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At least 379 records · Page 21Linked to original sources
PubMed2025

Transcriptome atlases of rat brain regions and their adaptation to diabetes resolution following gastrectomy in the Goto-Kakizaki rat.

Brain regions drive multiple physiological functions through specific gene expression patterns that adapt to environmental influences, drug treatments and disease conditions. To generate a detailed atlas of the brain transcriptome in the context of diabetes, we carried out RNA sequencing in hypothalamus, hippocampus, brainstem and striatum of the Goto-Kakizaki (GK) rat model of spontaneous type 2 diabetes, which was applied to identify gene transcription adaptation to improved glycemic control following vertical sleeve gastrectomy (VSG) in the GK. Over 19,000 distinct transcripts were detected in the rat brain, including 2794 which were consistently expressed in the four brain regions. Region-specific gene expression was identified in hypothalamus (n = 477), hippocampus (n = 468), brainstem (n = 1173) and striatum (n = 791), resulting in differential regulation of biological processes between regions. Differentially expressed genes between VSG and sham operated rats were only found in the hypothalamus and were predominantly involved in the regulation of endothelium and extracellular matrix. These results provide a detailed atlas of regional gene expression in the diabetic rat brain and suggest that the long term effects of gastrectomy-promoted diabetes remission involve functional changes in the hypothalamus endothelium.

Animals↗
PubMed2005

Occipital-callosal pathways in children: Validation and atlas development.

Diffusion tensor imaging and fiber tracking were used to measure fiber bundles connecting the two occipital lobes in 53 children of 7-12 years of age. Independent fiber bundle estimates originating from the two hemispheres converge onto the lower half of the splenium. This observation validates the basic methodology and suggests that most occipital-callosal fibers connect the two occipital lobes. Within the splenium, fiber bundles are organized in a regular pattern with respect to their cortical projection zones. Visual cortex dorsal to calcarine projects through a large band that fills much of the inferior half of the splenium, while cortex ventral to calcarine sends projections through a band at the anterior inferior edge of the splenium. Pathways projecting to the occipital pole and lateral-occipital regions overlap the dorsal and ventral groups slightly anterior to the center of the splenium. To visualize these pathways in a typical brain, we combined the data into an atlas. The estimated occipital-callosal fiber paths from the atlas form the walls of the occipital horn of the lateral ventricle, with dorsal paths forming the medial wall and the ventral paths bifurcating into a medial tract to form the inferior-medial wall and a superior tract that joins the lateral-occipital paths to form the superior wall of the ventricle. The properties of these fiber bundles match those of the hypothetical pathways described in the neurological literature on alexia.

Anatomy, Artistic↗
PubMed1978

Lateral subluxation of the atlas in rheumatoid arthritis.

Two patients with lateral subluxation of the atlas resulting from rheumatoid disease involving the upper cervical spine have been described. The deformity can be suspected on clinical grounds and in one of our two patients spinal cord damage was a sequel. Erosion of the opposing surfaces of the odontoid and lateral masses of the atlas with detachment of the transverse ligament and deeper fibres of the posterior longitudinal ligament appear to underlie this deformity. Radiological confirmation may require AP views with the head tilted to one or other side.

Aged↗
PubMed1976

Isolated fracture of the medial portion of the lateral mass of the atlas: a previously undescribed entity.

Four cases of fracture of the medial aspect of the lateral mass of the atlas are presented. Unlike most cases of atlantal fracture, definite history of a blow to the vertex could not be established. While the exact mechanism of injury is unknown, it is postulated that the bone fragment is produced by a combination of stretching the ligamentum transversarium and pressure on the lateral mass due to contraction of the neck muscles. All four patients were neurologically intact and complained of pain in the distribution of the greater occipital nerve. It is suggested that this fracture might be identified more often in patients with similar histories and complaints by use of laminagraphy, since part or all of the atlas is frequently obscured on routine open mouth roentgenograms of the upper cervical spine.

Accidents, Traffic↗
PubMed1983

Malformations of the atlas vertebra simulating the Jefferson fracture.

Congenital clefts and aplasias of the atlas vertebra, while rare, are often first encountered in the emergency room setting. Thirty-six patients with atlas malformations and 10 with Jefferson fractures were encountered. Sixteen of the patients with congenital malformations showed bilateral atlantoaxial lateral offset, a finding generally considered to be the result of fracture. The diagnosis of these abnormalities is readily made from plain films by noting their characteristic features. Anomalies produce lateral offset of 1-2 mm. Jefferson fractures produce a greater offset (over 3 mm).

Atlanto-Occipital Joint↗
PubMed1991

Evaluation and treatment of atlas burst fractures (Jefferson fractures).

Although several large series of atlas fractures have been reported recently, none has concentrated on the evaluation and treatment of atlas burst fractures (Jefferson fractures). The treatment of this fracture is challenging. Its diagnosis may easily be missed due to concerns about associated trauma and absence of neurological signs. In addition, the open-mouth anteroposterior x-ray study, which is usually pathognomonic for the diagnosis, is often inadequate or not obtained. In order to clarify the diagnosis and treatment of this disorder, 17 cases of Jefferson fracture treated between 1982 and 1989 at the Louisiana State University Affiliated Hospitals are presented. The diagnosis was delayed in three patients because of a low index of suspicion and inadequate x-ray films. Four patients were noted to have unstable Jefferson fractures, all of these had an associated Type II odontoid fracture and were treated with occiput-C-2 wiring and fusion. The remainder of the patients had stable Jefferson fractures and were managed with Minerva jackets or rigid collar stabilization. No significant complications related to the treatment of the Jefferson fracture occurred in this series. One patient died from associated injuries; however, the remaining patients enjoyed an excellent long-term result with the acquisition of spinal stability and the resolution of subjective complaints.

Adolescent↗
PubMed1993

Atlas hypoplasia as a cause of high cervical myelopathy. Case report.

A high cervical myelopathy due to atlas hypoplasia is described in a 56-year-old man; the condition caused marked segmental compression of the spinal cord. A remarkable neurological recovery followed decompressive laminectomy of the atlas and adjacent regions. The authors discuss the embryology and etiology of this anomaly.

Cervical Atlas↗
PubMed1996

Recurrent transient quadriparesis after minor cervical trauma associated with bilateral partial agenesis of the posterior arch of the atlas. Case report.

The case of a 33-year-old woman with bilateral partial agenesis (type D) of the posterior arch of the atlas and recurrent transient quadriparesis due to contusion of the spinal cord after minor cervical trauma is described. At least some patients with type C or D congenital anomalies of the posterior arch of the atlas are prone to transient quadriparesis; thus a more aggressive management is advocated for them. Radiological and surgical findings showing the possible causative mechanism are presented and a review of the literature is given.

Adult↗
PubMed2001

Occipital neuralgia secondary to hypermobile posterior arch of atlas. Case report.

The authors report on the management of occipital neuralgia secondary to an abnormality of the atlas in which the posterior arch was separated by a fibrous band from the lateral masses, resulting in C-2 nerve root compression. The causes and treatments of occipital neuralgia as well as the development of the atlas are reviewed.

Adult↗
PubMed1997

Healthcare practices vary widely from town to town: regional Dartmouth Atlas.

Healthcare practices in neighboring towns vary as much as 33-fold, according to the Dartmouth Atlas of Health Care analysis of claims and census data. Still unknown is the effect that this variation has on outcomes. The new regional version of the atlas makes it possible to compare care at the local community level and decide what to do about it.

Atlases as Topic↗
PubMedDate not supplied

[Metastasis of non-small cell lung cancer to the atlas].

Metastatic lesions of the primary non-small cell lung cancer to the atlas have not been previously described. We report a 66-year-old female patient with the primary non-small cell lung cancer and a metastatic lesion to the atlas. Clinicopathologic, radiologic features and treatment of this tumor are discussed.

Aged↗
PubMed2003

[Hypoglossal nerve palsy caused by hypoplasia of the atlas and ossification of the posterior longitudinal ligament].

A 50-year-old woman developed discomfort of oral cavity and dysarthria. Her tongue showed a slight left-deviation and atrophy in the left side in a month. Examination with X-p, CT, and MRI showed hypoplasia of the atlas and high cervical ossification of the posterior longitudinal ligament (OPLL) from C1 to C5. Thus, combination of congenital hypoplasia of the atlas and acquired high cervical OPLL reduced a function of hypoglossal nerve, which resulted in the palsy. In a case of unilateral hypoglossal palsy, a possible lesion of foramen magnum should be considered.

Cervical Atlas↗
PubMedDate not supplied

[Atlanto-occipital instability due to the transverse atlas ligament rupture. Report of a case with symptoms persisting for 21 years].

The authors describe a case of a judo sportsman with a cervical spine injury sustained 21 years earlier. The injury initiated characteristic sensations of severe generalized pain with paraesthesias recurring whenever he was hit on the top of the head. In February 2001 the patient fell on his head, which resulted in tetraplegia with a complete sensory loss. The symptoms disappeared after ten minutes. Plain radiography, CT and MRI performed after this episode revealed occipitalization of the atlas and C1-C2 instability due to a rupture of the transverse atlas ligament. The patient underwent surgery by the posterior approach: decompression of the foramen magnum, fixation of the occiput and C-2 (with wiring and a bone graft). At one-year follow-up after the surgery the patient had limited movements of the neck without neurological symptoms. Plain radiograms confirmed stability of the occipitocervical fusion. There was no recurrence of the preoperative symptoms.

Adult↗
PubMed2004

Interpretation of genital findings in microbicide safety trials: review of the 'Photo Atlas for Microbicide Evaluation'.

The Photo Atlas for Microbicide Evaluation was published in May 2002 for distribution among researchers to be used as a training or reference document during microbicide clinical trials. We have reviewed the contents of the Photo Atlas, including the interpretation and documentation of genital findings. The rationale for the categorization of genital lesions into different lesion types is also discussed. Efforts will continue to standardize colposcopy until more accurate and objective methods become available to assess the safety of candidate microbicides.

Anti-Infective Agents↗
PubMed1991

Posterolateral approach to the atlas and the axis.

We have developed a new surgical approach to the atlas and the axis including the odontoid process, in which the vertebral artery is transposed and an access to their lateral aspects without exposing the anterior structures of the neck is achieved. A case of successful excision of a bone tumor of the lateral mass of the atlas and a hypertrophic odontoid process by this approach is described.

Adolescent↗
PubMedDate not supplied

[Congenital malformations of the atlas: classification and clinical significance].

A classification of congenital anomalies of atlas is proposed in order to make a systematic approach to its radiological diagnosis. Atlas is divided in four areas (posterior arch, union of posterior arch and articulation, articulation and anterior arch) for isolated malformations and two more for occipito-atloid and atlo-axoid anomalies. The common anomalies and its possible clinical relevance in each area are described.

Cervical Atlas↗
PubMedDate not supplied

Occipitalization of the atlas.

This paper discusses occipitalization of the atlas and its relationship to the chiropractic practitioner. Patients commonly consult a chiropractor with complaint of headache, suboccipital stiffness, restricted motion, dizziness and other symptoms related to the upper cervical region. Differential diagnosis of the exact etiological factor of these symptoms must be made via a thorough history, physical examination, and roentgenological examination. If occipitalization of the atlas is detected on the initial roentgenological examination, then follow-up magnetic resonance imaging, computerized tomography or linear tomographic studies may be warranted to rule out concomitant diverse osseous and/or neural anomalous conditions of the cervical spine which may easily mimic symptoms of disorders commonly treated by the chiropractic practitioner. The chiropractic practitioner must obtain appropriate roentgenological and other diagnostic imaging studies to ensure proper evaluation of the structural integrity of the cervical spine before appropriate treatment can be rendered.

Atlanto-Occipital Joint↗