Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Round Window, Ear”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 379 records · Page 21Linked to original sources
PubMed1991

Surgical anatomy of the singular nerve.

The course of the posterior ampullary (singular) nerve has been studied in 30 preserved human temporal bones. In 17 dissections (57%), the nerve was readily accessible in the floor of the round window niche without undue risk to the round window membrane or the ampulla of the posterior semicircular canal. In 5 bones (16%), the nerve was closely related to the round window membrane and could not have been approached without significant risk of damage to the membrane. In 8 (27%), the nerve ran more or less directly medially to the internal auditory meatus without entering the round window niche. The ampulla of the posterior semicircular canal would therefore have been at risk if the nerve were approached surgically.

Humans↗
PubMed1983

Computerized testing of signal-encoding strategies with round-window implants.

After extensive testing of a patient with two bipolar modiolar electrodes connected to a percutaneous plug in 1977, we provided four patients with a single-channel monopolar round-window electrode connected to a tuned radio-frequency receiver coil. Loudness and pitch discrimination and results of psychophysical scaling experiments of extracochlear electrodes are comparable to those with intracochlear stimulation. Extensive testing with a computerized test system and with tape-recorded and live speech material showed that accurate vowel and speaker identification by stimulation alone is possible and that discrimination by lipreading is considerably improved. Interactive training sessions further improve discrimination results. Different signal-encoding algorithms can be used to generate in real time stimulation signals from prestored speech parameters (such as pitch, gain, formants, and zerocrossing intervals).

Adult↗
PubMed2001

Microdose gentamicin administration via the round window microcatheter: results in patients with Meniere's disease.

Transtympanic gentamicin is becoming increasingly popular in the treatment of Meniere's disease. In this report we examine our experience with the use of microdose gentamicin via the Round Window Microcatheter for the treatment of Meniere's disease. Thirty-six patients were treated with gentamicin administration via the Round Window Microcatheter between July 1997 and August 2000. The patients all underwent 10 days of continuous treatment with a total dose of 2.4-3.75 mg of gentamicin (10 mg/ml). All patients had extensive pre-, intra-, and post-therapy auditory and vestibular testing. In this group, vertigo was eliminated in 89% of the patients, and tinnitus and pressure were significantly reduced in over 60% of the patients. Only one patient suffered a significant hearing loss and, most importantly, in all but one patient vestibular function was improved or normalized after treatment. Round Window Microcatheter-administered microdose gentamicin is an exciting new treatment for Meniere's disease. Preliminary results indicate that vertigo can be controlled without a significant reduction in cochlear or vestibular function in most patients. These results suggest that this therapy may be acting at a non-hair cell site. Our results are compared to the published literature examining transtympanic injection. In addition, the underlying science supporting this type of treatment is examined.

Adult↗
PubMed2003

Speech recognition under conditions of frequency-place compression and expansion.

In normal acoustic hearing the mapping of acoustic frequency information onto the appropriate cochlear place is a natural biological function, but in cochlear implants it is controlled by the speech processor. The cochlear tonotopic range of the implant is determined by the length and insertion depth of the electrode array. Conventional cochlear implant electrode arrays are designed for an insertion of 25 mm inside the round window and the active electrodes occupy 16 mm, which would place the electrodes in a cochlear region corresponding to an acoustic frequency range of 500-6000 Hz. However, some implant speech processors map an acoustic frequency range from 150 to 10000 Hz onto these electrodes. While this mapping preserves the entire range of acoustic frequency information, it also results in a compression of the tonotopic pattern of speech information delivered to the brain. The present study measured the effects of such a compression of frequency-to-place mapping on speech recognition using acoustic simulations. Also measured were the effects of an expansion of the frequency-to-place mapping, which produces an expanded representation of speech in the cochlea. Such an expanded representation might improve speech recognition by improving the relative spatial (tonotopic) resolution, like an "acoustic fovea." Phoneme and sentence recognition was measured as a function of linear (in terms of cochlear distance) frequency-place compression and expansion. These conditions were presented to normal-hearing listeners using a noise-band vocoder, simulating cochlear implant electrodes with different insertion depths and different number of electrode channels. The cochlear tonotopic range was held constant by employing the same noise carrier bands for each condition, while the analysis frequency range was either compressed or expanded relative to the carrier frequency range. For each condition, the result was compared to that of the perfect frequency-place match, where the carrier and the analysis bands were perfectly matched. Speech recognition in the matched conditions was generally better than any condition of frequency-place expansion and compression, even when the matched condition eliminated a considerable amount of acoustic information. This result suggests that speech recognition, at least without training, is dependent on the mapping of acoustic frequency information onto the appropriate cochlear place.

Adult↗
PubMed2003

Influence of hearing sensitivity on mechano-electric transduction.

This study examined the relation between the extent of permanent hearing loss and the change in a third-order polynomial transducer function (PTF) representing mechano-electric transduction (MET). Mongolian gerbils were exposed to noise for 1 to 128 h. A control group received no exposure. The cochlear microphonic (CM) was recorded from a round-window electrode and stapes velocity was recorded with a laser Doppler vibrometer in response to Gaussian noise. A nonlinear systems identification procedure provided the frequency-domain coefficients of the PTF and their associated coherence functions. In the control group, the PTF in the high frequencies was dominated by linear and cubic terms. In noise-exposed animals, the magnitude of these terms decreased with increasing threshold, suggesting a progressive decrease in the receptor currents through basal hair cells. Moreover, the linear coherence increased and the cubic coherence decreased, indicating that MET in the cochlear base became linear. In the low frequencies, noise exposure altered the group delay of the CM, demonstrating a redistribution of hair-cell currents. The low-frequency PTF was characterized by an increase in the contribution in the quadratic term. With increasing threshold, the slope of the PTF decreased and the saturation for positive CM was eliminated.

Action Potentials↗
PubMed1982

Input impedance of the cochlea in cat.

Tones were delivered directly to the stapes in anesthetized cats after removal of the tympanic membrane, malleus, and incus. Measurements were made of the complex amplitudes of the sound pressure on the stapes PS, stapes velocity VS, and sound pressure in the vestibule PV. From these data, acoustic impedance of the stapes and cochlea ZSC delta equal to PS/US, and of the cochlea alone ZC delta equal PV/US were computed (US delta equal to volume velocity of the stapes = VS X area of the stapes footplate). Some measurements were made on modified preparations in which (1) holes were drilled into the vestibule and scala tympani, (2) the basal end of the basilar membrane was destroyed, (3) cochlear fluid was removed, or (4) static pressure was applied to the stapes. For frequencies between 0.5 and 5 kHz, ZSC approximately equal to ZC; this impedance is primarily resistive ([ZC] approximately equal to 1.2 X 10(6) dyn-s/cm5) and is determined by the basilar membrane and cochlear fluids. For frequencies below 0.3 kHz, [ZSC] greater than [ZC] and ZSC is primarily determined by the stiffness of the annular ligament; drying of the ligament or changes in the static pressure difference across the footplate can produce large changes in [ZSC]. For frequencies below 30 Hz, ZC is apparently controlled by the stiffness of the round-window membrane. All of the results can be represented by an network of eight lumped elements in which some of the elements can be associated with specific anatomical structures. Computations indicate that for the cat the sound pressure at the input to the cochlea at behavioral threshold is constant between 1 and 8 kHz, but increases as frequency is decreased below 1 kHz. Apparently, mechanisms within the chochlea (or more centrally) have an important influence on the frequency dependence of behavioral threshold at low frequencies.

Acoustic Impedance Tests↗
PubMed1983

Acoustically derived auditory nerve action potential evoked by electrical stimulation: an estimation of the waveform of single unit contribution.

An experimental study of the electrical stimulation of the guinea pig cochlea is made using an electrode on the round window for both stimulation and recording. The neural response is separated from the electrical artifact with a masking procedure combined with a low amplification, "statistical" averaging method [Charlet de Sauvage et al., Hear. Res. 2, 343-346 (1980)]. The high electrical impedance required for recording physiological responses implies the use of a current pulse generator. Monitoring of evoked potentials from the auditory cortex provides evidence that the effects of electrical stimulation (and of masking noise) are of auditory origin. The electrically evoked round window response is of very short latency (less than 0.2 ms). There is a response threshold for both electrical stimulus and masking noise. The response amplitude varies monotonically as a function of masking noise or electrical stimulus intensity. Experiments with high-pass noise masking suggest that the electrical stimulus is mainly acting on basal fibers. The response latency and waveform are independent of electrical stimulus intensity, repetition rate, masker level, or spectrum. Little intersubject variation is noted. Our experiments (reciprocal forward masking by electrical and acoustic stimuli) suggest that a direct, instantaneous electrical stimulation of the fibers occurs. We believe that this response to electrical stimulation represents the mean unit response of the auditory nerve fibers. This approach may be useful in the separate study of cochlear and VIIIth nerve functions and in the analysis (deconvolution) of the acoustically evoked compound AP.

Acoustic Stimulation↗
PubMed1983

Effects of perilymph viscosity on low-frequency intracochlear pressures and the cochlear input impedance of the cat.

Cochlear model calculations are shown to be in reasonable agreement with recent low-frequency measurements of intracochlear pressures and the cochlear input impedance of the cat [V. Nedzelnitsky, J. Acoust. Soc. Am. 68, 1676-1689 (1980); T. J. Lynch, III, V. Nedzelnitsky, and W. T. Peake, J. Acoust. Soc. Am. 72, 108-130 (1982)]. Included in the cochlear model are perilymph viscosity, the measured variation of the area of the scala vestibuli with distance from the stapes [P. Dallos, J. Acoust. Soc. Am. 48, 489-499 (1970)], and finite impedance of the round window membrane. The WKB approximation and its extension to the low-frequency region is used in order to exhibit explicitly the dependence of the model results on the cochlear parameters.

Acoustic Impedance Tests↗
PubMed1985

Influence of direct current on dc receptor potentials from cochlear inner hair cells in the guinea pig.

Inner hair cell responses to sound were monitored while direct current was applied across the membranous labyrinth in the first turn of the guinea pig cochlea. The current injection electrodes were positioned in the scala vestibuli and on the round window membrane. Positive and negative current (less than 100 microA) caused changes in the sound-evoked dc receptor potentials which were dependent on the sound frequency and intensity. The frequencies most affected by this extracellular current were those comprising the "tip" portion of the inner hair cell frequency tuning characteristic (FTC). The influence of current increased with increasing frequency. Positive current increased the amount of dc receptor potential for the affected frequencies while negative current decreased the potential. Current-induced changes (on a percentage basis) were greater for low intensity sounds and the negative current direction. These frequency specific changes are evidenced as a loss in sensitivity for the tip area of the FTC and a downward shift of the inner hair cell characteristic frequency. Larger current levels (greater than 160 microA) cause more complex changes including unrecoverable loss of cell performance. In separate experiments positive and negative currents (less than 1.1 microA) were injected into the inner hair cell from the recording electrode during simultaneous measurement of the sound-evoked dc receptor potential. This condition caused a shift in IHC sensitivity that was independent of sound frequency and intensity. Positive current decreased the sensitivity of the level of the cell while negative current increased the responses. The effect of current level on sound-evoked dc receptor potential was nonlinear, as comparatively greater increases in cell response were observed for negative than decreases for positive current. The intracellular current injection results are accounted for by the mechano-resistive model of hair cell transduction, where nonlinear responses with current level may reflect outward rectification. Response changes induced by extracellular current are evidence of current effects on both inner and outer hair cells. The frequency and intensity dependences are hypothesized to represent voltage mediated control of inner hair cell response by the outer hair cells.

Action Potentials↗
PubMed1989

Characterization of an EPSP-like potential recorded remotely from the round window.

The whole-nerve cochlear action potential (CAP), to tone burst stimulation, was recorded before and after application of tetrodotoxin (TTX) to the intact round window (RW) membrane. TTX abolished the CAP leaving a residual negative potential without altering the summating potential (SP) or the cochlear microphonic (CM). The residual potential retained its polarity when recorded from scala vestibuli. The peak latency, amplitude, and tuning properties of the residual potential showed features similar to the CAP. Application of kainic acid to the RW membrane eliminated the residual potential, leaving the SP and CM unaltered. It is hypothesized that the sources of the residual potential are the excitatory post-synaptic potentials from the peripheral processes of afferent dendrites under the inner hair cells.

Acoustic Stimulation↗
PubMed1990

Asynchronous neural activity recorded from the round window.

Voltage recorded from an electrode on the round window (RW) of guinea pig has characteristics that reflect the activity of auditory-nerve fibers in the absence of acoustic stimulation. Fast Fourier transformation (FFT) of the noise recorded from the RW electrode shows a broad spectral peak from 0.8-1.0 kHz. The magnitude of the biological noise is increased by high-frequency, bandlimited acoustic noise stimulation. Pure tones can suppress or enhance the spectral components around 0.8-1.0 kHz depending on frequency and intensity. Kainic acid applied to the intact RW membrane eliminates the biological noise (and the evoked cochlear whole-nerve responses) without alteration of the cochlear microphonic or the summating potential. The spectral characteristics of the biological noise seem to be related to the elemental waveform contributed by the individual auditory-nerve fibers to the voltage recorded at the RW electrode [Kiang et al., Electrocochleography, edited by R. J. Ruben, C. Elbering, and G. Solomon (University Park, Baltimore, 1976)].

Animals↗
PubMed1999

Near-field responses from the round window, inferior colliculus, and auditory cortex of the unanesthetized chinchilla: manipulations of noiseburst level and rate.

Few studies have compared the response properties of near-field potentials from multiple levels of the auditory nervous system of unanesthetized animals. The purpose of this study was to investigate the effects of brief-duration noisebursts on neural responses recorded from electrodes chronically implanted at the round window, inferior colliculus and auditory cortex of chinchillas. Responses were obtained from seven unanesthetized chinchillas to a noiseburst-level and noiseburst-rate series. For the noiseburst-rate series, a 70 dB pSPL noiseburst was varied in rate from 10 to 100 Hz using conventional averaging procedures, and from 100 to 500 Hz using pseudorandom pulse trains called maximum length sequences (MLSs). Response thresholds were similar for the compound action potential (CAP), inferior colliculus potential (ICP) and auditory cortex potential (ACP). With decreasing noiseburst level, there were decreases in the amplitudes and increases in the latencies of the CAP, ICP and ACP. The shapes of the mean normalized amplitude input/output (I/O) functions were similar for the ICP and ACP, while the normalized I/O functions for the first positive peak (P1) and first negative peak (N1) of the CAP differed from each other and from the ICP and ACP. The slopes of the latency/intensity functions were shallowest for the CAP, intermediate for the ICP, and steepest for the ACP. With increasing rate, the latency shift was least for the CAP, intermediate for the ICP and greatest for the ACP. The amplitude of P1 of the CAP varied little with rate. All other potentials showed a pronounced decrease in amplitude at high stimulation rates. Excluding CAP P1, proportional amplitude decrease with rate was greatest for the ACP, intermediate for N1 of the CAP and least for the ICP. Responses were present in most animals at all recording sites, even for the highest rate (500 Hz) used in this study. For all potentials, the MLS procedure allowed the collection of a response at rates well above those where sequential responses would have overlapped using conventional averaging procedures.

Anesthesia↗
PubMed2000

A macro-mechanical model of the guinea pig cochlea with realistic parameters.

The post-mortem transfer function of the cochlea of the guinea pig was compared to the transfer function generated by a model with parameters derived from physical measurements of the guinea pig cochlea. Both the formulation and parameters of the model were carefully chosen to be realistic using evidence from published measurements. The fit between the transfer function of the model and recent mechanical measurements of the passive guinea pig cochlear response was good, with a root mean square ratio of 6.3 dB in amplitude and 0.33 pi rad in phase. The model was used to explore the effect of cochlear partition mode factor and duct geometry upon the mechanical response of the cochlea. Possible inadequacies of the model which could explain the remaining differences between the output of the model and measurements are discussed.

Animals↗
PubMed2006

Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals.

We tested and characterized the therapeutic value of round window membrane-delivered (RWM) d-JNKI-1 peptide (Bonny et al., 2001) against sound trauma-induced hearing loss. Morphological characteristics of sound-damaged hair cell nuclei labeled by Hoechst staining show that apoptosis is the predominant mode of cell death after sound trauma. Analysis of the events occurring after sound trauma demonstrates that c-Jun N-terminal kinase (JNK)/stress-activated protein kinase activates a mitochondrial cell death pathway (i.e., activation of Bax, release of cytochrome c, activation of procaspases, and cleavage of fodrin). Fluorescein isothiocyanate (FITC)-conjugated d-JNKI-1 peptide applied onto an intact cochlear RWM diffuses through this membrane and penetrates cochlear tissues with the exception of the stria vascularis. A time sequence of fluorescence measurements demonstrates that FITC-labeled d-JNKI-1 remains in cochlear tissues for as long as 3 weeks. In addition to blocking JNK-mediated activation of a mitochondrial cell death pathway, RWM-delivered d-JNKI-1 prevents hair cell death and development of a permanent shift in hearing threshold that is caused by sound trauma in a dose-dependent manner (EC50 = 2.05 microM). The therapeutic window for protection of the cochlea from sound trauma with RWM delivery of d-JNKI-1 extended out to 12 h after sound exposure. These results show that the mitogen-activated protein kinase/JNK signaling pathway plays a crucial role in sound trauma-initiated hair cell death. Blocking this signaling pathway with RWM delivery of d-JNKI-1 may have significant therapeutic value as a therapeutic intervention to protect the human cochlea from the effects of sound trauma.

Animals↗
PubMed1980

Acoustic responses after total destruction of the cochlear receptor: brainstem and auditory cortex.

Acoustically evoked neural activity has been recorded from the brainstem and auditory cortex of guinea pigs after complete destruction of the organ of Corti by the aminoglycosidic antibiotic amikacin. These responses to sound differ in important respects from the evoked potentials normally recorded from the auditory pathways. At the brainstem level they resemble the potentials reported by others after stimulation of the vestibular nerve.

Acoustic Stimulation↗