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Prospective evaluation of the systemic inflammatory marker C-reactive protein in patients with end-stage periodontitis getting teeth replaced with dental implants: a pilot investigation.

OBJECTIVES: Serum C-reactive protein (CRP) has been shown to be a risk predictor for cardiovascular disease. Periodontal treatment reduces elevated CRP levels. The aim of this pilot investigation was to evaluate if dental implants placed after extractions in patients with end-stage periodontitis affect the serum CRP levels. MATERIAL AND METHODS: Serum CRP levels in 10 subjects with end-stage periodontitis were measured prior to tooth extraction and placement of dental implants, and at 3-month intervals for a year post-operatively. Univariate repeated measures analysis of variance was used to estimate and test the changes in CRP levels over time. RESULTS: Mean CRP levels decreased significantly following tooth extraction and replacement with dental implants from 3.45 to 1.55 mg/dl after 12 months (P < 0.01). Six-, 9-, and 12-month post-implant placement mean CRP values were statistically significantly different from the mean pre-operative CRP value (P < 0.01). CONCLUSIONS: The pilot data suggest that extraction of advanced periodontally involved teeth and their replacement with dental implants lead to a decrease in CRP levels, and dental implant placement does not change the lowered CRP levels over a 12-month period.

Aged↗

Preliminary evaluation of a new dental implant design in canine models.

Problems with crestal bone resorption and bone adaptation to dental implants in compromised and weak bone present clinical challenges due to insufficient bone volume. Mathematical models have shown that a new, square-thread, dental implant design increases functional surface area and reduces shear loading at the implant interface. The aim of this investigation was to evaluate the ability of bone to grow between the threads of the new implant and its general biocompatibility in a canine model. Test implants were placed in the mandibles of four beagle dogs after posterior partial edentulism. Three months after implantation, the animals received independent fixed partial dentures, were followed for an additional 6 months, and then euthanized for histological analyses. Analyses revealed that bone grew between the threads and closely apposed the new implant design. Histological observations also revealed that the inferior aspect of the test implant threads were apposed by more bone than the coronal aspect, suggesting a biological advantage for the compressive load transfer mechanism of the new implant design. The results of this study revealed that the new implant design became osseointegrated with bone growing between the threads of the device.

Animals↗

Immediate loading dental implants: overview and rationale.

Brånemark established the concept of osseointegrated dental implants as a predictable modality for treatment of edentulous patients. He defined osseointegration as bone-to-implant contact at the microscopic level. Osseointegration was a revolutionary concept in implant dentistry. While earlier pioneers never considered direct bone anchoring of the implant, and even established interposition of fibrous tissue between implant and bone as desirable to mimic periodontal ligament function, Brånemark et al. demonstrated that direct bone apposition at the implant surface was not only possible, but long lasting.

Aged↗

Comparative analysis of bone stresses and strains in the Intoss dental implant with and without a flexible internal post.

The clinical success of any dental implant is dependent upon the maintenance of good-quality bone supporting it. Previous studies have shown high values of strain around the neck of an implant under lateral loading. These high values may lead to fatigue damage and resorption in lower strength cancellous bone. In this study, the finite element method has been used to study the bone strain distribution around the following implants: (a) an Intoss dental implant, referred to as the 'standard' implant; (b) a comparative Branemark implant and (c) a modified Intoss implant with a central flexible post, referred to as the 'modified' implant. Three different bone distributions have been investigated under axial and lateral loading: (a) implant surrounded by cortical bone; (b) implant tip supported by cortical bone with a thin layer of cancellous bone along the length and top of the implant; (c) implant tip and top supported by cortical bone with a thin layer of cancellous bone along the remaining length. For the standard implant, similar maximum equivalent strain values were predicted for the bone surrounding a comparable length Branemark-type implant. Modification of the standard implant design to include a flexible central post resulted in a decrease in the maximum von Mises stresses and equivalent strains in the cancellous bone. It is postulated that this will reduce the likelihood of bone fatigue failure and subsequent resorption in this bone. Thus the proposed design change is predicted to be highly beneficial in terms of bone load transfer.

Bone Resorption↗

Dental implant success-failure analysis: a concept of implant vulnerability.

This article shows the factors of importance in the long-term success and failure of oral implants based on literature review. Many factors are attributed to the failure of dental implants. The critical components leading to early and late implant failures are evaluated. The behavior of natural teeth and implants is compared in healthy and unfavorable local and systemic conditions. Similarities and differences among dental implants, healthy natural teeth, and ankylosed teeth are examined. Based on this comparison, the author attempts to draw a conclusion on the vulnerability of dental implants and their prognosis. The importance of ongoing clinical supervision of a patient's implant condition with a good recall program and the necessity to accumulate clinical data concerning implant failures over an extended period of time in a standardized manner are emphasized. It is also suggested that implant practitioners avoid giving guarantees of long-term implant success to their patients.

Biomechanical Phenomena↗

Quantitative histologic evaluation of LTI carbon, carbon-coated aluminum oxide and uncoated aluminum oxide dental implants.

The response of mandibular bone to identical geometry LTI carbon, carbon-coated aluminum oxide, and uncoated aluminum oxide blade-type dental implants in baboons for 2 years was evaluated using histologic, microradiographic, and scanning electron microscopic methods. In addition, a quantitative histologic analysis was performed identifying the type, amount, and distribution of tissue surrounding the dental implant systems. This is the final phase of a study investigating the effect of implant elastic modulus and implant surface chemical composition on the performance of dental implants. Previous studies have utilized clinical and radiographic evaluations, postretrieval mechanical testing, and finite element stress analysis to evaluate the dental implant performance. The results of the histologic study revealed a direct implant-bone interface with no intervening soft tissue in 16 of the 21 implants (76%). A fibrous tissue interface was observed in 5 of 21 implants (24%). Quantitative histologic results for the implants with a direct implant-bone interface showed statistically larger crestal cortical plates (p less than 0.05) and greater area fraction crestal cancellous bone (p less than 0.05) in the LTI carbon implant compared to the carbon-coated and uncoated aluminum oxide implants. The carbon-coated and uncoated aluminum oxide implants demonstrated statistically greater area fraction cancellous bone at the inferior region of the implant (p less than 0.05) and thinned and reduced crestal cortical plates when compared to the LTI carbon implants. The results indicate that significant stress shielding of the crestal bone had occurred with the rigid carbon-coated and uncoated aluminum oxide implants when compared to the LTI carbon implants which had a material elastic modulus similar to cortical bone. Based upon the histologic results, it appears that the LTI carbon implants with the direct implant-bone interface exhibited a greater potential for long-term successful performance compared to the aluminum oxide substrate implants.

Aluminum↗

[Computer-assisted intraoperative visualization of dental implants. Augmented reality in medicine].

In this paper, a recently developed computer-based dental implant positioning system with an image-to-tissue interface is presented. On a computer monitor or in a head-up display, planned implant positions and the implant drill are graphically superimposed on the patient's anatomy. Electromagnetic 3D sensors track all skull and jaw movements; their signal feedback to the workstation induces permanent real-time updating of the virtual graphics' position. An experimental study and a clinical case demonstrates the concept of the augmented reality environment--the physician can see the operating field and superimposed virtual structures, such as dental implants and surgical instruments, without loosing visual control of the operating field. Therefore, the operation system allows visualization of CT planned implantposition and the implementation of important anatomical structures. The presented method for the first time links preoperatively acquired radiologic data, planned implant location and intraoperative navigation assistance for orthotopic positioning of dental implants.

Computer Graphics↗

Ultrastructural characterization of the implant/bone interface of immediately loaded dental implants.

Primary stability and an optimized load transfer are assumed to account for an undisturbed osseointegration process of implants. Immediate loaded newly designed titanium dental implants inserted in the mandible of minipigs were used for the characterization of the interfacial area between the implant surface and the surrounding bone tissue during the early healing phase. Histological and electron microscopical studies were performed from implant containing bone specimens. Two different load regimens were applied to investigate the load related tissue reaction. Histological and electron microscopical analysis revealed a direct bone apposition on the implant surfaces, as well as the attachment of cells and matrix proteins in the early loading phase. A striking finding of the ultrastructural immunocytochemical investigations was the synthesis and deposition of bone related proteins (osteonectin, fibronectin, fibronectin receptor) by osteoblasts from day one of bone/biomaterial interaction. Calcium-phosphate needle-like crystallites were newly synthesized in a time-related manner directly at the titanium surface. No difference in the ultrastructural appearance of the interface was found between the two loading groups. Our experimental data suggest that loading of specially designed implants can be performed immediately after insertion without disturbing the biological osseointegration process.

Animals↗

Antibacterial activity of dental implant metals.

This study was conducted to investigate the specific in vitro antibacterial effect of seven dental implant metals on oral bacteria which have often been identified in failing implants. The metals chosen for evaluation were titanium, chromium, cobalt, aluminum, iron, gold, and vanadium. These metals were selected because they are contained in many commonly used dental implants. The bacteria selected for this study included isolates of Porphyromonas endodontalis, Porphyromonas gingivalis, Prevotella intermedia, Prevotella melaniogenica, Actinobacillus actinomycetemcomitans, Actinomyces naeslundii, and Actinomyces viscosus. Sets of tubes containing either supplemented trypticase soy broth, brain-heart infusion-yeast extract, or brain-heart infusion-yeast extract with 5 percent defibrinated rabbit blood were aseptically prepared with doubling dilutions of the seven metals starting at an initial concentration of 500 micrograms/ml and terminating at 0 microgram/ml. Cultures of each organism were inoculated into each set of broth tubes containing all concentrations of metals. Tubes were incubated either anaerobically or in an atmosphere of 5 percent carbon dioxide for 48 hours at 35 degrees C and then assayed for ATP content which was proportional to the viable cellular biomass. The results showed that, although being bacteria and concentration dependent, all seven metals suppressed the growth of each organism. The rank order of antibacterial activity expressed by dental implant metals was gold > titanium > cobalt > vanadium > aluminum > chromium > iron.

Actinomyces↗

[A study on glass-ceramic for dental implant. Histopathological response in animal experiment].

The endosseous dental implants of glass-ceramic were implanted and holes were drilled as control in edentulous areas of adult dog mandibles. The implants were kept without function. After 2-84 days, the biological reaction of the tissue was examined by histological and ultrastructural methods, while the glass-ceramic surface was examined by EPMA analysis and X-ray diffraction. The results were as follows: 1. After 4 days the bone matrix formation started on the surface of the glass-ceramic. After 14 days, the area of bone formation on the implant surface was enlarged and about all surface was covered with this woven bone. 2. Being compared with the control, glass-ceramic didn't prevent the healing process of bone. 3. On the surface of glass-ceramic, apatite and beta-whitlockite crystal formation was observed by X-ray diffraction. And analysis by EPMA showed this areas combined bone. 4. TEM observation showed that there were many hemidesmosomes in interface between the implant and attached epithelium. In the subepithelial fibrous tissue collagen fibers and fibroblasts were arranged in parallel on the implant surface.

Animals↗

Effects of the Nd:YAG dental laser on plasma-sprayed and hydroxyapatite-coated titanium dental implants: surface alteration and attempted sterilization.

The Nd:YAG dental laser has been recommended for a number of applications, including the decontamination or sterilization of surfaces of dental implants that are diseased or failing. The effects of laser irradiation in vitro (1) on the surface properties of plasma-sprayed titanium and plasma-sprayed hydroxyapatite-coated titanium dental implants, and (2) on the potential to sterilize those surfaces after contamination with spores of Bacillus subtilis have been examined. Surface effects were examined by scanning electron microscopy, energy dispersive spectroscopy, and x-ray diffraction after laser irradiation at 0.3, 2.0, and 3.0 W using either contact or noncontact handpieces. Controls received no laser irradiation. Melting, loss of porosity, and other surface alterations were observed on both types of implants, even with the lowest power setting. For the sterilization study, both types of implants were first sterilized by exposure to ethylene oxide and then contaminated with spores of B subtilis. After laser irradiation, the implants were transferred to sterile growth medium and incubated. Laser irradiation did not sterilize either type of implant. The spore-contaminated implants in the control group were successfully sterilized with ethylene oxide.

Bacillus subtilis↗

[Fundamental study on hybrid-type dental implant--effects of glass-ceramics on growth and differentiation of human periodontal ligament-derived cells].

The hybrid-type dental implants which are composed of substrates and periodontal ligament-derived cells are expected to form the periodontal ligament-like tissue around the dental implant. The purpose of this study was to investigate the possibility of the application of glass-ceramics (GC) as the substrate using the human periodontal ligament-derived cells (PL cells). The growth and differentiation of the PL cells on the GC were investigated, as compared to the hydroxyapatite plates and the conventional plastic dishes. The Ca concentration of the media was also measured. The results were as follows: 1) The PL cells were fibroblastic of spindle shape. The population doubling time was approximately 26 hours. 2) The PL cells exhibited an alkaline phosphatase (ALPase) activity, collagen productivity and responsiveness to 1 alpha,25-dihydroxyvitamin D3. 3) The PL cells proliferated favorably both on the mirror-polished and #2000-polished GC plates as well as on the hydroxyapatite plates. 4) The ALPase activity of the PL cells on the GC increased in a time-dependent manner. 5) The GC released Ca into the media. The PL cells possessed some characteristics of periodontal ligaments, and the growth and differentiation of the PL cells were not impaired significantly on the GC. The GC also provided the dental implant with enough biocompatibility and strength. These results promised the usefulness of the GC as the possible substrate for the hybrid-type dental implants.

Calcium↗

Success of dental implants placed in intraoral block bone grafts.

BACKGROUND: The purpose of this study was to evaluate the survival and success of dental implants placed in alveolar bone following augmentation using intraoral block bone grafts. METHODS: A consecutive retrospective study was conducted on patients who had onlay bone grafts for vertical or horizontal augmentations followed by dental implantation from 1999 to 2001. Files of 50 healthy patients who received 129 implants in augmented sites were reviewed. Implant survival, radiologic implant success (marginal bone loss), and complications were recorded. RESULTS: Follow-up from time of implantation ranged from 6 to 67 months (mean: 24.3 +/- 11.2 months). Ranges of implant widths and lengths were 3.25 to 4.7 mm and 10 to 16 mm, respectively. The overall survival rate was 96.9% (four implants were removed). Marginal bone loss around implants ranged from 0 to 3.3 mm (average: 0.22 +/- 0.45 mm). Only 5% of the implants presented marginal bone loss > or =1.5 mm over the follow-up time. CONCLUSIONS: Intraoral bone block graft surgery is a predictable operation for the use of dental implants. Implant placement in augmented areas presents high survival and radiologic success rates with minimal bone loss.

Adolescent↗

Oral rehabilitation with dental implants in oligodontia patients.

PURPOSE: The aim of this retrospective report was to evaluate the treatment outcome of oral rehabilitation with dental implants in oligodontia patients. MATERIALS AND METHODS: Thirteen oligodontia patients treated with dental implants were examined clinically and radiographically (follow-up 3 +/- 2 years, range 1 to 8 years). In addition, patient-mediated concerns of satisfaction, treatment experience, and level of impairment of oral functions were assessed with questionnaires. RESULTS: In general, all patients were satisfied with the implant treatment and experienced the treatment as nonaggravating. There was significant functional improvement, with an implant survival rate of 86% and 96% for the maxilla and mandible, respectively. CONCLUSION: Dental implants can play an important role in the oral rehabilitation of patients with oligodontia. Patients were generally satisfied with the overall treatment experience and reported significant functional improvement. Implant survival rate was comparable with previous reports.

Adolescent↗

[A clinical study of immediate dental implant and immediate restoration].

OBJECTIVE: To evaluate the clinical results of immediate implant and immediate restoration and to discuss the applying principles of these techniques. METHODS: Fourteen cases underwent immediate implant surgery for 37 dental implants immediately after the teeth or roots were extracted. Among them, 6 cases (14 implants) received immediate restoration after implant placement. The second stage operation and final restoration were performed 4 months on average postoperatively, and the mean follow-up time was 22 months. RESULTS: Two implants from 1 case were lost at 3 weeks after immediate implant and immediate restoration. The rest cases achieved good clinical results. Accumulative 4-year survival rate was 94.6%. CONCLUSIONS: The result of immediate implant and immediate restoration is predictable if the cases are properly selected.

Adolescent↗