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PubMed1991

[Experimental premises and 1st experiences in the clinical use of antibacterial vascular prostheses under circumstances of increased risk of suppuration].

It was shown on the basis of laboratory and experimental data that created antibacterial vascular prostheses are marked, on the main, by local bacteriostatic and anticoagulative effect. It was found that heparin concentration of 3 to 500 U per 1 kg collagen causes a hyperadhesive effect on blood platelets and facilitates the formation of the primary thrombocytic thrombus. The free surface energy grows in this case from 34 +/- 0.8 to 66.3 +/- erg/cm2. The optimal thromboresistant effect occurs in heparin content of 1 U per 1 mg collagen. That this choice is correct is confirmed on examination of the inner surface of the prostheses with an electron microscope after being in the blood flow for 45 minutes. Bifurcation and linear antibacterial prostheses were used in 9 patients with a high risk of suppuration verified by cultures of discharge from ulcers and lymph nodes, and the presence of lymphangitis and lymphadenitis. The effect was positive in 8 patients, 2 of them had superficial suppuration of the operative wounds.

Animals↗
PubMed1991

Lymphedema of the leg associated with rheumatoid arthritis.

A 14-year-old boy with a two year history of seronegative rheumatoid arthritis developed left leg lymphedema and subsequently a severe episode of lymphangitis. The diagnosis of "rheumatoid lymphedema" was confirmed by lymphscintigraphy and conventional lymphography. Treatment consisted of bedrest and antibiotic drugs. When the signs of inflammation had subsided, therapy with corticosteroids was started with improvement of both joint pain and leg swelling. Whereas lymphedema associated with rheumatoid arthritis has been described in the upper limb of adults, to our knowledge this is the first report of the coexistent condition in the lower leg of a child.

Adolescent↗
PubMedDate not supplied

[Clinical aspects and etiology of lymphedema of the lower limbs in adults].

Classical lymphedema, more than the most frequent complications, is the clinical manifestation of decompensated lymphopathies of the lower extremities. These edemas are supra-aponeurotic and always completely painless, when isolated. There are three types:distal lymphedema occurring on congenital lymphopathy, the most frequent, with are sudden onset with lymphangitis, usually insidious, intermittent, soon characterized by fibrosing edema of the toes and the ankle. Proximal lymphedema secondary to iliac nodes blocking, rarely benign, most of the time malignant and/or iatrogenic (surgery and/or radiotherapy), predominantly at the origin of the thigh, respecting the foot. Post-traumatic hanging lymphedema after extended impairment of the superficial paths, most often transient.

Humans↗
PubMedDate not supplied

[Value of a papain-treated homologous microfilarial antigen in the diagnosis of filariasis due to Wuchereria bancrofti var. pacifica. Analysis of 237 cases].

An indirect immunofluorescence assay using papaïn treated microfilariae (IFI-WBp) has been performed to attempt diagnosis of bancroftian filariasis. The authors have analysed 237 bed-rests of patients consulting for specific and non specific lymphangitis, chyluria, elephantiasis, hydrocele or just asymptomatic hypereosinophilia. Taking into account the clinical aspects, the parasitological and the serological results, they have shown the efficiency of IFI-WBp (titre greater than 80) to diagnose filariasis in French Polynesia where only one species of filaria is present (Wuchereria bancrofti var. pacifica.)

Animals↗
PubMed1985

[Clinical study of cefminox in respiratory tract infections].

A new cephem cefminox (CMNX, MT-141) was used in the treatment of 22 cases of respiratory tract infections without taking into account background factors of patients. The dosage was 2 to 4 g/day in 2 divided doses and the treatment was continued for a period 2 to 17 days. The breakdown of the diseases treated was; pneumonia in 7 cases, secondary lung abscess (rS3)+middle lobe syndrome in 1 case, chronic bronchitis in 3 cases, bronchiectasis in 10 cases and intrapulmonary lymphangitis carcinomatosa (suspected) in 1 case. The clinical results were rated as excellent in 7 cases, good in 11 cases, fair in 1 case and unknown in 3 cases, with an excellent rate of 36.8% and excellent+good rate of 94.7%. The causative organisms were identified in 10 cases and included H. influenzae for 8 cases, Klebsiella sp. for 1 case and S. aureus for 1 case. The analysis of bacteriological study revealed disappearance of all of these organisms. However, in 3 out of 8 cases where H. influenzae was isolated and in 1 case where Klebsiella sp. was isolated the changes of organisms to P. aeruginosa were observed. As the adverse reactions, rashes developed in 1 case and moreover laboratory test results revealed elevation in transaminase in 3 cases. All of these symptoms were mild in nature and none of our cases experienced serious adverse reactions attributable to CMNX. From these results, we believe that CMNX is one of the useful drugs for the treatment of respiratory tract infections.

Adult↗
PubMed1979

Primary cutaneous coccidioidomycosis in a dog and a cat.

Primary cutaneous coccidioidomycosis was diagnosed in a dog and a cat examined because of lymphangitis and lymphadenitis associated with skin wounds. This benign and self-limiting form of disease was distinguished from the skin lesions associated with systemic coccidioidomycosis by means of historic, physical, and serologic criteria established in human medicine.

Animals↗
PubMed1979

Lymphatic complications of manual herpes simplex infection.

In seven patients with typical recurrent herpes simplex of the hand, lymphatic complications, developed in the arm during periods of herpetic activity. Six of the patients presented with lymphangitis and lymphadenitis. In one patient, persistent lymphedema developed in the involved hand and forearm.

Adult↗
PubMedDate not supplied

[Indications for corticotherapy in phlebology].

Corticosteroid therapy has not revolutionised phlebology but it is very useful in certain cases. The following indications are considered, with or without associated antibiotics : anaphylactic shock after sclerosant injections, chronic lymphangitis of the lower limbs, sclero-inflammatory hypodermatitis, eczemas, phlebitis, ulcers and angiomas. Various forms of corticosteroid therapy are considered ; injectable, long-acting, local and oral.

Adrenal Cortex Hormones↗
PubMed1984

Pathology of experimental infection with Brugia malayi in ferrets: comparison with occult filariasis in man.

Ferrets experimentally infected with Brugia malayi (subperiodic strain) developed eosinophilia at patency and usually became amicrofilaremic. Ferrets necropsied within 3 months after becoming amicrofilaremic had granulomas and focal reactions to degenerating microfilariae in their livers, lungs and lymph nodes essentially identical to those of tropical eosinophilia. Four of 7 ferrets that received multiple inoculations of larvae, developed edema of the inoculated paw and leg after becoming amicrofilaremic and 6 of these 7 ferrets had granulomatous lymphangitis and lymphadenitis of inoculated limbs but not the lesions of lung and liver characteristic of occult infection.

Animals↗
PubMed1983

[Aging and development, growth and spreading of cancer].

In spite of steep elevation of cancer mortality in the aged, it has been believed that ageing reduces susceptibility to carcinogens. Ebbesen, however, presented contradictory result recently. We examined influences of ageing on chemical carcinogenesis using 6 different age groups of rats given N-bis (2-hydroxypropyl) nitrosamine (DHPN). The results suggested (1) susceptibility to initiating process did not differ much, but promoting process might be prolonged in aged rats, and (2) susceptibility difference was enlarged in aged individuals. These data were supported by doubling time of lung tumors. Another evidence suggesting retarded tumor growth in the aged was observed in frequency of organ metastasis of gastric cancer. The conspicuous finding was shown in the number of cases of gastric cancer without any organ metastasis, i.e. 42.3% in the aged male and 9.3% in the younger male. Occurrence of lymphangitis carcinomatosa in the lung also showed distinct difference between the aged and the younger groups. This type of metastasis mostly derived from gastric cancer, especially signet ring cell cancer. Degree of differentiation of developed tumor may be another point of consideration to estimate the age dependency of tumor metastasis. We also have to pay some attention to the cancers increasing with age.

Aged↗
PubMed1977

[Physical rehabilitation in mastectomized women].

The paper highlights the importance of rehabilitation programmes for women subjected to radical mastectomy. Within the Milan National Tumour Institute, the activity promoted by the antalgic and Rehabilitation Department concerning some 700 patients per annum takes in 3 phases: information; prevention; treatment of the disease. After thorough psychological and medical observation of the patient, all available treatment methods are deployed on conditions which present in the form of hypomobility of the homolateral extremity, lymphangitis, lymphoedema and possibly neurological damage to the brachial plexus. The results of this rehabilitation programme have meant a notable reduction in the forms and have led to rapid return to society.

Exercise Therapy↗
PubMed1995

MR imaging of soft-tissue infection.

MR imaging is the ideal technique to display the soft-tissue abnormalities produced by infectious processes. In general these soft-tissue alterations consist of signal intensity changes that reflect the increased water content of the soft tissues induced by the inflammatory reactions. In some cases these changes are nonspecific, but in others, MR imaging can be quite specific and helpful in detecting the presence and extent of the infection, which generally is suspected clinically on the basis of physical and laboratory findings. The MR manifestations of soft-tissue infection, including septic arthritis, tenosynovitis, bursitis, cellulitis, necrotizing fascitis, soft-tissue abscess, infectious myositis, HIV-related infection, lymphadenitis and lymphangitis, and a few unusual parasitic and fungal infections, are reviewed.

AIDS-Related Opportunistic Infections↗
PubMed1998

[A rare case of severe pulmonary artery hypertension. Thrombosing pulmonary microangiopathy due to tumor].

We report a case of acute respiratory insufficiency with acute cor pulmonale and a fatal outcome. Right cardiac catheterisation enabled a diagnosis of precapillary pulmonary arterial hypertension to be made with a mean pulmonary arterial pressure of 61 mmHg and a pulmonary capillary pressure of 12 mHg. An autopsy was carried out and this revealed a microscopic pulmonary tumour emboli with lymphangitis carcinomatosis. In particular, it showed an association of fibrocellular proliferation at the level of the intima in the small calibre pulmonary arteries and arterioles permitting the unusual diagnosis of thrombosing pulmonary microangiomathy due to tumour. The physiopathological mechanism of this particular form of pulmonary tumour emboli is discussed; it would be secondary to an activation of the coagulation systems by the embolic tumour cells. Once activated, it is the lesions in the intima and not the carcinoma cells which generate the pulmonary arterial hypertension by vascular obstruction.

Adenocarcinoma↗
PubMed1978

A phase I study of active specific intralymphatic immunotherapy (ASILI).

Twenty-one patients with advanced malignancies who had exhausted or refused conventional modalities of treatment were entered in a Phase I toxicology trial of active specific intralymphatic immunotherapy (ASILI). The patients were immunized with 1 X 10(7) to 1.2 X 10(8) viable autochthonous or allogeneic irradiated tumor cells intralymphatically each month and received no other antineoplastic treatment. To date, 274 intralymphatic injections have been performed and except for one case of bacterial lymphangitis, no adverse side effects have been observed. ASILI did not significantly alter peripheral blood lymphocyte counts, absolute E-rosette forming cell levels, or EA-rosette forming cell levels. PHA reactivity of peripheral blood lymphocytes increased slightly in all but one patient tested. Seven out of nine patients who had not had delayed hypersensitivity to recall antigens developed positive reactions following ASILI. Sixteen out of twenty patients tested also developed reactivity to their immunizing cells after treatment. Objective regression (greater than 50% reduction of tumor mass) was observed in five out of nineteen evaluable patients. Six patient showed stabilization of tumor growth and eight patients continued to progress under treatment.

Adult↗
PubMed1990

Superficial microwave-induced hyperthermia in the treatment of chest wall recurrences in breast cancer.

Our study concerns 42 patients with chest wall recurrences from breast cancer: 17 Stage 1 (less than 4 cm in diameter), 11 Stage 2 (more than 4 cm), seven Stage 3 (skin ulceration whatever tumor size), and seven Stage 4 (neoplastic lymphangitis and/or skin nodules covering chest wall beyond midline). All the patients were treated with 2450 MHz microwaves by means of a generator with 4 magnetrons (250 to 300 W) and arterial applicators delivering 5 to 10 W/cm2. Each applicator is coupled with an infrared thermometer allowing an atraumatic temperature control processed by a PC-compatible computer using a Turbo Pascal program. A temperature of 41.5 degrees C to 42.5 degrees C was maintained for 45 minutes from the skin surface to a 2.5-cm depth within tissues. Hyperthermia alone was done in four patients; hyperthermia was combined with chemotherapy in four patients, and with electrontherapy (2 X 450 cGy or 3 X 350 cGy/week) in 34 patients: tumor dose under 3000 cGy in seven patients and over 3000 cGy in 27 patients. We observed a complete response in 22 patients (52.3%), a partial response (greater than 50%) in 11 patients (26.1%), and no response in nine patients (21.4%). No complete response was observed in patients treated with hyperthermia alone or in conjunction with chemotherapy. The local control was demonstrated to be improved only in patients treated with hyperthermia and radiotherapy. The results were correlated with tumor stage: ten complete responses out of 12 Stage 1, and one complete response out of four Stage 4. We noted nine side effects completely reversible within a month with no late skin reaction. Our results show that hyperthermia can give improved local control without any morbidity in treating chest wall recurrences of breast cancer.

Adult↗
PubMed1994

Modern therapeutic approaches to postmastectomy brachial lymphedema.

Over the past 10 years we have treated 36 patients affected by upper limb lymphedema, associated with mastectomy and axillary dissection, by either macrosurgical exeresis or microsurgical techniques. All cases had been unresponsive to prior drug or physical therapy (pressure and thermal therapy). Preoperative upper limb status was thoroughly examined by evaluating volume measurements, dynamic lymphoscintigraphy, venous Doppler fluximetry, ultrasonography, and nuclear magnetic resonance. Selected tests were repeated during follow-up to obtain more statistically significant results. Twenty-five of the 36 patients in our series presented a grade II lymphedema and underwent Degni-Cordeiro's microsurgical indirect lymphatico-venous shunt (L.V.S.) surgery. Fifteen of the 25 also received fasciotomies performed along the posterior aspect of the forearm. Three of the 36 patients presented grade II lymphedema and upper limb venous hypertension. These were treated with multiple fasciotomies alone. The remaining eight patients presented grade III lymphedemas. Seven underwent Kondoleon's partial superficial lymphangectomy, and one was treated with Servelle's total superficial lymphangectomy. Of the 36 patients who underwent surgery, only 27 were checked at 6 months; 22 were seen at 18 months. The remaining patients were followed up for too short of a period of time to be considered. Results were arranged into three groups. Classification criteria were: reduction of upper limb dimensions and the presence of the pre-existing symptoms (episodes of lymphangitis, pain, functional deficits. Results were considered good (class 3), fair (class 2), or poor (class 1). A positive clinical picture (class 2-3) was seen in 74% (20/27) at 6 months and in 59% (13/22) at 18 months.(ABSTRACT TRUNCATED AT 250 WORDS)

Arm↗
PubMed1977

Pathology of ovine adenovirus type 4 infection in SPF lambs: pulmonary and hepatic lesions.

Seven lambs were challenged with an aerosol of OA4 virus. Four developed mild pulmonary oedema and a sparse accumulation of mononuclear cells around blood vessels similar to results reported previously. In addition, three had focal hepatic necrosis and one of these three had a non-suppurative occlusive cholangitis and portal tract lymphangitis and thrombosis. Basophilic intranuclear IB's were identified in many necrotic hepatocytes, in lymphatic endothelial cells involved in thrombi but in only one bile duct epithelial cell. Ultrastructurally, virions with the characteristics of adenovirus were seen in hepatocytes. Although only one IB was seen in the affected biliary system there was no evidence that it was caused by an agent other than OA4. Virus was considered to infect the respiratory system directly, be swallowed to infect the alimentary system and carried, possibly within cells, via a haematogeneous and/or lymphogenous route to the liver. The effect of naturally acquired virus on sheep is unknown but it is possible that it may predispose the host to more serious infections.

Adenoviridae↗