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Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis.

Fifty patients with chronic plaque psoriasis were treated with trioxsalen bath PUVA and 43 patients with oral methoxsalen PUVA. The two treatment regimens gave similar results; 75% and 77% of the patients had excellent or good clearing and a follow-up of one year revealed relapses in 61% and 58% of the patients, respectively. The cumulative UVA dose remained significantly lower in bath PUVA (mean 23.5 J/cm2) than in oral PUVA (mean 131 J/cm2). Nausea and headache occurred in 21% of the patients receiving oral PUVA but in none in the bath PUVA group. Local side-effects were found in 30% of the patients receiving bath PUVA and in 17% of the patients in the oral PUVA group.

Adult↗

Entrance of water into the bladder during sitz bath in elderly catheterized and noncatheterized females.

This study was conducted to determine if water enters the bladders of elderly catheterized and noncatheterized women during a sitz bath. Subjects were placed in a sitz bath containing fluorescein for 20 min. Serial urine specimens were collected at varying intervals up to 1 hr after the bath and compared to urine samples collected before the bath. No significant difference in fluorescence was found between the urine specimens in any subject which provides strong evidence that there is no detectable leakage in either group. Under the conditions of this experiment, the periurethral space was tightly sealed and did not permit passage of water.

Aged↗

Relationship between the occurrence of coliphages and E. coli in Danish marine bathing areas.

During 2 bathing seasons, 1978 and 1979, water samples were collected with intervals of 2 weeks from 17 marine bathing areas situated on the coast of the island of Fyn. Quantitative examinations for coliphages and fecal coliforms were carried out. Coliphages were present in approximately 50% of the samples. 75% of the positive samples contained less than or equal to 10 coliphages per 100 ml. 6 samples were found with greater than 100 coliphages per 100 ml. A positive correlation between coliphage and fecal coliform concentrations was demonstrated. The ratios of fecal coliforms to coliphages varied only little between individual sampling stations. The mean ratio was 1.9 and 2.0 for the 2 sampling periods. The mean concentration of fecal coliforms was gradually increasing from 2.4/100 ml in May to 7.2/100 ml in September. Conversely the coliphage concentrations were quite uniform during the bathing seasons. As a result of those 2 trends, the fecal coliform/coliphages ratio increased during the seasons from 0.86 to 3.13. Finally, the potential value of coliphages as an indicator of pathogenic microorganisms in marine bathing areas is discussed.

Bathing Beaches↗

A comparison of the anxiety-reducing potential of two techniques of bathing.

This study compared the effects of the towel bath and the conventional bed bath on patient anxiety. The sample of 105 patients were divided into two groups--those who would be having invasive procedures and those with unrelieved pain. Anxiety was measured using the State-Trait Anxiety Inventory (STAI), the Palmar Sweat Index (PSI), and the Behavioral Cues Index (BCI). The scores from the STAI A-State subscale supported the hypothesis that the towel bath resulted in a significant decrease in anxiety for the sample as a whole and for the invasive procedure subsample. The hypothesis was rejected for the unrelieved pain subsample. Scores from the Palmar Sweat Index and the Behavioral Cues Index did not support any of the hypotheses. Based on the findings of this study, bathing is recommended for its anxiety-reducing effects.

Adult↗

A new technique for evaluating bath oil in the treatment of dry skin.

Patients with moderate-to severe dry skin of the lower legs bathed daily for 17 days using either an emulsified lanolin and mineral oil bath additive (Treatment Group) or their usual bath soap (Control Group). The affected sites were evaluated and photographed before and at selected times following treatment, using a standardized technique. The severity of the dry skin as it appeared in projected color transparencies was evaluated on a 10-point grading scale by a second investigator under blinded conditions. The differential response between treatment and control groups increased with time and was found statistically significant (p less than 0.05), demonstrating the sensitivity of the method as well as the apparent therapeutic effects of the bath additive.

Aged↗

[Bathing water related diseases: the Carinthian Sentinel Project as the source of epidemiological data].

The federal country of Carinthia is known for its lakes and ponds, which are extensively used for bathing. The water quality is monitored regularly in accordance to the EC-Directive 76/160/EC and especially to the more rigorous Austrian Standard M6230. Since redevelopment measures of the lakes have been nearly finished the water quality found has improved essentially. In spite of these monitored data no effective correlation to data from the concerning ambulant sector of medical care could be established. The Carinthian Sentinel Practice Network started in summer 1994 to retrieve informations about occurrence and frequency of bathing related illness of children up to 16 years old. The 26 participating primary health care and pediatric physicians, having their own independent practices spread all over the country, reported the specific doctor-patient-contracts to the coordinating base. Criteria for inclusion in the medical report were headache, sore throat, otalgia, stomach-ache, nausea, emesis, diarrhoea, fever, rhinitis, cough, cold, moreover conjunctivitis, skin rash and specific dermatitis. In addition physicians reported where, how long and how often the children had been bathing and how long they had been free of symptoms afterwards. Each case was reported to the coordinating base including a presumed diagnosis. Statistic evaluation showed that bathing related illness may be divided into three main groups according to symptom frequency. The frequency of otalgia (32.4%) was significantly higher than any other symptom asked for. Two groups of symptoms correlate with each other: on one hand rhinitis, conjunctivitis, cough and sore throat (36.5%) and on the other hand nausea, emesis, diarrhoea and fever (41.9%). These data underline conclusions drawn by other authors but are not representative enough to correlate to data from water monitoring. First results suggest that conclusions for public health authorities can be drawn from this additional information about the state of the lakes and ponds-providing a sufficient number of data is reported.

Adolescent↗

[The use of sodium chloride baths in the treatment of diabetic patients with micro- and macroangiopathies].

Patients suffering from insulin-dependent or non-insulin-dependent diabetes mellitus with micro- and macroangiopathy took sodium chloride baths of diverse concentration (30 and 50 g/l). A control group consisted of patients who had taken "neutral" baths. The response to sodium chloride baths was registered in carbohydrate and lipid metabolism, microcirculation, hemorheology, lower limbs circulation, exercise tolerance. Baths with sodium chloride concentrations 50 g/l have advantages, especially in patients with insulin-dependent diabetes mellitus.

Adolescent↗

Comparison of the carcinogenic potential of trioxsalen bath PUVA and oral methoxsalen PUVA. A preliminary report.

BACKGROUND AND DESIGN: There is an increasing concern about the long-term carcinogenic effect of oral psoralen with long-wave UV radiation in the A range (PUVA). Most follow-up investigations indicate a definite risk of squamous cell carcinoma of the skin with long-term PUVA treatment. In a recently published study of 4799 Swedish patients who had received PUVA, it was noted that 833 patients who had received trioxsalen bath or oral trioxsalen did not show any increased risk of skin cancer in contrast to oral methoxsalen. This finding has been further investigated in this study. We compared four dermatologic university clinics in Sweden with regard to the carcinogenic potential of the PUVA regimen used. One clinic used trioxsalen bath PUVA exclusively and the other three used oral methoxsalen. Information on their PUVA-treated patients was collected and linked with information from the Swedish Cancer Registry to identify individuals with squamous cell carcinoma of the skin. RESULTS: A total of 18 squamous cell carcinomas of the skin were reported in 2975 PUVA-treated patients until 1987. The expected number was 3.1. The center using bath PUVA only had no increased risk of squamous cell carcinoma of the skin in contrast to the three centers using oral methoxsalen-PUVA. The increased risk for male subjects from those centers varied from six to 13 times that in the general population, but for female subjects a significant increased relative risk was found only at one center. CONCLUSION: In this preliminary report, PUVA treatment with trioxsalen bath seems to be less carcinogenic than the oral dosage. However, differences in the patient populations might also have affected the outcome of the study. More information on this field is needed.

Administration, Oral↗

Effect of active hand exercise and wax bath treatment in rheumatoid arthritis patients.

The effect of active hand exercise and warm wax treatment was evaluated in 52 rheumatoid arthritis patients randomized into four groups: (1) both exercise and wax bath, (2) exercise only, (3) wax bath only, and (4) controls. Treatment was given three times a week for 4 weeks. Deficits in flexion and extension in digits II-V bilaterally, grip function, grip strength, pain, and stiffness were measured before and after the treatment period. The control group was measured at corresponding times. Wax bath treatment followed by active hand exercise resulted in significant improvements of range of motion (ROM) and grip function. Active hand exercise alone reduced stiffness and pain with nonresisted motion and increased ROM. Wax bath alone had no significant effect.

Adult↗

The interplay of diffusional and electrophoretic transport mechanisms of charged solutes in the liquid film surrounding charged nonporous adsorbent particles employed in finite bath adsorption systems.

A model that describes the diffusive and electrophoretic mass transport of the cation and anion species of a buffer electrolyte and of a charged adsorbate in the liquid film surrounding nonporous adsorbent particles in a finite bath adsorption system, in which adsorption of the charged adsorbate onto the charged surface of the nonporous particles occurs, is constructed and solved. The dynamic behavior of the mechanisms of this model explicitly demonstrates (a) the interplay between the diffusive and electrophoretic molar fluxes of the charged adsorbate and of the species of the buffer electrolyte in the liquid film surrounding the nonporous adsorbent particles, (b) the significant effect that the functioning of the electrical double layer has on the transport of the charged species and on the adsorption of the charged adsorbate, and (c) the substantial effect that the dynamic behavior of the surface charge density has on the functioning of the electrical double layer. It is found that at equilibrium, the value of the concentration of the charged adsorbate in the fluid layer adjacent to the surface of the adsorbent particles is significantly greater than the value of the concentration of the adsorbate in the finite bath, while, of course, the net molar flux of the charged adsorbate in the liquid film is equal to zero at equilibrium. This result is very different than that obtained from the conventional model that is currently used to describe the transport of a charged adsorbate in the liquid film for systems involving the adsorption of a charged adsorbate onto the charged surface of nonporous adsorbent particles; the conventional model (i) does not consider the existence of an electrical double layer, (ii) assumes that the transport of the charged adsorbate occurs only by diffusion in the liquid film, and (iii) causes at equilibrium the value of the charged adsorbate in the liquid layer adjacent to the surface of the particles to become equal to the value of the concentration of the charged adsorbate in the liquid of the finite bath. Furthermore, it was found that a maximum can occur in the dynamic behavior of the concentration of the adsorbate in the adsorbed phase when the value of the free molecular diffusion coefficient of the adsorbate is relatively large, because the increased magnitude of the synergistic interplay between the diffusive and electrophoretic molar fluxes of the adsorbate in the liquid film allows the adsorbate to accumulate (to be entrapped) in the liquid layer adjacent to the surface of the adsorbent particles faster than the concentrations of the electrolyte species, whose net molar fluxes are significantly hindered due to their opposing diffusive and electrophoretic molar fluxes, can adjust to account for the change in the surface charge density of the particles that arises from the adsorption of the charged adsorbate. The results presented in this work also have significant implications in finite bath adsorption systems involving the adsorption of a charged adsorbate onto the surface of the pores of charged porous adsorbent particles, because the diffusion and the electrophoretic migration of the charged solutes (cations, anions, and charged adsorbate) in the pores of the adsorbent particles will depend on the dynamic concentration profiles of the charged solutes in the liquid film surrounding the charged porous adsorbent particles. The results of the present work are also used to illustrate how the functioning of the electrical double layer could contribute to the development of inner radial humps (concentration rings) in the concentration of the adsorbate in the adsorbed phase of charged porous adsorbent particles.

Adsorption↗

Effects of the tissue-bath interface on the induced transmembrane potential: a modeling study in cardiac stimulation.

During the initial stages of cardiac stimulation or defibrillation, the distribution of transmembrane potential generated in the myocardium by the external stimulus is determined by the local interactions between fibrous tissue organization and applied electric field. We hypothesize that the pattern of induced transmembrane potential is different, depending on whether the tissue is in insulator, such as air, or in contact with a low-resistance volume conductor, such as blood or perfuseate. The goal of this study is to evaluate the impact of the volume conductor bordering the myocardium on the pattern of stimulus-induced transmembrane potential. Presented here are computer simulations of the steady-state response of model tissue-bath preparations to extracellular current stimuli. Transmembrane potential distributions for various tissue and bath sizes, as well as locations of the stimulation electrodes, are examined. The results indicate that when the external stimuli are located in close proximity to or at the tissue-bath interface, both the magnitude and the distribution of transmembrane potential are significantly altered, compared with the case of an insulated preparation. Thus, the volume conductor seems to be another possible factor contributing to the pattern of membrane hyper- and depolarization in the myocardium. Its influence is, however, modulated by the promixity of the stimuli sites to the tissue-bath interface.

Animals↗

Effect of a perfusing bath on the rate of rise of an action potential propagating through a slab of cardiac tissue.

Experiments show that the rate of rise of the action potential depends on the direction of propagation in cardiac tissue. Two interpretations of these experiments have been presented: (i) the data are evidence of discrete propagation in cardiac tissue, and (ii) the data are an effect of the perfusing bath. In this paper we present a mathematical model that supports the second interpretation. We use the bidomain model to simulate action potential propagation through a slab of cardiac tissue perfused by a bath. We assume an intracellular potential distribution and solve the bidomain equations analytically for the transmembrane and extracellular potentials. The key assumption in our model is that the intracellular potential is independent of depth within the tissue. This assumption ensures that all three boundary conditions at the surface of a bidomain are satisfied simultaneously. One advantage of this model over previous numerical calculations is that we obtain an analytical solution for the transmembrane potential. The model predicts that the bath reduces the rate of rise of the transmembrane action potential at the tissue surface, and that this reduction depends on the direction of propagation. The model is consistent with the hypothesis that the perfusing bath causes the observed dependence of the action-potential rate of rise on the direction of propagation, and that this dependence has nothing to do with discrete properties of cardiac tissue.

Action Potentials↗

Primary structure of cytochrome c' of Methylococcus capsulatus Bath: evidence of a phylogenetic link between P460 and c'-type cytochromes.

Cytochrome c' of Methylococcus capsulatus Bath is involved in electron flow from the enzyme responsible for hydroxylamine oxidation, cytochrome P460, to cytochrome C555. This cytochrome is spectrally similar to other cytochromes c' but is larger (16,000 Da) and has a lower midpoint potential (-205 mV). By a combination of Edman degradation, mass spectroscopy, and gene sequencing, we have obtained the primary structure of cytochrome c' from M. capsulatus Bath. The cytochrome shows low sequence similarity to other cytochromes c', only residues R12, Y53, G56, and the C-terminal heme-binding region (GXXCXXCHXXXK) being conserved. In contrast, cytochrome c' from M. capsulatus Bath shows considerable sequence similarity to cytochromes P460 from M. capsulatus Bath (31% identity) and from Nitrosomonas europaea (18% identity). This suggests that P460-type cytochromes may have originated from a c'-type cytochrome which developed a covalent cross-link between a lysine residue and the c'-heme.

Amino Acid Sequence↗

A Turkish version of the Bath Ankylosing Spondylitis Disease Activity Index: reliability and validity.

The aim of this study was to develop a Turkish version of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and assess its reliability, validity, and sensitivity to change. The Turkish version was obtained after a translation and back-translation process. Seventy-one patients with ankylosing spondylitis were assessed with it. To assess its validity, patients were also evaluated with the Turkish version of the Bath Ankylosing Spondylitis Functional Index (BASFI), the Bath Ankylosing Spondylitis Metrology Index (BASMI), the Bath Ankylosing Spondylitis Patient Global Score (BAS-G), and physicians' assessments of disease activity. Over 24 h, the Turkish BASDAI did not show significant differences between the two assessments (P>0.05). Correlations were found between BASDAI and all of the evaluation parameters except BASMI (P<0.01). Both BASDAI and BASMI showed significant improvements after 8-week home exercise programmes. The results of this study show that the Turkish version of the BASDAI is reliable, valid, and sensitive to change.

Adolescent↗

A comparison between a detergent baby bath additive and baby soap on the skin flora of neonates.

A detergent based baby bath additive as an alternative to soap for bathing neonates was investigated. The yield of Staphylococcus aureus, Staph. epidermidis, Pseudomonas spp., Candida spp. and coliforms from skin swabs was compared in a group of 22 babies bathed in the detergent additive with a similar group of 22 babies bathed in soap. No differences were detected in the isolation rate of these organisms between the two groups.

Bacteria↗

Water bath evaluation technique for emergency ultrasound of painful superficial structures.

Researchers have described the use of bedside emergency ultrasound as an effective way to evaluate for and accurately drain potential abscesses. Similarly, descriptions exist of long bone fracture evaluation in the wrist and hands. Tendon injury can also be detected with ultrasound and exploration can be obviated or at least focused. Sonographic examination of painful extremity pathology such as abscesses or lacerations involving the hand or foot can be challenging. Patients may be uncooperative if they experience significant pain when the transducer is placed on the area of interest. While ample amounts of ultrasound gel can decrease the need for firm transducer contact with the skin it is still difficult to obtain a good evaluation without causing any discomfort. The solution may lie in an old technique that has been recently brought back to life for use in hand evaluation in which the patient's extremity is placed in a water bath. The water bath replaces the need for ultrasound gel or contact between the ultrasound transducer and the patient's skin, thus eliminating discomfort. We describe 7 cases in which, despite aggressive attempts at pain control, adequate evaluation of extremity pathology was not possible without the use of the water bath technique. Patients reported no discomfort and superior quality images were obtained due to the water bath properties. Emergency sonologists should keep this technique in mind when contact between skin and the ultrasound transducer is likely to cause a patient significant discomfort.

Abscess↗

pH effect of coagulation bath on the characteristics of poly(acrylic acid)-grafted and poly(4-vinylpyridine)-grafted poly(vinylidene fluoride) microfiltration membranes.

The poly(acrylic acid)-graft-poly(vinylidene fluoride) (PAAc-g-PVDF) and poly(4-vinylpyridine)-graft-poly(vinylidene fluoride) (P4VP-g-PVDF) copolymers were obtained by thermally induced molecular graft copolymerization of acrylic acid (AAc) and 4-vinylpyridine (4VP), respectively, with the ozone-pretreated poly(vinylidene fluoride) (PVDF) in N-methyl-2-pyrrolidone (NMP) solution. Microfiltration (MF) membranes were prepared from the respective copolymers by phase inversion in aqueous media. The effects of pH of the coagulation bath on the physicochemical and morphological characteristics of the membranes were investigated. The surface compositions of the membranes were determined by X-ray photoelectron spectroscopy (XPS). The surface graft concentration of the AAc polymer for the PAAc-g-PVDF MF membrane increased with decreasing pH value of the coagulation bath. Completely opposite pH-dependent behavior was observed for the surface graft concentration of the 4VP polymer in the P4VP-g-PVDF MF membranes. A substantial increase in mean pore size was observed for the PAAc-g-PVDF MF membranes cast in basic coagulation baths of increasing pH. In the case of the P4VP-g-PVDF MF membranes, a substantial increase in mean pore size was observed for membranes cast in low pH (acidic) baths. The permeation rate of aqueous solutions through the PAAc-g-PVDF and P4VP-g-PVDF MF membranes exhibited a reversible dependence on the pH of the solution, with the membranes cast near the neutral pH exhibiting the highest sensitivity to changes in permeate pH.

Acrylates↗