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PubMed1973

Familial hyperlipoproteinemia in an isolated part of Newfoundland.

Eleven cases of ischemic heart disease with or without myocardial infarction from two families in the Baie Verte Peninsula, Newfoundland, were studied. All were found to have hyperlipoproteinemia of the familial types. The family trees were traced and a definite genetic pattern detected. Diets were found to be rich in saturated fats, salt and carbohydrates. It is suggested that detection of similar families may play a significant role in the field of preventive medicine.

Adult↗
PubMedDate not supplied

[Transfer of the fecal microbial flora from holoxenic piglets and adult pigs to axenic piglets and axenic adult mice : effect of the animal host and of the diet on the fecal microbial pattern of these animals (author's transl)].

The purpose of the present work was to determine whether the axenic mouse inoculated with pig fecal microflora represents a valuable tool for studying the gastro-intestinal flora of holoxenic pigs. The microbial pattern of the feces of the different animals has been described by means of quantitative differential techniques of analysis, the limits and validity of which are discussed. The gnotoxenic mouse associated with the flora of piglet is a better model as the gnotoxenic mouse associated with the flora of adult pig. The gnotoxenic mouse represents an adequate means for preserving all the pig strains, especially if the inoculation is made in anaerobiosis, but the bacterial equilibrium is markedly affected by the host. In the case where the same holoxenic piglet flora is inoculated simultaneously into a gnotoxenic mouse and a gnotoxenic piglet placed in the same isolator in absolutely identical dietary and environmental conditions, the results observed in the mouse can be extrapolated to the piglet. However, this is only the case for short-term experiments. If the association between the piglet flora and the host mouse is prolonged, the microbial pattern changes, but these modifications seen to be reversible when the flora is transferred into another axenic either piglet or mouse. The nature of the different feeds absorbed by the gnotoxenic animals does not deeply change the bacterial equilibriums, except when the milk contains an antiseptic substance.

Animal Nutritional Physiological Phenomena↗
PubMedDate not supplied

Mossy fibers of the hippocampal formation in prenatal malnourished rats.

Timm's impregnated mossy fiber plexus, in five coronal levels throughout the hippocampal complex, of normal and prenatally protein deprived rats at 15, 30, 90 and 220 days of age were analyzed. Morphometric computer assisted image analysis, showed significant decrease in total extent of the mossy fibers area in the prenatally malnourished rats on postnatal day 15 at levels 2, 3, and 4; on day 90 at level 1, and on day 220 at all five levels. This pattern of diet effect is similar to that noted at the same ages in the prior studies of the granule cell dendrites (Brain, Res., 1990; 532:271-277, J. Comp. Neurol, 1991; 310:356-364). This similarity of effects at these loci suggests that the diet effects on the hippocampal trisynaptic circuit are closely linked to each other. In all loci the effect of the diet was most marked on P220, indicating the late appearance of dietary deprivation effects in the hippocampal formation.

Animals↗
PubMed1997

Nutritional status of the elderly.

Elderly become vulnerable to malnutrition owing to inappropriate dietary intake, poor economic status and social deprivation. Elderly are known to be easily subjected to inanition and avitaminosis resulting in multiple nutritional deficiencies. Urban slum dwellers, rural poor and those living alone appear to be at a higher risk of poor dietary intake. Though food consumption patterns of rural and urban elderly show a distinct difference, these are greatly influenced by regional dietary patterns. The diets of institutionalised and free living elderly reveal adequate nutrient intakes except iron and vitamin A. The nutrients least adequately supplied in the diets of Indian elderly are calcium, Iron, vitamin A, riboflavin and niacin along with energy deficits. Changes in body composition which mark the onset of the ageing process, include decline in lean body mass and increase in adipose tissue. A high prevalence of iron deficiency anaemia has also been reported among Indian elderly.

Aged↗
PubMed2006

Effect of various levels of imbalance between energy and nitrogen release in the rumen on microbial protein synthesis and nitrogen metabolism in growing double-muscled Belgian Blue bulls fed a corn silage-based diet.

Seven double-muscled Belgian Blue bulls (initial BW: 341 +/- 21 kg) with cannulas in the rumen and proximal duodenum were used in an incomplete replicated Latin square. The study examined the effect of imbalance between energy and N in the rumen on microbial protein synthesis and N metabolism by giving the same diet according to 3 different feeding patterns. The feed ingredients of the diet were separated into 2 groups supplying the same amount of fermentable OM (FOM) but characterized by different levels of ruminally degradable N (RDN). The first group primarily provided energy for the ruminal microbes (12.5 g of RDN/kg of FOM), whereas the second provided greater N (33.3 g of RDN/kg of FOM). These 2 groups were fed to the bulls in different combinations with the aim of creating 3 levels of imbalance (0, 20, and 40 g/ kg of DM) between energy and N supplies in the rumen. Imbalance was measured by the variation of the degradable protein balance (OEB value in the Dutch system) of the diet between the 2 meals each a day. Diurnal variations in ruminal NH3-N concentrations and plasma urea concentrations were greatly influenced by the feeding patterns of the diet. Introduction of imbalance affected neither microbial N flow at the duodenum (P = 0.97) nor efficiency of growth (P = 0.54). The feeding patterns of the diet had no negative impact on NDF degradation in the rumen (P = 0.33). Nitrogen retention was not affected by imbalance (P = 0.74) and reached 49.7, 52.0, and 51.3 g/d, respectively for 0, 20, and 40 g of OEB/kg of DM imbalance. It seems that introduction of an imbalance between energy and N supplies for the ruminal microbes by altering the feeding pattern of the same diet does not negatively influence the microbial activity in the rumen nor N retention of the animal. Nitrogen recycling in the rumen plays a major role in regulating the amount of ruminally available N and allows a continuous synchronization of N and energy-yielding substrates for the microorganisms in the rumen. Therefore, imbalance between dietary energy and N created over a 24-h interval was not detrimental to rumen microbial growth for the animal as long as the level of imbalance did not exceed 40 g of OEB/kg of DM. Thus, these feeding patterns of the diet can be used under practical feeding conditions with minimal impact on the performance of ruminant animals for meat production.

Animal Nutritional Physiological Phenomena↗
PubMed2006

Differences in whole-body protein turnover between Iberian and Landrace pigs fed adequate or lysine-deficient diets.

The capacity for protein deposition in Iberian pigs is lower than in modern (e.g., Landrace) pig breeds, and the reasons for this remain unknown. The hypothesis tested in this work is that under similar nutritional and physiological conditions, whole-body protein turnover as well as the protein synthesis to protein deposition ratio differs between Iberian and Landrace breeds, resulting in dissimilar protein deposition rates. As a main objective, these variables were compared at different protein and Lys intakes in growing gilts. The study examined the effect of Lys deficiency because this is the prevalent condition during the fattening period of the Iberian pig in the Mediterranean forest, where the main feed source is oak acorn, which provides approximately one-third of the available Lys present in an ideal protein. Three diets were tested within each breed: 2 diets with an optimal essential AA pattern, containing 12 or 16% CP as-fed, or a Lys-deficient diet (35% of the recommended Lys content). This diet was supplied at 12% CP for the Iberian and 16% CP for the Landrace pigs, respectively. The contrasts made were breed x dietary protein concentration and breed x AA pattern (adequate vs. inadequate Lys content). Cumulative urinary (15)N excretion over 60 h after receiving an oral dose of [(15)N]-glycine was used to calculate N flux. Mean BW for Landrace and Iberian pigs were 25.8 +/- 0.55 kg and 30.8 +/- 0.74 kg, respectively. Protein deposition (g of N/(kg(0.75).d) was lower in the Iberian than in the Landrace gilts (4 to 16%; P = 0.002) and increased with dietary protein content. In contrast, protein synthesis and degradation [g of N/(kg(0.75).d)] were greater for the Landrace breed (16 to 18 and 23%, respectively, for the 2 dietary protein contents studied; P < 0.05), but no breed differences were detected in fractional protein synthesis and degradation rates. The ratio of protein synthesis:protein deposition (S/PD) did not change with dietary protein concentration or breed and achieved a mean value of 5.4. Irrespective of breed, Lys deficiency had a strong negative effect on N balance (P < 0.001) and increased the ratio of S/PD (P = 0.012). The greater rates of protein deposition, synthesis, and degradation in Landrace pigs than in Iberian pigs fed optimal AA-pattern diets were then attributed to differences in body protein mass. Consequently, these results validate the hypothesis of unequal synthesis and degradation, but not of unequal S/PD, between breeds.

Animal Feed↗
PubMed1987

Changing patterns of hypertension, diabetes, obesity and diet among Melanesians and Micronesians in the Solomon Islands.

A cross-sectional survey of diabetes, hypertension, obesity and dietary patterns has been conducted in the Western Province of the Solomon Islands. Three groups--traditional and more urbanized Melanesians and semitraditional Micronesians--were compared. Abnormal glucose tolerance was rare (less than 1% over all) in Melanesians regardless of acculturation, but was present in 9.7% of adult Micronesians in whom it was associated with age; obesity; female sex; and a diet that was high in energy and refined carbohydrates. Hypertension, which was associated with advancing age and obesity, was recorded in 6.0% and 8.3% of traditional and partly urbanized Melanesians, respectively, and in 4.8% of Micronesians. Systolic and diastolic blood pressures correlated significantly with age for all except traditional Melanesian women among whom the association was limited to the systolic blood pressure only. Significant correlation coefficients were recorded between diastolic blood pressure and body mass index for both sexes and all groups, and between systolic blood pressure and body mass index for all women but only for Micronesian men. Dramatic differences in life-style and dietary patterns are described for rural and more urbanized Melanesians among whom the mean daily urinary sodium outputs were 67 and 119 mmol/L, respectively.

Acculturation↗
PubMed1987

Dietary patterns and metabolic control in diabetic diets: a prospective study of 51 outpatient men on unmeasured and exchange diets.

In a prospective, single blind study, 51 adult diabetic, male outpatients at or below ideal body weight (IBW), all but four of whom were insulin-treated, were randomly assigned to a calorically defined exchange diet (EXCH) or an unmeasured diet avoiding refined sugars (UNMEAS). Fasting chemistries, weights and 48-hr dietary recalls were obtained every 3 months for 3 years. There was no difference between groups in mean body weight, mean caloric intake, percentages of carbohydrate or fat intake, day to day consistency of caloric intake, or fasting chemistries. The patients whose actual weight tended to be less than IBW consumed more calories than their theoretical calculated needs (p = 0.002) without effect on glycemic control or stability of weight. Patients with low carbohydrate intake (less than 30%) had significantly higher triglyceride levels (p = 0.015). Otherwise, variations in dietary patterns were not reflected in fasting clinical chemistries. Individual fasting serum glucose levels were not related to consistency of carbohydrate intake, caloric distribution throughout the day or composition of diets. These results suggest that actual dietary patterns of subjects following exchange diabetic diets with precise caloric prescriptions are similar to those resulting from unmeasured diets with restriction of simple sugars. Other than correlation between carbohydrate intake and triglycerides, there was no detectable effect of variations in dietary patterns upon conventional chemical metabolic levels.

Adult↗
PubMed2001

Twenty-four hour energy expenditure and substrate oxidation before and after 6 months' ad libitum intake of a diet rich in simple or complex carbohydrates or a habitual diet.

OBJECTIVE: To investigate 24 h energy expenditure (24 h EE) and substrate oxidations in overweight and obese subjects before and after 6 months' ad libitum intake of a low-fat, high-simple carbohydrate diet (SCHO), a low-fat, high-complex carbohydrate diet (CCHO), or a habitual control diet (CD). SUBJECTS: Twenty-four healthy overweight and obese subjects (11 males and 13 females; body mass index 30.7+/-0.6 kg/m(2); age 42.2+/-1.8 y). MEASUREMENTS: Twenty-four hour EE, substrate oxidation rates and spontaneous physical activity (SPA) measured in a respiration chamber, and food intake. RESULTS: After the intervention no differences were seen in 24 h EE, postprandial thermogenesis, basal metabolic rate or SPA. Carbohydrate oxidation, adjusted for energy balance, increased on both carbohydrate-rich diets (SCHO 13.0%, CCHO 11.5%) and decreased on the CD diet (6.5%); however, the changes were not significantly different between diets. The opposite pattern was seen for fat oxidation, which increased by 2.9% on the CD diet and decreased by 17.1 and 25.6% on the SCHO and CCHO, respectively. The changes only differed between the CD and CCHO diet (P=0.03). CONCLUSION: Six months' ad libitum intake of a diet rich in simple or complex carbohydrates or a habitual diet induced a shift in the oxidation pattern to closely reflect the diet composition in overweight and obese subjects. No differences between diets were seen in 24 h EE.

Adult↗
PubMed2002

Metabolic responses to nocturnal eating in men are affected by sources of dietary energy.

Because night work is becoming more prevalent, we studied whether feeding at different times of a 24-h period would elicit different metabolic responses and whether dietary macronutrient composition would affect these responses. Seven men (26-43 y, 19.9-26.6 kg/m(2)) consumed two isocaloric diets, in a crossover design. The diets were a high carbohydrate (HC) diet [65 energy % (E%) carbohydrates, 20E% fat] and a high fat (HF) diet (40E% carbohydrates, 45E% fat). After a 6-d diet-adjustment period, the men were kept awake for 24 h and the food (continuation of respective diet) was provided as six isocaloric meals (i.e., every 4 h). Energy and substrate turnover, heart rate, mean arterial pressure (MAP), blood glucose, triacylglycerol (TAG), nonesterified fatty acid (NEFA) and glycerol were measured throughout the 24-h period. Significantly higher energy expenditure and NEFA concentration, and lower blood glucose and TAG concentrations were observed when the men consumed the HF diet than when they consumed the HC diet. Significant circadian patterns were seen in body and skin temperature (nadir, 0400-0500 h). When the men consumed the HF diet, significant circadian patterns were seen in fat oxidation (nadir, 0800-1200 h; plateau, 1200-0800 h), heat release (nadir, 0800-1200 h; plateau, 1600-0800 h), heart rate (nadir, 0000 h), blood glucose (nadir, 0800-1200 h; peak, 0000-0400 h), NEFA (nadir, 0800-1200 h; peak, 1200-2000 h) and TAG (nadir, 0800-1200 h; peak, 0400-0800 h) concentrations. Energy expenditure, carbohydrate oxidation, MAP and glycerol concentration did not display circadian patterns. Unequal variances eradicated most circadian effects in the HC-diet data. The increased TAG concentration in response to feeding at 0400 h might be involved in the higher TAG concentrations seen in shift workers. Distinct macronutrient/circadian-dependent postprandial responses were seen in most studied variables.

Adult↗
PubMed2004

Globalisation and income growth promote the Mediterranean diet.

OBJECTIVE: To examine global food demand patterns and how changing diets may stimulate demand for and trade of Mediterranean diet products. DESIGN: Literature review. Trends in global and US food consumption patterns are examined and trade data are reviewed to evaluate the impact of changing diets on trade of Mediterranean diet products. Market access issues are also addressed briefly to highlight the role of policy in the trade of Mediterranean diet products. RESULTS: Diets are shifting towards higher-value products such as meats, fruits and vegetables, and a wider array of packaged food products. Trade in these products has also grown in the past two decades, with several non-traditional importers and exporters becoming increasingly active in the global market. CONCLUSIONS: Income-driven demands for quality and variety are likely to increase the demand for Mediterranean diet products globally. While the middle-income countries appear to be the best growth prospects, the USA remains a potential growth market if these products can meet the growing consumer demand for variety, quality and convenience. Although consumer trends globally indicate growth in demand for Mediterranean diet products, the additional demand may not be reflected by a corresponding growth in trade. Trade in Mediterranean diet products continues to be hampered by higher than average trade barriers and high transportation costs for perishables.

Commerce↗
PubMed2001

The Mediterranean diets: What is so special about the diet of Greece? The scientific evidence.

The term "Mediterranean diet," implying that all Mediterranean people have the same diet, is a misnomer. The countries around the Mediterranean basin have different diets, religions and cultures. Their diets differ in the amount of total fat, olive oil, type of meat and wine intake; milk vs. cheese; fruits and vegetables; and the rates of coronary heart disease and cancer, with the lower death rates and longer life expectancy occurring in Greece. Extensive studies on the traditional diet of Greece (the diet before 1960) indicate that the dietary pattern of Greeks consists of a high intake of fruits, vegetables (particularly wild plants), nuts and cereals mostly in the form of sourdough bread rather than pasta; more olive oil and olives; less milk but more cheese; more fish; less meat; and moderate amounts of wine, more so than other Mediterranean countries. Analyses of the dietary pattern of the diet of Crete shows a number of protective substances, such as selenium, glutathione, a balanced ratio of (n-6):(n-3) essential fatty acids (EFA), high amounts of fiber, antioxidants (especially resveratrol from wine and polyphenols from olive oil), vitamins E and C, some of which have been shown to be associated with lower risk of cancer, including cancer of the breast. These findings should serve as a strong incentive for the initiation of intervention trials that will test the effect of specific dietary patterns in the prevention and management of patients with cancer.

Animals↗
PubMed1983

Palatability and meal patterns.

Investigations of palatability have often been confounded by nutritional, pharmacological or methodological problems. The present experiment examined the free-feeding meal patterns of two differentially preferred yet nutritionally equivalent diets. When the two diets were offered sequentially (Experiment 1), no differences were found in meal frequency, meal size, or meal duration. However, when the diets were offered simultaneously in Experiment 2, the preferred diet was consumed more frequently, in larger meals, and at a faster feeding rate than the less preferred diet. Further, the meal patterns in Experiment 2 of the preferred diet were identical with those found for both diets in Experiment 1. Therefore, the meal patterns of two diets with differing palatability depend upon the method of presentation with differences appearing when the diets are offered simultaneously but not when they are offered sequentially.

Animals↗
PubMed1986

Intake of a liquid diet after 2-deoxy-D-glucose injections in rats.

The effects of a liquid diet after 2-deoxy-D-glucose (2DG) were examined following water deprivation, after food deprivation, and at longer post-injection intervals when animals reportedly are hypophagic as a function of drug treatment. Water deprived rats were unable to increase their post-drug feeding when ingesting the liquid diet; and in food deprived subjects, intake patterns of liquid diet and of lab chow pellets were essentially identical after 2DG. The tendency of a 750 mg/kg dosage to produce a longer-term hypophagic reaction was more evident in animals given pellets instead of the liquid diet. While previous studies have found the liquid diet to promote 2DG-induced feeding in lesioned subjects, the present data demonstrate that such facilitation effects do not invariably occur during post-drug conditions in which animals are inhibited in their intake.

Animals↗
PubMed2002

Relationship between juvenile obesity, dietary energy and fat intake and physical activity.

OBJECTIVE: To determine the relationship of juvenile obesity to dietary fat, particularly saturated fat, and with dietary energy (controlling for activity patterns). DESIGN: Cross-sectional, evaluation of diet and activity patterns of obese and non-obese children and adolescents. SUBJECTS: A total of 181 children, aged 4-16 y. Subjects were divided into two groups: obese (body mass index, BMI, > 95th percentile for age and sex), 40 males and 51 females; and non-obese (BMI < 75th percentile for age and sex), 35 males and 55 females. MEASUREMENTS: Dietary intake was analyzed with a dietary history interview; activity patterns were analyzed with an activity interview and body fat was measured with bioelectrical impedance analysis. RESULTS: The obese subjects consumed significantly more total calories, total fat in grams and saturated fatty acids (SFA) in grams than did the non-obese subjects. Based on step-wise multiple regression, the total energy consumed, not total fat or SFA, had the strongest relationship to the subject's percentage body fat, controlling for activity levels. CONCLUSION: We suggest that, although obese children and adolescents consume more dietary energy and fat than non-obese children and adolescents, there is a stronger relationship between total energy consumed and juvenile adiposity than with dietary fat or type of dietary fat consumed.

Adolescent↗
PubMed2003

Sources of variation in consumer-diet delta 15N enrichment: a meta-analysis.

Measurements of delta15N of consumers are usually higher than those of their diet. This general pattern is widely used to make inferences about trophic relationships in ecological studies, although the underlying mechanisms causing the pattern are poorly understood. However, there can be substantial variation in consumer-diet delta15N enrichment within this general pattern. We conducted an extensive literature review, which yielded 134 estimates from controlled studies of consumer-diet delta15N enrichment, to test the significance of several potential sources of variation by means of meta-analyses. We found patterns related to processes of nitrogen assimilation and excretion. There was a significant effect of the main biochemical form of nitrogenous waste: ammonotelic organisms show lower delta15N enrichment than ureotelic or uricotelic organisms. There were no significant differences between animals feeding on plant food, animal food, or manufactured mixtures, but detritivores yielded significantly lower estimates of enrichment. delta15N enrichment was found to increase significantly with the C:N ratio of the diet, suggesting that a nitrogen-poor diet can have an effect similar to that already documented for fasting organisms. There were also differences among taxonomic classes: molluscs and crustaceans generally yielded lower delta15N enrichment. The lower delta 15N enrichment might be related to the fact that molluscs and crustaceans excrete mainly ammonia, or to the fact that many were detritivores. Organisms inhabiting marine environments yielded significantly lower estimates of delta15N enrichment than organisms inhabiting terrestrial or freshwater environments, a pattern that was influenced by the number of marine, ammonotelic, crustaceans and molluscs. Overall, our analyses point to several important sources of variation in delta15N enrichment and suggest that the most important of them are the main biochemical form of nitrogen excretion and nutritional status. The variance of estimates of delta15N enrichment, as well as the fact that enrichment may be different in certain groups of organisms should be taken into account in statistical approaches for studying diet and trophic relationships.

Animals↗