Night waking in infants during the first 14 months.
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Early experience in the context of suckling at the nipple is a crucial determinant of neurobehavioral development in mammals. In particular, milk has been recognized by developmental psychobiologists as an ecologically relevant sensory stimulus and should be viewed by clinicians as more than a source of nutrition in early human development. Gaining access to and processing milk during suckling serves as a primary focus of activity in the newborn. Because the rat fetus lacks prior exposure to milk or other suckling stimuli, it provides an excellent model system for investigating the development of milk-related responses. Fetal exposure to milk results in a cascade of behavioral, physiological and neurochemical consequences. Milk-induced activation of the endogenous opioid system plays an important role in reorganizing fetal motor activity, altering sensory responsiveness and supporting associative learning in the fetus. Subtle changes in contextual stimulation alter the ability of milk to engage different neurochemical systems. These findings suggest that the infant's first experiences with milk and other suckling stimuli may have lasting consequences for neurobehavioral development.
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Breastfeeding the premature infant is both possible and desirable. Premature infants derive benefits from breast milk that they can not receive from formula. Nutritional issues look at the components of breast milk as they relate to brain growth and development and disease protection in the acute setting and later in childhood. Recommendations for clinical practice are provided, as are information on expressing and collecting milk, breastfeeding readiness, putting the infant to breast, and discharge planning.
BACKGROUND: Oral feeding is one of the most complicated tasks for a preterm infant to achieve. AIM: To identify the factors associated with the start and extension (time) of oral feeding transition in preterm infants. METHOD: 40 preterm infants born with gestational ages of 34 weeks and 6 days maximum. RESULTS: Pulmonary, cardiac, hematological medical complications and the presence of infection present statistically significant relation to the start and extension of oral feeding transition in preterm infants. CONCLUSION: The speech-pathologist who works at Neonatal Care Units should have the knowledge about the factors that interfere in the ability of preterm infants to be orally fed, so that the assistance given by this professional is more efficient and secure.
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Pregnant rats were exposed to ethanol (two doses of 6.4 g/kg spaced by an interval of 6 hours, administered through an intragastric cannula) on the 8th day of gestation; control rats received two identical administrations of isocaloric sucrose. No significant differences were found in body weight and litter size of experimental and control pups 24 hours after delivery. When offsprings of ethanol treated mothers were tested in different postnatal behavioral tasks, significant developmental delays (suckling behavior and surface righting) were revealed during the lactation period, and an impaired passive avoidance performance was found at 40 days old compared to control offsprings.
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Polychlorinated biphenyls are environmental contaminants known to affect neurobehavioral development in many laboratory studies using different animal models. Because of their bioaccumulation and long half-life they are a serious concern for our own species. The dioxin-like PCB congener 3,4,3',4'-tetrachlorobiphenyl (PCB 77) has estrogenic and anti-estrogenic properties, and has been shown to affect brain chemistry and behavior of developing rats when administered during gestation. Since many developmental outcomes in mammals depend upon the type of maternal care provided by the dams, we investigated the effects of two doses of PCB 77 (2 and 4 mg/kg administered during gestational days 6-18) on the maternal behavior of the treated dams. Both doses of PCB 77 reduced the amount of nursing time in which the dams displayed the high-crouch posture over postnatal days 1-6. In addition, the high dose increased the amount of maternal licking and grooming of the litters and the amount of time the dams spent on the nest. The high dose also increased pup mortality, and both doses reduced the weight gain of the litters during the first 6 days of life. These results document effects of PCB 77 on maternal behavior and serve to raise questions about the importance of maternal contributions to the developmental effects of this and similar contaminants.
Maternal behavior in rats consists of active behaviors, such as retrieval and licking of pups, and quiescent nursing, including the suckling-induced kyphotic (upright, dorsally-arched) posture. Because lesions of the dorsolateral, but not of the dorsal, columns are known to prevent the suckling-induced milk-ejection reflex, we asked whether the same is true for kyphosis as well. Bilateral lesions of the dorsolateral funiculus (DLF) or dorsal columns (DC) at spinal segments C(4-6) were made on day 5-8 postpartum; controls (CON) were subjected to a sham procedure. All aspects of maternal behavior and lactation were present in CON and DC dams soon after treatment. Among DLF dams, two had poor postural, ambulatory, and ingestive recovery that was associated with large lesions extending to the ventrolateral columns, while one with very small lesions continued to lactate. Of the remaining eight DLF dams, milk ejection was lost while recovery of retrieval and licking of pups occurred in all (between 1 and 4 days after surgery). All eight were quiescent for long periods in response to suckling but they did not display sustained kyphosis; rather, they nursed while prone or hunched over the pups, with little or no leg support, or while supine. Ventral trunk cutaneous sensitivity was present in all subjects. These data suggest that the dorsolateral funiculus relays both suckling-induced neuroendocrine and postural nursing reflexes that are mediated by separate supraspinal regions, hypothalamus and the ventrolateral sectors of the caudal periaqueductal gray, respectively.
1. To determine the relative roles of the prenatal and postnatal (preweaning) environment on the development of blood pressure and growth rate in the spontaneously hypertensive rat (SHR) of the Okamoto strain, we used combined embryo transfer and cross-fostering techniques between SHR and normotensive Wistar-Kyoto (WKY) rats to produce offspring whose development was examined during the first 20 weeks of life. 2. We measured litter sizes, bodyweights and tail-cuff blood pressures in offspring at 4, 8, 12 and 20 weeks of age. We also recorded heart, kidney and adrenal weights at 20 weeks of age, when the study concluded. 3. We found that both the in utero and postnatal environments provided by the SHR mother could significantly affect WKY rat offspring growth rates, but blood pressure was unaffected in this strain. In SHR offspring, the SHR maternal in utero and suckling period both contributed to the rate of blood pressure development in the SHR, but not the final blood pressure of offspring at 20 weeks of age. This effect was greater for male than female offspring. Organ weights were largely unaffected by the perinatal environment in either strain. 4. We conclude that although the SHR maternal in utero and immediate postnatal environment both contribute to the rate of blood pressure development in the SHR, they do not appear to contribute to the final blood pressure of offspring at maturity. The SHR maternal environment also alters growth rate that may, in turn, underlie these effects on SHR blood pressure development, particularly in males.
The purpose of this study was to describe the dietary habits of infants and toddlers living in Sweden with special reference to caries prevalence at 2 and 3 years of age and to immigrant status. The study was designed as a prospective, longitudinal study starting with 671 children aged 1 year. At 3 years, all children were invited to a further examination. A total of 298 individuals, randomly selected from the original group, were also examined at 2 years. The accompanying parent was interviewed about the child's dietary habits. Children with caries at 2 and 3 years of age and immigrant children had, when they were 1 year old, consumed caries-risk products and been given nocturnal meals and sweetened liquid in a feeding bottle more often than caries-free 2- and 3-year-olds and non-immigrant children. Although a great variation in dietary habits was found in infants and toddlers, the use of sugar-containing products is widespread in Sweden even in early childhood.
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