunoreactivity in all segments examined from human and normal rat specimens. In colchicine-treated rat specimens, nerve cell bodies in the myenteric plexus were stained. Because the antibody does not cross react with tyrosine hydroxylase as defined in Western blotting or brain sections, these positive structures may contain TPH. The present results show evidence that EC cells, mast cells, and nerve cell bodies and fibers in the gastrointestinal tracts of both the human and the rat contain TPH and therefore may have the ability to synthesize serotonin from tryptophan.

Animals↗
PubMed1985

A benign cystic teratoma with gastrointestinal tract development.

The clinical and histologic features of a benign cystic teratoma with histologic evidence of almost full gastrointestinal tract development are discussed. The literature has previously described only bowel epithelium, segments of bowel, appendix, and esophagus separately. This is the first report of almost complete development of the gastrointestinal tract in a benign cystic teratoma. In this teratoma, the entire gastrointestinal tract from esophagus to colon is represented histologically.

Adult↗