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At least 397 records · Page 22Linked to original sources
PubMed2006

[Reserves for enhancing the efficiency of treatment for pulmonary tuberculosis in adolescents].

Out of 222 adolescents with pulmonary tuberculosis, 115 received a short-term intensive DOTS chemotherapy and 107 had a conventional triple antibacterial treatment (TAT) regimen. The advantages of intensive chemotherapy were relatively better results with a reduction in the duration of treatment by 1.5-2 months; its disadvantage was more frequent (37.7% versus 18.7%) adverse toxic reactions. The local administration of TAT (lymphotropic as aerosols) promotes a decrease in toxic reactions and an increase in the efficiency of treatment for the destructive and bacillary forms of pulmonary tuberculosis. This is also favored by the timely use of collapse therapy--artificial pneumothorax and pneumoperitoneum (following 1.5-3 months).

Adolescent↗
PubMed1991

[The role of surgery in pulmonary tuberculosis infected by tubercle bacilli with multiple drug resistance].

The first, definition of pulmonary tuberculosis bacilli with multiple drug resistance was decided as "bacilli completely resistant to RFP 50 mcg + SM 20 mcg and/or INH 1 mcg + KM 100 mcg and/or EB 5 mcg and/or another antituberculosis drug" based on 118 cases examined for drug resistance pre-operatively in 35 institutions belonging to the Tuberculosis Research Committee, during the 6 years period 1984 to 1989. Next, 48 pulmonary tuberculous cases with multiple drug resistance were analysed, and the following conclusions were obtained: 1) Pulmonary tuberculosis cases with multiple drug resistance were 36% of 133 cases of positive tuberculosis bacilli before operation. 2) 52% were more than 50 years old. One third showed less than 40 in respiratory index. 3) Most of them did not have effective anti-tuberculosis drug to be used after operation. 4) There was a high rate of pneumonectomy and collapse therapy such as thoracoplasty. 5) Successful rate of treatment was 72.9%, which is rather good for multiple drug resistant tuberculous cases. But bacilli positive rate after operation and mortality were 12.5% and severe complications such as bronchial or pulmonary fistula, thoracic empyema and worsening of tuberculosis after operation was 25%. Therefore surgical treatment for pulmonary tuberculosis with multiple drug resistance needed careful application considering sensitive drug to be used after testing of resistance for all anti-tuberculosis drugs. Surgical treatment should be considered especially if pulmonary tuberculosis cases have complete resistance to RFP and to one drug among SM, INH, KM and EB.

Adult↗