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At least 397 records · Page 22Linked to original sources

Clinical application of high speed B mode echocardiography.

This study discusses the clinical application of high speed B mode echocardiography to a wide variety of heart diseases. We used a rapid mechanical sector scan at 30 frames per second and 120 scanning lines per frame, resulting in real time observation of cardiac structures. The sector angle was relatively wide (maximum 90 degrees). The tomograms were synchronized with the electrocardiogram and recorded on ordinary 35 mm or Polaroid film in conjunction with 8 mm cinematography. Heart cross sections could be recorded even in the presence of arrhythmia. We used a flat or focused, 10 mm diameter transducer made of lead zirconate-titanate with a resonant frequency of 2 or 3 MHz at a repetition rate of 3.6 kHz. High speed B mode echocardiography is a means of observing cross sections of the heart that can contribute to the improvement of accuracy in cardiac diagnosis.

Echocardiography↗

Clinical application of adenosine and ATP for pain control.

This review summarizes clinical application of adenosine and adenosine 5'-triphosphate (ATP) in pain conditions. Investigations have been performed in patients with acute perioperative pain or chronic neuropathic pain treated with intravenous adenosine or ATP, or intrathecal adenosine. Characteristic central adenosine A1 receptor-mediated pain-relieving effects have been observed after intravenous adenosine infusion in human inflammation/sensitization pain models and in patients with chronic neuropathic pain. Adenosine compounds, in low doses, can reduce allodynia/hyperalgesia more consistently than spontaneous pain, suggesting that these compounds affect neuronal pathophysiological mechanisms involved in central sensitization. Such pain-relieving effects, which are mostly mediated via central adenosine A1 receptor activation, have a slow onset and long duration of action, lasting usually for hours or days and occasionally for months. With acute perioperative pain, treatment with a low-dose infusion of adenosine compounds and the A1 receptor-mediated central antisensitization mechanisms may play only a minor part in the total perioperative pain experience. By administering sufficient doses of adenosine compounds during surgery, however, significant and long-lasting perioperative pain relief can be achieved via central A1 receptor-mediated antinociceptive/analgesic actions as well as via peripheral A2a or A3 receptor-mediated antiinflammatory actions. Thus, adenosine compounds have significant potential for alleviating various types of pain.

Acute Disease↗

Direct assay of cortisol in human saliva by solid phase radioimmunoassay and its clinical applications.

Direct determination of cortisol (F) in human saliva and its clinical applications were investigated. For this purpose, a solid phase radioimmunoassay (RIA) was carried out. The detection limits for F in 50 and 400 microliter of saliva were 0.125 and 0.0156 micrograms/100 ml, respectively, and the intra-assay coefficient of variation was 5.9--12.2%. Salivary F levels measured by this method were in good agreement with those by the RIA after extraction with dichlormethane reported previously. Salivary F levels were studied in 10 healthy adults with regard to diurnal rhythms, in rapid ACTH tests, and following intravenous injections of 20 mg F, and they showed almost similar changes to serum unbound F levels. Diurnal variations of salivary F in 8 normal children were nearly the same as those in healthy adults. In patients with Cushing's syndrome, neither normal diurnal rhythm of salivary F nor suppressed salivary F with dexamethasone were observed. Patients with adrenocortical insufficiency showed a lack of responsiveness in salivary F levels to stimulation with ACTH or lysin-vasopressin. These findings suggest that salivary F can be measured directly by the solid phase RIA and accurately reflects serum unbound F. The method is simple, accurate and useful for assessing adrenocortical function, especially in pediatric subjects and/or outpatients.

Adrenocorticotropic Hormone↗

Clinical application of computerized continuous-infusion pressure-monitored sialography.

The clinical application of computerized continuous-infusion pressure-monitored sialography using an aqueous contrast medium during the investigation of 296 salivary glands is described. A comparison between the pressure changes and the sialographic features revealed a significant (P less than 0.001) correlation between raised filling pressure (greater than 60 mmHg) and the presence of an obstructive lesion (stricture, mucous plug, sialolith). Occasionally a raised filling pressure was observed although the associated sialography films were normal. The sensitivity of the technique was 86.4%. It is concluded that the monitoring of pressure changes occurring during sialography can alert the clinician to the presence of high filling pressure and may also provide additional evidence of obstructive changes within salivary glands.

Adolescent↗

Occlusal principles and clinical applications for endosseous implants.

Endosseous implant dentistry has become a predictable clinical modality. The role of the restorative dentist is to minimize overload to the crestal bone by utilizing implant occlusal principles. The prosthetic stages of treatment should follow a disciplined sequence. This article reviews occlusal principles and clinical applications for long-term success of endosseous implants.

Alveolar Process↗

[Clinical application of ventriculoperitoneal shunt assisted by laparoscope].

OBJECTIVE: To compare the clinical effectiveness of ventriculoperitoneal shunt (VPS) assisted by laparoscope versus the clinical effectiveness of VPS via traditional laparotomy in treating hydrocephalus. METHODS: The clinical data on 26 cases of VPS with laparoscope assistance and on 234 cases of VPS via traditional laparotomy were summerized and analyzed retrospectively. The operation efficacy and the complication rate were compared between the two groups. RESULTS: In the traditional laparotomy group, there were 6 cases of peritoneal catheter obstruction or displacement, 5 cases of postoperative infection, and 2 childhood cases where the peritoneal catheter made a way into the rectum and through the anus. But in the laparoscope group, there was only one case of postoperative infection. Postoperatively the laparoscope group was better than the traditional laparotomy group in respect to the postoperative outcome, complication rate and the clinical improvement. Thirteen cases were treated by the VPS using right liver-diaphragm interspace drainage and another 13 cases were treated by the VPS using pelvis cavity drainage in the laparoscope group, respectively. CONCLUSION: The technique of VPS assisted by laparoscopies safe, reliable, and has the advantages of accurate positioning, minimal injury and less postoperative complications; it is worthy of clinical application and popularization. Positioning the peritoneal catheter to the liver-diaphragm interspace can avoid the complications caused by perforation of the cavity organs.

Adolescent↗

[Clinical application of a Biballoon indwelling intraluminal shunt system for carotid endarterectomy].

Clinical applications of newly developed shunt system for carotid endarterectomy were described. The shunt is a silicone tube equipped with balloons at both ends (Biballoon indwelling intraluminal shunt). The blood leak from the gap between a shunt tube and the inner wall of the carotid artery is prevented by inflating balloons after shunt insertion. This shunt system was used in seven cases of cerebral infarction resulted from the carotid stenosis and was proved to be more convenient than other known shunts.

Aged↗

[Clinical application of alkaline phosphatase bone-isoenzyme determination with acetate foil].

Clinical application of alkaline phosphatase bone isoenzyme determination using acetate foil is investigated in patients with known underlying disease and is compared with diagnostic evaluation of 112 bone-scans. The separation of alkaline phosphatase isoenzymes proves a valuable diagnostic support of bone scintigraphy. Isoenzyme determination moreover reveals primary and secondary bone changes in early stages of the disease and also offers the possibility of quantitative follow-ups.

Adenocarcinoma↗

New perspectives on the clinical applications of functional radiology of the liver.

Preliminary results of "new clinical applications" of functional imaging of the liver are reported. In 20 healthy volunteers portal flow measurement with Doppler US at the level of right, left portal branch and main portal trunk, showed the preferential distribution in baseline conditions of portal flow to the right liver (about 68%) as compared to the left portal branch. This influenced MRI volumetry of right liver as compared to left liver. After meal intake, flow increase was significantly higher at the level of left portal branch suggestive for a "functional reserve" in left liver. Portal flow physiology was examined in preparation of portal imaging before and after portal vein embolization, a procedure performed preoperatively before enlarged hepatectomies.

Diagnostic Imaging↗

Clinical applications of neuroimaging in psychiatry.

New techniques are dramatically expanding current clinical applications of neuroimaging in neuropsychiatry. Neuroimaging research that examines brain structure and function relationships in neuropsychiatric disorders is also enhancing our understanding of the pathophysiology of neuropsychiatric illnesses such as dementia, focal CNS insult, schizophrenia, affective disorders, and neurodevelopmental disorders.

Brain↗

Clinical applications of 2D and 3D CT imaging of the airways--a review.

Hardware and software evolution has broadened the possibilities of 2D and 3D reformatting of spiral CT and MR data set. In the study of the thorax, intrinsic benefits of volumetric CT scanning and better quality of reconstructed images offer us the possibility to apply additional rendering techniques to everyday clinical practice. Considering the large number and redundancy of possible post-processing imaging techniques that we can apply to raw CT sections data, it is necessary to precisely set a well-defined number of clinical applications of each of them, by careful evaluation of their benefits and possible pitfalls in each clinical setting. In diagnostic evaluation of pathological processes affecting the airways, a huge number of thin sections is necessary for detailed appraisal and has to be evaluated, and information must then be transferred to referring clinicians. By additional rendering it is possible to make image evaluation and data transfer easier, faster, and more effective. In the study of central airways, additional rendering can be of interest for precise evaluation of the length, morphology, and degree of stenoses. It may help in depicting exactly the locoregional extent of central tumours by better display of relations with bronchovascular interfaces and can increase CT/bronchoscopy sinergy. It may allow closer radiotherapy planning and better depiction of air collections, and, finally, it could ease panoramic evaluation of the results of dynamic or functional studies, that are made possible by increased speed of spiral scanning. When applied to the evaluation of peripheral airways, as a completion to conventional HRCT scans, High-Resolution Volumetric CT, by projection slabs applied to target areas of interest, can better depict the profusion and extension of affected bronchial segments in bronchiectasis, influence the choice of different approaches for tissue sampling by better evaluation of the relations of lung nodules with the airways, or help to detect otherwise overlooked slight pathological findings. In the exploration of the air-spaces of the head and neck, targeted multiplanar study can now be performed without additional scanning by retro-reconstructed sections from original transverse CT slices. Additional rendering can help in surgical planning, by simulation of surgical approaches, and allows better integration with functional paranasal sinuses endoscopic surgery, by endoscopic perspective rendering. Whichever application we perform, the clinical value of 2D and 3D rendering techniques lies in the possibility of overcoming perceptual difficulties and 'slice pollution', by easing more efficient data transfer without loss of information. 3D imaging should not be considered, in the large majority of cases, as a diagnostic tool: looking at reformatted images may increase diagnostic accuracy in only very few cases, but an increase in diagnostic confidence could be not negligible. The purpose of the radiologist skilled in post-processing techniques should be that of modifying patient management, by more confident diagnostic evaluation, in a small number of patients, and, in a larger number of cases, by simplifying communication with referring physicians and surgeons. We will display in detail possible clinical applications of the different 2D and 3D imaging techniques, in the study of the tracheobronchial tree, larynx, nasal cavities and paranasal sinuses by Helical CT, review relating bibliography, and briefly discuss pitfalls and perspectives of CT rendering techniques for each field.

Humans↗

Clinical applications of tumour necrosis factor.

Tumour necrosis factor (TNF) is a polypeptide hormone produced in vivo by activated macrophages and lymphocytes. TNF has diverse effects in vivo and has a physiological role as an immune modulator, as a mediator of the immune response, both through activation of neutrophils and eosinophils, and also affects the vascular endothelium. TNF also has antiviral activity and causes alterations in lipid metabolism. In disease states excessive production of TNF may have adverse affects. TNF has been implicated as a mediator of endotoxic shock, inflammatory joint disease, immune deficiency states, allograft rejection, and in the cachexia associated with malignant disease and some parasitic infections. When used in pharmacological doses, TNF is cytotoxic to many malignant cells in vitro and in vivo. The mechanisms underlying cytotoxicity are not fully elucidated but involve both a direct toxic effect to the cell and an indirect effect on tumour vasculature. Cytotoxicity is not universal and TNF may act as a differentiating agent or growth factor for some haematological cell types. So far the clinical application of TNF has been as a treatment for cancer in Phase I and II trials in patients with advanced disease and its efficacy here is still unproven. TNF may have potential for clinical application in combination therapy for cancer. There is experimental evidence for its interaction with other biological agents and cytotoxic drugs. The use of specific antibodies to inhibit production of TNF, or other agents to antagonise the toxic effects of TNF may have clinical relevance in counteracting septic shock and the clinical manifestations of TNF in inflammatory and neoplastic disease.

Animals↗

Accuracy of volume measurements of computed tomography and magnetic resonance imaging phantoms by three-dimensional reconstruction and preliminary clinical application.

RATIONALE AND OBJECTIVES: Using an independent three-dimensional workstation, the accuracy of volume measurements of phantoms was assessed using three-dimensional reconstruction of two-dimensional computed tomography (CT) and magnetic resonance (MR) images. METHODS: Round, cylindrical, and irregularly shaped high-contrast phantoms of known volume were imaged in a water bath. The effect of object contrast on volume estimation was tested using phantoms of known volume diluted serially with a contrast agent. The effect of changing field of view and slice thickness was assessed. A clinical application was performed, in which nine shoulders were injected with a known quantity of contrast material, to test the accuracy of the technique in vivo. RESULTS: A strong paired correlation (r = .99) between estimated and true volumes was obtained for high-contrast phantoms ranging from 17 to 128 mL. The weighted average absolute error was 1.42 mL (MR) and 3.50 mL (CT). Accuracy of the serially diluted 27-mL phantoms was essentially unaffected by contrast differences greater than 133 units (MR) and 102 units (CT). The weighted average absolute error was 1.33 mL (MR) and 1.56 mL (CT). Changing field of view had no effect on accuracy, but increasing the slice thickness resulted in over-estimation of volume. The mean error for the clinical application was 4.4% (range: 1.7%-8.3%). CONCLUSION: Under certain circumstances, three-dimensional reconstructive volume estimation can be a convenient and accurate method for volume determination.

Humans↗

Dynamic contrast-enhanced MR imaging of musculoskeletal tumors: basic principles and clinical applications.

The purpose of this article is to review the basic principles and clinical applications of dynamic contrast-enhanced MRI in the musculoskeletal system. This method of physiologic imaging provides clinically useful information by depicting tissue vascularization and perfusion, capillary permeability, and composition of the interstitial space. Different imaging, evaluation, and postprocessing techniques are described. The most important applications in the musculoskeletal system are identification of areas of viable tumor for biopsy, tissue characterization, and monitoring of preoperative chemotherapy. Practical guidelines for performing a dynamic contrast-enhanced MR examination are proposed.

Adolescent↗

Flow cytometry: clinical applications in haematology.

The time interval between the development of a new technique or methodology and its acceptance, if successful, as a recognized clinical application can be many years. The application of flow cytometry to reticulocyte counting, for example, has taken 8 years from the appearance of the first publication, and in 1990 it is still in its infancy as a clinical method. It is therefore a challenging task to anticipate which of the methodologies currently under development will achieve acceptance. It would be impossible to deal with all the candidates in the space available, and so a review is provided to those methods that may have potential applications in clinical haematology, together with some of the more practical details of methods that have recently been demonstrated to be viable in the clinical laboratory. The first category consists of leukocyte enumeration and studies on bone marrow, neutrophils, platelets and cellular DNA content, whilst the second covers reticulocyte counting and total red cell volume measurement. The contribution of flow cytometry to the field of immunophenotyping haematological disorders is probably unique in already being clinically acceptable. Finally, the question of quality control is addressed, as this is an essential prerequisite to the adoption of any new method in the clinical laboratory.

Blood Cell Count↗

[Telomerase activity in gastrointestinal, bladder and breast carcinomas and their clinical applications].

Telomere ends are known to be shortened at every division of the cells. Telomerase is a ribonucleoprotein which compensate for the telomere ends and indispensable for the immortalization of the cells. It is reported that the enzyme is activated in a variety of cancer cells. In the present report, the enzyme was activated in more than 70% of gastrointestinal, bladder and breast cancer by TRAP assay. Moreover, in order to elucidate whether the enzyme activity is useful for the non-invasive detection of exfoliated cancer cells in the colon bowel washings, urine and fine needle aspirate of the breast tumors, TRAP assay was performed. In most of the cases, the positive findings were observed which support that the enzyme activity is useful for the clinical application. The expression of mRNA and protein for hTERT was detected in cancer cells, however, the assay contains the pitfall including the Taq inhibitor or telomerase inhibitor. Moreover, the activity is also detected although it is weak, in the benign or premalignant lesions. Further analysis is required for the clinical application of the method.

Adult↗

Distraction arthroplasty. Clinical applications.

The concept of a hinged-joint distraction device appears to have broad clinical application in those circumstances in which both joint motion and joint stability are simultaneous treatment goals. Under these circumstances, difficult clinical conditions can be effectively treated with the judicious application of this device.

Arthroplasty↗

Clinical application of event-related potentials in dementing illness: issues and problems.

Many of the problems associated with the clinical application of event-related potentials (ERPs) are well recognized. These include the broad inter-subject variability of peak latencies and amplitudes in control groups, as well as the apparent non-specificity of some ERP tests. In addition, it is often the case that the same test yields a different proportion of 'hits' (in terms of identification of abnormality in patients classified by other means as having dementia) when used by different research groups. This is almost certainly due to differences in the disease state of the patients being tested. The difference between hit rates identifies another important factor which is not often considered in the application of ERP tests in clinical medicine. This is that although an ERP test may identify abnormality in the later stages of disease, the true task for the test is to identify abnormality in early disease when evidence of cognitive dysfunction will be different and less frank than in later stages of the disorder. It is therefore, necessary to identify the cognitive deficits associated with the early stages of dementia and devise appropriate ERP tests to detect these deficits. A recent paper by Fox et al. (Fox, N.C., Warrington, E.K., Seiffer, A.L., Agnew, S.K., Rossor, M.N., 1998. Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer's disease. A longitudinal prospective study. Brain 121, 1631-1639.) suggests that ERP tests of verbal memory function may be the most sensitive for detecting the early stages of Alzheimer's disease.

Cognition Disorders↗