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Results for “RADIATION-PROTECTIVE AGENTS”

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At least 379 records · Page 21Linked to original sources
PubMed1977

[Toxicity and side effects of antibiotics in radiation sickness and during the use of aminothiol group radioprotective agents].

It was shown in experiments on mice, rats and rabbits that resistance of animals in the state of acute radiation sickness to severe intoxication by aminoglycoside antibiotics, such as streptomycin, dihydrostreptomycin and monomycin did not significantly change. The exception was kanamycin the toxicity of which during the period of the acute state of radiation sickness increased by 30 per cent. The use of cystamine and merkamine before irradiation or their administration to non-irradiated animals resulted in lowering of the antibiotic tolerance by 1.5--2 times. The above aftereffects of the radioprotectors was observed within 3--12 days after their use and was most pronounced for the combination of cystamine and streptomycin. The acute toxicity of tetracyclines did not significantly differ at various stages of radiation disease and at the background of cystamine use. No significant cumulation of the toxicity of aminoglycoside antibiotics and tetracyclines or signs of adaptation in the healthy and irradiated animals was observed on prolong treatment with therapeutic doses. Cystamine had no effect on the tolerance of the antibiotics on their prolonged use.

Animals↗
PubMed1977

[Evaluation of the protective effect of Prussian blue, sodium alginate and calcium phosphate according to tumor development after single and chronic exposure to strontium 90 and cesium 137 mixture].

The mixture of radionuclides was employed in the concentrations of 100.0, 400.0 and 0.8, 2.0 mc/rat for strontium-90 and cesium-137 in single and chronic administration correspondingly. Prussian blue, sodium alginate and calcium were employed in amounts of 50 mg, 800 mg and 258 mg per rat a day. The data obtained are correlated with the results of the same experiments without using the protection. In compared doses of the irradiation the protective action of the substances under study was noted only in chronic experiments. In this case, the appearance of malignant neoplasms was nearly twice less, and the survival was 120 days longer. The absorbed doses were decreased by 17 times for cesium-137 in the whole body and nearly by 4 times for strontium-90 in the skeleton.

Alginates↗
PubMed1979

Induction of interferon and radioprotective activity of polyriboguanylic-polyribocytidylic acid complex in mice.

The effect of polyriboguanylic-polyribocytidylic acid complex was investigated against acute X- and prolonged 60Co-gamma irradiation. Prophylactic administration of the polyribonucleotide complex increased endogenous spleen colony formation and the percentage of survival of irradiated BALB/c mice. The most pronounced effect was observed when the animals had been irradiated at the time of maximum interferon accumulation in blood, i.e. 24 hr after interferon induction by the polyribonucleotide complex.

Animals↗
PubMedDate not supplied

[Several features of the antioxidant action of chemical carcinogens].

Comparative studies of antioxidative effects of phenole inhibitors (vitamine E) amino-and sulfur-containing radioprotectors, and chemical cancerogens on oxidation of unsatured fatty acid were carried out. Some polycyclic hydrocarbons and azo-compounds produce a prolonged and stable decrease of peroxide accumulation rate in oxidized oleic acid. Due to this property in the in vivo systems chemical cancerogenes can induce prolonged stable changes in the parameters of vitally important redox processes.

9,10-Dimethyl-1,2-benzanthracene↗