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At least 397 records · Page 22Linked to original sources
PubMed1991

Entrance and exit TL-dosimetry in the conservative treatment of breast cancer: a pilot study for the EORTC-Radiotherapy Cooperative Group.

Mailed dosimetry, using thermoluminescent dosimeters, can play an important role in quality assurance procedures in radiotherapy. In 1989, a pilot study was started with the main aim to show the feasibility of this method for the multicentre EORTC trial 22881 on the conservative management of breast carcinoma. Two anthropomorphic breast phantoms and six patients with breast carcinoma were irradiated according the prescriptions of the protocol. TLD measurements of the entrance and exit dose were performed in 6 MV tangential X-ray beams. It proved to be possible to correlate the dose measured in the entrance and exit points of the beams to the calculated dose closely under the surface. A thickness of at least 5 mm bolus material must be applied over the dosimeters and a distance of at least 3 cm from the lateral and medial field borders must be maintained in order to reach a clinically acceptable accuracy in the measurements.

Breast Neoplasms↗
PubMed1993

Pseudomonas infection of the catheter exit site successfully managed with topical acetic acid.

A case of recurrent catheter exit site infection with Pseudomonas aeruginosa is presented in a patient receiving home parenteral nutrition. The past episodes were managed by elective catheter replacement following extrusion of the catheter cuff. We describe the successful use of acetic acid to the exit site which resulted in the eradication of the organism and complete resolution of all signs.

Journal Article↗
PubMed1993

Entrance and exit dose regions for a Clinac-2100C.

PURPOSE: While significant advances have taken place in confirming dose in homogeneous media and accounting for changes due to distant heterogeneities, interface dosimetry is still a dose assessment problem. The entrance and exit surfaces of the patient are a prime example where dose assessment is questionable, but important, in many clinical situations. METHODS AND MATERIALS: Data were taken to examine the effect of such parameters as field size, source-to-skin distance, blocking tray, compensation materials (lead, aluminum and brass) and various patient support materials (Mylar, graphite, thermal plastic, and foam) on the surface doses from a dual energy (6 MV, 18 MV) linear accelerator. Measurements were conducted with a thin window parallel-plate chamber. RESULTS: Relative surface dose was found to have a proportional dependence on field size for both energies with surface doses ranging from 6% to 53%. A surface depth dose of 22.6% for a 15 cm field was measured for the low energy beam while a surface dose of 22.3% was observed for the 18 MV beam. The surface dose increased significantly for short source to skin distances and with the presence of a blocking tray. Compensating filter materials had little influence on surface dose. However, patient support devices such as Alpha Cradle and the graphite of the table can increase the surface dose to as much as 92%. CONCLUSION: We found there was a loss in dose at the exit surface (in comparison with percent depth dose tables, which assume infinite depth) on the order of 15% and 11% for the 6 MV and 18 MV beams, respectively. However, this loss is quickly compensated for with the introduction of most inherent backscattering media, [which in fact can increase the dose] for example, graphite in the patient support assembly tabletop.

Humans↗
PubMed1994

Delayed sympathetically maintained pain caused by electrical burn at the current's entry and exit sites.

It is not uncommon for sympathetically maintained pain (SMP) to follow electric burns at the site of current entry. The occurrence of SMP at the exit point has not been reported. This report describes a patient who was exposed transiently to a 220W electrical current. After a delay of 3 months, the typical manifestations of SMP appeared on the right hand (entry point); symptoms appeared on the left foot (exit point) after 11 months. Ultrasonography was helpful in identifying the bony and soft tissue changes that occurred with SMP. Serial sympathetic blocks, oral phenytoin, and an intensive physical rehabilitation program were useful in treating this electrically induced SMP.

Adult↗
PubMed2004

Ex utero intrapartum surgery (EXIT): indications and anaesthetic management.

The ex utero intrapartum treatment (EXIT) procedure is a technique for safely managing airway obstruction at birth, in which placental support is maintained until the airway is evaluated and secured. In addition to the usual considerations of anaesthesia in obstetrics there are special considerations relating to the EXIT procedure: maintaining fetoplacental circulation by profound uterine relaxation and achieving fetal anaesthesia for airway manipulations. This chapter focuses on the key issues involved in managing this procedure: the indications, preoperative concerns, organization of a multidisciplinary team, problems of maternal and fetal anaesthesia, maintenance of the uterine relaxation and control of fetal airway.

Airway Obstruction↗
PubMed2006

IQGAP and mitotic exit network (MEN) proteins are required for cytokinesis and re-polarization of the actin cytoskeleton in the budding yeast, Saccharomyces cerevisiae.

In budding yeast the final stages of the cell division cycle, cytokinesis and cell separation, are distinct events that require to be coupled, both together and with mitotic exit. Here we demonstrate that mutations in genes of the mitotic exit network (MEN) prevent cell separation and are synthetically lethal in combination with both cytokinesis and septation defective mutations. Analysis of the synthetic lethal phenotypes reveals that Iqg1p functions in combination with the MEN components, Tem1p, Cdc15p Dbf20p and Dbf2p to govern the re-polarization of the actin cytoskeleton to either side of the bud neck. In addition phosphorylation of the conserved PCH protein, Hof1p, is dependent upon these activities and requires actin ring assembly. Recruitment of Dbf2p to the bud neck is dependent upon actin ring assembly and correlates with Hof1p phosphorylation. Failure to phosphorylate Hof1p results in the increased stability of the protein and its persistence at the bud neck. These data establish a mechanistic dependency of cell separation upon an intermediate step requiring actomyosin ring assembly.

Actin Cytoskeleton↗
PubMed2005

Development of a framework with specific reference to exit-level outcomes for the education and training of South African undergraduate physiotherapy students.

The aim of the study was to develop a framework for undergraduate programmes for the education and training of physiotherapists in South Africa. The research comprised a literature survey, interviews with United Kingdom physiotherapy educators and departmental workshops in South Africa. The Delphi technique was employed as research method to evaluate the proposed framework. The measuring instrument was a questionnaire comprising of amongst others, statements related to exit-level outcomes, which were rated on a five-point rating scale. Two rounds of the Delphi technique were required before acceptable consensus was reached and a framework for the development of a physiotherapy education and training programme was compiled. The framework has been designed as a benchmark for the development of innovative physiotherapy curricula in South Africa. This paper provides information of the exit-level outcomes specified in the framework.

Competency-Based Education↗
PubMed2006

Dramatic lightning injury with exit wound.

This is a case report of an environmental accident due to lightning where one school boy sustained current, blast, and flame effects of it. A bolt of lightning directly struck the pole of a football ground and the scatter struck the child. In addition to burn injuries, he showed an exit wound of lightning in left foot. The exit wound of lightning current is a very rare finding. The body of victim had flame and heat effect of atmospheric electricity on head and neck, face, and trunk. In this incidence of lightning other team mates of the victim were safe. The patient survived the attack.

Burns↗
PubMed2005

Genome-wide analyses reveal RNA polymerase II located upstream of genes poised for rapid response upon S. cerevisiae stationary phase exit.

The resting state of eukaryotic cells (G0) is relatively uncharacterized. We have applied DNA microarray expression profiling of S. cerevisiae to reveal multiple transitions during a complete 9-day growth cycle between stationary phase (SP) exit and entry. The findings include distinct waves of transcription after the diauxic shift (DS), identification of genes active in SP, and upregulation of over 2500 genes during the first minutes of lag phase. This provides a framework for analyzing large-scale reprogramming of gene expression. Despite global repression, the general transcription machinery is found to be present in quiescent cells but is largely inactive. Genome-wide location analysis by chromatin immunoprecipitation (ChIP on chip) reveals that RNA polymerase II is more predominantly bound at intergenic regions in SP, upstream of hundreds of genes immediately induced upon exit. In contrast to current models of activation-coupled recruitment, the results show that RNA polymerase II is located and maintained upstream of many inactive genes in quiescence.

Chromatin Immunoprecipitation↗
PubMed2006

Erythrocyte exit: Out, damned merozoite! Out I say!

A new study has combined video microscopy with fluorescent labeling of host and parasite membranes to follow Plasmodium falciparum merozoites as they exit their host erythrocyte. The result has yielded some arresting images, which make compelling viewing irrespective of whether or not you have an interest in cell motility in general or P. falciparum erythrocyte exit in particular. Moreover, this work injects important new insights into the long-running debate about the biological mechanisms that underpin merozoite release.

Animals↗
PubMed2004

Exit wave reconstruction at atomic resolution.

An iterative method for exit wave function reconstruction based on wave function propagation in free space is presented. The method, which has the potential for application to many forms of microscopy, has been tailored to work with a through focal series of images measured in a high-resolution transmission electron microscope. Practical difficulties for exit wave reconstruction which are pertinent in this experimental environment are the slight incoherence of the electron beam, sample drift and its effect upon the defocus step size that can be utilised, and the number of image measurements that need to be made. To gauge the effectiveness of the method it is applied to experimental data that has been analysed previously using a maximum likelihood formalism (the MAL method).

Crystallography↗
PubMed2006

Projected potential profiles across interfaces obtained by reconstructing the exit face wave function from through focal series.

An iterative method for reconstructing the exit face wave function from a through focal series of transmission electron microscopy image line profiles across an interface is presented. Apart from high-resolution images recorded with small changes in defocus, this method works also well for a large defocus range as used for Fresnel imaging. Using the phase-object approximation the projected electrostatic as well as the absorptive potential profiles across an interface are determined from this exit face wave function. A new experimental image alignment procedure was developed in order to align images with large relative defocus shift. The performance of this procedure is shown to be superior to other image alignment procedures existing in the literature. The reconstruction method is applied to both simulated and experimental images.

Journal Article↗
PubMedDate not supplied

An analysis of human comfort when entering and exiting the rear seat of an automobile.

This paper describes a study of human motion and human comfort when entering and exiting the rear seat of an automobile. A simulator was used to test several possible door frame configurations, and various positions of the front and rear seats. Thirty-six human subjects were asked to enter and exit the simulator five times for each configuration and to answer a subjective questionnaire. The motion performed by each test subject was recorded by means of a VHS recorder and an ELITE motion measurement system. A statistical analysis was performed on the data from the questionnaires and comfort rankings were produced for the various configurations. The most influential design parameters were identified and iso-comfort surfaces were defined and fitted which provided a simple means of quantifying the effect of one of the main parameters.

Adult↗
PubMed2003

TolC--the bacterial exit duct for proteins and drugs.

The TolC structure has unveiled a common mechanism for the movement of molecules, large and small, from the bacterial cell cytosol, across two membranes and the intervening periplasm, into the environment. Trimeric TolC is a remarkable cell exit duct that differs radically from other membrane proteins, comprising a 100-A long alpha-barrel that projects across the periplasmic space, anchored by a 40-A long beta-barrel spanning the outer membrane. The periplasmic entrance of TolC is closed until recruitment by substrate-specific translocases in the inner membrane triggers its transition to the open state, achieved by an iris-like 'untwisting' of the tunnel alpha-helices. TolC-dependent machineries present ubiquitous exit routes for virulence proteins and antibacterial drugs, and their conserved structure, specifically the electronegative TolC entrance constriction, may present a target for inhibitors of multidrug-resistant pathogens.

Bacterial Outer Membrane Proteins↗
PubMed2003

Atrial escape-capture bigeminy in dominant atrial rhythm with 2:1 exit block.

A 27-year-old woman with atrial bigeminy is reported in whom long PP intervals alternate with short PP intervals. All P waves are negative in lead II and all PR intervals measure 0.12 s. In the 12-lead electrocardiogram, however, these P waves were definitely different in configuration from each other, and were divided into two groups. Namely, these negative P waves are divided into those of dominant atrial rhythm J1 with 2:1 exit block, and those of atrial escape J2. Long J1-J2 intervals alternate with short J2-J1 intervals. These electrocardiographic findings show the presence of atrial escape-capture bigeminy. Such atrial escape-capture bigeminy in dominant atrial rhythm with 2:1 exit block has never been reported before.

Adult↗
PubMed1981

Rapid ventricular parasystole with possible multilevel exit block.

A case of ventricular parasystole firing at the extremely rapid rate of 214 beats per minute in a 73 year old woman is described. Manifest cycle lengths of parasystolic complexes varied widely due to variable degrees of exit block, which could be best interpreted by the concept of multilevel block or alternating Wenckebach periodicity in the ventriculo-ectopic junction. Discontinuation of digoxin reduced the degree of exit block and unmasked parasystolic tachycardia.

Aged↗
PubMed1982

Parasystolic ventricular tachycardia with variable exit block.

This case is an example of ventricular parasystolic tachycardia associated with variable expressions of ectopic-ventricular (E-V) exit block. The exit block manifested with 2:1, 3:2, 4:3 and higher ratios of E-V conductions, interspaced with periods of 1:1 conduction. Concealed E-V conduction of the ectopic impulse could also be deduced.

Aged↗
PubMed1997

Intermittent parasystole with exit block.

A 53-year-old patient had a complex ventricular arrhythmia, which most likely was an intermittent pure (nonmodulated) parasystole, due to protection limited to the first part of the cycle coexisting with exit block. However, other interpretations of the observations were possible. Foremost among these was modulated parasystole with partial protection or with an attenuated or nondetectable early delaying phase, with exit block. Interestingly, the parasystole appeared to have fulfilled the dynamic rules regarding the number of sinus beats interposed between manifest parasystolic beats, as has been reported for pure or weakly modulated parasystole. This case corroborates unusual manifestations of an arrhythmia, which because of its newly found complexities and various possible interpretations seems to be discussed with decreasing frequency in most textbooks on general cardiology.

Electrocardiography↗