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PubMed1979

[Six-monthly administration of medroxyprogesterone acetate (MPA) (author's transl)].

For more than six years the authors have studied the acceptability and the effectiveness of Medroxyprogesterone Acetate (450 mg) as a long acting contraceptive (six months). With a Pearl index of 0.85, the method was considered as effective whereas its acceptability was adversely influenced by the bleeding irregularities that take place during the first year of use. A good patient-doctor relationship could lessen this influence.

Drug Administration Schedule↗
PubMedDate not supplied

Cytologic findings in oral contraceptive users among Israeli Jewish women.

A group of 3,317 Jewish Israeli women were studied to evaluate a possible correlation between previous and recent oral contraceptive usage and cervical cytopathologic findings in Papanicolaou smears. A positive correlation was established between oral contraceptive usage and the occurrence of inflammatory findings: the rate of inflammatory changes depended on the length of usage, with a time lapse of at least one year preceding the appearance of such inflammatory changes. The cessation of oral contraceptive usage was associated with a decrease in the rate of inflammatory findings. No cases of cervical intraepithelial neoplasia or malignancy were found.

Adolescent↗
PubMed1984

Lack of an elevated risk of malignant melanoma in relation to oral contraceptive use.

Epidemiologic and laboratory data suggest an effect of oral contraceptives (OC) on the risk of malignant melanoma. This relationship was explored in a hospital-based case-control study of 160 women with malignant melanoma and 640 matched controls, all of whom were white and 20-59 years of age. A total of 63 cases (39%) had used OC compared with 270 controls (42%), yielding a relative risk estimate of 0.9 (95% confidence interval: 0.6-1.3). When a number of potential confounding factors were simultaneously controlled, the relative risk estimate was 0.8 (0.5-1.3). For use that lasted 5 or more years the estimate was 0.9 (0.5-1.6). The level of tumor invasion was not related to OC use. The evidence from this study suggests that OC, even when used for 5 or more years, do not increase the risk of malignant melanoma.

Canada↗
PubMed1982

Galactorrhea in oral contraceptive users.

One hundred women who had been employing combination estrogen/progestin oral contraceptives (OCs) for a minimum of six consecutive months were evaluated for the presence of galactorrhea. It was found in 9%. The incidence did not vary significantly with age, gravidity, duration of OC use of estrogen content. Only six subjects had breast fed previously, preventing assessment of the effect this may have on the incidence of galactorrhea. Twelve OC users with galactorrhea were evaluated for the presence of pituitary microadenomas. Two had radiologic and hormonal findings consistent with the presence of prolactinomas, one had functional hyperprolactinemia, one had an empty sella, one had a partially empty sella, and two with normal basal prolactin levels had both polytomography and computerized axial tomography findings suggestive of pituitary microadenomas. Galactorrhea in OC users who have not breast fed is frequently associated with significant intrasellar pathology and should be an indication for further evaluation.

Adenoma↗
PubMedDate not supplied

Pill and IUD discontinuation in the United States, 1970-1975: the influence of the media.

Analysis of the 1975 National Fertility Study data on pill and IUD discontinuation shows an upward trend in discontinuation rates for both methods between 1970 and 1975, with particularly sharp increases in pill discontinuation starting in 1972. Almost 40 percent of pill discontinuation was attributable to problems of use; three-fifths of these problems were physical. About one-quarter of pill discontinuation was for reasons other than problems of use. The single most common of these was that the woman wanted to become pregnant. Almost 40 percent of IUD discontinuation was due to method-related problems; only 13 percent was due to the women's desire to become pregnant, a finding which suggests that women do not use this method for childspacing. Examination of the relationship between pill and IUD discontinuation and unfavorable news stories about these two methods reveals that after specific news events, discontinuation rates for both methods tend to increase. Rates climb for 5-6 months following specific unfavorable news stories, with peaks in the rate of change in discontinuation reached 3-5 months after a pill-related story and 2-4 months after an IUD-related story. General media coverage of the adverse effects of pill use in particular (where general coverage is defined as the cumulative number of pill articles appearing between 1970 and 1975) accounts for 34 percent of the variance in pill discontinuation rates. This correlation is strongly suggestive of a causal relationship between general mass media coverage of the adverse effects of the pill and discontinuation rates for this method.

Contraceptives, Oral↗