[New problems in the treatment of ocular melanoma].
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Hepatic angiosarcoma is an infrequent neoplasm representing 1-3% of all the primary liver cancers. One fourth of the cases have demonstrated a relation with chemical carcinogens with the most frequent being thorium dioxide (thorotrast) and vinyl chloride. The case of an hepatic angiosarcoma which presented as an intraperitoneal hemorrhage in a patient who had undergone treatment with Neosalvarsán (dioxidiaminoarsenobenzol) 46 years beforehand is reported. The previous published reports include 6 cases of hepatic angiosarcoma related with treatment with arsenic salts and 4 cases in whom exposure was environmental.
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For the first time salvarsan treatment in Cracow was successfully held in Opthalmology Clinic of Jagiellonian University by Prof. Bolesław Wicherkiewicz, who used preparation 606 in three cases at ophthalmic complications caused by syphilis infection. He received this preparation directly from P. Ehrlich.