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At least 379 records · Page 21Linked to original sources
PubMed1990

[Pathology of developmental defects of the digestive system in human embryos].

Total incidence of the alimentary system defects was 1.05 +/- 0.12% in the non-selected material of medical abortions performed at 5-12 weeks of the intrauterine development. Atresia and stenosis of the duodenum are described for the first time in the embryos of the above age, the possibility of differential diagnosis between physiological and pathological atresia is established. The connection between the ducts of the ring-like head of pancreas and ductus choledochus is observed thus confirming the hypothesis of the additional pancreatic part developing from the ventral anlage. Diagnosis of Mekkel's diverticulum became possible beginning from stage 17. The existence of atresia, stenosis and gastro-intestinal tract doubling in the embryos of the above age indicate that at least some of these defects are not connected with a secondary damage of the intestinal tube due to circulation disturbances, recanalization or inflammation but represent a primary developmental anomaly arising in the early ontogenesis.

Digestive System↗
PubMed1988

[Pharmacological studies on the clathrate compound of mobenzoxamine with beta-cyclodextrin. (I). Effects on the digestive system].

Effects of the clathrate compound of mobenzoxamine (MBX) with beta-cyclodextrin (MBX-CD), a new gastro-intestinal function modulator, on the digestive system were studied in comparison with those of metoclopramide, domperidone and trimebutine. MBX-CD showed inhibitory effects that were approximately 1/4 times as potent as metoclopramide on both apomorphine- and copper sulfate-induced emesis and about 1/40 times as potent as domperidone on apomorphine-induced emesis in dogs. In rats, MBX-CD enhanced gastric emptying as potently as metoclopramide, and only MBX-CD showed a clear amelioration of the delayed gastric emptying induced by BaCl2. Similarly, only MBX-CD showed an ameliorative effect on small intestinal transport accelerated by BaCl2 in mice. Though both MBX and trimebutine inhibited spontaneous contractions of the isolated guinea pig stomach and rabbit intestine, it seemed that the properties of these effects were different from those of papaverine. On isolated guinea pig ileum, MBX inhibited contractions induced by various agonists equally to or more potently than trimebutine or papaverine. The results suggest that MBX-CD or MBX acts extensively on the gastro-intestinal system for the reason that it has not only the respective properties of the gastro-intestinal function modulators used as the standards, but also its own characteristic effects.

Animals↗
PubMed2003

Left-right asymmetric morphogenesis in the Xenopus digestive system.

The morphogenetic mechanisms by which developing organs become left-right asymmetric entities are unknown. To investigate this issue, we compared the roles of the left and right sides of the Xenopus embryo during the development of anatomic asymmetries in the digestive system. Although both sides contribute equivalently to each of the individual digestive organs, during the initial looping of the primitive gut tube, the left side assumes concave topologies where the right side becomes convex. Of interest, the concave surfaces of the gut tube correlate with expression of the LR gene, Pitx2, and ectopic Pitx2 mRNA induces ectopic concavities in a localized manner. A morphometric comparison of the prospective concave and convex surfaces of the gut tube reveals striking disparities in their rate of elongation but no significant differences in cell proliferation. These results provide insight into the nature of symmetry-breaking morphogenetic events during left-right asymmetric organ development.

Animals↗
PubMed1999

[Digestive system carcinoid tumors: treatment].

INTRODUCTION: Non-metastatic digestive carcinoid tumors are treated surgically, allowing in most cases recovery. In patients with metastasis and intestinal primary tumor, resection of the latter is proposed to avoid occlusion. CURRENT KNOWLEDGE AND KEY POINTS: Cytoreductive surgery of liver metastasis should be both contemplated and discussed if 80 to 90% of the tumor can be resected. In all other patients, intravenous chemotherapy or hepatic arterial chemoembolization should be discussed if metastases are located mainly in the liver. Response rates related to both treatments reach 30% and 50-80%, respectively, without clearly proven benefit in regard to survival. However, carcinoid tumors are often slowly progressive and symptomatic treatment of the carcinoid syndrome is a major concern. Long-acting somatostatin analogs, particularly slow-release formulations, have greatly improved patients' management. Diarrhea and flushing are controlled by long-term treatment involving either octreotide or lanreotide, a recently available somatostatin analog with slow release, without major side-effects even at high dosages. PERSPECTIVES: Randomized studies currently in progress are aimed at comparing these various therapeutic modalities.

Carcinoid Tumor↗
PubMedDate not supplied

[Intraoperative and early postoperative intraperitoneal chemotherapy--adjuvant treatment for locally advanced digestive system cancer].

UNLABELLED: Surgical treatment for locally advanced digestive cancers (invasion beyond the serosa, adjacent structures penetration and perforated tumors) is followed by a high rate of peritoneal recurrence and distant metastasis. Simultaneous intraperitoneal chemotherapy with surgical resection, which is continued over the early postoperative period act on the tumor cells which can be mobilized during the surgical dissection. This adjuvant treatment could lead to better control of local recurrence. Moreover, high levels of the agents are reached in the portal circulation which could be profitable for preventing hepatic metastasis. The main drawback of the method is represented by the impaired immunologic activity of the peritoneum, which can cause, at least theoretically, detrimental complications. OBJECTIVE: The efficiency of the intraoperative and early postoperative intraperitoneal chemotherapy is the subject of a prospective randomized study, started 8 months ago in our department. METHOD: Patients with locally advanced (penetration of the tumor beyond serosal layer, without liver metastasis) are randomized for adjuvant intraperitoneal chemotherapy or standard treatment. Intraoperative chemotherapy is commenced after surgical resection but before accomplishing any anastomosis. We use 50 mg of cisplatinum for washing the peritoneal cavity and continue to instill 20 mg/m2 of cisplatinum intraperitoneally in the first four days after surgery. (8 patients were selected to be treated according to this protocol). CONCLUSION: Immediate postoperative outcome does not seem to be influenced by this treatment. The disease free interval and the overall survival rates can not be assessed at this moment of the study.

Aged↗
PubMedDate not supplied

[Digestive system manifestations in Steinert's disease. Analysis of 19 cases of which 10 with digestive symptoms].

We studied digestive manifestations occurring during follow-up of 19 cases of myotonic dystrophy. GI symptoms occurred in 10 patients (53%), mainly dysphagia (n = 7). In patients undergoing investigations (n = 7), their digestive troubles were probably or definitively related to the neurological disease in 6 cases. Upper GI endoscopy was normal in 5 dysphagic patients. The oesophageal manometry was abnormal in 3 of 4 patients. Complications developed in 3 cases (16%). One patient presented two episodes of spontaneous pneumoperitoneum. A second one developed a chronic colonic pseudo-obstruction with megacolon treated by subtotal colectomy. Manometric studies revealed oesophageal aperistalsis, low amplitude of gastro-jejunal contractions but persistence of migrating motor complexes and a normal recto-anal reflex. A third patient developed an acute pseudo-obstruction with ischemic colitis. In conclusion, myotonic dystrophy frequently disturbs digestive tract motility and may cause complications such as intestinal pseudo-obstruction.

Adult↗
PubMed1993

[Digestive system carcinoid tumor and synchronous malignant tumors].

270 digestive carcinoid tumors have been diagnosed at the Pathology Institute of Lausanne between 1971 and 1990; of these 21 were associated with other, synchronous, tumors: 7 of the carcinoids were from the appendix (33%), 8 from the small bowel (38%), 4 were from the colorectum (25%), one from the duodenum (4.5%) and finally one from the stomach (4.5%). Two thirds (14) were associated with adenocarcinomas of the colon, the rest with 2 gastric tumors, 1 tumor of the appendix, 1 of the gallbladder, 1 of the small gut, 1 of the duodenum and 1 of the peritoneum. The mean age of the patients was 70 years, which correlates with the large proportion of carcinomas of the colon. The males (16) clearly outnumbered the females (5) for no obvious reason. 80% of the carcinoids were discovered during the treatment of the associated tumor. Survival was directly related to the stage and aggressivity of the malignant tumor. The carcinoid itself hardly changed the prognosis, except for one case of liver failure due to metastases from carcinoid of the stomach associated with an adenocarcinoma. The histologic features of the carcinoid tumors were unexceptional. Different hypotheses to explain the associations are formulated.

Adenocarcinoma↗
PubMed1978

Microscopical anatomy of larva of cheladonta costulata (Acarina: Trombiculidae) II. Body tegument and digestive system.

The cuticle of gnathosoma of Cheladonta costulata larva consists of a smooth and firm epicuticle and sclerotized procuticle. The cuticle of the idiosoma is elastic. The wall of the digestive system is formed by cells lying on the basal membrane. During the process of sucking, however, the intestinal cells, which were originally spherical, get an appearance of a club reaching up to the lumen of intestine. In a fully engorged larva the intestine appears to be united and fill the major part of body. The lumen of the intestine is filled with eosinophilic granules of various size, among which are minute granules with basophilic tinge. The excretory bladder is located between posterior lobes of the intestine. In an unengorged larva, the excretory bladder is conical and possesses a conspicuous wall of a cellular structure. Its lumen is empty. In a fully engorged larva, the excretory bladder is oval, covered with a thin membrane, and its lumen is filled with guanine crystals.

Animals↗
PubMed1989

Class II MHC antigens in the rat digestive system. Normal distribution and induced expression after interferon-gamma treatment in vivo.

The normal and interferon-gamma induced expression of class II MHC antigens was investigated immunohistologically in the digestive system of LEW rats. In the normal state class II molecules were present in interstitial dendritic cells, B lymphocytes and epithelial cells. Epithelial class II expression was restricted to enterocytes in certain portions of the small intestine and to some duct epithelia in salivary glands. After continuous intravenous infusion of interferon-gamma (IFN-gamma) for 3 days, class II MHC antigens were induced in large vessel endothelium and in the surface epithelia of the tongue, oesophagus and proventricle. In the gastric glands class II molecules appeared in mucous neck cells and in parietal cells, while adjacent mucous surface cells and chief cells did not acquire class II reactivity. All enterocytes, including the previously negative colonic epithelium, were induced to express class II antigens. In the salivary glands class II antigens appeared in all duct epithelia. Serous acinar cells were induced in the parotids, but in the submandibular glands and in the pancreas the serous gland epithelium stayed negative. Our study thus shows that the effects of IFN-gamma on class II MHC antigen expression in vivo depend on the differentiation pathway of the individual cell. The normal distribution in rats suggest that class II MHC antigens may play a role in peptide transport across specialized epithelia. It remains to be determined whether such a function is enhanced after IFN treatment.

Animals↗