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PubMed2005

[Study on effect of Astragalus membranaceus injection on hematopoiesis in anemic mice with myelosuppression].

OBJECTIVE: To investigate the effect of AMI on hematopoiesis in anemic mice and explore the possible mechanisms. METHODS: Anemic mice model resulted from myelosuppression by irradiation and cytotoxic chemotherapeutic compounds were randomly divided into three groups: treated group I, treated group II and anemic control group. Intraperitoneal doses of AMI(500 mg/kg, 1000 mg/kg) were given to the treated group, and equal doses of physiological saline were given to the anemic control group. On 7 days after treatment, the count of whole blood cells and bone marrow cells were determined by blood auto-analyzer. The numbers of CFU-GM (granulocyte and macrophage colony forming unit), CFU-E (colony forming unit-erythroid), BFU-E (burst forming unit-erythroid), CFU-Meg(colony forming unit-megakaryocyte) were determined by using technique of hematopoietic progenitor cells culture in vitro. Expression of anti-apoptosis protein BcL-XL and BcL-2 in BMC were determined by immunohistochemistry. RESULTS: RBC, HB, PLT (P < 0.05) and BMC (P < 0.01) in treated group I were significantly higher than that of anemic control. The number of CFU-E, BFU-E and CFU-Meg as well as expression of anti-apoptosis protein BcL-XL of BMC in treated group I also were significantly higher than that of anemic control (P <0. 05 or P <0. 01), while numbers of CFU-E as well as expression of anti-apoptosis protenin BcL-XL of BMC in treated group II were higher than that of anemic control (P < 0.05). CONCLUSION: AMI can lesson apoptosis of bone marrow cells and promote hematopoietic progenitor cells to differentiate along the erythroid and megakaryocytoid line by up-regulating expression of antiapoptosis protein BcL-XL of BMC.

Anemia↗
PubMed1989

[Influence of Astragalus membranaceus (AM) polysaccharide FB on immunologic function of human periphery blood lymphocyte].

Chemotherapy and/or radiotherapy are believed to further lower the already low cellular immunologic response of cancer patients giving poorer prognosis. A number of Chinese medicinal herbs known as Fuzheng therapy (FZT), in which AM is an active one, are being used to enhance the natural host defence function in cancer patients. Among some fractions of AM polysaccharide extracts, FB was the strongest. In vitro restorative effects of FB in 18 normal healthy individuals and in 9 previously untreated advanced cancer patients are reported. Local graft versus host (GVH) reaction and blastogenic response of lymphocytes in vitro (BRL) were used as test index for T-cell function. GVH reaction nodules with a volume greater than or equal to 50 mm3 were considered as positive GVH reaction. FB 100 micrograms/ml induced a restored reaction in 18 normal donors with an increase in local GVH reaction from 69.6 +/- 20.8 mm3 to 148.9 +/- 40.8 mm3 (P less than 0.001) and in 9 cancer patients with an increase in local GVH reaction from 29.3 +/- 9.5 mm3 to 137.2 +/- 35.8 mm3 (P less than 0.001). The local GVH reaction of the 9 cancer patients went from negative to positive. FB on BRL was detected. 10 micrograms/ml of FB augmented the spontaneous 3H-TdR incorporation in the lymphocyte of 18 normal subjects from 310.2 to 910.9 counts per minute (cpm) and of 9 patients from 248.5 to 642.2 cpm, but the effects were not strong. The effect of single mitogen was not remarkable.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗