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Flat on your back or back to your flat? Sources of increased hospital services utilization among the elderly in British Columbia.

Between 1969 and 1985, the British Columbia hospital system allocated an increasing proportion of the province's total hospital days to elderly patients who stayed for 60 days or more. By 1985/86, long stay patients accounted for almost 50% of all days. In this paper, we explore the diagnoses which contributed the greatest number of patient days of increase among the elderly as a first step in evaluating the appropriateness of this response to the pressures of an aging population. Patient days of increase were not distributed smoothly across a large number of diagnoses, but could be explained by a small number of chronic conditions. Most important were conditions related to senility and senile dementia, the chronic sequelae of heart disease and stroke, and persons awaiting admission to adequate facilities elsewhere. Eighty percent of the increases were seen in extended care and rehabilitation beds and 20% in acute care beds. Seventy-seven percent of the increased patient days were attributable to females and only 23% to males. Since the major sources of increase in patient days were not related to conditions for which new, effective hospital care modalities are available, they call into question the appropriateness of the system's response to the health care needs of the elderly population.

Aged↗

A concise modular synthesis of 2,5-diethynyl-3,4-dibutyl-thiophene-bridged back-to-back terpyridine ligands.

The efficient synthesis of soluble and rigid terpyridine-based ditopic ligands bearing an increasing number of 2,5-diethynyl-3,4-dibutylthiophene (DEDBT) modules has demonstrated the advantages of a single convergent strategy based on a double coupling in a final step of monoterpyridine building blocks carrying the adequate number of thiophene modules with a diiodo-substituted thiophene subunit. This protocol enjoys the advantages of both efficiency and versatility and requires pivotal intermediates, which were produced by a step-by-step implementation of monoterpyridine fragments with a key thiophene intermediate carrying an iodo function, a propargylic-protecting group, and two butyl-solubilizing fragments. One set of experimental conditions is required to produce all the intermediates and the final ligands. Oxidative dimerization of monosubstituted terpyridine skeletons bearing one or two thiophene substituents and a terminal alkyne function, in the presence of cupric salts and oxygen, afforded the homotopic ligands with a central dithienylbutadiyne spacer. Optical properties for the new oligomers have been investigated and are discussed in terms of effective conjugation length and pi-electron conjugation. Upon increasing the number of interspersed DEDBT units, a significant lowering in energy of absorption and fluorescence transitions as well as of the quantum yields is observed.

Journal Article↗

Back to back autoradiography: a method for ultrastructural analysis of light microscopic autoradiographs.

A method for studying radiolabeled cells is described that combines the simplicity of light microscopic autoradiography with the high resolution of electron microscopy. Serial thin (600 A) and thick (1 micron) sections are placed on Formvar-coated slot grids and glass slides, respectively. Labeled cells are visualized on the thick section by autoradiography and may then be studied in the electron microscope by locating the corresponding fields on the grid. This technique permits accurate ultrastructural identification and analysis of radiolabeled cells, yet avoids the need for electron microscopic autoradiography.

Animals↗

Back to Europe: back to Bismarck?

Since 1989 there have been enormous changes in all aspects of health policy, and the Former Socialist Economies (FSEs) are facing similar challenges. The general restructuring of politics and economies has resulted in two leading orientations in the transformation of health care systems: the separation of funding and service provision from the state, and the separation of funding and service provision from each other. Many FSEs have already passed legislation establishing a sickness insurance system under a single national funding institution, or a combination of compulsory and voluntary insurance, or a system involving private sector insurance companies in generating compulsory or voluntary health care funding. Due to the peculiarities and specific features of the German health care system, the uncritical intention to implement the "Bismarck model" in the FSEs faces several problems. These can be summarized in one main point: the relative stability of the German health care system, which may be attractive to the FSEs, is based on economic prosperity and on a strong ability to assert the will of the central state institutions: these preconditions are not present in the FSEs.

Adult↗