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At least 379 records · Page 21Linked to original sources
PubMedDate not supplied

X-File: a program for maintaining a radiographic teaching file.

Software designed for entry, retrieval, and maintenance of radiographic case-file data on a microcomputer offers considerable help in maintaining such records in a radiology department. The case files are based on the Index for Roentgen Diagnoses, published by the AmericanCollege of Radiology. The terms and code numbers of the index are included in the software, so that the user need only enter the diagnostic term desired; the code numbers and exact terminology are assigned automatically. The software is written for an IBM-compatible microcomputer. Residents and staff radiologists have been using the program for the past two years to store and find both confirmed cases and other interesting cases. The system's capacity exceeds 70,000 entries on a 20-megabyte had disk. The program has five features not found in previous similar programs and not attainable with manual methods.

Hospital Information Systems↗
PubMedDate not supplied

Frequent sampling reveals dynamic responses by the transcriptome to routine media replacement in HepG2 cells.

Cultured cell lines are employed extensively for biological research. Large-scale differential gene expression (LSDGE) is being used to study mechanisms of toxicity in such cultures. 'Normal' gene expression dynamics could have a major impact on the design and interpretation of these studies. In order to provide understanding of such dynamics, we investigated LSDGE responses to media replacement in human hepatoblastoma cells (HepG2) using 5-minute sampling frequencies for 6 hours post routine media replacement. Each mRNA transcript was found to exhibit a characteristic 'operating range' based on signal intensity. Following media replacement, which replenishes nutrients (eg, glucose and glutamate) and removes excretory products (eg, lactate), a complex set of gene expression changes was observed. Some transcripts appeared to switch on from a quiescent state to a very active one (eg, CYP1A1), others exhibited 'clocklike' oscillations (eg, asparagine synthetase), or a synchronous burst (chirp) of expression up regulation (eg, timeless). Mathematical analysis (Fourier Transform, Singular Value Decomposition, Wavelets, Phase Analysis) of oscillating expression patterns identified cycle lengths ranging from 11.8 to 210 minutes. There were prominent 36.5- and 17.4-minute cycles, for subsets of genes, and transcript-specific differences in phase angle with respect to these cycles. The functional consequences of these novel observations remain to be determined. It is clear that dense time-course studies provide a valuable approach to the investigation of physiological responses to nutrients, toxicants, and other environmental variables. This research also highlights the need for an understanding of biological dynamics when using cell culture systems. An Excel data file representing individual transcripts from the respective Clontech cDNA arrays referred to in this article is available at http://taylorandfrancis.metapress.com/openurl.asp?genre=journal&issn=0192-6233. Rows represent data for individual transcripts and columns represent the time-points from 0 to 360 minutes. To access this file, click on the issue link for 31(4), then select this article. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org.

Cell Culture Techniques↗
PubMed2006

Java applets for viewing one- and two-dimensional NMR spectra.

Two Java applets, which allow viewing and simple reprocessing operations of one- and two-dimensional NMR spectra from within a web page, are described. For the 1D viewer, phasing, integration, peak picking and referencing are supported. Bruker, Varian and JCAMP-DX processed data files can be opened. The 2D viewer allows f2 phasing and referencing, and can read native Bruker processed data. The compiled applets are available from the author on request.

Magnetic Resonance Spectroscopy↗
PubMed1991

Autospec: computerized processing of the data output from a spectrophotometer in a biochemical laboratory.

Autospec was designed to acquire data output from a Beckman DU series 60 spectrophotometer and to process these data with an IBM or IBM-compatible computer. It functions in conjunction with the Beckman DU Data Capture and Lotus 1-2-3 softwares. Autospec automatically stores data produced by the spectrophotometer, determines standard curves and calculates unknown concentrations of the substance being assayed. The principal features of Autospec are simplicity of use, adaptability and flexibility, minimal intervention from the operator, standardized print-outs of all data in tabular and graphic forms, accuracy of computations, speed of operation, and ease of storage and back-up of data files.

Biochemistry↗
PubMed1988

Evaluation of a digitizer and computer system designed to analyze articulator-generated occlusal tracings.

Occlusal tracings generated on a Denar fully adjustable articulator were photographed, projected, digitized, and stored in a computer data file. These steps were accomplished with sufficient accuracy for clinical analysis. This study demonstrated that appropriately referenced tracing data can be transferred accurately into a machine-readable form. Studies of pantographic tracings for mandibular movements are facilitated by this convenient and accurate method of handling data.

Dental Articulators↗
PubMed2004

Development of a preliminary diabetes dietary satisfaction and outcomes measure for patients with type 2 diabetes.

Adopting dietary lifestyle changes for diabetes management is often difficult for patients; yet the health-related quality of life (HRQOL) outcomes of dietary management for the patient are not extensively developed in the HRQOL assessments now widely used in diabetes research. This study developed a preliminary instrument, the diabetes dietary satisfaction and outcomes measure, to assess outcomes of individuals' experiences in following a meal plan for the treatment of type 2 diabetes. A theoretical framework and preliminary focus group data guided the design of a 47-item questionnaire, administered to 239 patients with type 2 diabetes. Medical file data was obtained on 180 of these patients. Fifty-four percent of respondents were women, with mean age of 64 +/- 12 years and diabetes duration of 10 +/- 8 years. Scores for the satisfaction and other outcome measures discriminated between patient groups by age, gender, medication use, depression diagnosis, meal plan status, and employment status. Significant correlations also occurred with diet adherence, number of co-morbidities, and glycemic control as measured by glycolated hemoglobin (HbA1c). Future research with additional patient samples is needed to refine the measure for use in diabetes education programs.

Adult↗
PubMed1995

A compression mechanism for sequence databases to improve the efficiency of conventional tools.

This paper describes a method to compress molecular biology databases that are characterized by an increasing proportion of data derived from genome projects. The performance of our tool has been tested on various data files of the EMBL nucleotide sequence database. The best compression ratios were achieved on EST (Expressed Sequence Tags) data, typically derived from large-scale sequence projects. The compression of sequence database updates was tested in combination with the common Unix compression program 'compress'. Our tool improved the efficiency of 'compress' on average by 16%.

Base Sequence↗
PubMed2005

[Has the mortality rate from acute myocardial infarction fallen substantially in recent years? Single center data on elderly patient population].

OBJECTIVE: We aimed to compare the trend in clinical approach and interventions, in-hospital mortality rate in elderly patients with acute myocardial infarction (AMI) in a single reference center within subsequent years, 2000-2002. METHODS: In our retrospective analysis within years 2000 and 2003 we could reach 160 eligible patients' data files, who were hospitalized for of AMI and aged above 70 years. RESULTS: Within three years we evaluated data of 105 male and 55 female eligible patients (mean age: 74.0+/-3.3 years). In-hospital mortality was observed in 39 (24%) patients with a median admission-to-mortality time of 24 hours. In 33 (20%) of the cases AMI involved more than one myocardial wall. Sixty-one percent of the whole population and 80% of the patients with early in-hospital mortality had reduced left ventricular ejection fraction. The comparison of treatment approaches within three years revealed a growing tendency for application of percutaneous transluminal coronary angioplasty (PTCA), surgical interventions and for the use of beta-blockers, angiotenzin converting enzyme inhibitors and lipid lowering agents (p<0.05). We did not observe any difference in mortality rates at subsequent years. CONCLUSION: In our single center analysis we observed changes in treatment policy in elderly AMI population, which was in concordance with the trends in international arena. But we were not able to show any reduction in mortality rate. Beyond the diverse ethnicity of our patient population, the relative delayed time to hospital admission, more extensive infarct area, lower administration of interventional procedures and primary PTCA, and most importantly the relative short time interval we analyzed may be contributing factors for still high in-hospital mortality in elderly population.

Aged↗
PubMed1990

[Centralization of all medical laboratory data by laser disk filing system].

In recent years, the medical laboratory system is being widely applied. We describe the medical laboratory system of our Saga Medical School Hospital, including the electrocardiogram (ECG) and electroencephalogram (EEG) laser disk data filing systems. The main computer system of FUJITSU M-730/4 (main memory of host computer 13 MB) handles a large amount of data, in the fields of chemistry, hematology, serology, microbiology, blood banking and histology laboratory. All 17 chemistry and hematology automatic analyzers are linked through communication lines to the main computer. The important tasks of this system are data processing, storing of information in the database, data reporting and quality control statistics. This laboratory system is also connected to the total hospital information system of FUJITSU M-760, main memory 48 MB. For pattern recognition, ECG and EEG laser disk data filing systems have been constructed. The main purpose of these filing systems is mass storage of analog data signals in laser disk, computer assisted analysis and data communication. ECG and EEG analog data are converted into digital form by the analog-to-digital converter, and then transmitted over hospital telephone lines to the central computer system for analysis. The computer assisted statements are then sent back to the ECG terminals at the nurse station. As necessary, after the physician reads over the ECG, statements are printed in the final reports. These optical reporting systems are also linked to the total hospital information system. One of the main tasks in the laboratory is the control of the seemingly endless paper work.(ABSTRACT TRUNCATED AT 250 WORDS)

Clinical Laboratory Information Systems↗
PubMedDate not supplied

An overview of the National Survey of SSI Children and Families and related products.

The National Survey of SSI Children and Families (NSCF) is the first nationally representative survey since 1978 of noninstitutionalized children and young adults who currently receive or formerly received Supplemental Security Income (SSI). Over 8,500 interviews were completed between July 2001 and June 2002. The primary objective of the NSCF is to provide data to support research and policy evaluation on the current cross section of children (ages 0 to 17) and young adults (ages 18 to 23) receiving SSI. Following that objective, the survey was designed to answer questions such as those presented below. What are the general characteristics of children and young adults receiving SSI and their families? What are the patterns of access to and utilization of health care among children and young adults receiving SSI? What services are utilized by children and young adults receiving SSI? What are the unmet health care and service needs of children and young adults receiving SSI? What costs are associated with caring for a disabled child? What is the impact on the family of having a disabled child? What is the status of young adults with disabilities as they make the transition to adulthood? How well are they prepared for that transition? In addition, the NSCF questionnaire and sample were designed to be comprehensive enough and large enough to address numerous additional policy issues as they emerge. The NSCF fills a gap in the data available to policy analysts by addressing a wide range of topics that cannot be addressed with SSI administrative data and by providing a large sample in contrast to major national survey databases that cover this target population fairly sparsely. A companion article to this overview describes general characteristics of SSI beneficiary children and their families (see Rupp and others 2005/2006, pages 21-48 of this issue). Other topics being examined include disability-related expenditures for SSI children and young adults and labor force participation of the parents of SSI children. The NSCF data files are accompanied by a detailed User's Manual, which includes a detailed codebook and information about the NSCF sample design, questionnaire design and content, data collection procedures, variable construction, editing, and variance estimation procedures. In order to facilitate research, the Social Security Administration published the NSCF Public-Use File and survey documentation on its Web site. These products are available at http://www.socialsecurity.gov/disabilityresearch/nscf.htm. The NSCF is an outstanding tool for conducting research and policy analysis regarding children and young adults receiving SSI.

Adolescent↗
PubMed1995

Changes in incidence of carcinoma in situ after the Chernobyl disaster in central Europe.

The data files from an extensive cytological screening program for cervical intraepithelial neoplasia from a regional Czech hospital were analyzed. The data collection span is from 1985 to 1991 and shows highly significant maximum effects in the years 1988-1989, i.e., shortly after the Chernobyl accident. The increase was concordantly found in all the age categories, but the reaction seems to be faster in younger women. The delayed maximum effect (two years after the accident) also corresponds to the course of total foodstuffs burden and total-body activity.

Adult↗
PubMed1996

Client and birth record linkage: a method, biases, and lessons.

"Due to rising data collection costs and the availability of extant data files, record linkage is becoming increasingly important in evaluation research. We begin by discussing record linkage as a data-generating technique and its applicability to evaluation studies. This paper--part of a larger study assessing the perinatal outcomes of a comprehensive prenatal program for poor, urban women--describes a method for linking client records to live and stillbirth records [in Cleveland, Ohio]. Biases which can enter into the linkage process and general issues which need to be addressed early in an investigation are also discussed."

Americas↗
PubMed1998

Using hospital performance data in quality improvement: the Cleveland Health Quality Choice experience.

BACKGROUND: Cleveland Health Quality Choice is a regional initiative to assess hospital performance which was implemented in 1989. The project developed and validated CHOICE, a severity adjustment system that includes diagnosis-specific models for medical, surgical, and obstetrical patients which are based on clinical data abstracted from patients' medical records. METHODOLOGY: Since 1992 Cleveland Health Quality Choice has disseminated semi-annual reports that profile hospital mortality rates, lengths of stay, and cesarean section rates using the CHOICE severity adjustment models. Hospitals receive tabular and graphical representations of hospital outcomes and electronic patient-level data files that can be used to further examine outcomes in clinical subgroups. RESULTS: Four case studies illustrate how outcomes data derived from the CHOICE models led to the development of successful hospital programs to decrease lengths of stay, cesarean section rates, and hospital mortality rates. Although each case study reflected a unique approach to process improvement, several common characteristics were observed: (1) establishment of interdisciplinary process improvement teams with senior physician and nursing leadership; (2) detailed review of the process of care to identify modifiable clinical practices likely to affect outcomes; (3) development of practice guidelines based on group consensus or published recommendations that were designed to affect modifiable practices; and (4) aggressive sharing of serial data with individual practitioners. CONCLUSIONS: Although outcomes data can provide powerful insight on where to target quality improvement efforts, hospitals must identify influential and modifiable clinical practices. Such efforts are most likely to be successful if driven by interdisciplinary work groups, supported by senior clinicians and administrators, and based on locally accepted practice standards.

Adult↗
PubMed1995

Absolute measures of image quality for the Sens-A-Ray direct digital intraoral radiography system.

To study the noise characteristics of the Sens-A-Ray (Regam Medical Systems AB, Sundsvall, Sweden) system, 20 radiographs were obtained at each of three different exposure levels at 70 and 90 kVp with a homogeneous x-ray field. Exposures were measured with an ionization chamber. Noise power spectra were calculated over three areas within each radiograph, and ensemble averages were subsequently found from 60 data files at each exposure level. Noise equivalent quanta were calculated with the noise power spectra and modulation transfer function data from previous studies. Finally, the detective quantum efficiency was calculated by dividing the noise equivalent quanta by the estimated incident photon fluence at the different exposures. The system has a maximum detective quantum efficiency of approximately 0.030 at 70 kVp and 0.025 at 90 kVp. A broad maximum exists at approximately 2 cycles/mm, indicating that the signal-to-noise ratio is most favorable at this spatial frequency.

Algorithms↗
PubMed1990

Purposely self-inflicted injury resulting in death and hospitalisation in New Zealand.

Purposely self-inflicted injury is the second most common cause of injury death in New Zealand and is also a major cause of hospitalisation. Despite the significance of the problem there has been relatively little research undertaken in New Zealand. Injury mortality and morbidity data files for 1984 were examined and upgraded to provide as comprehensive an overview of this injury problem as the data would permit. The results show that the fatality rate was highest amongst the elderly, and males had higher death rates than females for all ages. In contrast to this, hospitalisation rates peaked among the 15-20 year olds and females had higher rates than males for all ages. Whereas Maori had a significantly lower fatality rate than non-Maori the converse was the case for hospitalisation. A more consistent effect occurred for marital status, the married group had significantly lower fatality and hospitalisation rates than the non-married group. The major occupational group "production, transport and labourers" had the highest mortality rate, whereas service workers, in particular house staff, had the highest rate of morbidity. Whereas hanging was the most common method (33%) used in fatal injury events, poisoning was the most common method (91%) used for those events which resulted in hospitalisation. In the latter case, psychotropic agents, in particular tranquillisers, accounted for 50 per cent of all poisoning. These data show that mortality experience is not a reliable guide to injury morbidity experience. Prevention is discussed in the context of limiting the availability and lethality of agents.

Cause of Death↗
PubMed2003

Implementation of a fast 16-Bit dynamic clamp using LabVIEW-RT.

The dynamic-clamp method provides a powerful electrophysiological tool for creating virtual ionic conductances in living cells and studying their influence on membrane potential. Here we describe G-clamp, a new way to implement a dynamic clamp using the real-time version of the Lab-VIEW programming environment together with a Windows host, an embedded microprocessor that runs a real-time operating system and a multifunction data-acquisition board. The software includes descriptions of a fast voltage-dependent sodium conductance, delayed rectifier, M-type and A-type potassium conductances, and a leak conductance. The system can also read synaptic conductance waveforms from preassembled data files. These virtual conductances can be reliably implemented at speeds < or =43 kHz while simultaneously saving two channels of data with 16-bit precision. G-clamp also includes utilities for measuring current-voltage relations, synaptic strength, and synaptic gain. Taking an approach built on a commercially available software/hardware platform has resulted in a system that is easy to assemble and upgrade. In addition, the graphical programming structure of LabVIEW should make it relatively easy for others to adapt G-clamp for new experimental applications.

Analog-Digital Conversion↗
PubMed1991

Development of a computerized adverse drug event monitor.

Adverse events during drug therapy are receiving renewed attention. Some adverse drug events (ADEs) are identified only after the widespread clinical use of a drug. The Food and Drug Administration advocates post-marketing surveillance systems to provide early warnings of previously undetected ADEs. The identification of ADEs by U.S. hospitals is now required by the Joint Commission on Accreditation of Healthcare Organizations. We developed a series of computer programs and data files on the HELP System to help identify ADEs. The HELP System monitors laboratory test results, drug orders, and data entered through a computerized ADE reporting program. A nurse or pharmacist verifies computer alerts of possible ADEs. The computerized system identified 401 ADEs during the first year of use compared to 9 by voluntary reporting methods during the previous year (p less than 0.001). This paper describes the development and early use of the computerized ADE surveillance system.

Adverse Drug Reaction Reporting Systems↗