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Results for “Azauridine”

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At least 379 records · Page 21Linked to original sources
PubMed1974

Hereditary orotic aciduria: evidence for a structural gene mutation.

Orotic aciduria is a rare autosomal recessive disease in man due to a deficiency of orotate phosphoribosyltransferase (EC 2.4.2.10; orotidine-5'-phosphate:pyrophosphate phosphoribosyltransferase) and orotidine-5'-phosphate decarboxylase (EC 4.1.1.23; orotidine-5'-phosphate carboxy-lyase). We have compared certain physicochemical properties of orotidine-5'-phosphate decarboxylase from normal and mutant fibroblasts grown under identical conditions. Orotidine-5'-phosphate decarboxylase from homozygous mutant cells was more thermolabile and exhibited a different electrophoretic mobility when compared to the enzyme from normal cells; orotidine-5'-phosphate decarboxylase from one heterozygous cell strain exhibited an intermediate thermolability while the other heterozygote displayed a thermal inactivation curve indistinguishable from normal. The enzyme from both normal and mutant cells exhibited biphasic kinetics with the same apparent Michaelis constants. These data suggest that the molecular defect in the enzyme of this patient with orotic aciduria is due to a mutation in a gene that affects the structure of either orotate phosphoribosyltransferase or orotidine-5'-phosphate decarboxylase and cannot be attributed to a mutation in a regulatory gene, as previously suggested.

Azauridine↗
PubMedDate not supplied

Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase.

The synthesis and X-ray crystal structures of a series of 5-substituted-6-aza-2'-deoxyuridines is reported. These nucleoside analogues inhibit the phosphorylation of thymidine by HSV-1 TK but have no effect on the corresponding human enzyme. Detailed examination of one analogue proves it to be a competitive inhibitor of thymidine with a Ki of 0.34 microM and is a very poor substrate. The analogues are not substrates for the enzyme and also do not inhibit the degradation of thymidine by thymidine phosphorylase. Molecular modelling showed that the inhibitors fit well in the active site of HSV-1 TK, provided the conformation of the sugar moiety is the same for thymidine in the complex.

Antiviral Agents↗
PubMed1983

Pulse radiolysis studies of some aza analogues of nucleic acid components.

The technique of pulse radiolysis has been utilized to study the reactions of some aza analogues of nucleic acid components with hydrated electrons and OH radicals. The absorption spectra of the transient free radical adducts which result from these reactions and their decay kinetics were determined. The 5-aza analogues gave similar results to those of pyrimidine bases. The 6-aza analogues also showed similar kinetics, however, transient spectra were different. The presence of the sugar moiety in these aza analogues changed the rate law of the OH adduct transient decay from second order to first order kinetics. This finding may have implications for the understanding of the radiation chemistry of DNA.

Aza Compounds↗
PubMed1975

Double-blind controlled crossover high-dose study of Azaribine in psoriasis.

Azaribine used in high doses of 200 mg/kg a day is an effective agent in inducing temporary remissions in patients with severe psoriasis but potentially serious neurotoxicity may occur. Therapy should be initiated at lower doses of 125 mg/kg a day and advanced carefully only if clinical response does not ensue at the lower level.

Adult↗
PubMed1976

Chemotherapy of psoriasis: ten years of experience.

The hunt for an effective, easier to administer, more acceptable therapeutic modality for extensive chronic psoriasis continues. The chemotherapy of psoriasis is reviewed in 246 patients from 1964 to 1974 treated with methotrexate, 92 patients from 1971 to 1974 with hydroxyurea, and 36 patients from 1972 to 1974 with azaribine. Currently, the available chemotherapy agents are the least palatable and desirable form of treatment. Methotrexate continues to be the most predictable, effective and least expensive. The use of photochemotherapy may prove to be more effective, less toxic, and more practical until a more specific and effective etiologically directed form of therapy becomes available.

Azauridine↗
PubMed1973

Orotic acid.

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Allopurinol↗