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PubMed1980

Syphilis serology today.

Serologic testing is an important adjunct in the diagnosis and management of syphilis. In this review, the various currently used serologic tests, both non-treponemal and treponemal, are considered. Special emphasis is placed on their relative advantages, applications, and limitations. Conditions under which these tests may be falsely positive are discussed. Additional diagnostic tools cited are the dark-field examination, for use in early-lesion syphilis, and cytological and immunochemical techniques for determining potentially active neurosyphilis. The analysis of every serologic report, and its correlation to the historical, epidemiological, and clinical findings, is highlighted.

Complement Fixation Tests↗
PubMed1975

Acute tropical polyarthritis in Sri Lanka patients.

This paper described the clinical manifestations and laboratory findings in 20 patients with an unusual form of arthritis. All but two were above the age of 20 years (range 14-79). There were eight males and 12 females. The majority of them had fever. All had multi-joint involvement. The erythrocyte sedimentation rate was elevated (mean 74 mm./hr.). All recovered completely with penicillin and salicylates; there were recurrences in two, but no tendency to chronicity.

Acute Disease↗
PubMed1985

The lupus anticoagulant. A disease marker in antinuclear antibody negative lupus that is cross-reactive with autoantibodies to double-stranded DNA.

The lupus anticoagulant (LA) was demonstrated in 37% of 52 consecutive systemic lupus erythematosus (SLE) patients and patients with lupus-like syndromes, who were referred to our unit. The LA was found to be associated with a biologic false-positive VDRL (P less than 0.005), and the apparently paradoxical association of LA with vascular thromboses was confirmed (P less than 0.05). The presence of LA and a biologic false-positive VDRL defined a group of 7 antinuclear antibody negative patients with characteristic features of recurrent thromboses, spontaneous abortions, neurologic involvement, and renal disease. Further studies on 6 selected sera demonstrated LA in all 6 IgM fractions and in 3 of 6 IgG fractions. Inhibition of LA was shown in 6 of 9 Ig fractions after absorption with double-stranded DNA (dsDNA). Anticardiolipin antibody was shown by immunodiffusion in 3 LA positive IgG fractions from VDRL negative sera. Cardiolipin micelles partially inhibited anti-dsDNA binding of 4 IgG fractions, 3 of which were LA negative. In this report we discuss the overlapping specificities due to cross-reactivity between LA, anticardiolipin, and anti-dsDNA antibodies in human SLE, and we suggest that LA be considered equivalent to the biologic false-positive VDRL as a criterion for the diagnosis of SLE.

Antibodies, Antinuclear↗