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PubMed1993

Evaluation of the disinfectant effect of a quick drying rubbing type povidone-iodine alcoholic solution by the glove juice method.

The antiseptic effect of povidone-iodine alcoholic solution (HAD Hand Wash), a newly developed quick drying rubbing type disinfectant, was evaluated in 40 subjects. Samples of hand bacteria were collected by the glove juice method. The bacteria were incubated, and a cell count was performed. Disinfection was carried out by rubbing 3 ml of HAD Hand Wash carefully on to the skin of the subjects' hands. The efficacy of the solution was evaluated by computing the bacterial reduction rates as compared to the pre-disinfection bacterial count after disinfecting once and three times. The bacterial cell count was significantly reduced from the pre-disinfection count for one hour after disinfecting once and for two hours after disinfecting three times. In addition, the bacterial reduction rate after disinfecting three times remained superior to that after disinfecting once over a period of two hours. We concluded that disinfecting once with HAD Hand Wash is sufficient for routine hygienic hand washing, while disinfecting three times is desirable when, as with surgical hand washing, the strictest antisepsis is required. HAD Hand Wash produced no adverse side effects.

Antisepsis↗

PubMed1977

[Asepsis and hospitalization in surgery].

The authors renews the interest in care of "hospital infection". Recent advances in clinical and epidemiologic research give us important informations and caution than we shall not be able in futher avoid them. Special care is needed and the frequency of post operative wound infections can be lowered due to respect asepsis and antisepsis principles. Of great importance are the hygienic, technical, surgical and education measures taken for preventing infections.

Antisepsis↗

PubMed1997

[Infectious risk in medical offices: a reality to be fought].

The notion of nosocomial infection is intimately related with that of working or sejourning in a health care institution and would thus not concern the physician's office. Nevertheless, the risk of infection does exist in this setting, both for patients and personnel, and requires adequate preventive measures. The practitioner is called upon to care for patients who have community-acquired or possibly nosocomial infections following hospitalization and must therefore know the type of germ involved, its characteristics, particularly antibiotic sensitivity, the predominant modes of transmission and preventive measures against propagation, latrogenic infections such as abscess formation at a point of injection or septic arthritis after infiltration may also occur. Other more technical procedures (endoscopy, minor surgery) may also be a cause of contamination. The practitioner also produces wastes (needles, vaccine syringes, dressings) which must be disposed of in accordance with legal regulations. One must avoid contaminating oneself in order not to contaminate others. This requires adequate knowledge and application of elementary rules concerning hand washing, asepsis, antisepsis, and waste disposal, essential links in the chain of infection transmission.

Antisepsis↗

PubMed2002

Simultaneous gastrointestinal surgery in patients with elective abdominal aortic reconstruction: an additional risk factor?

HYPOTHESIS: The management of simultaneously occurring intra-abdominal abnormalities and abdominal aortic aneurysms or aortoiliac occlusive disease is controversial. The aim of this retrospective study was to analyze whether gastrointestinal operations performed at the same time as aortic repair increase the postoperative morbidity and mortality rate. METHOD: Between January 1, 1989, and December 31, 1997, a total of 42 patients underwent open aortic tube (n = 33) or bifurcated grafting (n = 9) and simultaneous surgery of 1 or more gastrointestinal abnormalities. In a matched-pairs analysis for each of the aforementioned patients, a control patient with an exclusive aortic procedure was selected. For each matched pair the following aspects were noted: the type of operative procedure, time of execution, duration of the surgical procedure, the duration of postoperative ventilatory assistance, intensive care unit and hospital stays, the number of blood units transfused, the use of antibiotics, and the main postoperative complications. RESULTS: The comparison between the matched pairs revealed no statistically significant difference for postoperative morbidity or mortality rate or length of intensive care unit and hospital stays. There were no operative or hospital deaths. None of the patients has (median follow-up, 68 months) shown evidence of graft infection. CONCLUSION: A 1-stage operation management is feasible if appropriate care is given to the technical details and if the rules of antisepsis are followed.

Aged↗

PubMed1978

'Lethal' burns. A progress report.

Sixteen consecutive patients, nine of whom also had inhalation injury, had burns over 72% body surface area or more. The expected death rate was 94%. In fact, all of the eight patients still alive after 48 hours survived. The early deaths were primarily due to inhalation injury, the treatment of which remains an unsolved problem. A mixture of cerium nitrate and silver sulfadiazine was used for topical wound antisepsis. The wound flora was sparse: 447 of 814 wound-surface cultures were sterile; Gram-negative bacteria were recovered in 13%. This efficacious wound bacteriostasis appeared primarily responsible for the absence of late death.

Adolescent↗

PubMed1989

The efficacy of oral antimicrobials in reducing aerobic and anaerobic colonic mucosal flora.

We investigated the impact of intestinal antisepsis on the colonic mucosa-associated flora. Four groups of dogs were studied: group A received no bowel preparation, group B received a three-day clear-liquid diet, group C underwent mechanical cleansing of the bowel, and group D had mechanical cleansing followed by oral neomycin and erythromycin. Mucosal biopsy specimens were obtained for bacteriologic and scanning electron microscopic (SEM) studies. No significant difference in recovery of mucosal bacteria was observed between groups A and B. A significant decrease in recovery of aerobes was observed in group C, and a significant decrease in both aerobes and anaerobes was observed in group D compared with group A; Enterobacteriaceae and Bacteroides were either eliminated or greatly reduced. The SEM analysis of group D revealed a marked decrease in mucosa-associated microflora compared with groups B and C. Oral neomycin-erythromycin produced a significant quantitative reduction in the colonic mucosa-associated bacterial population, including the potentially pathogenic Escherichia coli and Bacteroides fragilis group isolates. These mucosa-associated bacteria are a likely source of contamination of the abdominal cavity and wound at the time of colon surgery.

Administration, Oral↗

PubMed1991

History of liver surgery.

Although battle surgeons had débrided small bits of liver protruding through wounds since ancient times, formal entry into the peritoneal cavity to staunch hemorrhage due to trauma or to remove tumors or drain cysts had to await the advent of general anesthesia and antisepsis. After a burst of pioneering activity from 1880 to 1910, little progress was made until after World War II. In the last 40 years, remarkable advances have been made in the techniques of liver resection, our understanding of liver diseases requiring operation, and our ability to support patients through major resections. Liver transplantation epitomizes the challenges that can now be accepted, and its success augurs well for an increase in liver operations in the future.

Hepatectomy↗

PubMed1976

Nosocomial pseudobacteremia. Positive blood cultures due to contaminated benzalkonium antiseptic.

Pseudomonas cepacia or Enterobacter species or both were isolated from blood cultures of 79 patients in a community hospital between April 1971 and March 1972. No common exposures other than venipuncture correlated with positive blood cultures. Pseudomonas cepacia, Enterobacter, and other Gram-negative enteric bacteria were cultured from aqueous benzalkonium chloride used for skin antisepsis prior to ordinary and blood culture venipuncture. Contamination of blood cultures by organisms from the antiseptic most likely accounted for positive cultures in 35 to 38 patients (92%) with P cepacia. The remaining three patients had repeated blood cultures positive for P cepacia and circumstantial clinical evidence of bacteremia; they may have contracted disease through exposure to the contaminated antiseptic. Substitution of an iodine-alcohol antiseptic abruptly reduced the isolation of P cepacia and Enterobacter.

Bacteria↗

PubMed2006

Prevention of infection in arterial reconstruction.

BACKGROUND: Arterial reconstructions with prosthetic graft materials or vein are susceptible to infection with a resultant high patient mortality and risk of limb loss. To reduce the risk of infection effective perioperative measures are essential. OBJECTIVES: To determine the effectiveness of perioperative strategies to prevent infection in patients undergoing peripheral arterial reconstruction. SEARCH STRATEGY: We searched the Cochrane Peripheral Vascular Diseases Group trials register (last searched May 2006) and the Cochrane Central Register of Controlled Trials (CENTRAL) (last searched Issue 2, 2006), and reference lists of relevant articles. SELECTION CRITERIA: All randomised controlled trials (RCTs) evaluating measures intended to reduce or prevent infection in arterial surgery. DATA COLLECTION AND ANALYSIS: AS and PSE independently selected and assessed the quality of included trials. Relative risk was used as a measure of effect for each dichotomous outcome. MAIN RESULTS: Thirty-five RCTs were included. Of these, 23 were trials of prophylactic systemic antibiotics, three of rifampicin-bonded grafts, three of preoperative skin antisepsis, two of suction wound drainage, two of minimally invasive in situ bypass techniques, and individual trials of intraoperative glove change and wound closure techniques. Wound infection or early graft infection outcomes were recorded in all trials. Only two trials, both of rifampicin bonding, followed up graft infection outcomes to two years. Trials of antibiotics versus placebo were of highest quality with six double-blind studies of the ten included. Prophylactic systemic antibiotics reduced the risk of wound infection (Relative Risk (RR) 0.25, 95% Confidence Interval (CI) 0.17 to 0.38) and early graft infection in a fixed-effect model (RR 0.31, 95% CI 0.11 to 0.85, P = 0.02). Antibiotic prophylaxis for greater than 24 hours appears to be of no added benefit (RR 1.28, 95% CI 0.82 to 1.98). There was no evidence that prophylactic rifampicin bonding to dacron grafts reduced graft infection at either one month (RR 0.63, 95% CI 0.27 to 1.49) or two years (RR 1.05, 95% CI 0.46 to 2.40). There was no evidence of a beneficial or detrimental effect on rates of wound infection with suction groin-wound drainage (RR 0.96 95% CI 0.50 to 1.86) or of any benefit from a preoperative bathing or shower regimen with antiseptic agents over unmedicated bathing (RR 0.97, 95% CI 0.70 to 1.36). AUTHORS' CONCLUSIONS: There is clear evidence of the benefits of prophylactic broad spectrum antibiotics. Many other interventions intended to reduce the risk of infection in arterial reconstruction lack evidence of effectiveness.

Antibiotic Prophylaxis↗

PubMedDate not supplied

Facial fractures: Hippocratic management.

Hippocrates, the famous Greek physician of the fifth century B.C., is considered to be the "Father of Medicine." Little, however, is known about his principles for the management of facial trauma. In this article, the Manuscripts in Ancient Greek, which deal with the management of mandibular fractures and dislocations, and with nasal and midfacial fractures have been translated and discussed. Hippocrates' methods for reducing mandibular dislocations and treating fractures of the mandible by wiring the teeth and immobilizing the jaw are described. His technique of closed reduction and immobilization of deviated nasal fractures with internal packing and rigid dorsal splints remains timeless. Hippocrates has taught us how to achieve medical wisdom through accurate clinical observation and practical creative ideas. The discovery of x-rays and antisepsis only furthered his established sound principles for the management of facial trauma.

Facial Bones↗

PubMed1998

Ligand binding to the (1 --> 3)-beta-D-glucan receptor stimulates NFkappaB activation, but not apoptosis in U937 cells.

Recent data suggest that sepsis stimulates macrophage apoptosis (Ao) with subsequent induction of macrophage dysfunction. Nuclear factor-kappaB (NFkappaB) activation has been linked to Ao in either a pro- or antiapoptotic role. Glucans are biological response modifiers which exert antisepsis activity. This investigation examined the effect of (1-3)-beta-D-glucan receptor binding by a high affinity ligand on Ao and NFkappaB activation in U937 cells in the presence or absence of LPS. A high affinity glucan ligand (IC50 = 23 nM) activated NFkappaB, but did not induce Ao or significantly alter LPS induced U937 Ao. These data indicate that: i) modulation of the macrophage (1-3)-beta-D-glucan receptor stimulates NFkappaB; ii) does not induce Ao or significantly diminish LPS induced Ao and iii) activation of the U937 FAS receptor does not alter the relative Ao responses in glucan and LPS treated cells.

Antibodies↗

PubMed1999

Removal of Formaldehyde by Activated Carbons Containing Amino Groups.

Formaldehyde has been used for disinfection and antisepsis in hospitals due to its bactericidal action, but it is toxic to humans. Hence, we developed adsorbates for the removal of formaldehyde. The adsorbate was prepared by the amination of an activated carbon surface. The removal efficiency and the adsorption mechanism of formaldehyde onto the aminated activated carbon were studied. The concentrated sulfuric acid and nitric acid treatment introduced nitro groups onto the surface of the activated carbon. The nitro groups were reduced by the reaction of powdered iron and hydrochloric acid to the amino groups. The amount of formaldehyde adsorbed onto the activated carbon increased with the amination of the activated carbon because of the increasing interaction between the surface of the activated carbon and the formaldehyde. Copyright 1999 Academic Press.

Journal Article↗

PubMed1985

Resolution of late-developing periprosthetic breast infections without prosthesis removal.

Based on prior experience with implant exposure, an aggressive regimen to eradicate periprosthetic infections has proven successful in delayed gram-positive and gram-negative bacterial infections and in atypical microbacterial infections. The objective of the "salvage" procedure is to retain a prosthesis, to maintain breast contour, and to avoid psychological and physical consequences of prosthesis removal. The "salvage" procedure involves topical antisepsis, contracture release if needed, systemic and topical antibiotics with intermittent or continuous irrigation, and reinforcement of incision lines in selected cases using local tissue flaps.

Breast↗

PubMedDate not supplied

A new simple test for evaluation of intestinal bacteria.

We investigated a newly synthesized conjugate of ursodeoxycholic acid with para-aminobenzoic acid (PABA) to determine its suitability to evaluate enteric bacteria. This compound, PABA-UDCA, is deconjugated by cholylglycine hydrolase to release free PABA whereas it is completely resistant to deconjugation by pancreatic and intestinal mucosal enzymes. In bacteriological experiments, almost all of the microorganisms which split glycocholic acid deconjugated this compound. In animal experiments, urinary excretions of PABA were measured for 6 hours following oral administration of 10 mg PABA-UDCA. Ten control rats excreted 338.5 +/- 43.8 micrograms (mean +/- SD) of PABA; 10 rats with intestinal bacterial overgrowth due to enteric stagnant loops excreted more (673.6 +/- 222.1 micrograms; p less than 0.01), whereas 10 rats in each of 8 groups with intestinal antisepsis by oral administration of various antibiotics excreted significantly less (p less than 0.001) (ampicillin + doxycycline + fradiomycin: 18.3 +/- 16.7, polymixin B + tinidazole: 14.0 +/- 8.0, polymixin B: 224.9 +/- 74.3, tinidazole: 42.7 +/- 27.3, kanamycin: 50.3 +/- 18.2, clindamycin: 57.4 +/- 23.3, vancomycin: 70.4 +/- 27.0, and paromomycin: 160.4 +/- 51.9 micrograms). These observations indicate that this compound is likely to offer a simple and rapid method for evaluation of intestinal microorganisms without the use of radioisotopes or expensive, special apparatus.

4-Aminobenzoic Acid↗

PubMedDate not supplied

Preperitoneal herniorrhaphy: a historical review.

From ancient times, both the transabdominal (posterior) and the groin (anterior) approach have been used either singly or in combination in the management of inguinofemoral herniation. Development accelerated in the nineteenth century after Lister introduced antisepsis. Although Bassini and Halsted conducted their classic procedures in the preperitoneal plane, it was Cheatle, in 1920, who first performed transabdominal preperitoneal herniorrhaphy. In 1950, McEvedy described the lateral approach, which was made popular by Nyhus and Condon in the 1960's. The problem of relaxing incisions and the importance of prosthetic repair through this exposure are substantiated along with the anatomy of the preperitoneal fatty layer and the results of sutureless bilateral herniorrhaphy.

General Surgery↗

PubMed1980

Air conditioning systems.

There are some basic requirements for air conditioning systems in operating theatres. 1. Obviously the regulation of temperature and humidity is necessary, but cleaning of fresh air and circulating air is much more important. 2. Concerning cleaning, a high standard of filtration of air is demanded to avoid contamination of wounds. 3. So far only HEPA-filters, a technical description, give security and safety. They filter particles down to under 1 micrometer and have a filtration rate of more than 99.9%. 4. The ventilation rate is directly related to the germ concentration in the air. The higher the ventilation rate the cleaner the air during working. 5. To avoid turbulences unidirectional or uniform flow is necessary. This technique has become popular as the laminar flow technique. To get such a flow an air flow velocity of 0 45 +/- 0.1 m/s is necessary. 6. The arrangement of the different working places in an operating theatre is very important. Instrument tables and the operation field itself have to be in the zone of first air. 7. One of the commonest germ dispersion sources is the human body. Proper dressing and behaviour have to be observed. The airflow behind a person (in laminar cross flow) or under a person (in laminar down flow for instance when the neurosurgeon bends his head over the operating field) has to be regarded as contaminated. 8. Hygienic controls must be made in the operation theatre when unused and also under working conditions, in a sophisticated manner. If all these points are respected a real clean room technique is possible with considerable lowering of the risk of infection for the patient. Obviously all the other rules of hygiene, i.e., asepsis and antisepsis, elaborated since the days of Lister, have to be strictly respected.

Air Conditioning↗

PubMed1996

Hook-needle puncture. A new technique of local anesthesia for anorectal surgery.

PURPOSE: Anorectal surgery has been increasingly performed as an ambulatory procedure using general, regional, and local anesthesia. Local anesthesia is classically performed through infiltration of four quadrants around the anal verge, which renders the procedure painful and uncomfortable for most surgeons and patients. We present a new, painless technique of local anesthesia for anorectal surgery. METHODS: Patients with surgical risk Classes I and II (American Society of Anesthesiologists) bearing anorectal pathologies were sedated and placed on the operating table in the prone jackknife position. After local antisepsis, the anal canal was lubricated with 2 percent lidocaine gel, and the mucosa was punctured by a hook-shaped, curved, 22-gauge needle just above the pectinate line. A solution of local anesthetics was slowly infused in all four quadrants to the submucosal level. If needed, more anesthetics were infused during the operation. RESULTS: This technique was easily and painlessly applied in more than 60 patients and permitted execution of several ambulatory anorectal procedures with comfort and safety. CONCLUSIONS: The hook-needle puncture for local anesthesia is an effective and safe procedure and may be routinely used for ambulatory anorectal surgery in selected patients.

Ambulatory Surgical Procedures↗

PubMed1994

[Local antiseptics in surgery--rebirth and advances].

The history of antisepsis is marked by names such as Pringle, Lister, Billroth, Koch, Kocher, von Volkmann, von Nussbaum, Schloffer and Carrel. The revolutionary initial success of Lister's method was followed by severe setbacks because persisting biological intolerance of the chemical and physical antiseptics prevented the main purpose of application: killing bacteria without damaging cells. Until the discovery of penicillin the predominantly used antiseptics were perubalsam (balsamum peruvianum), azo-dyes (Rivanol), and sulphonamides (Cibazol). The dawn of the "antibiotic age" demonstrated once more the limits of locally applied therapeutic effectiveness of these substances (antiseptics, antibiotics) and was often outweighed by the damage caused. For the same reason systemicly applied substances frequently lack satisfactory effectiveness in the area of tissue damage. Experiences with intraoperative and postoperative wound lavage have shown that favourable results achieved by this surgical procedure are more likely due to the mechanical cleaning process than to the effectiveness of the locally applied substances being limited by the restricted duration of influence and the restricted depth of tissue penetration. Taking into account earlier studies and long-term experiences, antiseptic solutions were tested in view of their tissue compatibility, their biologic availability, and their effectiveness in close cooperation of clinic, bacteriology and laboratory medicine. The coordinated investigations resulted in a solution of biguanid (Lavasept) which is free from iodine, quicksilver, PVP and aldehyde. It can be applied for local treatment of wounds liable to infection, as an adjuvant for wound treatment in cases of acute tissue infections, as well as in the surgival practise to take care of acute and chronic infections of soft tissue. Sofar locally applied antiseptics in surgery have proved to be less satisfactory than considered in the course of their history due to side effects, e.g. tissue damage. Coordinated investigations now present an antiseptic solution of biguanid which can be used in various cases of wound treatment to prevent or counteract infections.

Administration, Topical↗