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At least 379 records · Page 21Linked to original sources
PubMed1991

[Immunologic studies in patients with ovarian carcinoma during radio-chemotherapy. I. Studies of lymphocyte subpopulations].

In this article we have studied the behaviours of different lymphocyte subpopulations (T11, T8, T4, B4 and B1) in the peripheral blood of 60 patients suffering from ovarian cancer during radio- and chemotherapy with the APAAP-technique. The most important results of our study are that compared with the chemotherapy the radiotherapy causes greater lymphocyte depression, that the subpopulations of T-lymphocyte with the exception of T8 show greater radio-sensitivities than B-lymphocyte, that T8-subpopulation is not radio-sensitive, and that the T11-, T4-, B4- and B1-subpopulations of the patients at stage I and II can recover from the depression caused by radiation much better than the corresponding subpopulations of the patients at stage III and IV.

Adult↗
PubMed1990

[Radio-ulnar bridge callus following osteosynthesis of forearm fractures].

137 patients with forearm fractures and internal plate fixation were investigated for postoperative radio-ulnar synostosis. 10 patients (7.3%) developed such a complication, 7 after complete, 3 after either ulnar or radial lesion. Of 73 patients with complete forearm fractures, 50 had separate incisions, and developed radio-ulnar synostosis only secondary to severe soft tissue injury. Of 12 other patients, by contrast, who were operated on for radial and ulnar plate fixation via one common incision (Boyd's approach), synostosis occurred in 5. After isolated ulnar fractures in 32 cases, synostosis was seen in two cases - in one after severe soft tissue injury, in the other after a modified Boyd's approach. Only one patient with isolated and open fracture of the radius presented later with radio-ulnar synostosis.

Adolescent↗
PubMed1990

[Morphology of the distal radio-ulnar joint. Surgical orthopedic consequences].

Morphologic and biomechanical changes are often the causes of osteoarthrosis in a joint. Complete integrity is necessary, if a joint will be intact the whole life. This integrity is very often disturbed in the distal radio-ulnar joint by trauma and also by surgical treatment. To avoid any incongruence in this joint, which seemed to be neglected by surgeons and orthopaedics, in 1985 about 700 wrists were examined by X-ray, to study the exact morphology with regard to the relation between ulna, radius, declinations and lengths. The aim was to avoid failures in future by all therapeutic procedures. 31 negative ulnar variances (4.4%) and 9 (1.4%) non-traumatic positive variances with a difference of more than 2 mm were revealed. The declination of the distal radio-ulnar joint in relation to the axis of the radius was measured by a special goniometer. To find out the three-dimensional structure of this joint, oblique X-ray photographs were also taken. The results were: in joints with negative ulnar variance declinations of 100 degrees and more were found, and the stereoscopic pictures were conical; in the presence of positive ulnar variance the declinations amounted to 80 degrees or less and the distal radio-ulnar joint surfaces were spherical; in neutral ulnar variances the angle was found to be about 90 degrees and the joints were cylindrical in form. Nearly all operative or traumatic changes were associated with incongruence of this joint. Therefore all therapeutic methods must be planned exactly with reference to this stereoscopic relations between radius and ulna. In traumatic cases the three-dimensional integrity must be reconstructed.(ABSTRACT TRUNCATED AT 250 WORDS)

Biomechanical Phenomena↗
PubMed1986

[Proposal for radio-oncologic needs planning].

The demand planning for radio-oncologic treatment considers the population density and structure of the region served by the hospital, the geographic conditions of this region, the medical prescriptions of the hospital institution, the incidence of cancer, the part of radiotherapy in the treatment of the tumor, hospital-specific factors and, finally, the minimum requirements for technical equipment and staff of a radiotherapeutic functional unit. The most important factors are certainly the incidence of cancer and the number of tumor patients actually receiving a radiotherapy. For the Federal Republic of Germany, an incidence of annually 300 to 320 new cancers per 100,000 inhabitants is determined, based on the mortality statistics of the Federal Republic of Germany, England, Wales and Norway as well as the cancer incidence statistics of Hamburg, Baden-Württemberg, Saarland and the very reliable registers of Scandinavia and the German Democratic Republic. The part of radiotherapy is probably between 32 and 35% of primary treatments, repeated treatments must be added. With respect to technical equipment and staff, some minimum requirements have to be fulfilled by a radiotherapeutic functional unit if its work shall be satisfactory in the medical and economical domain. A concentration of radiotherapeutic resources is recommended. The number of beds required for a radio-oncologic hospital applying modern techniques and combined methods is 40 to 45% of the number of patients irradiated per day. A three-category system for radio-oncologic treatment is presented. Future planning, however, should only be based on two categories.

Germany, West↗
PubMed1985

Radiography and computerized tomography in the diagnosis of incongruity of the distal radio-ulnar joint. A prospective study.

The diagnosis of subluxation or dislocation of the distal radio-ulnar joint may be difficult to confirm by routine radiographs. We undertook a prospective evaluation of fifteen patients with acute or chronic pain in the distal radio-ulnar joint, using both standardized radiographs and computer assisted tomography. In the absence of a deformity of the distal end of the radius, a lateral radiograph made with the wrist in the neutral position accurately revealed incongruency of the distal radio-ulnar joint. When pain or cast immobilization prevented optimum positioning of the wrist for radiography, or when a deformity of the distal end of the radius was present, computer assisted tomography gave a more accurate determination of the congruency of the joint.

Adult↗
PubMed1985

Comparison of radio-labeled DNA probe with a nonisotopic probe for assay of serum hepatitis B virus DNA.

A biotin-labeled DNA probe was compared to a 32P radio-labeled DNA probe for the detection of serum hepatitis B virus (HBV) DNA. Serum specimens were treated with proteolytic enzyme and detergent. DNA was extracted using phenol, denatured in sodium hydroxide and applied to a nitrocellulose filter paper using a vacuum filter device. The nitrocellulose filters were then incubated with either the biotin-labeled or the radio-labeled probe. Annealing of the probe, indicating the presence of HBV-DNA in the sample, was detected either by autoradiography for the 32P-labeled probe or by measuring the presence of an acid phosphatase attached to a streptavidin molecule for the biotin-labeled probe. Using the same 2-day time to complete the assays, excellent correlation of the qualitative and semiquantitative measurements were obtained using 20 HBsAg-positive and 9 HBsAg-negative sera. The nonisotopic assay detected 1.0 pg of HBV-DNA, a sensitivity comparable to reported sensitivities of 32P-labeled HBV-DNA probes when similar assay times are used. 0.02 pg/microliter of HBV-DNA was detected in a normal serum to which HBV-DNA in a recombinant plasmid was added. Our results indicate that the biotin-labeled HBV-DNA probe is approximately as sensitive as the radio-labeled probe for the detection of HBV-DNA using a similar assay time. Isotopic probe assays are more sensitive with longer assay times. The biotin-labeled probe offers the advantage of a longer shelf life and a nonisotopic assay procedure.

Acid Phosphatase↗
PubMed1972

Radio-immunoassay of gastrin in human plasma.

1. A radio-immunoassay for gastrin has been developed using partially purified porcine gastrin to raise antibodies and highly purified natural porcine gastrin I for radio-iodination with (125)I. The separation of antibody-bound from free hormone was performed by a double-antibody method.2. In this assay highly purified natural porcine gastrin I, synthetic human gastrin I, radio-iodinated porcine gastrin I, gastrin in the plasma of a healthy volunteer, a patient with pernicious anaemia and another patient with the Zollinger-Ellison syndrome were immunologically identical.3. The fasting plasma gastrin concentration of fourteen gastric ulcer patients was significantly higher than that of the 113 hospital controls with no history of gastro-intestinal disease, while twenty-seven duodenal ulcer patients had gastrin levels within the normal range.4. Plasma gastrin concentration was significantly elevated in pernicious anaemia (fifty-one patients), achlorhydria (thirty-three patients), hypochlorhydria (eleven patients) and in nine patients with histologically proven Zollinger-Ellison syndrome.5. In human volunteers a protein meal stimulated endogenous gastrin release while a carbohydrate meal did not. Atropine sulphate I.M., and hydrochloric acid orally, produced a significant fall in the level of circulating gastrin.

Achlorhydria↗
PubMedDate not supplied

[Treatment of Grave's disease by radio iodine. Observation of 277 patients (author's transl)].

277 patients treated by radio iodine for Graves' disease were observed during a one to twenty three years period. 24 % relapse, always during the first three years. Hypothyroidism is ineluctable : 20 % from the first year and 3,4 % more each year. Goiter increases the delay for hypothyroidism occurrence. There is no linkage between hypothyroidism and radio iodine dose. Radio iodine does not cure graves' disease but give a "non hypo-non hyper" status, before secondary hypothyroidism.

Female↗
PubMed1982

[Radio-synoviorthesis with yttrium 90 of the knee joint in polyarthritis].

The radio-synoviorthesis with yttrium 90 in the knee-joint in rheumatoid arthritis was performed and controlled in 106 knees of patients with rheumatoid arthritis over a span of time between 6 and 49 months. The results are similar to those of other authors. As compared to synovectomy radio-synoviorthesis seems less successful as far as long-term results are concerned. As local treatment radio-synoviorthesis seems a good supplementory element in the therapeutic plan of rheumatoid arthritis. The indication to alternative procedures has to be considered carefully for each individual case and joint.

Adult↗
PubMed1981

[The contribution of radio-isotopes to urological investigation (author's transl)].

The authors, with a wide experience in the radio-isotopic investigation of the urinary system, undertake a general review and describe the principal advantages of the use of radio-isotopes in urology: quantitative study of renal function, dynamic study of renal transit, isotope cystography, gallium scintigraphy, vascular, skeletal, hepatic, cerebral and pulmonary isotope scans. Finally, the authors recall the possible use of radio-immunological measurements for the detection of prostatic acid phosphatase, the measurement of renin, angiotensin I and angiotensin II activity on cases of hypertension and finally the measurement of HCG and alpha-foeto proteins in patients with carcinoma of the testis.

Glomerular Filtration Rate↗
PubMedDate not supplied

[Congenital radio-ulnar synostosis of children (author's transl)].

29 congenital radio-ulnar synostosis have been observed in 16 childrens. The authors review the clinical patterns of this affection: most often bilateral, it results in impossibility of pronosupination of the wrist which has but little functional consequence, if the hand is in an intermediary position. On the X-ray its almost always a superior radio-ulnar synostosis but the inferior radio-ulnar joint is abnormal and non functional. Only the children severely handicapped by a hand fixed in pronation should be operated upon. No good result can be hoped from a surgery that tries to restore pro-supination. The best surgical technique seems to be a simple horizontal osteotomy through the synostosis itself which allows a derotation of the forearm into the functional intermediary position. Severe complications can occur. Indications and technique must be very careful since this congenital abnormality is very well tolerated.

Child↗
PubMedDate not supplied

Programmed serial CT scans in the surgical and radio-chemotherapeutic management of cerebral gliomas.

On the basis of a 4 year experience with CT scan in cerebral gliomas and of previous personal contributions in this field, a neuroradiological protocol of these patients is proposed. The protocol consists of a complete preoperative neuroradiological evaluation and of CT assessments at the end of the surgical procedure, before initiating radio-chemotherapy, and at the completion of each of its cycles, respectively. Attention is drawn to the importance of contrast enhancement, to the role played by the changes in the blood-brain barrier (BBB), either due to surgery or to the effect of radio-chemotherapy and to the identification of residual tumor or of recurrences. CT scan to be performed at the end of the operation is proposed on the assumption that, in spite of the increased possibility of artifacts due to blood, air, etc., it may provide an immediate and better evaluation of the surgical results as compared to the CT picture at the beginning of radio-chemotherapy, when changes in the patient's brain may already have occurred.

Brain Neoplasms↗
PubMed1980

Hyperthyroidism in the land of Graves: results of treatment by surgery, radio-iodine and carbimazole in 837 cases.

A review of the outcome of treatment by subtotal thyroidectomy, radio-iodine and carbimazole of 837 patients with hyperthyroidism seen consecutively over the period 1954--78 inclusive is presented. The age and sex distribution, the male to female ratio, the ABO blood group distribution and the prevalence of pernicious anaemia and diabetes mellitus in these patients was also analysed. Life-table data showed that the five-year and ten-year cumulative relapse rates following a two-year course of carbimazole (n = 162) were 56 per cent and 62 per cent; following surgery (n = 266), 6 per cent and 10 per cent and following radio-iodine (n = 43), 3 per cent and 14 per cent. Five-year and ten-year cumulative hypothyroid rates after surgery were 10 per cent and 18 per cent, and after radio-iodine 10 per cent and 30 per cent. Hypothyroidism did not occur after carbimazole therapy. Of 31 patients who took carbimazole for less than two years (mean 11 months, range 6--19 months), 91 per cent had relapsed at five years. Of 79 patients treated for longer than two years (mean 3.8 years, range 2 1/2--14 years), relapse rates at five and eight years were 49 per cent and 62 per cent. Nine patients (3.4 per cent) suffered permanent vocal cord paralysis and five (1.9 per cent) had permanent hypocalcaemia. The male/female ratio was 9.9 to 1, with a peak female prevalence between 25 and 30 years and a peak male prevalence between 40 and 45 years. The ABO blood group distribution among patients did not differ significantly from the distribution in the general population (chi 2 = 13.4, p = 0.2). Forty-seven patients (5.6 per cent) had diabetes mellitus and thyrotoxicosis whilst two patients (0.23 per cent) had diabetes, thyrotoxicosis and pernicious anaemia.

ABO Blood-Group System↗
PubMed1995

[The role of radio-inhalation scintigraphy in diagnosing tumors of the main bronchi].

The distribution of inhaled radio preparation has been studied in 7 cases of main bronchus neoplasms and 25 healthy subjects. Patterns of radio aerosols deposition have been followed versus regime of inhalation. Application of said procedure serves to improve the existing methods of radio inhalation scintigraphy as well as diagnostic procedures for tumors of main bronchi which X-ray examination and functional assessment of external respiration fail to detect.

Administration, Inhalation↗
PubMed1995

[In vitro synergic lymphocyte stimulation in HIV-1 infected patients using inosine derivatives and radio-detoxified endotoxin].

Restoration of immune functions through promoting cell cycle might delay acquired immunodeficiency syndrome development. Therefore, stimulation of peripheral lymphocytes of human immunodeficiency virus-1 infected patients in successive clinical stages was studied by phytohaemagglutinin and other stimulants. In vitro blastogenesis was quantitated by 3H-thymidine uptake. Stimulation by phytohaemagglutinin decreased in patients with AIDS related complex to 63.1%, with AIDS to 13.6% of control values. Small amount of recombinant interleukin-2 or indomethacin solely not promoting lymphocytes, increased response to phytohaemagglutinin minimally. Alone ineffective methyl-ester and methyl-phosphonate inosine derivatives augmented phytohaemagglutinin-response of controls and patients with AIDS related complex by approx. 1.5-fold, but the effect in the case of AIDS patients was minimal. Radio-detoxified endotoxin alone or in combination with phytohaemagglutinin stimulated lymphocytes of both controls and patients with AIDS related complex slightly. Lymphocyte stimulation of patients with AIDS related complex was augmented in concentration-dependent manner, and by synergic effect it approached phytohaemagglutinin-stimulated blastogenesis of controls. Anergy due to human immunodeficiency virus-1 infection damages synchronisation of secondary messenger systems induced on cell surface receptors, therefore their selective influence by recombinant interleukin-2 or indomethacin is less efficient. Inosine derivatives promote cell cycle by inhibiting cyclic adenosine 3',5'-monophosphate production. In the early stage of virus infection, radio-detoxified endotoxin might bind to receptors of immature T cells and facilitate cell cycle through cyclic guanosine 3',5'-monophosphate stimulation. The clinical trials of radio-detoxified endotoxin (Tolerin) have already been launched.

AIDS-Related Complex↗
PubMed1994

Radio-opacity of the paranasal sinuses. Conventional views and CT.

In order to examine the reliability of conventional views in predicting the degree of radio-opacity, irrespective of soft tissue or fluid seen in chronic sinusitis in adults, a comparison has been made between the results of evaluations by two routine views (Caldwell's and Waters') and by CT in axial scans. Ninety-seven sides (61 case) were included in the study. The radio-opacity was classified into three groups according to the degree of aeration or radiolucency. The diagnosis of plain films were classified into three categories (matched diagnosis, over-diagnosis, and under-diagnosis) in comparison to the radio-opacity depicted by corresponding CT scans. The incidences of matched diagnosis are, in the order of percentages: maxillary sinus (78.4%), frontal sinus (71.1%), nasofrontal area (66.0%), anterior ethmoidal cells (52.6%), and posterior ethmoidal cells (52.6%). The incidence of over-diagnosis is highest in the posterior ethmoidal cells (52.6%) and lowest in the maxillary sinus (20.6%). The incidence of under-diagnosis is highest in the anterior ethmoidal cells (24.7%) and lowest in the maxillary sinus (1.0%).

Adolescent↗
PubMed1994

The efficacy of compression immobilization technique in retarding spread of radio-labeled Russell's viper venom in rhesus monkeys and 'mock venom' NaI131 in human volunteers.

The efficacy of the modified compression immobilization technique in retarding spread of radio-labeled Russell's viper venom in 3 rhesus monkeys (Macaca mulata) and "mock venom" NaI131 in 14 human volunteers was studied. 0.1 microgram of Russell's viper venom having 10 microCi radioactivity in 0.2 ml normal saline containing 0.5% bovine serum albumin was injected subcutaneously at the lateral aspect of the right hind limb of a rhesus monkey. A hand-tight bandaging of a rubber pad measuring 55 x 28 x 16 mm over the injection site and splinting effectively retard spread of radio-labeled venom for the entire length of time applied, although complete immobilization was not achieved. In human volunteers, application of a pad measuring 60 x 50 x 17 mm over the subcutaneous injection site of 20 microCi or 12 microCi/0.2 ml NaI131 with a hand-tight bandaging (60 +/- 10 mmHg) and immobilization of limb was found to be effective in retarding the movement of radioactive NaI131. These results suggested that the compression pads tried in this study effectively retard the spread of radio-labeled Russell's viper venom (MW ranging from 20,000-90,000) and radioactive NaI131 (MW 150) from the site of injection. Thus, it is highly likely that the present compression pad will be useful as a first-aid measure in Russell's viper bite victims.

Adult↗
PubMed1993

[Correction of posttraumatic disorders of the distal radio-ulnar joint with the Sauvé-Kapandji surgical procedure].

The Sauve-Kapandji procedure was performed on 21 patients with posttraumatic lesions between May of 1985 and May of 1991; average clinical and radiological follow-up was 3.4 years. Causal mechanisms were as follows: 12 cases were sequelae of fractures of the distal extremity of the radius; 5 cases were sequelae of fractures of the diaphyses of the two forearm bones and/or of the head of the radius; 2 cases of instability of the distal radio-ulnar joint; 2 cases of posttraumatic isolated arthritis of the distal radio-ulnar joint. Subjective evaluation by the patients of the results of surgery was as follows: 8 excellent, 6 good, 2 satisfactory and 5 poor. The most consistent improvement was a gain of mobility in pronation and supination which averaged 87 per cent of that of the healthy contralateral side. Nine patients were free of pain, 6 experienced some pain only during effort, and 6 still suffered constant pain. Grip strength was the factor that changed the most: it averaged 55 per cent of that of the healthy contralateral side. Indications for the Sauve-Kapandji procedure and its results in posttraumatic lesions are discussed. This procedure is compared to other techniques used to correct posttraumatic disorders of the distal radio-ulnar joint.

Adolescent↗