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At least 379 records · Page 21Linked to original sources
PubMed1992

Reproduction toxicity of sertaconazole. Segment II (teratology) and Segment III (peri-postnatal toxicity).

The reproduction toxicity of 7-chloro-3-[1-(2,4-dichlorophenyl)-2- (1H-imidazol-1-yl)ethoxy-methyl]benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) (50, 100 and 150 mg/kg by oral route) has been investigated by performing two studies: the embryotoxicity or teratology study in rats and rabbits, and the peri-postnatal toxicity study in rats. According to the results obtained from the embryotoxicity studies, there was no maternal toxicity in either of the two species studied. The only embryofoetal abnormalities with statistical and toxicological significance were observed at the dose of 150 mg/kg in the teratology study on rabbits: hepatomegalia, pericardial oedema and peritoneal and hepatic haemorrhages. The results of the peri-postnatal study showed that the only maternal effect relating to the drug was an increase, proportional to the dose, in the weight of the ovaries, which was significant at the dose of 150 mg/kg. With reference to the offspring, only a reduction in the viability index at 150 mg/kg was observed. The non observed effects level (NOEL) for all three studies can be estimated at 100 mg/kg.

Aging↗
PubMed1989

[Segment-by-segment histological analysis of the cervical part of the spinal cord, roots of the cerebrospinal nerves and ganglia in severe cranio-cerebral trauma].

Sectional material has been investigated by means of Nissl, Bielschowsky-Gros, Mallory methods, staining with hematoxylin -- eosin. At a severe craniocervical trauma, at its acute and subacute periods, in the cervical part of the spinal cord, predominantly at the level CI-II and CV-VIII congestive phenomena, plasmorrhagia, diapedesic hemorrhagias, slightly and greatly altered neural cells are observed; the destroyed elements are predominantly localized in the posterior horns and in the intermediate zone. In the spinal ganglia among many moderately altered nervous cells, severely damaged ones are observed. However, they appear earlier and occur more often than in the spinal cord. The death of the nervous cells is accompanied with decay of their neurites in the corresponding roots. As demonstrate the results obtained, the severe craniocerebral trauma can be considered from anatomical positions, as a cerebrospinal lesion. Thus, it is possible to interpret the pathogenesis of complications more fully (especially from the visceral sphere of the patient) and in accordance with it, improve the diagnostic and treatment problems.

Brain Injuries↗