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At least 379 records · Page 21Linked to original sources
PubMed1985

[Acute acalculous cholecystitis after digestive caustic burn].

A case is reported of acute acalculous cholecystitis in a patient who suffered a digestive burn treated by total parenteral nutrition. Pain in the right upper abdominal quadrant and fever occurred 26 days after the start of parenteral nutrition and 24 h after abruptly resuming oral feeding. Ultrasonography showed a distended gall-bladder with a thickened wall and the formation of sludge. Cholecystectomy was followed by a complete recovery. The part played by each of the corrosive burn, the total parenteral nutrition and the abrupt resumption of oral feeding in the pathogenesis of this complication is reviewed.

Acute Disease↗
PubMed1999

The effects of colchicine treatment on wound healing in a caustic murine injury model.

OBJECTIVE: The present study determined the effects of colchicine on wound repair in a murine model of dermal chemical injury. METHODS: Standardized 4.15 cm2 circular lesions were induced on the dorsum of adult male mice with NaOH. Five minutes of IN or 3N caused lesions of graded depth. Mice received colchicine (1 mg/kg) or phosphate-buffered saline intraperitoneally in equivalent volumes. Treatment began immediately postinjury and was continued on an alternating day schedule for 14 days. Wound size was measured every third day postinjury. On day 15 postinjury, wounds were histologically graded for depth of injury, degree of fibrosis, inflammatory cell response, and revascularization. All histological determinations and wound measurements were performed in a blinded fashion. RESULTS: All mice had a similar initial wound size and completed the experimental protocol. In dermal wounds of superficial depth, colchicine-treated mice (n = 20) had a larger wound size during days 6 through 9 of the experimental trial when compared to phosphate-buffered saline-treated mice (n = 18). In the deeper wounds, there were no significant differences in wound size between colchicine and phosphate-buffered saline-treated groups. Colchicine (n = 54) did not affect the degree of fibrosis at all depths of injury vs phosphate-buffered saline treatment in mice (n = 55). The degree of wound revascularization was less in colchicine-treated mice (n = 54) than phosphate-buffered saline-treated mice (n = 55). CONCLUSION: Colchicine did not improve wound healing in an alkaline-induced dermal injury.

Animals↗
PubMed1998

Caustic ingestion and foreign bodies in the gastrointestinal system.

Infants and young children commonly explore their environment by placing objects in their mouth. Although accidental ingestion can happen in older children and adolescents, recurrent foreign body ingestion is usually seen in mentally retarded and psychiatric patients. These patients present the primary care physician with a challenge of distinguishing these patients who require intervention from the majority who need observation only.

Burns, Chemical↗