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Chronic cutaneous polyarteritis nodosa simulating recurrent thrombophlebitis.

A 30-year-old man who had 12 repeated hospital admissions within a period of 7 years for localized pain and swelling of the extremities is described. Excision biopsy of several subcutaneous lesions revealed histologic changes typical of polyarteritis nodosa (PN). Systemic disease was excluded because of a normal testicular biopsy, negative abdominal angiogram, and the lack of evidence for renal or other visceral involvement. Response to steroid therapy was excellent. Cutaneous PN is a distinct subset of polyarteritis with a chronic course and excellent prognosis. The present case underlines the need for a greater awareness, and for considering early biopsy of suspected lesions in patients with multiple episodes of apparent superficial thrombophlebitis.

Adult↗

[The treatment of thrombophlebitis in a specialized polyclinic].

Under analysis are results of treatment of 150 patients with different forms of acute and chronic thrombophlebitis under conditions of polyclinic. Methods of treatment are described which allowed the time of invalidism to become 2-3 times shorter.

Ambulatory Care↗

Pitfalls in establishing the diagnosis of deep venous thrombophlebitis by indium-111 platelet scintigraphy.

Forty-seven 111In-platelet scintigraphs (In-PS) were analyzed retrospectively to identify sources of diagnostic error and to optimize the diagnostic criteria for active deep venous thrombophlebitis (DVT). The results of In-PS were compared with contrast venography, additional diagnostic studies, and clinical outcome. Three patterns of platelet localization emerged as the best predictors of active DVT: (a) focal or (b) linear 4-hr localization, or (c) an asymmetric blood-pool pattern on 4-hr imaging that evolved into a focal or linear pattern by 16 to 24 hr. All false-positive studies had abnormal patterns confined to the inguinal region at 24 hr. All patients with false-negative studies had received heparin between 4 and 24 hr. The potential pitfalls encountered in the evaluation of the iliac, femoral, and popliteal veins are reviewed and the importance of delayed imaging in selected cases is emphasized.

Blood Platelets↗

Audit of anticoagulant therapy of pulmonary embolus, deep vein thrombosis and thrombophlebitis.

The use of heparin sodium and warfarin sodium in the treatment of pulmonary embolus (PE), deep vein thrombosis (DVT) and thrombophlebitis (TP) was studied by a hospital pharmacy department. During a four-month period, the charts of 26 patients were audited for anticoagulant dosages used; laboratory test monitoring of anticoagulant dosage used; laboratory test minitoring of anticoagulant therapy; complications of, contraindications to, and patient compliance with anticoagulant therapy. These variables were evaluated on the basis of compliance with a written anticoagulant protocol. Initial doses of heparin sodium and warfarin sodium were acceptable in 43% of patients. Maintenance dosing with heparin sodium was acceptable in 89% of patients. Activated partial thromboplastin times (APTT) were ordered correctly for 65% of patients. APTTs were within therapeutic ranges in 31% of patients. The duration of heparin-warfarin overlap was possibly to definitely acceptable in 71% of patients. Prothrombin times were properly monitored in 50% of patients. Complications of anticoagulant therapy were evident in only one patient. There were a number of potentially serious diversions from the protocol. The pharmacy department planned to issue bulletins designed to correct the problems.

Adult↗

[Behçet's disease and vascular malformations: double etiology of recurrent thrombophlebitis].

Repeated thrombophlebitis with pulmonary embolism in a 28-year-old female led to the discovery of a complex malformation of the inferior vena cava which required the insertion of a clip. Three years later, recurrence of phlebitis with appearance of bipolar aphthae, arthritis and a meningeal syndrome led to the diagnosis of Behçet disease. Despite various medications for this disorder and heparin or oral anticoagulant therapy, the thromboembolic disease remained active, accompany with new exacerbations of Behçet disease. Diminished plasma fibrinolytic activity was demonstrated, probably resulting from venous endothelial vascularitis, which aggravates the consequences of the preexisting vascular malformation.

Adult↗

Haemophilus influenzae septic thrombophlebitis following use of a "scalp-vein" needle.

Indolent Haemophilus influenzae type B septic thrombophlebitis developed in a 14-year-old boy two weeks after completing a course of intravenous antibiotics administered via a "scalp-vein" needle for an unrelated infection. Presumably, the primary disease (common variable immunodeficiency) contributed to the simultaneous occurrence of this uncommon complication of scalp-vein needle use, with an unusual pathogen.

Adolescent↗

A posterior ascending popliteal cyst mimicking thrombophlebitis following total knee arthroplasty (TKA).

Pain and swelling of the lower extremity following total knee arthroplasty are not infrequent. The most frequent conditions responsible for these symptoms include thrombophlebitis, prosthetic loosening, infection, and fracture of either the prosthesis or the bones. In addition to these conditions, a dissecting or ruptured popliteal cyst should be considered in the differential diagnosis of acute calf pain and swelling following total knee arthroplasty. Two patients with symptoms of phlebothrombosis were evaluated retrospectively two to three years following total knee arthroplasty. In both patients the popliteal cysts dissected proximally into the thigh. A dissecting popliteal cyst is diagnosed by arthrography. The usual arthrographic films evaluated for a Baker's or popliteal cyst are anteroposterior and lateral views of the calf. These films are inadequate in patients who have undergone total knee arthroplasty; the dissecting cysts observed in the patients of the present report dissected proximally above the knee and were diagnosed on anteroposterior and lateral views of the distal femur. The more common symptoms noted after total knee arthroplasty should not be excluded due to the presence of a dissecting or ruptured cyst, as one of the patients of the present report also had a superimposed infection. Clinical considerations of a dissecting popliteal cyst are emphasized so that arthrography can be performed early in the course of the symptoms and proper treatment initiated.

Aged↗

The diagnosis of puerperal ovarian vein thrombophlebitis by computed axial tomography scan.

The diagnosis of puerperal ovarian vein thrombophlebitis by computed axial tomography (CAT) scan is reported. The characteristic finding, ie, a soft tissue mass with a diameter of 2 cm and length of 14 cm, extending from the uterine cornua to the level of the renal vein, can be seen by CAT scan. The near total resolution of the mass on follow-up CAT scan confirmed successful treatment with antibiotics and heparin. Observation of these findings will allow future cases to be definitively diagnosed and treated without invasive procedures.

Adult↗

The usefulness of fibrin degradation products (FDP) in detection of postphlebographic thrombophlebitis.

In 8 out of 9 patients with postphlebographic thrombophlebitis (DVT), increased amounts of fibrin degradation products (FDP) were recorded on one or more occasions during six days' follow up, as compared to 20 out of 45 patients in the DVT negative group. FDP determination is insufficient as a sole parameter in identifying patients developing postphlebographic DVT.

Fibrin Fibrinogen Degradation Products↗

[Clinico-epidemiological study of patients with phlebolymphatic diseases admitted to the hospitals of the Piedmont region 1976-1979. IV. Analysis of thrombophlebitis].

In the 1976-79 period, 8040 cases of thrombophlebitis, equivalent to 0.17% of the population, were admitted to Piedmontese hospitals, an average of 1 admission every 4 hours and 3 minutes. The present study revealed a numerical and percentage increase with increasing age. The figures per age group from each individual clinic revealed two large areas in the East and South West of the Region where phlebitis cases were numerically lower than the regional average. In other areas figures were higher than estimated, while still others produced statistically insignificant figures. An interpretation of these results is attempted.

Adult↗

[Controlled study on the efficacy of external treatment in surface-near thrombophlebitis].

The efficacy of an organo-heparinoid ointment (Hirudoid 40,000) compared with a placebo ointment was tested in a double blind trial on 40 patients with post-operative infusion thrombophlebitis. It was possible to provide objective data by means of the 125I-fibrinogen test for accelerated regression of thrombi following treatment with organo-heparinoid. The differences found between the 2 treatment groups were statistically significant. The clinical results conformed largely to the measured data. Especially pain and swelling were favourably affected by treatment with the active compound. 1 case of local allergic reaction to organo-heparinoid was observed. No further side-effects were seen.

Drug Evaluation↗

[Thrombophlebitis in the minor pelvis in problems with differential diagnosis in gynecologic oncology].

The oncologic-gynecology practice shows that vein thrombophlebitis of the pelvis minor causes retroperitonal spreading of malignant tumor of the cervix or growth of the ovarian neoplasm. In cases of unexplained etiology, the existance of malignant tumors as an etiologic factor, should be excluded by the examination performed by an experienced gyneocologist-oncologist, by ultrasonography, computerized tomography and in case of doubt by explorative laparotomy.

Adult↗

Papillophlebitis associated with systemic thrombophlebitis: case report.

This 36-year-old white man developed signs and symptoms of mild reversible papillophlebitis associated with calf thrombophlebitis and subsequent mammary and antecubital vein phlebitis after fluorescein angiography.This in flammatory process in conjunction with phlebitis elsewhere in the body strongly suggests that localized phlebitis of the central retinal vein, perhaps near its exit from the optic nerve, is etiologic in papillophlebitis. Response to corticosteroids tends to support this theory.

Adult↗

[Complications of superficial thrombophlebitis].

Phlebitis and varicophlebitis are regarded as harmless diseases easily treated by compression and local measures such as incisions and applications. However, recent experience has revealed that they are often complicated by growth of the superficial thrombus into the deep veins, by noncontiguous calf thrombosis, and by usually asymptomatic pulmonary embolism. We prospectively examined 25 consecutive patients using duplex scanning (21x) and/or ascending venography (15x). The phlebitic process involved a varicose greater saphenous vein or a branch thereof (19x), the lesser saphenous vein (3x) or a nonvaricose superficial vein (3x). In 11 cases (44%) we found direct extension to involve the deep vein system and/or noncontiguous isolated calf or popliteal vein thrombosis. The presence of risk factors for deep vein thrombosis and a painful calf muscle were good clinical indicators of such complications. Patients with complications were anticoagulated on an outpatient basis. The course was uneventful in most cases. Our study confirms the notion that superficial thrombophlebitis is often part of a more extended thromboembolic process. This implies diagnostic and therapeutic consequences, although the prognostic significance of such complications is not clear at the moment.

Adult↗

Thrombophlebitis and varicosis syndrome in pregnancy.

Venous stasis of the lower limbs is common in pregnancy; the thromboembolic complications are 1 in 1000 and become reduplicated in puerperium. The management of 13 patients with deep venous thrombophlebitis of the lower limbs during pregnancy, the fetal outcome and delivery were evaluated retrospectively. The delivery indications were the classic ones. Therapy was administration of calcium heparin and an angio-protector like diosmina. Good results, whether fetal outcome or mother morbidity in puerperium, were obtained.

Adolescent↗