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At least 379 records · Page 21Linked to original sources
PubMed1977

Appearance of a gastric ulcer during diphosphonate therapy in a woman with CRST syndrome.

A 46-year-old woman with the CRST variant of scleroderma (calcinosis, Raynaud's phenomenon, sclerodactyly, and telangiectasis) was treated with a diphosphonate (disodium etidronate) in an effort to reduce her dystrophic calcifications or retard their progression. After 18 months of therapy, no improvement in her calcinosis was noted. In addition, she developed bloody diarrhea, epigastric burning, and weight loss during the last two months of Therapy. Upper gastrointestinal series revealed a gastric ulcer. Endoscopy with biopsy proved it to be benign. Gastric ulcerations has been seen in animals given disodium etidronate but only at much higher doses than are currently recommended for humans. Although a cause and effect relationship cannot be established with certainty in this patient, it is suggested since she was not receiving other ulcerogenic drugs chronically. This information may be important to other investigators of disodium etidronate.

Calcinosis↗
PubMed1982

Cosmetic dermatologic surgery.

This article deals with the office treatment of several common cosmetic problems. The topic of benign lesions is discussed, which includes the management of lentigines, milia, spider nevi, telangiectasis, xanthelasma, and keloids. The use of several modalities for the treatment of acne scarring is advocated; these include dermabrasion, punch-transplant replacement techniques, and collagen implants. Chemical face peels for actinic damage and premature wrinkling are described, and the use of hair transplants, scalp-reduction techniques, and scale flaps to surgically correct male-pattern alopecia are discussed.

Acne Vulgaris↗
PubMed1982

Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis.

Antinuclear and/or antinucleolar antibodies were demonstrated in the sera of 74 of 76 patients (97%) with progressive systemic sclerosis, using tissue culture cells (HEp-2) as substrate in the indirect immunofluorescent method. Six patterns of nuclear staining and three nucleolar patterns were recognized. The nuclear patterns were centromere, fine speckles, coarse speckles, diffusely grainy, homogeneous and nuclear dots. The nucleolar patterns were speckled, homogeneous and clumpy. The results of digestion studies with ribonuclease, deoxyribonuclease and trypsin suggested that the nuclear antigens are proteins, some of which may be associated with chromatin. The nucleolar antigens appeared to be nucleic acid in nature. Certain characteristic serologic and clinical features associated with staining patterns were observed. The diffusely grainy pattern was seen only in sera containing antibody to Scl-70 antigen. Centromere staining was confirmed to be highly selective for the CREST (Calcinosis, Raynaud's phenomenon, esophageal involvement, sclerodactyly and telangiectasis) variant of progressive systemic sclerosis with rheumatoid factor titres higher in these patients with anti-centromere antibodies.

Adult↗
PubMed1995

[Castleman's lymphoma presenting marked bronchial obstruction and compression of the great vessels: a case report].

A 24-year-old Caucasian male from Chile developed mediastinal Castleman's lymphoma, hyaline-vascular type, occupying from upper pre-tracheal to sub-carinal region, severely compressing the trachea, left main bronchus, pulmonary artery, and pericardium. Bronchofiberscopy demonstrated complete obstruction of the left main bronchus and the severe telangiectasis of the mucosa. The patient complained of the stridor and shortness of breath. The left thoracotomy had been performed in Chile, but unsucceeded in extirpation because of the adherence and the hypervascularity of the tumor. After 24 Gy irradiation, we performed the right thoracotomy and succeeded in extirpation of the tumor. It was the key for success that we could approach from right side under left sided unilateral ventilation. Castleman's lymphoma is not a rare disease, but the manifestation due to the bronchial obstruction is uncommon. So we present this case and review the literatures.

Adult↗
PubMed1997

Ovarian cancer and unilateral naevoid telangiectasia: a rare association.

The Authors describe the case of a 58-year-old woman affected by erythematous telangiectasis lesions on the antero-lateral surface of the right hip during papillary serous cystoadenocarcinoma of the right ovary. The diagnosis, based on clinical and histological findings, was unilateral naevoid telangiectasia. After a review of literature the Authors assume a possible role of the oestrogens in the pathogenesis of such infrequent disease.

Cystadenocarcinoma, Serous↗
PubMed2004

Laser treatment of rosacea: a pathoetiological study.

OBJECTIVE: To study the effect of laser treatment on rosacea, a common facial skin disease with symptoms of blushing, redness, telangiectasis, papules, pustules, and diffuse swelling of the skin, we focused on the stinging sensation and performed immunohistochemical evaluation of nerve density and neuropeptide expression. DESIGN: Clinical investigation as well as the lactic acid (stinger) test was performed before and 3 months after the treatment with flashlamp pulsed dye laser, when skin biopsy specimens were also taken. SETTING: University hospital. PATIENTS: Thirty-two patients with rosacea, all with positive results from the lactic acid "stinger" test, were treated by flashlamp pulsed dye laser. MAIN OUTCOME MEASURES: The biopsy specimens were taken from the stinger-positive areas in the nasolabial folds, fixed in Lanas fixative (10% formalin and 0.4% picric acid), and analyzed for the expression of protein gene product 9.5 (general nerve marker), substance P, calcitonin gene-related peptide, and vasoactive intestinal polypeptide, using a biotinylated streptavidin technique. RESULTS: Thirty-one patients who were stinger positive before treatment showed decreased scores after treatment, and 1 patient had the same stinger test score before and after treatment. The number of protein gene product 9.5-positive fibers in the epidermis (P< .05) as well as the papillary dermis (P< .01) was decreased. This was also the case for substance P in the papillary dermis (P< .001), whereas no evident difference was noted for vasoactive intestinal polypeptide and calcitonin gene-related peptide. No difference was found for contact between nerves and vessels (factor VIII positive). CONCLUSIONS: Laser treatment of rosacea that destroys small vessels has a good medical relevance because it reduces the unpleasant symptoms of the sensitive skin. A neurogenic etiology of stinging may be possible.

Adult↗
PubMed2000

Retinal vasoproliferative tumors: surgical management and histological findings.

Vascular masses occurring in the peripheral retina have been described extensively in the literature. Many terms, including "presumed acquired hemangiomas," "hemangioma-like," "angiomatous masses," "angioma-like," "peripheral retinal telangiectasis," and "vasoproliferative tumors," have been suggested that reflect the lack of the known histological features and the potentially variable causes. We describe the histological features of 2 patients who underwent transcleral local resection as management for suspected choroidal melanoma. Pathological examination of these tumors reveals the constituents to be primarily benign glial cell proliferation with secondary vasoproliferation. The weight of the literature agrees with a reactionary process. We therefore suggest the term "reactionary retinal glioangiosis." Transcleral resection has a place where diagnosis is difficult. It prevents an unnecessary enucleation and allows accurate tissue diagnosis.

Cell Division↗
PubMed1982

Visual field changes in cone-rod degenerations.

The visual field test results from 20 patients with con-rod degeneration (CRD) from all inheritance patterns were reviewed. Typical fundus findings of CRD included optic disc pseudoedema, temporal disc atrophy, parapapillary and disc telangiectasis, and few to no retinal pigmentary deposits. Visual field changes were seen to be distinctive and, like electrophysiologic tests, were helpful in pointing to a retinal degenerative process rather than an optic neuropathy.

Adolescent↗
PubMedDate not supplied

Electron beam therapy for eyelid carcinomas.

Forty-six (85%) basal cell and eight (15%) squamous cell carcinomas of the eyelids were treated with electron beams between 1963 and 1983. Lesion sizes ranged from microscopic to 4 cm, with 28 lesions larger than 1 cm. Thirty-eight lesions were treated with radiotherapy after incisional biopsy, and 16 were treated after excisional biopsy (specimens showed positive margins). Doses varied from 45 to 72 Gy, with daily fractions ranging from 2.12 to 4.0 Gy. There were six disease recurrences (10.9%): three in the treatment field and three at the treatment margin. Four of six recurrences were subsequently controlled by limited surgical excision and repair with preservation of the eye, whereas the other two required enucleation. Treatment sequelae such as skin atrophy, telangiectasis, and cosmetic results were evaluated in terms of radiotherapy parameters, pretreatment surgery, and size of the lesion. In 44 patients, the overall cosmetic result was judged as good to excellent, five patients had a mild to modest degree of deformity, and five had significant deformity. Such deformity was usually associated with tumor destruction or previous surgery. No major complications were noted.

Aged↗
PubMed2006

Acute toxicity, behavioral changes, and histopathological effects of deltamethrin on tissues (gills, liver, brain, spleen, kidney, muscle, skin) of Nile tilapia (Oreochromis niloticus L.) fingerlings.

Deltamethrin, a synthetic pyrethroid contaminating aquatic ecosystems as a potential toxic pollutant, was investigated in the present study for acute toxicity. The purpose of this study was to evaluate LC(50) values of deltamethrin on Nile tilapia (Oreochromis niloticus L.) fingerlings and investigate histopathological responses of fish exposed to deltamethrin. The 48 h LC(50) value for Nile tilapia fingerlings was estimated as 4.85 microg/L using static test system. In addition, behavioral changes at each deltamethrin concentration were observed closely. All fish, exposed to 5 microg/L deltamethrin revealed severe morphological alterations in the gills and liver. In the gills hyperemia, fusion of secondary lamellae and telangiectasis were observed; whereas hydropic degenerations in liver were observed in all examined fish. The results are significant for reporting acute deltamethrin toxicity in terms of behavioral and histopathological changes: Deltamethrin is highly toxic to fingerlings.

Animals↗
PubMedDate not supplied

Hepatic color Doppler sonography for hereditary hemorrhagic telangiectasia.

Liver involvement with hereditary hemorrhagic telangiectasis (HHT) is not a rare condition. Its angiographic abnormalities are well known, but reports of the sonographic and, especially, color Doppler sonographic findings are limited. We present a patient with HHT and describe the hepatic color Doppler sonographic findings.

Female↗
PubMed2002

Side effects after radiotherapy of age-related macular degeneration with the Nijmegen technique.

BACKGROUND: In a randomized trial concerning radiotherapy for age-related macular degeneration, fluorescein angiograms were taken of controls and patients. In this study the frequency of side effects in eyes receiving radiotherapy with the Nijmegen technique is compared with the findings in the eyes of controls. METHODS: Patients receiving treatment were irradiated by two isocentric photon beams in four fractions of 6 Gy that were directed to the macular area at 30 degrees and -30 degrees with regard to the optical axis. The most recent fluorescein angiograms of the randomized eyes (32 treated and 31 control eyes) were scored by two independent researchers, using a scoring form with nine features of radiation retinopathy: nonperfusion, macular edema, microaneurysms, retinal hemorrhages, cotton-wool spots, perifoveal telangiectasis, vascular sheathing, retinal neovascularization, and radiation-associated choroidal neovasculopathy. The results were graded as: no retinopathy (grade 0), mild retinopathy (grade 1), moderate retinopathy (grade 2), and severe retinopathy (grade 3). RESULTS: In the treated group 6 patients (18.8%) were grade 1, 10 patients (31.2%) were grade 2 and 7 patients (21.9%) were grade 3. In the control group 9 patients (29.0%) were grade 1, 11 patients (35.5%)were grade 2 and 2 patients (6.5%) were grade 3. There were no patients with retinal neovascularization. CONCLUSION: With the Nijmegen technique a relatively high dose of radiation can be applied to a small retinal area. In only a minority of cases does some evidence of radiation retinopathy occur.

Aged↗
PubMed1987

Barrett's metaplasia and adenocarcinoma of the esophagus in scleroderma.

Gastroesophageal reflux is well documented in scleroderma, but the complications of Barrett's metaplasia and adenocarcinoma are not well described. The records of 75 patients with scleroderma seen over a four-year period at the Hospital of the University of Pennsylvania were retrospectively reviewed to determine the prevalence of Barrett's metaplasia and adenocarcinoma of the esophagus and to identify clinical, manometric, laboratory, or radiographic criteria that might predict the presence of these lesions. Twenty-four of these patients underwent endoscopy. In this group, the prevalence of Barrett's metaplasia was 37 percent (nine patients) and adenocarcinoma was also present in two of these patients. The patients with and without Barrett's metaplasia were similar in age (range, 22 to 64 compared with 28 to 79, respectively), sex (six of nine compared with 12 of 15 female, respectively), frequency of esophageal motility disorders, presence of proximal skin involvement, digital ulceration, and pulmonary involvement as measured by diffusion capacity. Barrett's metaplasia was diagnosed on the basis of double-contrast esophagographic results in only one of eight patients with Barrett's metaplasia so-studied. Patients with Barrett's metaplasia tended to have longer duration of heartburn (90 +/- 40 months compared with 11 +/- 35 months) and dysphagia (39 +/- 22 months compared with 7 +/- 3 months). Patients with Barrett's metaplasia also tended to have greater impairment of lower esophageal sphincter pressure either at end-expiration (4.0 +/- 2.1 compared with 6.1 +/- 1.8 mm Hg) or mid-respiration (13.0 +/- 3.0 compared with 16.9 +/- 2.5 mm Hg). Using chi-square analysis, however, none of these differences reached statistical significance. Discrimination did occur on the basis of the presence of the CREST (calcinosis, Raynaud's phenomenon, esophageal manifestations of scleroderma, sclerodactyly, and telangiectasis) variant (55 percent compared with 7 percent, p less than 0.01), a duration of dysphagia of more than five months (p less than 0.03), and mid-respiratory lower esophageal sphincter pressure of less than 10 mm Hg (p less than 0.05). It is suggested that: Barrett's metaplasia of the esophagus occurs in one third of patients with scleroderma; clinical, manometric, laboratory, and radiographic features are poor predictors of the presence of Barrett's metaplasia; patients with CREST syndrome, prolonged dysphagia, or a very low lower esophageal sphincter pressure may have an increased risk for the development of metaplasia; patients with scleroderma and Barrett's metaplasia have an increased risk of complications such as stricture or adenocarcinoma.(ABSTRACT TRUNCATED AT 400 WORDS)

Adenocarcinoma↗
PubMed1992

Primary hepatic tumours in cattle. A classification of 66 cases.

A study of 66 primary hepatic tumours was carried out on cattle. These consisted almost entirely of adult females. Fifty hepatocellular tumours (10 adenomas and 40 carcinomas), 10 cholangiocellular tumours (three adenomas and seven carcinomas), two cavernous haemangiomas, two haemangioendothelial sarcomas, one fibroma and one Schwannoma were diagnosed. The 50 hepatocellular tumours were classified into adenomas (20 per cent) and carcinomas (80 per cent), both prevalent in the solitary macronodular form. The hepatocellular carcinomas were divided into six groups based on their distinctive histological arrangement and the morphology of the neoplastic cells: trabecular (55 per cent), pseudoglandular (10 per cent), solid (12 per cent), scirrhous (12 per cent), pleomorphic (7 per cent) and fibrolamellar (2 per cent). Twenty-seven of 50 hepatocellular tumours (54 per cent) were associated with features of blood-filled lakes resembling telangiectasis within the neoplastic tissue. Metastasis was uncommon (10 per cent of hepatocellular carcinomas) and grading according to Edmondson's system (1958) showed a low level of anaplasia in most carcinomas (55 per cent). An association with cirrhosis was never found.

Adenoma, Bile Duct↗
PubMed1977

Ataxia telangiectasia: the effects of chemical mutagens and x-rays on sister chromatid exchanges in blood lymphocytes.

It is now possible to examine in detail exchanges between sister chromatids (SCEs) and to attempt to investigate the relationships of such exchanges to aberration formation and DNA-repair mechanisms. The frequency of SCEs is dramatically increased by chemical mutagens and may reflect the level of DNA damage. Lymphocytes from patients with ataxia telangiectasis (AT) show high levels of spontaneous chromosome damage and are hypersentive to ionising radiations and it was of interest to examine the levels of SCE induced in these cells by various mutagens. The frequencies of SCE after treatment with X=rays or three chemical mutagens were equivalent to those in normal cells. The effects of fluorodeoxyuridine and deoxycytidine on SCE frequencies were also tested.

Ataxia Telangiectasia↗
PubMed1989

Effects of crude oil on the air-breathing organs of the striped gourami, Colisa fasciatus: a SEM study.

Pathological effects of crude oil on the air-breathing organs of the striped gourami, Colisa fasciatus, were studied using SEM. Buccal epithelium appeared to be more sensitive to crude oil than epithelia of the suprabranchial chamber and the labyrinthine organ. Lower doses of crude oil caused mucous cell hyperplasia, shrinkage of respiratory epithelium, and telangiectasis of blood capillaries in the air-breathing organs. Manifestations of lethal pathological effects including mucous cell hypertrophy, lesions, and sloughing of air-breathing epithelium increased with increasing crude oil concentration and exposure period.

Animals↗
PubMed1984

Chronic toxicity/carcinogenesis study of temazepam in mice and rats.

The benzodiazepine temazepam was given to Charles River CD rats for 2 years in the diet at dosages of 10, 40, and 160 mg/kg day. An 18-month study was performed in Charles River CD-1 mice via dietary admixture at dosages of 10, 80, and 160 mg/kg/day. Mean body weights were significantly decreased for high dose rats of both sexes from Treatment Week 39 until termination. All drug treated male groups had a higher rate of mortality when compared to the male control groups, primarily due to deaths occurring between 19 to 24 months. Compound-related hepatic lipidosis accompanied by an increase in liver weights was observed at the high dose level in the 6- and 12-month and terminal sacrifices, as well as the middle dose level at the 12-month interim sacrifice. No evidence was found of compound induced carcinogenicity at any time period. Mortality for male mice was significantly higher in the two higher dose groups; this resulted from bite wounds associated with a drug-related increase in fighting behavior. An isolated finding of borderline statistical significance (p = 0.0556) was noted for hepatocellular adenomas in high dose female mice (4/100) at the 18-month terminal sacrifice. This incidence is well within the reported historical control range (0-14%). Minimal hepatoproliferative (hyperplastic nodules) and vascular effects (telangiectasis) were seen in the high dose male and female mice at the 18-month terminal sacrifice. Thus, these results were similar to those previously reported for oxazepam although meaningful effects on neoplasia did not occur with temazepam. Unlike in man, temazepam is primarily metabolized to oxazepam in the mouse and thus these results are not adverse with regard to human safety evaluation.

Animals↗
PubMed1983

Combined moderate dose electron beam radiotherapy and topical chemotherapy for cutaneous T-Cell lymphoma.

Between October, 1978 and June, 1979, nine patients with biopsy-proven cutaneous T-Cell lymphoma were treated with combined total-skin electron beam radiation (TSEB) and topical chemotherapy. TSEB was administered using 3.8 MeV electron and dual exposure technique. All patients received skin dose of 400 rad once weekly to a total dose of 2000 to 2400 rad followed by topical chemotherapy with mechlorethamine hydrochloride (HN2) two to four weeks after completion of radiation. A complete response followed TSEB in seven of nine patients, but a relapse of disease activity has subsequently occurred within the first year for all the patients despite adjunct therapy, except for one patient who remains disease free for more than 21 months. Generalized severe erythema developed during or shortly after completion of radiation in six of nine patients, with blistering at the overlapping treatment fields and body folds in four patients. In addition four patients developed diffuse permanent telangiectasia of skin and one patient developed linear sclerosis, telangiectasis and painful ischemic ulceration on the fingertips two years after completion of electron beam therapy. Most patients had evidence of mild depression of lymphocyte responsiveness to Phytohemagglutinin after TSEB. Our conclusion is that the short-term benefits and convenience of this particular technique do not justify the acute and chronic toxicity encountered.

Administration, Topical↗