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PubMed1991

Digitally calibrated eye movement measurement system.

A less expensive instrumentation alternative to record horizontal eye movements is presented in the form of a feasibility study. Currently, there are several techniques used to accurately measure eye position for research purposes. To implement these techniques, significant financial resources are required. The proposed technique costs less than $3000.00 and is based upon the limbus position technique. A linear charged coupled device (CCD) image array sensor and a biconvex lens are used to determine the position of the pupil. The self scanned CCD array is controlled by four analog clock signals generated from digital logic. The CCD video output signal is converted to a TTL compatible signal. The TTL signal is used to create a digital number based upon the limbus image formation upon the CCD pixels. This digital number is processed using standard signal acquisition techniques and is recorded on the hard drive disk of an IBM PC/AT compatible system. The C programming language is used to acquire the data and control calibration of the system. FORTRAN software is used to implement digital signal processing algorithms and estimate eye position.

Calibration↗

PubMed1990

A general numerical method evaluating three-dimensional eye rotations by scanning laser ophthalmoscopy.

A general computational method is described to specify completely the rotational state of the eye in three dimensions by scanning laser ophthalmoscopy (SLO). The method uses the simplex algorithm to fit the eye's rotational parameters to data given by n individually selected ocular fundus landmarks before and after the eye rotation. The rotational parameters are expressed as the rotation vector and three spherical Euler angles. The method, which was implemented in the C programming language, can be applied for various eye movement measurements in clinical and laboratory environments, including SLO.

Algorithms↗

PubMedDate not supplied

[Informatics in mental sciences: clinical data management and "expert systems"].

The role of information systems and particularly that of expert systems in medicine is analysed in brief. It is pointed out that, unlike other branches of medicine, in mental sciences the role of expert systems has so far been more limited because of certain intrinsic problems of programming on the one hand, and the scientific models of the psychiatrist on the other. An improvement in information technology and programming languages and better empirical classification of mental disturbances could provide useful bases for the realisation of computerised consultancy systems in mental sciences.

Algorithms↗

PubMedDate not supplied

Turbidimetric microbiological assay results calculated by a BASIC computer program.

A BASIC computer program was used to calculate the results of microbiological vitamin assays. The program, which incorporates the official AOAC guidelines for microbiological methods, reduces the uncertainty inherent in manual curve plotting and interpolation and minimizes the human error of repetitive calculations. Because the BASIC programming language is well suited for use on self-contained personal computers, it can be easily adapted by small laboratories.

Food Microbiology↗

PubMed1989

[A computerized system for the management of clinical data in a cardiology service].

The authors describe a computerized system for medical records built in order to obtain rapid information about the data of the overall patients and to quickly manage the clinical research of the Institution. The hardware, an Olivetti M 19 personal computer with a 10 Mbyte hard disk, can manage the clinical data on 3000 patients or more; the software, DBase III Plus, by Ashton-Tate, has a programming language easy to use, even by non-experts. The system allows immediate statistical analysis of all patients and of all 350 parameters included in the database.

Database Management Systems↗

PubMed1989

[The use of iridoscopy in prophylactic examinations].

To study the method of iridodiagnosis, clinical and iridoscopic examinations were conducted in 1104 patients and healthy persons, of them 516 men and 588 women, aged from 18 to 65 years. The contingent of the subjects represented 6 groups of patients with the most frequently observed pathology and a control group. The results obtained allow to consider that iridoscopy is indeed a sufficiently informative method for diagnostics of organ pathology without differentiation, in most of cases, between nosologic units, and achieves the highest effect in combination with detailed collected complaints and the anamnesis. The method can be used in prophylactic examinations of big contingents. The attempt to formalize iridoscopic data has shown that it is possible, in principle, to draw up a diagnostic algorithm, to describe it in one of programming languages and to work out an iridodiagnostic complex.

Adolescent↗

PubMed1989

BioGraf 3D: an algorithm for optimization and graphical representation of nuclear structure spatial distributions.

BioGraf 3D is a computer algorithm for rapid three dimensional visualization and analysis of digitized three dimensional biological data to aid in the subsequent generation of models of nuclei or cells. This graphically oriented program permits unlimited three dimensional perspective viewpoints of data in onscreen single frame, zoom or stereo forms. Analysis of data is enhanced by an optimization problem solution which determines viewpoint coordinates whereby maximum clustering of preselected structures is achieved. Mathematical representation of the transformations and optimization is presented in detail. Biograf 3D is written in the C programming language for IBM and compatible personal computers. In this study BioGraf 3D is utilized to examine the infrastructure of the nucleus and the spatial distribution of meiotic chromosomes in the hermaphroditic nematode Caenorhabditis elegans.

Algorithms↗

PubMed1986

[Computer-assisted instruction in training and continuing education in veterinary medicine].

The microcomputer is an excellent instrument for stimulation in training in clinical problem-solving. However, the construction of computerprogrammes requires far too much time of teachers. At the Department of Surgery of the University Hospital at Leiden, a software package was developed, called 'CASES' (Computer-Assisted Simulation and Education System). This authoring system enables the clinical teacher to create a new 'case' within a few hours. When this type of computer-assisted instruction is used a student must attempt to solve a problem and in doing so will make a few, or possibly several, mistakes. The author of the programme will comment upon all the mistakes which are made. It is, as if the teacher were personally present and giving private instruction to his student. To create a case the teacher does not need any knowledge of computers nor of programming-languages. Other fields of use could be post-graduate training. By mailing floppy-discs to the doctor's home he could have his interactive training by experts at home in his own study. With little if any modifications, this system may also be used in veterinary medicine. It runs on IBM-PC's (128 K) and all compatible hardware.

Computer-Assisted Instruction↗

PubMedDate not supplied

[Simulation modelling of cell systems in definitive and developing tissues].

A review of simulation models of cells is provided, with a description of the basic methods of simulation. The deterministic and stochastic models of cell kinetics are considered on a few examples. A tendency has been revealed to applying the method computer reflection of the structure of heterogeneous cell systems. The utilization of specialized programmed languages of simulation is considered as promising.

Animals↗

PubMed1985

Microcomputer applications in health population surveys: experience and potential in developing countries.

Regrettably, because the content and technology are evolving so rapidly the literature on the application of microcomputer technology to health and development is either out of date, or hard to find (e.g. unpublished reports from consultants working with development agencies or universities). The time needed to review and publish an article or a book dictates that by the time it is published, any statements about current hardware will be obsolete. For example, a recent volume by Ingle et al., quite sound from the theoretical and practical point of view is already out of date with respect to hardware details. For that reason no hardware suggestions are made in this article. On the other hand, detailed reports of experience with first-generation microcomputers are very useful to the individual planning a developing country application. From the literature and our own field experience with respect to microcomputer applications in health/population surveys in developing countries, the following are useful summary points for projects currently going into the field. Careful planning is absolutely necessary if microcomputer technology is to be applied successfully to field data collection problems. Search out organizations with similar experiences. Collaboration among staff at all levels is essential for a system to be installed and utilized effectively. The particular technology combination selected must be adapted to the field situation. Remember survey complexity and size. Training is essential, and should be on-the-job and oriented towards specific tasks. If time consuming and repetitive tasks are given over to the microcomputer the technology will be readily accepted and fully utilized. To the extent that a community of users can be formed, the entire adoption process will be stimulated and results improved. Most maintenance and some repairs should be carried out in the field by local project personnel. For most survey and data acquisition problems some custom programming will be needed; this requires a good working knowledge of a powerful programming language (although this is likely to change in the near future). For descriptive statistics and small data management problems off-the-shelf software is appropriate but can be expensive. Compare options. Standardization and compatibility must be considered in all applications. This is important!(ABSTRACT TRUNCATED AT 400 WORDS)

Computers↗

PubMed1979

Quantitative image analysis: applications using sequential transformations.

The theoretical foundations of quantitative image analysis and its implementation in the Leitz T.A.S. have been discussed in the preceeding paper [4]. Especially the Mathematical Morphology and its recent developments have been pointed out. Sequential image transformations are a new approach of morphological analysis. Elementary transform steps, which are hardwired in the device, performed in specific sequences, which are implemented as macroinstructions in the programming language have proven to be a very useful tool in image analysis. A specific sequence of elementary steps will be referred to as morphological function. This new approach will be illustrated by four general examples: analysis of fibers, computing the number of edges for metallic grains, separation of overlapping cells, analysis of minerals which occur free and locked to another one.

Cell Separation↗

PubMedDate not supplied

Mirex kinetics in the rhesus monkey. II. Pharmacokinetic model.

14C-Mirex was given iv and po to female rhesus monkeys (Macaca mulatta) and radioactivity was measured in plasma, urine, and feces at intervals after dosing and in tissues when animals were killed. Graphical analysis of plots of the logarithm of plasma concentration vs. time was used to provide estimates of the values of the first-order rate constants required by the proposed pharmacokinetic models. A BASIC-language program, FITKIN, was used to obtain numerical solutions to the differential equations for each model and to adjust the estimates to obtain a normalized, least squares fit. Of several models postulated, a mammillary, four-compartment, open-system model, providing for the urinary excretion of Mirex from a "central" compartment and for the fecal excretion of Mirex from a "fast" tissue compartment, yielded theoretical data in agreement with observed values. This model predicted that the accumulation of Mirex into fat would be retarded by the presence of a "slow" tissue compartment so that distribution equilibrium would take about half a year. From that time to the end of a 5-year projection, little decline in the quantities of Mirex was predicted for any compartment. Sequestration in fat and a lack of metabolism were responsible for the long biological half-life of Mirex in the rhesus monkey.

Adipose Tissue↗

PubMedDate not supplied

[Superposition of scintigraphic images using a computer].

A new method of coincidence of scintigrams received from a patient laying in an arbitrary position is proposed. Coincidence of point sources at 2 anatomical reference points is made before examination. Coincidence is realized by rotation and movement of one image relatively to the other one. This method is realized on a specialized data processing system MDS. Programming language is FORTRAN-4. The method is applied to complex examinations of the lungs and liver.

Computers↗

PubMed1982

[Mathematical methods in flow cytometry: the problem of evaluating DNA histograms of partially synchronous cell populations].

There is presented a procedure for determining the phase fractions in a cell population (i.e. the fractions of the G1-, S- and G2 + M-cells) from the corresponding DNA histogram obtained by flow cytometry. The evaluation procedure can regard arbitrary apriori information about the model parameters. It is based on a mathematical model of the DNA distribution for a growing cell population which contains the phase fractions and some further values as parameters. The parameter estimations rest on the Maximum-Likelihood-Principle by which the parameters of the theoretical model must be determined in such a way that the measured histogram corresponds to a maximum probability. As a consequence of the model flexibility especially the S-phase fraction which can be determined independently by labeling techniques, can be regarded as a fixed predetermined value. Such apriori information enhances the preciseness of the parameter estimation. The applications have shown that the determination of the S-phase fraction by means of flow cytometry can be very unprecise especially under partial synchronization. For the application of the evaluation programs (programming language ALGOL) the histograms must be free of cell detritus and clumping.

Animals↗

PubMed1994

Information revolution in nursing and health care: educating for tomorrow's challenge.

Current emphasis on the national electronic highway and a national health database for comparative health care reporting demonstrates society's increasing reliance on information technology. The efficient electronic processing and managing of data, information, and knowledge are critical for survival in tomorrow's health care organization. To take a leadership role in this information revolution, informatics nurse specialists must possess competencies that incorporate information science, computer science, and nursing science for successful information system development. In selecting an appropriate informatics educational program or to hire an individual capable of meeting this challenge, nurse administrators must look for the following technical knowledge and skill set: information management principles, system development life cycle, programming languages, file design and access, hardware and network architecture, project management skills, and leadership abilities.

Computer User Training↗

PubMed1994

A computer-based instrumentation system for measurement of breath-by-breath oxygen consumption and carbon dioxide production.

Improvements are implemented (Version 4) in a Computer-Based Respiratory Measurement System (CBRMS) identified as Version 3. The programming language has been changed from Pascal to C. A Gateway 2000 desktop computer with 486 DX2/50MHz CPU and a plug-in data I/O board (KEITHLEY METRABYTE/ASYST/DAC's DAS-HRES 16-bit Analog and Digital I/O board) replaces an HP 9836 system used in Version 3. The breath-by-breath system consists of a mass spectrometer for measuring fractional concentrations of oxygen and carbon dioxide and the accommodation of a turbine or pneumotachometer for measuring inspiratory and expiratory flows. The temperature of the inspiratory and expiratory gases can be monitored if temperature corrections are necessary for the flow measurement device. These signals are presented to the PC via the data acquisition module. To compare the two Versions, ten significant respiratory parameters were investigated and compared for physiological resting states and steady states obtained during an exercise forcing. Both graphical and statistical (analysis of variance, regression, and correlation) tests were carried out on the data. The results from the two versions compared well for all ten parameters. Also, no evidence of a statistically significant difference was found between the resting and steady-state results of the present CBRMS (Version 4) and the previous CBRMS (Version 3). This evidence suggests that Version 3 (Pascal) has been successfully converted to Version 4 (C). Implementation of the CBRMS in C on a PC has several advantages.(ABSTRACT TRUNCATED AT 250 WORDS)

Carbon Dioxide↗

PubMed1994

An object-oriented tool for the generation and management of multimedia patient folders.

Computer-based patient folders are evolving from the simple reproduction of traditional paper documents toward active tools, able to support the whole diagnostic and therapeutic process. The advent of multimediality has given emphasys to the idea of computerized folder, i.e. a collection of heterogeneous kinds of documents pertaining different media. In this paper we present a tool implementing generation and management of multimedia patient folders showing its architecture and functionalities and the innovative interaction paradigms adopted. The tool realized allows medical users to choose the concepts desired in their target application and generates a customized patient folder management system by means of a friendly interface and without the need of a programming language. The system automatically created can be effectively employed for reporting and storing clinical cases.

Computer Systems↗

PubMed1994

Realistic modeling of clinical laboratory operation by computer simulation.

An important objective of laboratory management is to adjust the laboratory's capability to the needs of patients' care as well as economy. The consequences of management may be changes in laboratory organization, equipment, or personnel planning. At present only one's individual experience can be used for making such decisions. We have investigated whether the techniques of operations research could be transferred to a clinical laboratory and whether an adequate simulation model of the laboratory could be realized. First we listed and documented the system design and the process flow for each single laboratory request. These input data were linked by the simulation model (programming language SIMSCRIPT II.5). The output data (turnaround times, utilization rates, and analysis of queue length) were validated by comparison with the current performance data obtained by tracking specimen flow. Congruence of the data was excellent (within +/- 4%). In planning experiments we could study the consequences of changes in order entry, staffing, and equipment on turnaround times, utilization, and queue lengths. We conclude that simulation can be a valuable tool for better management decisions.

Chemistry, Clinical↗