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At least 379 records · Page 21Linked to original sources
PubMed2004

The worm's sense of smell. Development of functional diversity in the chemosensory system of Caenorhabditis elegans.

Animals sense their chemical environment using multiple chemosensory neuron types, each of which exhibits characteristic response properties. The chemosensory neurons of the nematode Caenorhabditis elegans provide an excellent system in which to explore the developmental mechanisms giving rise to this functional diversity. In this review, we discuss the principles underlying the patterning, generation, differentiation, and diversification of chemosensory neuron subtypes in C. elegans. Current knowledge of the molecular mechanisms underlying each of these individual steps is derived from work in different model organisms. It is essential to describe the complete developmental pathways in each organism to determine whether functional diversification in chemosensory systems is achieved via conserved or novel mechanisms. Such a complete description may be possible in C. elegans.

Animals↗
PubMed1991

Disorders in taste and smell.

Although many conditions and medications have been associated with chemosensory disturbances, data from major chemosensory clinical research centers support three major disorders as being causative: nasal and paranasal sinus disease (21%), post-upper respiratory tract viral infection (19%), and head trauma (14%). Despite extensive evaluation, 22% of patients do not demonstrate identifiable causation.

Craniocerebral Trauma↗
PubMed2002

Effect of sex steroids and coital experience on ferrets' preference for the smell, sight and sound of conspecifics.

Previous research showed that ferrets of both sexes recognize potential opposite-sex mates on the basis of volatile body odors. We compared the ability of estrogen and androgen treatments to activate a preference in gonadectomized male and female ferrets for distal cues (volatile body odors alone or volatile odors+sight+sounds) from male versus female stimulus ferrets using an airtight Y-maze and a "stimulus proximity" or a "discrete trials" testing paradigm. Sexually naive, gonadectomized male and female ferrets that received either testosterone propionate (TP) or estradiol benzoate (EB) spent equal time in proximity to goal boxes that provided either volatile odors alone or odors+sight+sounds of male and female stimulus animals. After they received coital experience, male and female subjects (treated with either EB or TP) showed a significant preference for both types of opposite-sex stimuli. When discrete trials tests were given to these ferrets prior to receiving coital experience, EB-treated females preferred to approach odor only cues, as well as odors+sight+sounds of stimulus males, and this preference was further strengthened after coital experience. Sexually naive, TP-treated males preferred to approach volatile odor cues from stimulus females; however, these animals showed an equal preference for odors+sight+sounds of stimulus females and males. Again, after coital experience, males' preference for both sets of cues from stimulus females was significantly enhanced. Thus, in sexually naive ferrets, discrete trials, but not stimulus proximity tests, revealed a preference for distal cues (body odors with or without concurrent sight and sounds) from opposite-sex conspecifics in subjects of both sexes. Coital experience significantly enhanced these preferences for heterosexual distal cues under both testing paradigms.

Animal Communication↗
PubMed1994

Does the newborn baby find the nipple by smell?

We studied the involvement of naturally occurring odours in guiding the baby to the nipple. One breast of each participating mother was washed immediately after delivery. The newborn infant was placed prone between the breasts. Of 30 infants, 22 spontaneously selected the unwashed breast. The washing procedure had no effect on breast temperature. We concluded that the infants responded to olfactory differences between the washed and unwashed breasts.

Breast Feeding↗
PubMed1992

Olfactory pathways and the sense of smell.

Rats were trained using operant conditioning to detect isoamyl acetate vapor generated by an olfactometer. They received lesions of olfactory pathways and were tested for retention of the odor detection task and trained on two-odor tasks. Deficits in odor detection and two-odor discrimination were related to the extent to which lesions disconnected the olfactory bulb from the forebrain. Transection of only the lateral olfactory tract, only the anterior limb of the anterior commissure, or lesions of the olfactory tubercle had little effect but combined lesions of these structures produced severe deficits in both odor detection and discrimination. Only rats with almost complete transection of the olfactory peduncle or cortex were anosmic; those with transections that spared a small segment of tissue between the olfactory bulb and olfactory cortex had detectable olfactory function. The results are discussed with regard to efferent connections of the olfactory bulb.

Animals↗
PubMed2002

A bug's smell--research into insect olfaction.

The olfactory system has become an important model system for neurobiological function and sensory processing. In insects, odours play a vital role in all aspects of life. From the late 1950s until very recently, research into the structure and function of the insect olfactory system has often preceded similar investigations in vertebrates and has been important in the formulation of general principles.

Animals↗
PubMed2003

Putting smell on the map.

The vertebrate olfactory system must cope with a staggering developmental problem: how to connect millions of olfactory neurons expressing different odorant receptors to appropriate targets in the brain. Recent studies demonstrate remarkable plasticity in integrating novel olfactory neurons into this circuitry.

Animals↗