[76...80...89...pedagogic aids].
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Audiovisual Aids↗
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Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
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Audiovisual licensing: purchasing is not owning.
Discusses the use of licensing agreements for health sciences audiovisuals. The difference between productions covered by the copyright law vis-a-vis those with licensing agreements is explored and representative examples of agreements are provided. Health sciences producers have turned to licensing agreements for several reasons including the protection of their productions from illegal duplication. Whereas these agreements may protect producers, they also may unintentionally bar legitimate users from viewing programs and may also create additional work for LRCs and libraries.
Audiovisual Aids↗
The biochemistry of bone.
The study of mineralized tissues has witnessed unprecedented advances as a result of recent technical breakthroughs in protein chemistry, and cell and molecular biology. Procedures for the nondegradative extraction of proteins present in mineralized matrices, along with improved chromatographic techniques, have resulted in the identification and purification of most, if not all, of the major structural proteins as well as less abundant (growth factors) proteins in these tissues. Many antibodies have become available against the intact proteins, as well as against synthetic peptides of the amino acid sequence from different parts of molecules. Along with mRNA determinations by in situ hybridization, these have been instrumental in determining when and where a matrix constituent is present in bone. Development of cell culture methods that maintain phenotypic expression has provided experimental systems to study the synthesis, secretion, and deposition of matrix, and the regulation of these processes. These model systems also have served as a source of genetic material for the making of cDNA libraries, which have been used for isolation of cDNA probes and ultimately for the isolation and characterization of the genes. By using these techniques, it is now feasible to develop procedures for the assessment of the role of matrix proteins in mineralized tissue, which will most certainly provide information that is critical to our understanding of bone metabolism in health and disease.
Animals↗
Audiovisual services: University of Connecticut Health Center Library.
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Audiovisual Aids↗
Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35.
BACKGROUND: Cysteinyl leukotrienes (LT) are mediators involved in inflammatory and allergic disorders LTC4 synthase catalyzes the first committed step in the synthesis of these inflammatory mediators, and its cellular distribution appears to be unique. MATERIALS AND METHODS: A human genomic library was screened by polymerase chain reaction (PCR) with primers that were designed based on the reported cDNA sequence for the LTC4 synthase gene. The gene was identified in one clone by Southern blotting of restriction enzyme digests, subcloning of fragments containing regions of interest, and DNA sequencing of these subclones. The transcription initiation site was determined by primer extension analysis. Chromosome location was determined by fluorescent in situ hybridization and screening of somatic cell hybrids by PCR. RESULTS: The LTC4 synthase gene is approximately 2.5 kb in length, consisting of five exons (136, 100, 71, 82, and 257 bp, respectively) and four introns (1,447, 102, 84, and 230 bp, respectively). Transcription initiation occurs at a single site 78 bp upstream of the coding region. The 5'-flanking region contains neither a TATA nor a CAAT box. The first 1 kb of the 5'-flanking region, however, contains putative DNA binding motifs for SP-1, AP-1, AP-2, ets factors, and CREB/ATF. A STAT binding motif is present in the first intron. The LTC4 synthase gene is located in the distal region of the long arm of chromosome 5 in 5q35. CONCLUSIONS: The LTC4 synthase gene does not contain elements of a typical regulated gene and may therefore contain novel regulatory elements. This gene is also located in a region on chromosome 5 that appears to play a role in allergic and inflammatory disorders, such as asthma.
Animals↗
Summaries of clinically relevant studies of dental materials from the 1995 meeting of the American Association for Dental Research.
The object of this review is to provide clinical research information. Each year, several hundred dental materials research papers are presented at the AADR meeting. For additional information about these studies, consult the abstracts published in J Dent Res 1995;74(special issue):12-257. Papers presented to the AADR Dental Materials Group are published in microfilm and microfiche, available in dental school libraries.
Composite Resins↗
Natural products in combinatorial chemistry: an andrographolide-based library.
The generation of a natural-product-based library starting from andrographolide is described. Utilizing andrographolide itself in parallel solution-phase synthesis leads to a 360-membered library. The initial transformation of the starting material via ozonolysis is followed by the conversion into a suitable template by introduction of a thiazole moiety. Subsequent decoration at two points of diversity yields the desired natural product derivatives. The selection of actually synthesized compounds is based on a virtually generated library and the assessment of its members with respect to physicochemical parameters, thus ensuring pharmacological relevance of the compounds.
Biological Products↗
Using GIS to establish a public library consumer health collection.
BACKGROUND: Learning the exact demographic characteristics of a neighborhood in which a public library serves, assists the collection development librarian in building an appropriate collection. Gathering that demographic information can be a lengthy process, and then formatting the information for the neighborhood in question becomes arduous.As society ages and the methods for health care evolve, people may take charge of their own health. With this prospectus, public libraries should consider creating a consumer health collection to assist the public in their health care needs. Using neighborhood demographic information can inform the collection development librarians as to the dominant age groups, sex, and races within the neighborhood. With this information, appropriate consumer health materials may be assembled in the public library. METHODS: In order to visualize the demographics of a neighborhood, the computer program ArcView GIS (geographic information systems) was used to create maps for specified areas. The neighborhood data was taken from the U.S. Census Department's annual census and library addresses were accumulated through a free database. After downloading the census block information from http://www.census.gov/geo/www/tiger/ the data was manipulated with ArcView GIS and queried to produce maps displaying the requested neighborhood demographics to view in respect to libraries. RESULTS: ArcView GIS produced maps displaying public libraries and requested demographics. After viewing the maps the collection development librarian can see exactly what populations are served by the library and adjust the library's collection accordingly. CONCLUSIONS: ArcView GIS can be used to produce maps displaying the communities that libraries serve, spot boundaries, be it "man-made or natural," that exist prohibiting customer service, and assist collection development librarians in justifying their purchases for a dedicated consumer health collection or resources in general.
Journal Article↗
Selecting for health sciences library collections when budgets falter.
The economic plight of the 1970s often limits the librarian, who should be the final selector, to insufficient funds for acquiring essential publications. The librarian, in addition to making every effort to acquire the best possible collection, must provide access from other libraries, within and outside one's parent institution, to materials not acquired; for this purpose, an effective document delivery network has proved more significant than formal plans for shared acquisitions. Too much is published, but the choices become more manageable with selection criteria that include limiting subject scope and keeping within the English language. In regard to journals, new titles should be added only reluctantly; cancellation lists compiled with the help of selective lists, the librarians' judgment, and users' responses; and newsletters and state journals pruned to a mimimum. As to books, selective lists should be consulted; congress proceedings generally ignored; and reprinted collections, multiple copies, and gifts considered with care. Book reviews are more useful selection aids now that lack of funds causes delays in purchasing than when new titles were acquired promptly with less discrimination. Audiovisual media, although widely pushed, do not replace printed materials, are not of central importance to many faculties, are expensive, and thus comprise a bandwagon which the impoverished library cannot afford to board without extra funding. The less money there is, the more need for a librarian's selection skills.
Audiovisual Aids↗
Isolation of human scFv antibody fragments against ABO blood group antigens from a phage display library.
BACKGROUND AND OBJECTIVES: Phage display has proven very useful for the isolation of antibodies against a number of antigens. We used this technology to isolate scFv antibody fragments against A and B red blood cell antigens. MATERIALS AND METHODS: Phages from a phage display library were selected using unmodified red blood cells as a source of antigen. Bound phages were absorbed onto cells lacking the antigen of interest and used to infect Escherichia coli cells. Phages were rescued and assayed for specificity by enzyme-linked immunosorbent assay (ELISA). RESULTS: After several rounds of panning and subtraction on red blood cells, one anti-A and one anti-B human scFv antibody fragments were isolated. CONCLUSION: Isolation of anti-A and anti-B scFv antibody fragments on whole cells is an alternative method of obtaining antibodies against native cell-surface antigens.
ABO Blood-Group System↗
Influencing advance directive completion rates in non-terminally ill patients: a systematic review.
PURPOSE: To conduct a systematic review of educational advance care planning interventions directed at patients without terminal illness to determine their influence on the completion rate of advance directives (AD). MATERIALS AND METHODS: We searched MEDLINE; Cochrane Library, and reference lists of all pertinent retrieved articles for randomized trials (RCTs), restricted to English language and adults > or =18 years. Two investigators independently and in duplicate determined trial eligibility. We included published RCTs evaluating an educational intervention comprised of at least one of; written, audio, or video materials, or direct counseling, and if an outcome included AD completion rate. RESULTS: Nine RCTs (N=3,206) were included. Overall, methodologic quality and reporting transparency were poor. The median composite quality score was 5 (range, 0-10). The odds ratios for AD completion rates ranged from 0.41 to 106.0 across the trials (test of heterogeneity P <.001). The summary odds ratio for these educational interventions was 3.71 (95% C.I. 1.46, 9.40). Trials with greater methodologic rigor and reporting transparency produced a more conservative estimate of effect, 2.42 [0.96, 6.10] versus 28.69 [5.08, 162.06] for less rigorous and poorly reported trials (P =.013). CONCLUSIONS: Advance directive completion rates documenting patient preferences for end-of-life care may be increased by simple patient-directed educational interventions.
Adult↗
Children in hospital: I. Survey of library and book provision.
Between 1989 and 1991 two related research projects were undertaken by the authors at the Department of Information and Library Studies, Aberystwyth, into services for children in hospital. This article summarizes the findings of the first of the projects, a survey of book and library services to children in hospital, giving a national profile of provision. It demonstrates a substantial provision of reading and other materials available to children in hospital but a small number of library services, as such. Nurses, teachers and hospital play staff generally exploited these materials for pleasure, educational and therapeutic purposes. The survey was based on questionnaires sent to all hospitals in the UK which treated children and was addressed, where possible, to hospital librarians, otherwise to the senior paediatric nurse. A shorter questionnaire was also addressed to all local authority Young People's and Schools Library services for a public library or school library perspective. Where there was evidence of the use of reading therapy, a further questionnaire was sent to explore its practice. A second article will discuss the results of the second project, which was devoted to a further exploration of reading therapy with children in hospital.
Bibliotherapy↗
Modified serial analysis of gene expression method for construction of gene expression profiles of microbial eukaryotic species.
Serial analysis of gene expression (SAGE) is a powerful approach for the identification of differentially expressed genes, providing comprehensive and quantitative gene expression profiles in the form of short tag sequences. Each tag represents a unique transcript, and the relative frequencies of tags in the SAGE library are equal to the relative proportions of the transcripts they represent. One of the major obstacles in the preparation of SAGE libraries from microorganisms is the requirement for large amounts of starting material (i.e., mRNA). Here, we present a novel approach for the construction of SAGE libraries from small quantities of total RNA by using Y linkers to selectively amplify 3' cDNA fragments. To validate this method, we constructed comprehensive gene expression profiles of the toxic dinoflagellate Pfiesteria shumwayae. SAGE libraries were constructed from an actively toxic fish-fed culture of P. shumwayae and from a recently toxic alga-fed culture. P. shumwayae-specific gene transcripts were identified by comparison of tag sequences in the two libraries. Representative tags with frequencies ranging from 0.026 to 3.3% of the total number of tags in the libraries were chosen for further analysis. Expression of each transcript was confirmed in separate control cultures of toxic P. shumwayae. The modified SAGE method described here produces gene expression profiles that appear to be both comprehensive and quantitative, and it is directly applicable to the study of gene expression in other environmentally relevant microbial species.
Animals↗
YAC cloning of DNA embedded in an agarose matrix.
Yeast artificial chromosome (YAC) cloning of DNA in agarose is an alternative method to cloning from aqueous solutions. It minimizes any shearing that may result from handling of high molecular weight DNA and can be done with nanogram to microgram amounts of material, which facilitates construction of YACs from sources of DNA other than genomic DNA isolated from cells. The average size of the YACs recovered (200-1000 kb) and efficiency of transformation of ligation products (200-1000 cfu/micrograms) are similar to those reported using aqueous protocols. This method has been used to construct chromosome specific YACs, and it should be possible to apply the technique to the construction of chromosome specific libraries using flow sorted chromosomes as source material, and the cloning of restriction fragments isolated by preparative pulsed field gel electrophoresis.
Animals↗
Collection development and outsourcing in academic health sciences libraries: a survey of current practices.
Academic health sciences libraries in the United States and Canada were surveyed regarding collection development trends, including their effect on approval plan and blanket order use, and use of outsourcing over the past four years. Results of the survey indicate that serials market forces, budgetary constraints, and growth in electronic resources purchasing have resulted in a decline in the acquisition of print items. As a result, approval plan use is being curtailed in many academic health sciences libraries. Although use of blanket orders is more stable, fewer than one-third of academic health sciences libraries report using them currently. The decline of print collections suggests that libraries should explore cooperative collection development of print materials to ensure access and preservation. The decline of approval plan use and the need for cooperative collection development may require additional effort for sound collection development. Libraries were also surveyed about their use of outsourcing. Some libraries reported outsourcing cataloging and shelf preparation of books, but none reported using outsourcing for resource selection. The reason given most often for outsourcing was that it resulted in cost savings. As expected, economic factors are driving both collection development and outsourcing practices.
Budgets↗
The DERWeb project--dental education resources on the Internet.
The delivery of dental education, in common with other forms of higher education, has altered considerably over the last decade. The introduction of the World Wide Web enabled resources for dental education to be delivered in a new and innovative manner. DERWeb was funded by HEFC-JISC. The primary resource consists of a library of 1600 clinical dental images each with keywords and a description. Selected images were used to create teaching materials to demonstrate to dental educators world wide how the image library could be used by individual institutions. Hands-on courses were held to demonstrate the new resource and to evaluate computer skills in the dental community. Since the commencement of the project in September 1994 DERWeb has become one of the leading resources for dental education world wide. The site has been accessed by 79 countries with approximately 107000 accesses in October 1996. DERWeb also designs and maintains the British Dental Association pages together with other professional organisations. Its resources also include dental contact addresses and links to quality dental sites world wide. Further funding has enabled DERWeb to expand further and explore new technologies to develop interactivity on the Web.
Computer Communication Networks↗
AVLINE: a data base and critical review system of audiovisual materials for the education of health professionals.
The AVLINE data base, operated by the National Library of Medicine, was designed to aid in the selection, use, and sharing of quality audiovisual material in the education of health professionals and to promote the quality production of such materials. AVLINE provides standardized bibliographic and critical review information in both online and printed catalog form. In this report the evolution of AVLINE is traced, and the development of its companion review system is examined.
Audiovisual Aids↗
Personnel administration: the case method of teaching.
Only recently are case materials being used in the area of personnel administration, general library administration, and reference services. These permit more intellectual involvement on the part of the student than do the generalizations which result from the traditional lecture-discussion techniques. The medical library field has a professional character quite particular to itself. This is illustrated by its highly specialized clienteles, the quite special nature of the materials involved and their control, and the aura of special ethical considerations involved in any aspect of medicine. The development of a body of case materials would seem to have merit as a teaching vehicle for the medical library course, for in-service training in larger medical libraries, for workshops and institutes, and as a learning vehicle for the individual medical librarian.
Education↗