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372 records · Page 21Linked to original sources
PubMed1986

[Immunological activity of the blood sera from cattle with chronic mycotoxicosis].

Attempts were made to disclose and reproduce the immunologic activity of the blood sera of cows, aborted fetuses, and newborn calves in feeding the cows with feeds acted upon by small amounts of toxic moulds. Studied were blood samples of cows in advanced pregnancy or such that had freshly calved, of cows with liver dystrophy, and of newborn calves with toxic dyspepsia. The methods of immunodiffusion and immunoelectrophoresis were employed. It was found that in continuous feeding with mould-affected forages the toxins that gained access into the body attacked chiefly the liver. Along with other changes it induced the release of a complex antigen that was likely to bear the character of both the toxin and the liver proteins. It is believed that the process of building up of specific immune defense against mycotoxins is more complex and continuous. Thus, the immunity obtained is not so effective as in the case of microbial infections.

Abortion, Veterinary↗
PubMed1984

Inhibition of human lymphocyte natural cytotoxicity and antibody-dependent cell-mediated cytotoxicity by K-76 COONa, a reagent that blocks complement activity.

K-76 COONa is a 440 m.w. fungal product that can inhibit complement activity of C5 and Factor I. K-76 COONa abrogated both human natural killer (NK) cell activity and antibody-dependent cell-mediated cytotoxicity (ADCC) (ID50 approximately 1.5 mM). To be effective, K-76 COONa had to be present during the assay, because pretreatment of lymphocytes with highly inhibitory concentrations of K-76 COONa did not inhibit cytolysis. The monocarboxylic K-76 derivative was more inhibitory to NK than the dicarboxylic derivative. This relative efficacy is similar to that observed for inhibition of complement lysis. K-76 COONa inhibited NK when added before NK conjugate formation, but had little effect when added after conjugate formation. The compound also inhibited the formation of conjugates by NK and K cells. Therefore, this reagent selectively affected events that occurred between the initial effector-target cell interactions and the formation of stable conjugates. It had little influence on the post-binding "lethal hit" stage of cytolysis. These data imply a) that if any molecules similar to C5 are activated during the "lethal hit" stage of cytolysis, then they are inaccessible to K-76 COONa , and b) that C3bi-like molecules may be involved in lymphocyte binding.

Antibody-Dependent Cell Cytotoxicity↗
PubMed1980

Currently available methods for home mold surveys. II. Examples of problem homes surveyed.

Results of mold surveys in seven homes are reported. The advantages and disadvantages of the different techniques for mold evaluation are illustrated. No one sampling technique is adequate for detection of endogenous mold problems. Ideally, one should incorporate direct Scotch tape imprints, direct cultures of suspected material, Andersen sampling and a rotorod study to obtain an accurate assessment of the endogenous mold population.

Alternaria↗
PubMed1997

Update: pulmonary hemorrhage/hemosiderosis among infants--Cleveland, Ohio, 1993-1996.

In November 1994, private physicians and public health officials in Cleveland, Ohio, and CDC reported a cluster of eight cases of acute pulmonary hemorrhage/hemosiderosis that had occurred during January 1993-November 1994 among infants in one area of the city. Two additional cases were identified in December 1994. All 10 infants lived within seven contiguous postal tracts in eastern metropolitan Cleveland. Pulmonary hemorrhages recurred in five of the infants after they returned to their homes shortly after hospital discharge; one infant died as a result of pulmonary hemorrhage. This report summarizes the findings of the follow-up investigation, including a case-control study and an assessment by the county coroner of cases of infant death. These findings documented an association between acute pulmonary hemorrhage/hemosiderosis in this cluster of cases and mold growth in their water-damaged homes.

Acute Disease↗