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The psychology of premature ejaculation: therapies and consequences.

INTRODUCTION: Premature ejaculation (PE) is a common male sexual dysfunction characterized by the loss or absence of ejaculatory control, marked distress or interpersonal difficulty and by a short intravaginal ejaculatory latency time (IELT). PE can impact both the patient's and his partner's quality of life. AIM: To review evidence concerning the psychologic influences of PE on the self-esteem and self-confidence of men with PE and the impact on their partners. To review the role of psychotherapy in the management of men with PE. METHODS: The Sexual Medicine Society of North America hosted a State of the Art Conference on Premature Ejaculation on June 24-26, 2005 in collaboration with the University of South Florida. The purpose was to have an open exchange of contemporary research and clinical information on PE. There were 16 invited presenters and discussants; the group focused on several educational objectives. MAIN OUTCOME MEASURE: Peer-reviewed medical literature was reviewed concerning management of men with PE by psychologic and sexual therapy. Premature ejaculation has long been viewed as a psychological concern involving psychological interventions, although recent research also focuses on the neurobiological underpinnings of the dysfunction. Psychosexual therapies combine behavioral interventions to help the patient learn to control or delay his ejaculation and to assist him in regaining confidence and lessening performance anxiety. Psychosexual therapy can be combined with pharmacotherapies to provide an improved prognosis to the patient with PE. CONCLUSIONS: Healthcare providers do not manage the majority of patients with PE with the same consideration and attention provided men with erectile dysfunction (ED). PE has been perceived as a psychological concern, either a learned behavior or a response to a meaningful event/interaction or sexual anxiety. Primary treatment has involved psychosexual therapy. Regardless of etiology, psychological/sexual therapy can play an important role in the management of PE.

Adult↗

The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa.

AIM: To investigate the distribution of cation channel of sperm 1 (CATSPER1) protein and the presence of CATSPER1 mRNA in human testis and ejaculated spermatozoa. The influence of anti-human CATSPER1 antibody upon human sperm motility was used to evaluate the function of human CATSPER1 and to estimate its possible use as a target for immunocontraception. METHODS: Human ejaculated sperm from normozoospermic donors (n = 12) and liquid nitrogen frozen human testis were used for the study of mRNA and protein expression of CATSPER1 by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry, respectively. Spermatozoa from normozoospermic donors (n = 12) were individually processed using a swim-up procedure and were then incubated with CATSPER1 antibody at final concentrations of 20, 4 and 0.8 microg/mL. After 1, 2 and 6 h incubation, progressive motility and fast progressive motility were measured by means of computer-assisted semen analysis. RESULTS: CATSPER1 transcript was detected in both human testis and each human ejaculated semen sample. CATSPER1 protein expressed in the membrane of spermatid and was localized in the principal piece of the sperm tail. The application of CATSPER1 antibody at all concentrations significantly inhibited both progressive motility and fast progressive motility after 1, 2 and 6 h incubation, and significant dose-dependent changes were observed. CONCLUSION: CATSPER1 is meiotically and post-meiotically expressed in human testis tissue. CATSPER1 mRNA in human ejaculated spermatozoa could be a more feasible target for study and infertility screening than testis biopsy. In addition, our results suggest that human CATSPER1 could be a possible target for immunocontraception.

Antibodies↗

Vasoseminal vesiculography before and after ejaculation.

Vasoseminal vesiculographies before and after ejaculation were compared in 16 cases of male sterility. In 12 cases the contrast medium was excreted into the ejaculate and the contours of the seminal vesicles were contracted after ejaculation. In 4 cases, however, there was little or no contraction of the seminal vesicles. Here the seminal tracts were considered to be abnormal and this dysfunction seems to be the cause or at least one of the cofactors responsible for sterility. The degree of excretion of contrast medium into the ejaculate seems to depend on the function of the seminal tract. Therefore, a postejaculation seminal vesiculogram is useful as a parameter for estimating the function of the seminal tract.

Adult↗

Evaluation of seminal vesicle characteristics by ultrasonography before and after ejaculation.

Twenty males underwent transrectal ultrasonography before and after ejaculation to examine possible alterations that could influence interpretation of seminal vesicle ultrasonography. The preejaculation length of 35 mm was significantly (p < 0.05) decreased to 30 mm after ejaculation. The mean width of the seminal vesicles was 13 mm before and 11 mm after ejaculation. The seminal vesicle volume was significantly diminished after ejaculation (p < 0.05). It therefore seems important to maintain a period of abstinence when evaluating the seminal vesicles by ultrasonography.

Adult↗

Can chlamydial conjunctivitis result from direct ejaculation into the eye?

The majority of cases of chlamydial conjunctivitis are thought to result from autoinoculation by the patient of infected genital secretions from themselves or their sexual partners. We noted that some patients had developed symptoms following direct ejaculation into the affected eye. We describe four cases of chlamydial conjunctivitis following ejaculation of semen directly into the eye, which have not been previously described. In only one case was chlamydia detected in the genital tract. In three cases, there was no evidence of genital chlamydial infection; the sources of the eye infection being either from infected genital material of their sexual partners transferred by hands to the eyes, or more likely from direct ejaculate inoculation. It is likely that this mode of transmission is underestimated as a history of ejaculation into the conjunctiva is not normally asked for.

Adult↗

Contribution of individual compartments of the genital tract to oestrogen and testosterone concentrations in ejaculates of the boar.

The investigation of steroids in compartments of the genital tract of boars revealed that in the tubular fluid a pattern apparently exists which is unique in this compartment. It is characterized by high concentrations of unconjugated testosterone (35 ng/ml) and even higher amounts of oestradiol-17 beta (42.6 ng/ml) whereas in other compartments oestrone is the predominant oestrogen. At least in the ejaculate half of the total amount of oestrogens is bound to sperms and it is concluded that sperms act as a carrier for oestrogens. The accessory sex glands contribute to ejaculate concentrations to a varying degree (unconjugated testosterone 55%, conjugated testosterone 20%, unconjugated oestrogens 22%, conjugated oestrogens 12%) as could mainly be demonstrated by vasectomy with and without administration of hCG. Increasing the frequencies of ejaculations (up to three times a day) shows that the steroid transfer into the ejaculate is a rapid process.

Animals↗

The lack of effect of ejaculate sequence on sex ratio in rabbits.

The influence of the order of the ejaculate on the sex ratio was determined by ejaculating 1 of 5 experimental males 20 times over a period of 2 to 8 h. The sex ratio was noted for the offspring of ejaculates 1, 5, 10, 15 and 20 in a total of 32 litters. The sex ratio of these offspring did not deviate signigicantly from 50:50 (P greater than 0.1) for any ejaculate in the sequence.

Animals↗

Quantitative assessment of testicular germ cell production and kinematic and morphometric parameters of ejaculated spermatozoa in the grey mouse lemur, Microcebus murinus.

Germ cell production and organization of the testicular epithelium in a prosimian species, the grey mouse lemur, Microcebus murinus, was investigated to extend knowledge of comparative primate spermatogenesis. In addition, semen samples collected from adult male lemurs (body weight 53-92 g; n = 16) by rectal probe electroejaculation were evaluated using computer-assisted morphometric and kinematic analysis of spermatozoa. Epididymidal spermatozoa were collected from six animals after hemicastration; the testes were weighed and prepared for stereological analysis and flow cytometry. The relative testis mass (as a percentage of body weight) ranged between 1.17 and 5.6%. Twelve stages of testicular seminiferous epithelium as described for macaques were applied and only a single stage was observed in most of the seminiferous tubule cross-sections. On average (mean SD), a single testis contained 1870 +/- 829 x 10(6) germ cells and 35 +/- 12 x 10(6) Sertoli cells. Germ cell ratios (preleptotene:type B spermatogonia = 2, round spermatid:pachytene = 3; elongated spermatid:round spermatids = 1) indicated high spermatogenic efficacy. Sperm head dimensions and tail lengths of the ejaculated and epididymidal spermatozoa were similar. Percentages of defects (neck/mid-piece and tail) were low ( 10%) and similar for ejaculated and epididymidal spermatozoa. Spermatozoa were highly motile, characterized by extensive lateral head displacement, but relatively low progressive motility. In conclusion, the grey mouse lemur has unusually large testes with a highly efficient spermatogenic process and large sperm output. These features, together with the high proportion of morphologically normal and highly motile spermatozoa in the ejaculates, indicate that Microcebus murinus is a species in which sperm competition after ejaculation is likely to occur. The predominantly single spermatogenic stage system seems to be an ancestral feature among primates.

Animals↗

Identification of sperm morphometric subpopulations in two different portions of the boar ejaculate and its relation to postthaw quality.

A statistical approach using sequentially principal component analysis (PCA), clustering, and discriminant analyses was developed to identify sperm morphometric subpopulations in well-defined portions of the fresh boar ejaculate. Semen was obtained as 2 portions (the first 10 mL of the sperm-rich fraction and the rest of the ejaculate, respectively) and frozen using a conventional protocol. Before freezing, an aliquot was used for computer-assisted sperm morphometry analysis (ASMA). Postthaw quality was evaluated using computer-assisted sperm analysis (CASA), and an annexin-V/PI assay evaluated sperm membranes. The PCA revealed that 3 variables represented more than 78% of the cumulative variance in sperm subpopulations. The clustering and discriminant analyses, based on 5780 individual spermatozoa, revealed the existence of 4 sperm subpopulations. The relative percentage of these subpopulations varied between boar and ejaculate portions. Linear regression models based on measured morphometric characteristics could account for up to 36% of the percentage of intact sperm membranes postthaw. The ASMA protocol used in our study was useful to detect subtle morphometric differences between spermatozoa, and the combination of this analysis with a multivariate statistical procedure gave new information on the biological characteristics of boar ejaculates that is not given by conventional sperm analysis.

Animals↗

Evaluation and treatment of premature ejaculation: a critical review.

OBJECTIVE: Premature ejaculation is the most prevalent male sexual dysfunction. The present article is a comprehensive review of the literature on premature ejaculation. METHOD: This critical discussion of the literature evaluates the definitional issues, theoretical conceptualizations, assessment strategies, and treatment alternatives for premature ejaculation. RESULTS: The review integrates the most recent findings on the diagnosis and treatment of premature ejaculation updating an earlier review with the addition of more than fifty recent articles and adding sections on treatment generalization and maintenance, medical evaluation, pharmacological intervention, and a discussion of methodological issues in the literature. CONCLUSIONS: The pause-squeeze technique remains the current treatment of choice for the disorder. However, this unitary treatment recommendation disguises a multidimensional disorder which has yet to evolve an operational definition, psychometrically sound assessment procedures, or clearly articulated etiology.

Combined Modality Therapy↗

Influence of abstinence and ejaculation-to-analysis delay on semen analysis parameters of suspected infertile men.

No significant differences were found between mean values calculated for daily increases in abstinence for any semen analysis parameter, with the exception of ejaculate volume between 1 and 2 days of abstinence. However, graphical analysis revealed significant trend lines for both ejaculate volume and total sperm count. The mean ejaculate volume increased by 1.0 ml between the first and second days of abstinence, and at approximately 0.3 ml/day thereafter until the 5th day. The total sperm count showed a mean daily increase of 50-60 x 10(6) spermatozoa/day. Quantitative differences exist in the evolution of these two parameters in comparison to normal fertile men. There were decreased mean percentages of motile and viable spermatozoa at short periods (less than or equal to 1 day) of abstinence, increasing up until the 2nd (% viable) or 3rd (% motile) days of abstinence, with decreased values at greater than 5 days. The mean percentage of morphologically normal spermatozoa was unaffected by the duration of abstinence. Delays of up to 3 hr between ejaculation and analysis did not seriously affect the mean semen parameters.

Ejaculation↗

Beta2-microglobulin, carcinoembryonic antigen and prostatic acid phosphatase in split ejaculates and urine voided before and after massage of the prostate.

Analyses of split ejaculates and urine voided before and after prostatic massage have been used to evaluate the origin of beta2-microglobulin (b2m) and carcinoembryonic antigen (CEA) in human semen. CEA and b2m were present in rather high concentrations in all the fractions of the split ejaculates. The urine voided after massage of the prostate also contained increased levels of CEA and beta2-microglobulin. Split ejaculates, selected from the electrophoretic pattern obtained for each fraction, revealed that b2m in seminal plasma originates from the prostate and seminal vesicles in equal amounts. Besides the "free" b2m in seminal plasma, human semen contains a sperm-bound b2m fraction. Carcinoembryonic antigen was found in the highest concentrations in the second fraction of split ejaculates indicating that it originates mainly from the prostate.

Acid Phosphatase↗

Biochemical parameters of slowly liquefying human ejaculates.

Abnormality in liquefaction of human semen is associated with poor scoring in postcoital tests and may lead to subfertility. A relative study on the seminal plasma characteristics of slowly and normally liquefying human ejaculates has been made. A multitude of seminal vesicular and prostatic components in the seminal plasma of eight slow-liquefying ejaculates from 4 men were compared with ten normally liquefying ejaculates from different healthy volunteers. For 60% liquefaction, the time taken by these two types of ejaculates was 46 and 7 min, respectively. The levels of the components that are mainly secreted by the seminal vesicles were similar in both the groups. But all the prostatic components demonstrated significantly (p less than 0.001) decreased levels in the slow-liquefying group from those in the group being compared. It was concluded that relative decrease in the prostatic activity with respect to that of the seminal vesicles appears to be the cause of slow-liquefaction.

Adult↗

The rationale for requesting a second consecutive sperm ejaculate for assisted reproductive technology.

We assessed the value of requesting a second semen sample provided within 1 hour of the first in cases of unacceptable ejaculate quality (compared to previous occasions) or very poor semen characteristics. The study population consisted of 109 males with severe oligo-terato-astenospermic (OTA) syndrome in an assisted reproduction program. Semen volume, sperm count and sperm motility were recorded in the first and second samples with a Makler Counting Chamber before sperm processing, and total motile sperm in the ejaculate was calculated. Differences in sperm parameters between the consecutive samples were determined by paired-sample t test. In 36 cases (33%) the second sample was found to be superior in quality to the first and was therefore used for the fertilization process. Of the 12/109 cases in which the first ejaculate demonstrated no motile sperm, five (41%) had detectable motile sperm in the second (total 0.1 x 10(6), 0.2 x 10(6), 0.3 x 10(6), 8.4 x 10(6) and 20.8 x 10(6)). We conclude that a request for second ejaculate immediately after the first in males with poor semen quality or no detectable motile sperm can yield a better sample in a significant percentage of cases. Using this method, clinicians can avoid the utilization of elaborate sperm processing techniques and the need for unnecessary micromanipulative fertilization.

Ejaculation↗

Anxiolytic-like effect of ejaculation upon frustration.

In three experiments, we studied the consequences of ejaculation upon the frustrative or contrast response of male rats exposed to reward downshift situations (i.e., surprising changes from 32% to 4% sucrose solutions). Similar to what has been found after treatment with anxiolytic agents, consummatory suppression was partially reversed by previous ejaculations in a second postshift trial (Experiments 2 and 3), such a result not having been obtained in a first postshift trial (Experiment 1). Moreover, the effect of ejaculations upon males' behavior during a second postshift trial was transitory, disappearing when assessed during the third and fourth postshift trials (Experiment 3). These results are in accordance with both Amsel's (1958, 1992) frustration theory and Flaherty's (1996) multistage hypothesis of successive negative contrast; the diverse factors that are known to modulate contrast effects are considered, including an interpretation of the present data in terms of the anxiolytic-like effect of the ejaculation.

Animals↗

The effects of fluoxetine on several neurophysiological variables in patients with premature ejaculation.

PURPOSE: Fluoxetine, a selective serotonin re-uptake inhibitor, has been shown to increase the intravaginal latency of patients with premature ejaculation. We demonstrated the effects of fluoxetine on intravaginal latency, penile sensory threshold, and variables of sacral evoked response and cortical somatosensorial evoked potential in patients with premature ejaculation. MATERIALS AND METHODS: Of 48 patients 40 who presented to our clinic with premature ejaculation met the study criteria, gave written or oral consent, and were divided randomly in a double-blind fashion into 2 groups of 20 patients. The study group received 20 mg. fluoxetine daily and the control group received placebo for 1 month. The patients were evaluated during visits before and after treatment for intravaginal latency, penile sensory threshold values, and the variables of sacral evoked response and cortical somatosensory evoked potential tests. RESULTS: Patient ages, intravaginal latencies, penile sensory threshold values, and amplitudes and latencies of sacral evoked response and cortical somatosensory evoked potential tests in both groups were not significantly different at the beginning of treatment (p >0.05). At the end of treatment intravaginal latencies and penile sensory threshold values were increased in the study group compared to before treatment and the control group (p <0.05). No change was observed in either group for the amplitudes and latencies of sacral evoked response and cortical somatosensory evoked potential tests (p >0.05). CONCLUSIONS: These findings suggest that fluoxetine is effective treatment for premature ejaculation probably due to its effect of increasing the penile sensory threshold, without changing the amplitudes and latencies of sacral evoked response and cortical somatosensory evoked potential.

Adult↗

Ejaculated spermatozoa in patients with non-mosaic Klinefelter's syndrome.

BACKGROUND: Non-mosaic Klinefelter patients are generally azoospermic and there is no therapy to improve the spermatogenesis. Some patients have a few spermatozoa in their ejaculates, which can be used for intracytoplasmic sperm injection (ICSI), but only a few cases resulting in a successful birth have been reported. METHODS: Out of 52 non-mosaic 47,XXY Klinefelter patients, four cases having spermatozoa in their ejaculates were retrospectively studied. RESULTS: Intracytoplasmic sperm injection was performed in three cases using their ejaculates and resulted in one chemical abortion and one death in utero (8 weeks). Using testicular sperm, one patient had a healthy baby with a normal karyotype. CONCLUSION: Some non-mosaic Klinefelter patients have ejaculated sperm that can result in a successful birth following ICSI. However, the birth rate is very low compared with the fertilization rate, suggesting increased risk of chromosomal abnormalities.

Adult↗

Comparison of the efficacy of fluoxetine alone vs. fluoxetine plus local lidocaine ointment in the treatment of premature ejaculation.

OBJECTIVE: The present study compares the efficacy and side effects of fluoxetine alone vs. fluoxetine plus local lidocaine ointment in the treatment of premature ejaculation. METHODS: Forty-three patients suffering from premature ejaculation were studied. The exclusion criteria were erectile dysfunction, loss of libido, alcohol and substance abuse, mental retardation, diabetes mellitus, thyroid disease, hypotension, previous use of these drugs and urogenital infections. The patients' ages ranged from 19 to 48 years (mean age 28 +/- 1.6). They had regular sexual lives. They had normal psychiatric consultation and the Glombock Rast Sexual Satisfactory Test (GRISS) psychiatric test were in accordance with premature ejaculation. RESULTS: The patients were assigned to two groups. Twenty-six patients, aged 21 to 36 years (mean age 27), received only fluoxetine 20 mg/day (1 capsule) for a week which was later increased to 40 mg/day (2 capsules). Seventeen patients, aged 19 to 48 years (mean age 31), were given fluoxetine 20 mg/day plus local application of lidocaine ointment. The patients and partners were re-evaluated 8 weeks after the treatment. The results were classified as unsuccessful, improvement and cure. The chi-square test was used for statistical analysis. In the fluoxetine group, 8 (30.8%) patients cured, 11 (42.2%) showed improvement and there were 7 failures (26.9%). In the combination treatment group, 9 (52.9%) patients cured, improvement was observed in 5 (29.4%) and failure in 3 (17.6%). Side effects in group I were observed in 6 patients (23%) and in 5 (29.4%) in group II. There were no statistical differences between the two groups according to the side effects (p > 0.01). No patients were excluded from the study due to side effects. CONCLUSION: The combination of fluoxetine plus local application of lidocaine ointment was found to be more effective than fluoxetine alone in the treatment of premature ejaculation. However, the results should be confirmed in further studies with a placebo group to rule out the placebo effect.

Administration, Topical↗