Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “MELIOIDOSIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 379 records · Page 21Linked to original sources
PubMedDate not supplied

[Some properties of plasmocoagulase of the causative agents of glanders and melioidosis].

Criteria for the evaluation of the plasmocoagulase activity of natural isolates and mutant strains of the causative agents of glanders and melioidosis were worked out, which made it possible to subdivide them by this sign into pathogens with high, moderate and low activity. Plasmocoagulase produced by pathogenic Burkholderia was shown to be a thermolabile enzyme, comparatively stable with respect to the action of such chemico-biological agents as hydrogen peroxide and chloramine.

Animals↗
PubMed2005

Seroprevalence of melioidosis in diabetic patients in Taiwan.

Diabetes mellitus is a major predisposing factor for Burkholderia pseudomallei infection. This study surveyed serum samples from 356 Taiwanese patients with diabetes mellitus for anti-flagellin antibodies against B. pseudomallei. Antibody titer to B. pseudomallei was positive in 3.0% (11/365) of diabetes mellitus patients. All seropositive individuals were aged > or =60, indicating that elderly and diabetic adults are at high risk of B. pseudomallei infection. In this study, diabetic females, who were usually housewives, had a seropositive rate of 81.1%. However, the incidence of melioidosis in males (usually working outdoors) was 93.7% based on clinical cases. We suggest that exposure of males and females to B. pseudomallei in this study was via different routes of infection.

Adult↗
PubMed2005

Melioidosis in Pahang, Malaysia.

We conducted a retrospective review of 135 patients with melioidosis in Pahang from January 2000 to June 2003. Patients were mostly male (78.5%) and Malay (83%) with a median age of 51 years. Seventy four percent of patients were diabetic. Common presentations were pneumonia (40.7%), septicaemic without obvious source of infection (19.3%) and multiple organ involvement (15.6%). Only 32.7% were given appropriate antibiotics empirically. The overall mortality was 54% with most deaths (65%) occurring within 48 hours of admission. Patients with pneumonia, multiple organ involvement and septicaemic of unknown source had higher mortality as compared to patients with subcutaneous, musculoskeletal or single internal organ involvement without pneumonia (p < 0.001). The relapse rate was 19.2%.

Adult↗
PubMed2006

Short report: Melioidosis in Myanmar: forgotten but not gone?

A serologic survey of adults resident in Myanmar was conducted to define the presence of antibodies to Burkholderia pseudomallei, the cause of melioidosis. Antibodies were detectable by indirect hemagglutination assay (IHA) in 757 (78%) of 968 adults, of whom 69 (7%) had an IHA titer > or =1:160.

Adult↗
PubMed1991

[Problems of resistance of the causative agent of melioidosis to antibiotics].

It was shown that the pathogen causing melioidosis was highly resistant to antibiotics including beta-lactams. Antibiotic sensitive mutants of P. pseudomallei were isolated after mutagenesis induced by nitrosoguanidine. Permeability for 3H-tetracycline and tetracycline sensitivity of the mutant cells was respectively 3 and 20 times as high as those of the initial parent strain. Gas liquid chromatography revealed quantitative and qualitative changes in separate sugars of the lipopolysaccharide structure in antibiotic sensitive mutants as compared to the initial strain.

Anti-Bacterial Agents↗
PubMed1990

Melioidosis: epidemiology and antibiogram of cases in Singapore.

There has been an increased incidence of melioidosis in Singapore. The disease affects mainly males, older patients and a disproportionately higher number of Indians and Malays. Possible predisposing illness include diabetes mellitus. Most patients are bacteraemic. Mortality rate is 72% for bacteraemic patients, as compared to 32% for non-bacteraemic patients. Local strains of Pseudomonas pseudomallei have been consistently sensitive to ceftazidime, chloramphenicol and piperacillin, and nearly always sensitive to tetracycline.

Adolescent↗
PubMedDate not supplied

[The ultrastructural characteristics of the causative agent of melioidosis and its interaction with phagocytes in vivo].

The electron microscopic studies have established that the virulent strain of Pseudomonas pseudomallei C-141, an agent of melioidosis, being intraperitoneally administered to guinea pigs, forms in vivo three morphological variants. One variant is capsule-free, while two others have a capsule which in the second variant may be referred by its characters to the microcapsule and in the third one to the macrocapsule. It has been shown that under the interaction of these three morphological variants with the microorganism cells the bacteria of the first and second variants are absorbed by phagocytes, whereas the microbial cells of the third morphological variant are more resistant to the phagocytosis.

Animals↗
PubMed1988

[Prospects of the use of chromosomal transformation for the identification of the causative agent melioidosis].

Prospects for the use of chromosomal transformation for the identification of Pseudomonas pseudomallei and some other medically important Pseudomonas species are considered. The method is simple, reproducible and highly specific. It permits the screening of a great number of cultures and can facilitate further study of the biology of P. pseudomallei and the epidemiology of melioidosis.

Animals↗
PubMed1988

Acute systemic melioidosis: an autopsy study of six cases.

Autopsy findings of six cases of the acute systemic melioidosis from Siriraj Hospital, Bangkok, Thailand during the years 1977 to 1986 are presented. Five out of six cases had some underlying conditions. Multiple abscesses and multiple organs involvement were the rule. The organs most commonly involved were lung and liver. Three patients had pericardial and one had adrenal gland involvement. Other significant pathological findings were fibrin thrombi (5/6 cases), haemorrhage (6/6 cases), tissue necrosis (4/6 cases) and granular casts in renal tubules (1/6 case). Abscess alone cannot explain the death of patients. Toxaemia, both exotoxins and endotoxin, is the most likely explanation from the death of patients.

Adult↗
PubMed1988

[Ecological and biological maintenance of sapronoses exemplified by melioidosis].

The growth and death of Pseudomonas pseudomallei, the causative agent of melioidosis, in the soil and the antigenic properties of this microorganism in the soil, in culture media, and in the body of animals have been studied. As revealed in this study, P. pseudomallei can grow in nonsterile soil substrates without the loss of virulence and changes in its antigenic structure. In the body of animals this microorganism rapidly adapts its virulence to host species by the transformation of its antigenic structure. The pathogenicity factors of P. pseudomallei are mainly thermolabile antigens, probably exoenzymes. This microorganism has been shown to have close ecological relations with abiotic environmental objects. The author suggests that the type of relationship between saprophytic microorganisms acting as causative agents of diseases and warm-blooded hosts should be characterized as pseudoparasitic.

Animals↗
PubMed1987

Melioidosis: a new disease to New Zealand.

The first case of melioidosis diagnosed in New Zealand is described. The patient presented with an abscess overlying the liver, which resolved on oral cotrimoxazole therapy, without the need for surgical drainage.

Administration, Oral↗
PubMed1986

[Possible use of the indirect hemagglutination reaction for determining the sensitivity of the bacteria of glanders and melioidosis to antibiotics].

The use of IHAT for rapid assay of antibiotic sensitivity of bacteria causing malleus and melioidosis was shown to be possible. Pure bacterial cultures and suspensions of the spleen of infected animals were used as the investigation objects. The materials were additionally grown in meat-peptone broth with 5 per cent of glycerol at 37 degrees C with addition of an antibiotic or without it (control). Antibiotic efficacy was estimated by the difference in the titers in the main and control experiments. The test not requiring isolation of pure bacterial cultures provided a 2-3-fold decrease in the investigation time.

Animals↗
PubMed1985

A case comparison of acquired immune deficiency syndrome (AIDS) in homosexual males with spindle-endothelial cell abnormalities and with recrudescent melioidosis.

The AIDS syndrome includes cases of biopsy-proven Kaposi's sarcoma in persons under 60 years of age, or biopsy- or culture-proven Pneumocystis carinii pneumonia, or either of the life-threatening opportunistic infections in young previously healthy persons with no underlying cause of immunodeficiency (Center for Disease Control criteria). Here we described the first case of AIDS with early Kaposi's sarcoma-like lesions in homosexual male drug addict and have compared the clinical and laboratory findings with those of another homosexual male having recrudescent melioidosis due to Pseudomonas pseudomallei.

Acquired Immunodeficiency Syndrome↗
PubMed1983

[Precipitation of the antigens of the causative agents of plague, glanders and melioidosis using aqueous saline extracts of various plant species].

The interaction of the aqueous saline extracts of 55 plant species with the antigens of the causative agents of plague, glanders and melioidosis in the reaction of immunodiffusion (RID) in gel has been studied. The aqueous saline extracts obtained from the seeds of 12 plant species have been revealed to possess precipitating capacity. At the same time these extract have been found to ensure, as a rule, RID with several antigens under test.

Animals↗
PubMed1984

Melioidosis: certain interesting presentations and treatment.

Eight cases of melioidosis with different clinical presentations are described. The compromised host defense is evident in view of the underlying conditions in all cases. Treatment with appropriate antibiotic combinations proved to be effective in curing the disease.

Adolescent↗
PubMed1984

Pleuropulmonary melioidosis in a Cambodian refugee.

A 47-year-old Cambodian refugee presented with an acute respiratory illness that featured consolidation of the lower lobe of the left lung and progressive involvement of the adjacent pleura caused by Pseudomonas pseudomallei. Initial difficulty in identifying the organism resulted in an inadequate duration of therapy. Chronic pleural disease followed, and the organism became resistant to many antibiotics during therapy. A diagnosis of pleuropulmonary melioidosis should be entertained and the microbiology laboratory alerted when patients with pneumonia who are from endemic areas are encountered, so that a diagnosis can be made early and the appropriate treatment begun.

Anti-Bacterial Agents↗