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PubMed2001

Dapsone in rosacea fulminans.

Rosacea fulminans is a rare disease with female predominance characterized by abrupt onset of pustules, papules, and confluent nodules on the face. The conventional treatment consists of systemic glucocorticoids and isotretinoin. We present the case of a 56-year-old woman with a marked facial papulopustular eruption that had followed an initial period of severe seborrhoea. Conventional treatment produced no clear improvement. Dapsone treatment achieved complete healing in 5 weeks.

Administration, Oral↗
PubMed2002

Steroid dermatitis resembling rosacea: aetiopathogenesis and treatment.

BACKGROUND: Corticosteroids were first introduced for topical use in dermatology in 1951. Since then uncontrolled use (abuse) has caused many different reactions, often with manifestations resembling those of rosacea. OBJECTIVE: The prolonged use of local corticosteroids (usually 2-6 months) may lead to a clinical picture of severe dermatitis with erythema, papules and pustules that are classified according their localization to three types. The treatment of choice is tetracycline in combination with local application of neutral ointments. CONCLUSIONS: Trivial skin dermatoses, especially on the face, should not be treated with local corticosteroids.

Administration, Topical↗
PubMed2001

Treatment of rosacea.

Rosacea is an inflammatory disease of the face and eyes. Treatment is adjusted to the site of the disease and its severity.

Administration, Oral↗
PubMed2001

Cosmetics in acne and rosacea.

Cosmetics that are appropriate for use in patients with rosacea and acne must be noncomedogenic, nonacnegenic, nonirritating, and hypoallergenic. This requires a basic understanding of cosmetic fromulation and the selection of products that meet guidelines for sensitive skin.

Acne Vulgaris↗
PubMed2005

Pseudomonas aeruginosa keratitis in an atopic silicone hydrogel lens wearer with rosacea.

PURPOSE: This case report documents Pseudomonas aeruginosa corneal infection associated with daily wear of a silicone contact lens in a patient who also had bilateral, preexisting biomicroscopic findings of ocular rosacea, seborrheic blepharitis, keratoconjunctivitis sicca, and chronic punctate corneal epitheliopathy. CONCLUSIONS: Collectively, these problems produce increased risk of infection for wear of any contact lens; and underscore the importance of proper patient selection, education and post-fit monitoring even when hyper-oxygen transmitting silicone hydrogels are utilized.

Anti-Bacterial Agents↗
PubMed1981

Oral thermal-induced flushing in erythematotelangiectatic rosacea.

The effects of caffeine and coffee, agents widely alleged to provoke flushing in patients with erythematotelangiectatic rosacea, were investigated. Neither caffeine nor coffee at 22 degrees C led to flushing reactions. Both coffee at 60 degrees C and water at 60 degrees C led to flushing reactions with similar temporal characteristics and of similar intensities. It is concluded that the active agent causing flushing in coffee at 60 degrees C is heat, not caffeine.

Caffeine↗
PubMed1996

Association of Melkersson-Rosenthal syndrome with rosacea.

A rare case of Melkersson-Rosenthal syndrome with all the cardinal signs of the triad, including facial swelling, facial nerve palsy and glossitis, is described. The additional feature of this case was an association with rosacea.

Adult↗
PubMed2005

Chronic superficial pyoderma of the face: an unusual male case of rosacea fulminans.

A 62-year-old Japanese male developed acneiform papules on the face in November of 2002. The eruptions progressed to exudative erythema with central necrosis, and then to thick-crusted superficial abscesses in a short period. The shallow ulcers exposed by removal of the crusts and abscesses immediately re-epithelized without leaving scars. The histology of the eruption was a dense infiltration of neutrophils associated with granulomatous changes in the upper to middle dermis. Histology of the tiny white particles in the abscess showed an irregularly proliferated mass of keratinocytes including accumulated neutrophils. The skin lesions resisted intravenous injection of antibiotics but responded to systemic administration of a corticosteroid agent. Colchicine did not work well, but the additional administration of etretinate was effective. The patient is currently receiving combined therapy with prednisolone and etretinate, but eruptions are still episodically observed. We diagnosed this case as an unusual male case of rosacea fulminans.

Adrenal Cortex Hormones↗
PubMed1980

Immunopathological studies on rosacea.

Seven patients with papulo-pustular rosacea were investigated with immunofluorescence (IF) techniques. Indirect IF has been performed also with antibodies eluted from circulating lymphoid cells. Besides confirming the data in the literature on the positivity of the basal zone, anticollagen antibodies were found, and eluted antinuclear antibodies were detected against nuclei of cells in the epidermis and dermis, namely, scattered dermal, endothelial and eccrine duct cells.

Adult↗
PubMed1983

Treatment of rosacea with i% metronidazole cream. A double-blind study.

Eighty-one patients with rosacea were treated with either I% metronidazole cream or the cream base as a placebo for two months. The trial was performed double-blind, and the patients were assessed once each month. The variates studied were: (I) overall clinical assessment, (2) lesion counts, (3) degree of erythema, (4) independent photographic evaluation, and (5) patient's opinion. Four patients dropped out of the trial (one treated with metronidazole, three with placebo). In all the variates, I% metronidazole cream proved to be significantly more effective than placebo.

Administration, Topical↗
PubMed1983

A double-blind study of I% metronidazole cream versus systemic oxytetracycline therapy for rosacea.

In a randomized double-blind trial fifty-one patients with rosacea were treated for 2 months with either I% metronidazole cream and placebo tablets or with 250 mg oxytetracycline tablets taken twice daily, and placebo cream (the cream base). The patients were assessed before and at the end of the trial, using the following criteria: (1) overall clinical assessment, (2) lesion counts, (3) degree of erythema, (4) independent photographic evaluation, (5) patients' opinion. An improvement was shown in 90% of the patients of both groups, and there was no significant difference between the two treatments.

Administration, Oral↗
PubMed1995

Demodicidosis or rosacea: what did we treat?

We report a 75-year-old man with a fulminant rosacea-like eruption, suggestive of demodicidosis. Multiple Demodex folliculorum mites were found in facial scales and pustules and, on histological examination, in the infundibulum of pilosebaceous follicles and in the dermis. Intradermal mites were surrounded either by polymorphonuclear granulocytes and histiocytes, or by a granulomatous infiltrate containing foreign-body giant cells, which had phagocytosed the parasites. Complete recovery, with disappearance of facial mites, was achieved by treatment with a combination of oral and topical metronidazole, although this drug is not known to be miticidal.

Aged↗
PubMed2006

Wolf's isotopic response: rosacea appearing at the site of healed herpes zoster.

A 40-year-old man developed an erythematous rash on the right side of his face 3 weeks after a herpes zoster infection at the same location. Examination revealed an erythematous papular eruption and telangiectasias along the ophthalmic and maxillary divisions of the right trigeminal nerve, exactly at the site of the consistent with previous herpes zoster infection, Wolf's isotopic response. Histological examination showed vascular ectatic dilatation and perivascular and perifollicular infiltration of lymphocytes and histiocytes consistent with rosacea. The rash was resistant to oral doxycycline and topical metronidazole 1% cream and resolved with oral isotretinoin therapy.

Adult↗
PubMed2007

Facial Sweet's syndrome mimicking rosacea fulminans.

A 36-year-old man presented with a non-pruritic, erythematous facial rash with peri-oral and peri-orbital sparing. The initial clinicopathological diagnosis was rosacea fulminans, which was treated with 25 mg oral prednisolone and cephalexin. The patient re-presented 1 week later with exacerbation of his rash in addition to constitutional symptoms of fever and malaise. A further skin biopsy was taken and the marked neutrophilic infiltrate in the absence of vasculitis made the diagnosis of Sweet's syndrome (acute febrile neutrophilic dermatosis). High-dose prednisolone (50 mg daily), topical hydrocortisone cream and ichthammol in zinc ointment were commenced with rapid clinical improvement. This case highlights the importance of considering Sweet's syndrome as a differential diagnosis when presented with a facial eruption.

Administration, Cutaneous↗
PubMed1987

Nasal septal carcinoma masquerading as acne rosacea.

A 57-year-old woman developed diffuse erythema of the nose that had been diagnosed as acne rosacea for 18 months. Biopsy showed infiltration deep in the nasal skin of a squamous cell carcinoma that extended from the nasal septum. Nasal septal tumors are rare; the most common is squamous cell carcinoma.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Two AGAMOUS-like MADS-box genes from Taihangia rupestris (Rosaceae) reveal independent trajectories in the evolution of class C and class D floral homeotic functions.

Duplicate genes may be retained by sub- and/or neofunctionalization through changes in gene expression and/or coding sequence, and therefore have the potential to contribute to the genetic robustness and diversification of an organism. In this study, two MADS-box genes were isolated from Taihangia rupestris, a core eudicot species belonging to the Rosaceae. Sequence and phylogenetic analyses revealed that they are clade members of the euAG and PLE lineages, respectively, and hence the two genes are named TrAG (Taihangia rupestris AGAMOUS) and TrSHP (Taihangia rupestris SHATTERPROOF). Southern blot analysis shows that TrSHP is a single-copy gene in the T. rupestris genome. In situ hybridization analyses show that both TrAG and TrSHP are mainly expressed in the stamens, carpels, and ovules. When the stamen primordia are firstly observed, TrAG is initially expressed in the floral meristem domain that will initiate stamens and carpels. In contrast, no TrSHP signal is observed at this developmental stage. At late stages of carpel development, TrAG expression is detected in the ovules, ovaries, and developing styles and stigmas, whereas TrSHP expression is tightly restricted to the ovules. The transgenic Arabidopsis plants containing 35S::TrAG and 35S::TrSHP, respectively, showed similar phenotypes, including homeotic conversions of sepals into carpelloid structures bearing ovules and petals into staminoid organs, and the fruits shattering prematurely along the dehiscence zone. In addition, the phenotype of the transgenic 35S::TrSHP Arabidopsis plants revealed that perianth abscission was inhibited. Yeast two-hybrid assays indicated that TrAG can interact with TrSEP3, whereas TrSHP cannot. The data suggest that the euAG and PLE paralogs, TrAG and TrSHP, may have subfunctionalized and/or neofunctionalized through changes in expression patterns and accumulating variations in the coding regions. Taking these findings together with those available expression and functional data from Arabidopsis and other species, we conclude that the compensatory ways vary among the euAG and PLE lineage pairs in eudicot species.

Blotting, Southern↗
PubMedDate not supplied

A basal cell carcinoma mimicking a sign of rosacea.

A 55-year-old Caucasian man presented to a plastic surgeon for the treatment of two lesions on his nose, first a chronic indented area with some telangiectasia on the proximal nasal bridge (Figure 1) and second a hyperkeratotic nodule with central crusting on the ala nasi that developed rapidly over several weeks (Figure 2). The surgeon appropriately diagnosed the ala nasi nodule as a squamous cell carcinoma, keratoacanthoma type, but requested an opinion from dermatology for the proximal nasal bridge indentation that he suspected to be a morpheaform or erosive basal cell carcinoma possibly requiring Mohs micrographic surgery. Upon further questioning, the patient revealed that he has had persistent erythema and problems with facial flushing for many years, particularly with alcohol, coffee, and moderate exercise. He infrequently develops papulopustular lesions. Closer clinical inspection revealed a mild erythema, telangiectases, and a hypertrophied nose. He noted that he wore an old heavy pair of glasses every day. He was notified of a coexisting diagnosis of rosacea, and various treatment options were discussed. He was pleased that he would not need any further surgery to his nose.

Basal Cell Carcinoma↗
PubMed1978

Chronic lymphatic leukemia presenting as atypical rosacea with follicular mucinosis.

A case is described in which the initial clinical and histological features were suggestive of rosacea. Subsequent progress revealed the diagnosis to be chronic lymphatic leukemia. The initial biopsy specimens were reviewed and small but definite quantities of follicular mucinosis were noted after appropriate staining. If this had been noted earlier the diagnosis would have been made more rapidly. This case demonstrates the importance of detecting follicular mucinosis. We are not aware of follicular mucinosis having been described in association with chronic lymphatic leukemia previously. It is also rare for leukemias other than the monocytic type to present with cutaneous lesions, though skin lesions may occur in established cases.

Aged↗