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[Spontaneous epiphyseal injury as a complication of a simple bone cyst of the femoral neck? Case report and review of the literature].

A case of a spontaneous epiphyseal injury of the femoral neck in an 8-year-old boy is reported. The same boy had been seen 8 months before for a pathological fracture caused by a simple bone cyst of the femoral neck on the same side. At the second visit the boy showed spontaneous severe pain of the hip, and radiography was performed under the presumed diagnosis of a slipped capital femoral epiphysis. However, it demonstrated a separation through the growth plate cranially and a fracture through the metaphysis inferiorly, leading to the differential diagnosis of a Salter-Harris type II fracture despite a nontraumatic patient history.A review of the literature failed to reveal a similar report of simultaneous occurrence of a simple bone cyst and epiphyseal injury of the femur. However, slipping of the proximal humeral epiphysis in connection with a simple bone cyst has been described by some authors. We propose a pathophysiological model for the simultaneous occurrence of epiphyseal injury and a simple bone cyst. Physeal involvement by a simple bone cyst and varus deformity of the femoral neck could cause weakening of the growth plate and predispose for epiphyseal injury. Based on these findings, we suggest that a simple bone cyst of the proximal femoral metaphysis can develop into a severe condition. Children presenting with this clinical picture should be treated vigorously and monitored for the development of complications leading to epiphyseal injury.

Bone Cysts↗

Expression of insulin-like growth factor-I (IGF-I) in aneurysmal bone cyst.

The effects of insulin-like growth factor-I on bone tissue and its role in bone development have been extensively investigated, but there is little information on its role in the pathogenesis of aneurysmal bone cyst. Therefore, using the techniques of immunohistochemistry and in situ hybridization, the authors studied the expression of insulin-like growth factor-I in 19 specimens of aneurysmal bone cyst. Insulin-like growth factor-I or specific mRNA sequences encoding for insulin-like growth factor-I were detectable in all specimens tested and were mainly localized in multinucleate giant cells. In contrast, only insignificant levels of insulin-like growth factor-I expression were detectable in normal human bone tissue. Taken together with the previously reported role of insulin-like growth factor-I in the pathogenesis of giant cell tumor, the findings of this study suggest that insulin-like growth factor-I may play a role in the pathogenesis of aneurysmal bone cyst.

Adolescent↗

Aneurysmal bone cyst in a rib of a cat.

An aneurysmal bone cyst was identified in the rib of a 3 1/2-year-old domestic shorthair cat. Surgical excision of the cyst, with reconstruction of the thoracic wall, was performed. Though aneurysmal bone cyst is a benign neoplastic condition that may be associated with locally aggressive growth, it does not metastasize. The condition is rare in any species other than human beings, but has been reported in cats, dogs, and horses.

Animals↗

Cranial aneurysmal bone cyst "with special emphasis on endovascular management".

OBJECTIVE AND METHOD: Most of the literature about cranial aneurysmal bone cyst represents case reports, the aim of this paper is to gather information in solid clear statements about this disease in the region of the skull. This is a retrospective analysis of all available case reports on aneurysmal bone cyst involving the skull between 1960 and June 1998. The jaw was excluded. RESULTS: Sixty one cases of aneurysmal bone cyst involving the skull were found. 33 were males and 28 were females. The average age at presentation was 17.5 years. A painless enlarging mass was the most common mode of presentation. Features of pressure on intracranial structures with increased intracranial pressure were present in some patients. Most patients were managed by total excision of the lesion when feasible. Partial resection resulted in recurrence in some patients. Endovascular embolization has been used as a single mode of therapy or as pre-operative to decrease the intra-operative bleeding. CONCLUSION: Aneurysmal bone cysts not uncommonly affect the skull. The pathological changes are similar to those affecting other parts of the body. Clinical presentation varies and depends on the part of the skull involved. Endovascular embolization plays a very important role in the management either as pre-operative or as the only method of treatment.

Adolescent↗

[Treatment of simple bone cysts with methylprednisolone acetate in children].

OBJECTIVES: Steroid injections represent one of the simple treatment alternatives for simple bone cysts in pediatric age group. The aim of this study was to evaluate the results of steroid injections in the treatment of simple bone cysts. METHODS: Thirteen children (9 boys, 4 girls; mean age 9 years; range 4 to 14 years) with simple bone cysts were treated primarily with injection of methylprednisolone acetate with the use of the two-needle technique. The cysts were localized in the proximal humerus (n=7), femoral intertrochanteric region (n=4), and the proximal one-third of the femur (n=1). Four patients had fractures before treatment. Each patient received a maximum of three injections at six-week intervals, each consisting of 120-160 mg of methylprednisolone acetate. The patients were monitored by plain radiographs obtained in the sixth week, third month, sixth month, and at the end of a year followed by annual radiographic evaluations. Cyst healing was assessed according to the Neer classification. The mean follow-up was five years (range 1 to 11 years). RESULTS: Treatment with methylprednisolone acetate resulted in complete healing in five patients (38.5%) and healing with residual lesions in six patients (46.2%). One patient (7.7%) did not respond to steroid treatment and one patient developed recurrence. The results were satisfactory (84.6%) in patients with complete healing and healing with residual lesions, and unsatisfactory in two patients (15.4%). No procedure-related complications were encountered. CONCLUSION: Our results suggest that treatment with steroid injections offers satisfactory outcome in simple bone cysts in children, and thus, is worthy of consideration before more aggressive methods are to be applied.

Adolescent↗

An unusual appearance of an aneurysmal bone cyst of the thoracic spine.

Aneurysmal bone cysts (ABCs) have been reported in essentially every bone of the human skeleton. This case report documents a very unusual clinical appearance for this entity: a superior mediastinal mass. Also, the patient underwent multiple imaging studies that demonstrated both common (absence of septations) and unusual (extensive involvement of vertebral body with little involvement of posterior elements) characteristics of ABCs.

Adult↗

Aneurysmal bone cyst of the mandible.

The aneurysmal bone cyst (ABC) is a benign, solitary lesion of bone which is most commonly found in the long bones and vertebral column. Its occurrence in the mandible is uncommon. Because of its infrequent appearance, the ABC may be mistaken for neoplastic lesions. In the past, management has consisted of curettage, cryotherapy and local resection. In this publication we present a case of ABC of the mandible. We include a review of the literature, a discussion of the etiology, pathogenesis and management of this interesting lesion.

Adolescent↗

Aneurysmal bone cyst: a hereditary disease?

Recent genetic and immunohistochemical studies propose that the primary aneurysmal bone cyst is a tumour and not a reactive tumour-simulating lesion. Based on a familial case of aneurysmal bone cyst the authors contacted 135 patients with this disease. Sixty-eight females and 67 males (median age 14 years; range 2-73 years) were asked if other family members had bone lesions. One hundred and seven patients (79%) denied having other family members with lesions, 23 patients (17%) did not answer, and five patients (4%) gave evidence of other bone lesions in the family. These data indicate that a predisposing genetic defect could be part of a multifactorial pathogenesis in the development of some aneurysmal bone cysts.

Adolescent↗

The effects of methylprednisolone acetate in the treatment of bone cysts. Results of three years follow-up.

The treatment of bone cysts by topical injection of methylprednisolone acetate was initiated at the end of 1973, and the late results are reported in this paper. In seventy-two cases followed up for one to three years favourable results have been obtained in about 90 per cent. The technique of local injection and the surgical equipment employed, in the case of focal recurrences, are considered. With this method, surgical treatment of bone cysts in youth is seldom necessary.

Administration, Topical↗

Development of carpal bone cysts as revealed by radiography.

In 11 patients with carpal bone cysts the course of the intraosseous lytic lesion could be followed over periods from 2 to 27 years. The cysts were found to develop from an area of sparse trabeculae of reduced mineral content to a well-defined cavity, in some instances surrounded by a sclerotic zone. In 2 instances the lytic process caused progressive destruction of the subchondral layers of the affected bone resulting in communication with the adjacent joint space. The findings support the theory that carpal bone cysts are intraosseous lesions probably caused by vascular disturbances from mechanical stress and repeated trauma. The term intraosseous ganglion is a misnomer and should be avoided.

Adult↗

[Solitary bone cyst. A case of dual mandibular and humeral location].

Among cystic lesions of maxilla the solitary bone cyst always raises diagnostic and etiopathogenic problems. Typically observed as single lesions in maxilla, reports have been published of multiple localizations. Similitudes with solitary cyst of long bones have even been underlined, but no reports exist in the literature of the double localization: maxillary and extra-maxillary. A young man presented mandibular and humeral lesions possessing characteristics of solitary bone cysts.

Adult↗

[Juvenile bone cysts and giant cell tumors (author's transl)].

The attempt is made to demonstrate clinical, radiographical, morphological differences between juvenile bone cyst and giant cell tumor as shown in the patients of the Surgical Department of the University of Dusseldorf and literature. It is possible to derive inferences in differential diagnosis from the age of the patient, clinical course and statistically most frequent locations. Radiographically the bone cyst distinguishes itself by its central localisation in the metaphysis, where as the giant cell tumor has an excentric position in the epiphysis with a tendency of extending into the metaphysis. Giant cells occur in both diseases. While the bone cyst is an tumor-like lesion, the giant cell tumor is a real neoplasia. The therapeutical procedure varies according to different prognostical significance of the two diseases. Therefore, it is necessary to draw an exact line of demarcation between the comparetively harmless juvenile bone cyst and the semimalign giant cell tumor.

Adolescent↗

Percutaneous Ethibloc injection in aneurysmal bone cysts.

OBJECTIVE: To investigate whether the injection of Ethibloc into aneurysmal bone cysts can be an effective treatment modality. DESIGN AND PATIENTS: Ethibloc is an alcoholic solution of zein (corn protein) which has thrombogenic and fibrogenic properties. Ten patients with aneurysmal bone cysts were treated with CT-guided percutaneous injection of Ethibloc into the cyst cavity. Ethibloc injection was the primary treatment in five patients. Four patients had recurrence following previous curettage and bone grafting and one patient had not responded to injection into the lesion of autologous iliac crest bone marrow aspirate. Three patients needed a second injection. The median follow-up was 27 (6-60) months. RESULTS AND CONCLUSION: Symptoms were relieved in all patients. At imaging, seven patients had resolution of the lesion and three had partial response at the most recent follow-up. Complications consisted of a local transitory inflammatory reaction in two patients and an aseptic abscess in one patient. This relatively simple, minimally invasive procedure makes an operation unnecessary by stopping the expansion of the cyst and inducing endosteal new bone formation. This technique may be used as the primary management of aneurysmal bone cysts excluding spinal lesions.

Adolescent↗

Self-healing traumatic bone cysts.

The etiology and pathogenesis of traumatic bone cyst are still far from being conclusively established with multiple theories, names, and forms of management being proposed and used. The rarity of these lesions in the older age groups suggests that self-healing can occur. This article presents two well-documented cases of what clinically and radiographically were consistent with so-called "traumatic bone cyst" of the mandible, which have appeared to heal without surgical intervention, thus providing additional information to our understanding of the biologic nature of this entity. Case 1 involved a 14-year-old boy with a lesion of the anterior left mandible that was monitored for 7 years and 5 months. Case 2 involved a 19-year-old female patient with a lesion of the right mandible that was monitored for 2 years and 9 months. In both cases, intraosseous biopsy or other surgical procedures were not undertaken. By the time both patients approached age 22, their lesions had resolved and the trabecular bone pattern radiographically approached normal.

Adolescent↗

Magnetic resonance spin echo and fast field echo imaging of aneurysmal bone cyst: comparison with X-ray and computed tomography.

OBJECTIVE: To discuss the case of an 8-yr-old boy with an aneurysmal bone cyst of the right proximal humerus, including the features imaged on plain film radiography, computed tomography (CT), magnetic resonance imaging (MRI), including spin echo and fast field echo imaging. CLINICAL FEATURES: The patient suffered for 1 yr from intermittent but progressive pain in his right upper arm and shoulder area. There was no history of trauma or known systemic disease. There was decreased range of motion in abduction of the glenohumeral joint and pain on focal pressure along the deltoid muscle. A complete imaging evaluation consisting of plain film radiography, CT and MRI was performed, which revealed the classical imaging features of an aneurysmal bone cyst. An additional cystic lesion was detected by the MRI that was not appreciated on the plain films or CT. INTERVENTION AND OUTCOME: The patient was referred for biopsy to confirm the preliminary diagnosis of aneurysmal bone cyst. No treatment was instituted. CONCLUSION: Evaluation of aneurysmal bone cyst may be completed with CT scanning and more specifically with MRI MRI coronal T2, weighted images are advantageous for visualization of the main cystic lesion and any additional cysts. Fast field echo images show a better contrast between the cyst and bone marrow with extension of the cyst into the epiphysis as evident in this case. Follow-up studies revealed complete healing of the cyst with only residual densities in the humeral metaphyseal area.

Bone Cysts, Aneurysmal↗

Aneurysmal bone cyst of the rib in a child: report of a case.

An aneurysmal bone cyst (ABC) is a benign tumor of the skeletal system, which is rare in childhood and mostly occurs in long bones. An aneurysmal bone cyst of the rib is also very rare and it is difficult to distinguish from other rib tumors of childhood, especially Ewing's sarcoma. An unusual case of an aneurysmal bone cyst in the rib of a 12-year-old boy is presented herein. The entity is discussed with special emphasis on the clinicopathologic features, differential diagnosis, and treatment. The most important diagnostic aid in accurately identifying such cysts is to be aware of such a possible diagnosis when a child presents with a rib mass. An en bloc resection of the mass along with the affected portion of the rib is mandatory to obtain a satisfactory outcome.

Biopsy, Needle↗

Aneurysmal bone cysts of the skull: report of three cases.

We report three cases of aneurysmal bone cysts of the skull, a rare site for this type of lesion. The patients were 11, 15 and 44 years old, the duration of symptoms being 72, 24 and 6 months, respectively. The lesions were painful in two cases. Computed tomography in all three cases was suggestive of aneurysmal bone cysts. En bloc excision of the bone cysts demonstrated no dural involvement. There were neither mitotic figures nor any other associated pathology on histopathological examination. Two cases were recurrence free at follow-up of 8 months and 3 years, and the third patient was thought to be recurrence free at 2 years.

Adolescent↗