Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “SERRATIA”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 379 records · Page 21Linked to original sources
PubMed1986

Serratia liquefaciens mastitis in a dairy herd.

Serratia liquefaciens mastitis was detected and investigated in a 41-cow Holstein herd. Twenty cows were treated for mastitis over a 3-month period. Serratia liquefaciens was isolated from milk samples obtained from 8 of 12 cows tested during the epizootic. Results of an epidemiologic investigation suggested that extensive frostbite of the teats decreased the udder defense. Poor milking technique and hygiene were responsible for increased exposure of the damaged teats to potential udder pathogens. Treatment of each cow resulted in initial clinical improvement, but exacerbations occurred in 75% of the cows with documented S liquefaciens infections.

Animals↗
PubMed1979

Antibiotic-resistant Serratia marcescens infection in a hospital.

Over a 12-month period, 74 isolates of Serratia marcescens were obtained from various sources at Tygerberg Hospital. The majority of these isolates were from catheterized patients with urinary tract infections, and were non-pigmented and resistant to all antibiotics tested, excepting amikacin and neomycin. All isolates transferred resistance to tobramycin, gentamicin and tetracycline by conjugation to Escherichia coli recipients as separate markers at low frequency. A non-self-transmissible plasmid conferring resistance to kanamycin, ampicillin and gentamicin was mobilized from Serratia species to E. coli, and became fully self-transmissible in subsequent matings.

Cross Infection↗
PubMed1979

[Nuclease-antibodies in infections with Serratia marcescens (author's transl)].

A total of 467 presumable healthy men of age eighteen yielded titres of anti-serratia-nuclease that ranged from 1:4 to 1:6. One third of 56 patients, who had been infected with Serratia marcescens (urinary-, wound-, respiratory-infections, and bacteremia) yielded raised anti-nuclease titres, which amounted maximaly 1:16. The diagnostic utility of this serological test was discussed.

Adolescent↗
PubMedDate not supplied

Synergy of vancomycin with penicillins and cephalosporins against pseudomonas, klebsiella, and serratia.

A model of antibiotic synergy based on a molecular mechanism of action which blocked sequential steps in a single metabolic pathway was tested. Twenty-five strains each of Pseudomonas, Klebsiella, and Serratia were tested in vitro against three different two drug combinations of vancomycin, carbenicillin, or cephalothin. Synergy was observed when vancomycin was combined with either carbenicillin or cephalothin against isolates of Pseudomonas or Serratia, whereas the combination of carbenicillin and cephalothin did not result in significant synergy against these isolates. The presence of synergy was not related to the sensitivity or resistance of the isolates to the drugs in the combination. Synergy was also observed with all three antibiotic combinations against Klebsiella isolates which may be related to enzyme inactivation by one of the drugs in the combination. These observations support the hypothetical model of antibiotic synergy based on sequential blocking of one biochemical pathway.

Carbenicillin↗
PubMedDate not supplied

[Effect of cultivation conditions on lipase biosynthesis by Serratia marcescens].

The effect of cultivation conditions (the composition of the growth medium, pH, temperature) on lipase biosynthesis was studied with Serratia marcescens 345 and Serratia marcescens 348. The composition of the medium was found to be of key importance for lipase synthesis; the highest lipolytic activity of S. marcescens 345 was detected on the medium with 5% soybean flour broth while that of S. marcescens 348 was displayed on MPB. Sodium salts of cholic acids added at different concentrations to the growth medium had different effect on the biosynthesis of exo- and endolipases by the two strains.

Bile Acids and Salts↗
PubMed1984

Inhibitory effect of some transition metal ions on growth and pigment formation of Serratia marcescens.

The inhibitory effect of several first transition metal ions on growth and pigment formation on three strains of Serratia marcescens was studied by the method of minimal inhibitory concentration. From this study it can be concluded that several of the first transition metal ions, namely Cr (II), Mn (II), Fe (II), Co (II) and Cu (II), with the inclusion of Zn (II), have a definite inhibitory effect on both growth (strains 08, WF, 933) and pigment formation (strain 08) of Serratia marcescens. Based on their electron configuration and their effectiveness, these first transition metal ions can be divided into two groups: Cr (II), Mn (II), Fe (II) and Co (II), Ni (II), Cu (II) and Zn (II). Several suggestions were made to explain their inhibitory actions.

Chromium↗
PubMed1983

Serratia rubidae endophthalmitis following penetrating ocular injury.

A 10-year-old boy incurred penetrating trauma to his left eye by a small piece of wood. Immediate lens aspiration and repair of his corneal laceration were performed. The patient, however, demonstrated "persistent severe uveitis." On the fourth day following his injury, an uncomplicated pars plana vitrectomy was performed in combination with intracameral injection of gentamicin, cefazolin, and dexamethasone. Cultures of the vitrectomy specimen demonstrated Serratia rubidae. Postvitrectomy treatment with parenteral gentamicin, cefazolin, prednisone, and oral trimethoprimsulfamethoxazole resulted in a complete cure of the endophthalmitis and retention of good visual function. This patient represents the first reported case of Serratia rubidae endophthalmitis.

Bacterial Infections↗
PubMed1984

Serratia spp infection in 21 horses.

Twenty-three isolations of Serratia spp were made from 21 horses at the University of Florida Veterinary Medical Teaching Hospital between Jan 1, 1979 and July 1, 1983. Three Serratia spp were involved in single-organism and mixed infections of various tissues. Eight horses of this group died. All horses that died had massive, mixed, gram-negative infection. The other 13 responded to treatment, including systemic antibiotic therapy. Most of these horses were stressed and under antibiotic therapy prior to the time of culture. Possible nosocomial infection, variable antibiotic sensitivity, and a trend toward decreased antibiotic sensitivity after antibiotic administration were noted.

Animals↗
PubMed1982

Pulmonary clearance of Haemophilus pleuropneumoniae and Serratia marcescens in mice.

Bacterial counts (per lung) were made from Swiss White and/or C3H mice, inoculated intranasally with either Haemophilus pleuropneumoniae or Serratia marcescens and killed at specific times. The percentages of bacterial survival and clearance at each time were determined. Serratia marcescens was cleared progressively, but not completely, from the lungs of C3H and Swiss White mice. The overall pulmonary clearance of S marcescens by Swiss White mice was significantly greater than that of C3H mice (P less than 0.01). The pulmonary clearance pattern of H pleuropneumoniae in C3H mice differed according to the dose inoculated. With a larger H pleuropneumoniae median lethal dose (0.1 LD50), the organism multiplied consistently up to 25 times by 12 hours after the inoculations were done, when clinical signs and lesions appeared in a few of the mice. The clearance rates at 24 and 48 hours after inoculations were 60.65% and 10.3%, respectively. Mice given 0.04 LD50 H pleuropneumoniae showed a 10-fold increase of H pleuropneumoniae in the first 4 hours, with clearances reaching 33%, 66%, and 99% at 8, 12, and 24 hours, respectively.

Animals↗
PubMed1980

In vitro investigations on the action fosfomycin alone and in combination with other antibiotics on Pseudomonas aeruginosa and Serratia marcescens.

86.4% of the Pseudomonas aeruginosa and 91% of the Serratia marcescens strains were sensitive to fosfomycin. In combination with mezlocillin, cefoxitin, gentamicin and nalidixic acid a synergistic action was detected against these bacterial strains. It was most marked in the combination fosfomycin/nalidixic acid against Serratia marcescens. An acceleration of the fosfomycin action on the bacterial cells and the speed of bacteriolysis was observed in weakly acid medium (pH 6.0), in the presence of 10% active human serum and with increasing glucose-6-phosphate concentrations in the test medium. There is no parallel resistance between gentamicin and fosfomycin against Pseudomonas aeruginosa.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Hospital infection due to Serratia marcescens and its sensitivity to antibiotics].

A total of 164 isolations of Serratia marcescens achieved during 1978-1979 at the Hospital Infantil de México in children with various pathology due to this bacteria were studied. Most of the cases were debilitated patients from the newborns and prematures wards and contagious and surgery departments. The most frequent isolations were from wounds and abscesses (76 cases), the same as from meningitis (22 cases) and sepsis (12 patients). Serratia marcescens showed a high degree of resistance (87-100%) to the following antibiotics: carbenicillin, colimycin, chloramphenicol, phosphomicin, ampicillin and cephalothin. To gestamicin and kanamycin, 42% of strains were sensitive. Amikacin was the most effective drug with 92% of strains susceptible to it. The history of this bacteria, its mode of transmission, frequency of infections and resistance to antibiotics found in foreign institutions are commented. Likewise, the difficulty for the precision bacteriologic diagnosis is emphasized as the possible main cause for the ignorance in Mexico of infections due to this bacteria.

Anti-Bacterial Agents↗
PubMed1980

["Serratia marcescens" in neonatology: epidemiology of a hazard (author's transl)].

A case of meningitis, caused by Serratia marcescens in a 6-day old newborn triggered a search for Serratia in the Neonatology ward. Fifteen out of 38 newborns were found fecal carriers of S. marcescens. The source of S. marcescens was found in flasks containing almond oil with 1% cetyltrimethylammonium bromide used for skin care. All strain of S. marcescens belonged to pigmented biotype A6a and serotype 014 : H10. The spread of S. marcescens was controlled by heat sterilizing and renewing twice a week the almond oil flasks. Means of control of contamination sources are discussed.

Dermatologic Agents↗
PubMed1982

[Morphological alterations in Escherichia coli and Serratia marcescens induced by cefotetan (author's transl)].

The effects of cefotetan (CTT, YM09330) and cefmetazole (CMZ) on the morphological changes of Escherichia coli NY-17 and Serratia marcescens IID 620 were examined with scanning electron microscope. 1) CTT and caused E. Coli NY-17 filamentous forms at 0.024 microgram/ml but CMZ showed same morphological changes at 0.2 microgram/ml which is about 10 fold higher concentration than that of CTT. Spheroplast like structures and cell lysis were observed at lower concentrations than those of CMZ. 2) In case of Serratia marcescens IID 620, filamentous forms, spheroplast like structures and cell lysis were also observed at lower concentrations than those of CMZ. The action of CTT against the both strains was bactericidal.

Anti-Bacterial Agents↗
PubMed1980

Serratia: a continuing health menace.

Species of Serratia, particularly S marcescens, are being isolated with increasing frequency from human sources. These organisms are responsible for serious infections, especially in hospitalized and/or compromised patients. The authors reviewed the frequency of isolation of Serratia species at Howard University Hospital and analyzed isolation and identification techniques and factors predisposing patients to colonization by these organisms. This paper presents the findings of the study.

Anti-Bacterial Agents↗
PubMed1976

Intraventricular treatment of Serratia marcescens meningitis with gentamicin. Pharmacokinetic studies of gentamicin concentration in one case.

A neurosurgical patient with postoperative meningitis caused by Serratia marcescens was treated with intraventricular as well as intramuscular gentamicin. Gentamicin concentration in serum and CSF was determined at different times after the administration. Serratia marcescens could not be isolated from CSF after 3 days of therapy. Determination of gentamicin concentrations in CSF showed that gentamicin should not be given intraventricularly more than once a day to avoid accumulation of the drug. No adverse effect was noticed although the CSF concentration reached 450 mug/ml.

Bacterial Infections↗
PubMedDate not supplied

[Urinary infections due to Serratia marcescens: clinico-statistical pictures of patients hospitalized in the S. Maria della Scala Hospital in Siena during 1971, 1972, and 1973].

The Authors have carried out a clinical-statistical research into cases of urinary tract infection by Serratia marcescens isolated in 42 of 2500 urine-cultures effected during the period 1971-1973 by patients hospitalized in "S. Maria della Scala" Hospital of Siena. The Authors point out the high incidence of isolation of Serratia marcescens in urological patients and show some control measures to prevent the diffusion of such infections in hospital.

Cross Infection↗
PubMed1976

Inositol as a selective substrate for the growth of Klebsiellae and Serratiae.

A synthetic basal salts medium containing inositol as the sole source for carbon and energy and bromothymol blue as pH indicator, selectively supports the growth of Klebsiella pneumoniae and Serratia spp. On this medium incubated at 37 degrees C for 24 hr, all cultures of Kl. pneumoniae, Serratia liquefaciens and S. marcescens form yellow colonies. The medium may be used selectively for the primary isolation of the aforementioned bacteria from faeces and as a differential medium for their isolation from saliva and urine.

Culture Media↗
PubMed1997

The role of outer membrane in Serratia marcescens intrinsic resistance to antibiotics.

Three different porins from Serratia marcescens were described. They were named Omp1, Omp2 and Omp3 and their molecular weights were 42, 40 and 39 kDa respectively. Omp2 and Omp3 showed osmoregulation and thermoregulation in a similar way to OmpC and OmpF of Escherichia coli. Permeability coefficients of the outer membrane of this species were calculated following the Zimmermann and Rosselet method. P values were similar to those obtained in Escherichia coli, which suggests that the chromosomal beta-lactamase would play a major role in the resistance of Serratia marcescens to beta-lactam antibiotics. Both MIC values and permeabilities were modified by salycilates and acetylsalycilate. Synergism between the outer membrane and the beta-lactamase was also evaluated. When bacteria grew in the presence of a beta-lactam in the medium, the beta-lactamase accounted for most of the resistance.

Bacterial Outer Membrane Proteins↗