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At least 379 records · Page 21Linked to original sources
PubMed1992

Importance of establishing appropriate local reference values for the screening of hemochromatosis: a study of three different control populations and 136 hemochromatosis family members. Hemochromatosis Clinical and Research Group.

Hemochromatosis is a human leukocyte antigen-linked (HLA-linked), potentially lethal disorder of iron metabolism with a high prevalence in white populations albeit an autosomal recessive mode of transmission. The diagnosis and treatment at early stages of the disease are critical to the prevention of the morbidity and mortality caused by the iron overload. After the identification of the first cases of hemochromatosis in Portugal, a screening program was started with a systematic search for the disease among family members of the patients, as well as in subjects from the normal population. In this study we analyze the results obtained with a total of 136 family members from 15 different families and 353 control subjects from three different villages, two in the north and one in the south of Portugal. We establish reference values for the biochemical tests used in the screening for iron overload and analyze the factors that affect those results. Besides sex-related differences, factors that were found to influence biochemical parameters most significantly included age and levels of daily alcohol intake. In addition, differences in iron status were identified between the populations from the regions in the north and the south of the country. We estimate, by HLA typing and family studies, a gene frequency for hemochromatosis of 0.14 that corresponds to a frequency of homozygotes and heterozygotes of 0.019 and 0.24, respectively.

Adolescent↗
PubMed1994

[Comparative study of lipids, apoproteins and lipoproteins in patients with coronary disease and in a control population].

We carried out a comparative study of various lipid parameters (apo AI and B, LpAI, Lp(a) and LpBCIII) in coronary heart disease patients (19 males and 4 females, mean age 61 +/- 11 years) and in controls (18 males and 14 females, mean age 55 +/- 3 years) selected so that cholesterol and triglycerides levels be beneath 6 and 2.3 mmol/l in both populations. Apo AI and B were analysed by immunonephelometry and lipoparticles by electroimmunodiffusion. Nonparametric statistics tests were performed on account of the small numbers in both groups. Our study confirms the protective effect of Lp AI but did not show an obvious superiority of Lp AI quantification compared to apo AI. It highlights the interest of Lp(a) as an independent and additional risk factor for atherogenesis: no obvious correlation with any other lipidic parameter was demonstrated. An increase in Lp(a) beyond 0.30 g/l increases atherogenic risk 2.5 fold. We did not show any benefit of LpBCIII quantification in 'normolipemic' coronary patients. In conclusion, a discriminant analysis including the apo B/apo AI and apo B/LpAI ratios and Lp(a) allows an accurate classification of 67% of the patients.

Apolipoproteins A↗
PubMed1967

Health, population, and economic development. International health programs have an important role in promoting economic development and population control.

Health as a basic human value is particularly important to people in the developing world. Rates of economic development lower than had been hoped for and ever more steeply rising population growth have precipitated a reaction against public health programs. Among economists, agriculturalists, and even health professionals the philosophy arose that one should "hold back" on using modern weapons against disease because they are "too effective." To satisfy the recognized popular demand, simple and relatively ineffective measures of curative medicine could be substituted. It was said that the emphasis should be, instead, on agriculture, community development, education, and industrialization and that family planning should be pushed as a separate program. Documentation presented here sharply challenges such a point of view. No segment of the total development process can be effective without the other sectors.

Demography↗
PubMed1976

Similar serum IgM concentrations in Greek endemic goiter and control populations: failure to confirm previous experience.

Circulating immunoglobulin M (IgM) concentrations were determined in 47 nontoxic goiter patients from four Greek endemic goiter areas, and in 13 patients from Athens, a non-goitrous area; and compared with 38 control non-goitrous subjects from the same goiter regions, and 23 more controls from Athens. The values in both goitrous and non-goitrous groups were indistinguishable. Current techniques for single radial immunodiffusion were employed. The results are expressed in standardized international units/ml serum, instead of the formerly used mg/dl. The present findings are in disagreement with the earlier observation from this laboratory that 40 per cent of goitrous patients had elevated IgM values compared with 10 per cent of control subjects.

Adolescent↗
PubMed1977

[Epidemiology of C57 black/6M mouse strain: statistical findings in a control population].

Non-linearity in age specific gompertzian rates regression versus age was observed in actuarial analysis of all causes of death, tumor incidence and tumor/tumor-host index in 503 male and 497 female control C57 Black/6M mice. The overall tumor incidence averaged 66.7% in males and 84.4% in females during a maximum lifespan of 1,300 days. In males as well as in females, time related incidence peaks were identified for lymphocytic lympho-sarcomas, reticulum cell sarcomas, histiocytic type and reticulum cell sarcomas of reticular type.

Age Factors↗
PubMed2003

Prevention of severe hypoglycaemia in type I diabetes: a randomised controlled population study.

AIMS: To investigate use of targeted self study material in type I diabetes patient education regarding dissemination, perceived patient benefit, and prevention of severe hypoglycaemia. METHODS: In a randomised 1:1:1 controlled study, 332 patients with type I diabetes (aged 2.6-18.9 years) were studied; 313 completed clinical follow up, 261 completed endpoint questionnaire. The intervention group received videotapes and a brochure designed to review skills for self control and treatment, aimed at preventing severe hypoglycaemia. Two control groups received a videotape and brochure with general diabetes information, or traditional treatment only, respectively. RESULTS: Yearly incidence of severe hypoglycaemia decreased from 42% to 27% in the intervention group, but not in controls. HbA1c remained unchanged. Levels of use ranged from 1 to 20 times (median 2); 40-49% had shown the materials to friends, relatives, school staff, sports coaches, etc (there was little difference between intervention and control groups). Higher benefit and learning levels resulted from the intervention material, especially in patients with severe hypoglycaemia. CONCLUSIONS: Mass distributed pedagogical devices such as high quality video programmes and brochures may contribute to the prevention of severe hypoglycaemia. Such self study materials can reach high dissemination levels and constitute a cost effective complement to regular visits to a diabetes team and to other types of education. The findings may have implications for other topics, other ages, and other diagnosis groups.

Adolescent↗
PubMed1989

Comparison of serum beta-2-microglobulin levels in patients with symptoms of allergic rhinitis and elevated modified RAST scores vs. a control population.

Forty-four subjects, having clinical histories consistent with allergic rhinitis with modified RAST score(s) of two or more for at least one of five locally prevalent aeroantigens, were compared with 48 control subjects with modified RAST scores of zero for all given aeroallergens. There was no significant difference between these two groups in mean levels of serum beta-2-microglobulin (Student's t, p greater than 0.05).

Adult↗
PubMed1980

Psychometric comparisons of sociopathic and psychopathological behaviors of alcoholics and drug abusers versus a low drug use control population.

Scales derived from a self-administered questionnaire were used to assess the degree of sociopathy, alcohol/drug abuse, low moods, and sleep disturbances in 53 outpatient alcoholics, 11 prisoner-addicts, and 54 controls. Separate preadult and adult scales assessed pre- and postaddiction behaviors. Methodology differs from previous studies in that scaling permitted assessment of sociopathy, alcoholism, and drug abuse as graded phenomena; and drug scoring, as a function of number, frequency, and seriousness, was established prior to data collection. Data provide support for an affective-antisocial spectrum disorder characterized by early onset, low moods, and alcohol abuse, drug abuse, and/or antisocial behaviors.

Adult↗
PubMed1984

Epidemiological survey of dementia in parkinsonism and control population.

In a 13-year (1967-1979) survey of Rochester, Minnesota residents, 138 new cases of parkinsonism were recognized. For each case, 2 age- and sex-matched residents from the community were identified who attended the same medical facility as the patient did. Original medical records for 40 years preceding the diagnosis and control selection were reviewed on all patients and controls. Diagnosis of dementia was made three times more frequently in patients than in the controls, but the age at diagnosis was similar in the two groups. Those cases where neither of the three matched individuals had dementia at the time of initial recognition of parkinsonism were further followed. Dementia emerged significantly more frequently in patients than in controls. The subgroup of patients treated with levodopa had higher frequency of dementia than the controls. It is concluded that dementia is significantly more common in parkinsonian patients than in a comparable population. Dementia is believed to be either an integral part of the disease process or these patients are prone to some other illness that produces dementia. Our data conclusively show that dementia is not a reflection of old age. Higher incidence of dementia in levodopa-treated cases may be due to case-selection artifact or an as yet unrecognized effect of levodopa.

Age Factors↗