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Datura stramonium and related species are relatively common causes of atropine-like poisoning by ingestion or inhalation. Toxic absorption after mucosal application is evident in 24 h of atropinism sustained by a woman who used a toothpaste mixed with the leaves and flowers of Datura sp., table salt, vinegar and an alcoholic beverage.
The purpose of this work was to assess the in vitro antibacterial effectiveness of three dentifrices containing antimicrobial agents and to test the in vivo anti plaque and anti gingivitis effect of a toothpaste containing triclosan (CAOLA). The in vitro tests showed a marked antibacterial effect of both triclosan and chlorhexidine containing dentifrices. The randomized clinical trial presented good evidences that the triclosan had some but statistically non significant plaque and gingivitis reduction in patients even without previous mechanical cleaning. Nevertheless the triclosan dentifrice was effective in reducing the plaque and gingivitis scores in combination with initial mechanical debridement and oral hygienic instructions.
Random tests made in school children of the Ludwigsburg district showed that after 3 years of uncontrolled use, the number of new DMF surfaces is smaller in children using Na2PO3F toothpaste and regularly cleaning their teeth than in the corresponding placebo groups. The caries-inhibiting effect was statistically significant (significance level p=0.05%). The increase in caries impact in school children regularly but insufficiently cleaning their teeth was also significant in the placebo groups.
Despite the fact that many mouthrinses are available and much research is being devoted to better and new mouthwashes, as yet there is no form of chemical plaque control that can totally replace mechanical plaque removal. However, at this moment there is a promising compound. Triclosan, in combination with a copolymer, has already been added to a toothpaste and mouthrinse.
The objective of this randomized, crossover study was to compare the effectiveness of Colgate Total Advanced Fresh toothpaste to a commercially available breath-freshening dentifrice containing fluoride for its ability to reduce volatile sulfur compounds (VSC) responsible for breath odor overnight. The study followed a two-treatment, two-period crossover design. Subjects were given a test product, along with a soft-bristled toothbrush, and instructed to brush their teeth for 1 minute, twice daily (once in the morning and the evening) using the assigned dentifrice for 7 consecutive days. After their evening brushing on the seventh day, subjects reported to the testing facility without oral hygiene, eating, or drinking for the overnight evaluation. After a washout period, subjects repeated the same regimen, now using the other test product. The levels of breath VSC were evaluated instrumentally using a gas chromatograph equipped with a flame photometric detector.
The aim of the present study was to determine the ability of a dentifrice containing a mixture of ion-exchange resins (named NMTD), which supplies calcium, fluoride, phosphate, and zinc ions, to promote remineralization and/or inhibit demineralization of dental human enamel in a pH cycling model in vitro. A fluoride toothpaste was used as the control. The enamel specimens were tested for microhardness before and after 10 days and 16 days of the demineralizing and remineralizing treatments. The results of this study showed both dentifrices were effective in limiting in vitro enamel demineralization although the effects were not significantly different from each other. Inclusion of calcium and phosphate ion-exchange resins in the dentifrice containing a fluoride ion-exchange resin maintained a similar net outcome of the conventional dentifrice in the demineralization/remineralization process under the experimental conditions employed.
Sensitivity in determining low melting point metals is highly improved by means of platform technique in graphite furnace AAS. In this paper we describe a method of determining trace lead in toothpaste by this technique. The method of making the platform and the selection of the platform coating were discussed and the results with and without the platform were compared. The optimum ashing temperature, atomization temperature and experimental conditions were investigated. The interference of large amount Al and Ca in the matrix on determination of trace lead can be minimized by using platform technique. The precision of about 0.9% and detection limit of about 15 ng obtained by this improved method are much better than those by methods without platform.
OBJECTIVE: The aim of the present study was to evaluate the ability of a new fluoride-containing dentifrice to protect surface-softened enamel against further erosive challenges in an in vitro cycling model, and to relate any effects to enamel fluoride uptake (EFU) and free fluoride. METHODOLOGY: Human enamel specimens were subjected to a daily cycling regimen comprising: three two-minute treatments; five two-minute challenges using 1% citric acid pH 3.8; and remineralization in a mixture of human saliva and mucin-containing artificial saliva. Surface microhardness (SMH) was measured at baseline, 10, and 20 days, and the fluoride content of biopsied specimens determined at 20 days. EFU studies were based on method #40 described in the United States Food and Drug Administration (FDA) testing procedures. Free-fluoride availability was determined from slurries of one part toothpaste plus three parts deionized water. RESULTS: SMH showed that a 1150 ppm NaF test dentifrice protected enamel specimens greater than Crest Cavity Protection (1100 ppm NaF) and a fluoride-free placebo at both 10 days and 20 days (p < 0.05). The fluoride content of specimens treated with this prototype was higher than either Crest or the placebo. SMH for a 1450 ppm NaF test dentifrice was greater than for Elmex Sensitive (1450 ppm amine F) and placebo at 10 days, while both products were greater than the placebo at 20 days. The fluoride content of specimens treated with this test dentifrice was higher than Elmex Sensitive, which was higher than placebo. The fluoride uptake seen in the cycling model correlated for the NaF dentifrices with a standard EFU procedure. Different EFU results for a series of commercial dentifrices demonstrated that EFU is not necessarily a function of free-fluoride availability. CONCLUSION: This study demonstrated that fluoride dentifrices can increase the protection of enamel against an erosive challenge in vitro, and that the increased protection correlated with fluoride uptake. The fluoride uptake seen in the cycling model correlated with a standard FDA EFU procedure for the NaF dentifrices. The present studies demonstrate the importance of formulation effects on driving performance in in vitro models.
The Sodiummonofluorophosphate is used in a large number of toothpastes, s, while clinical research proved that application of fluoride has an important contribution in caries prevention. This prevention is almost due to the reconstitution of the by acids disappeared hydroxylapatite Ca10 (PO4)6 (OH)2 in the toothsurface, which process goes two to three times faster in the presence of F- by sedimentation of hydroxyfluorapatite Ca10 (PO4)6 (OH)2-xFx, with a higher chemical resistance for acids. Therefore, the F- must been released from the FPO3-- during the application of the pasta, e.g. by hydrolysis in the mouth. Solutions of Na2FPO3 seem to release an important amount of free F- ions, without addition of acid, and as a function of concentration, time and temperature. The hydrolysis of FPO3-- is pH-dependent and can be studied as a pseudo-first-order reaction. The dependence of the pH is found in the kinetic expression: -dC/dt = k. [H2PO3F] [H+] = k1.C, where C is the total formal concentration of all monofluorophosphate species at time t. The Arrhenius energy of activation is 16.42 +/- 0.1 Kcal/mole. The hydrolysis of monofluorophosphoric acid has already been studied before. In the present work additional F(-)-determinations are performed with a specific F(-)-selectrode, without any interference of the monofluorophosphate species, which was warned for by other authors. More recent investigation showed that in samples of controlled ionic strength little interference occurs, and phosphates in particular do not interfere. Fresh prepared solutions of Na2FPO3 were used at different pH and different temperature.(ABSTRACT TRUNCATED AT 250 WORDS)
Toothpastes have improved significantly over the last 2000 years to the point where they are very proficient in their cleaning attributes. However, research continues, so further improvement may still be possible.
Caries reduction has been observed in certain parts of the western world. The reduction coincides with the timing of the introduction of fluoride-containing toothpastes and no other factors can explain the caries reduction. It is possible that improved oral hygiene and use of fluoride have a synergistic effect.
The results are presented of the investigations of the proposed method for determination of the abrasive properties of toothpastes and raw materials used for their production. The method is based on brushing of copper surface with the studied paste in a device of own design, followed by chemical analysis of copper content in the mass after brushing. The optimal parameters of the work of the abrasive device were determined and the method for determination of copper content is described. For chemical analysis absorption spectroscopy in visible light and atomic absorption spectroscopy were used. The advantages of the proposed method of abrasive force determination was discussed comparing them to those of radioisotope assay.
Short- and long-term testing of sanguinaria toothpaste and oral rinse used individually have yielded both positive and negative results. This review evaluates the results of a number of clinical trials testing the regimen use of sanguinaria products for periods ranging from 14 days to six months. Review of these trials establishes the clinical efficacy of the two products in combination. The regimen approach produces consistently positive reductions in plaque, gingival inflammation and bleeding parameters for up to six months with no adverse hard tissue effects and only one reversible adverse soft tissue effect observed among the 260 subjects tested. In addition, no adverse microbiological shifts in the normal oral flora were observed.
This report represents the findings of an Expert Panel on the safety of Sanguinaria extract used in Viadent oral rinse and toothpaste products and represents an independent review of the Sanguinaria extract toxicologic data base. It is based on reviews and discussions of the data base by all members of the Expert Panel on Sanguinaria extract. The Panel concluded that the data base on Sanguinaria extract is substantial and indicates that Sanguinaria extract is safe in its present use in Viadent products based on a large margin of safety between levels of human exposure and levels found to produce minimum effect or to be without adverse effect in animals. The panel further concluded that published literature suggesting an association between human exposure to Sanguinaria extract and potential reproductive, cardiovascular, or ocular toxicity, or carcinogenicity is largely anecdotal, unfounded, and not corroborated by or consistent with the substantial data base that was subjected to peer review.
The changes in the quantity, pH, protein and erythrocytes were studied in the gingival fluid of students with chronic catarrhal gingivitis and impaired oral hygiene due to dental-jaw deformities (DJD) after a 5-week hygienic-therapeutic course with the toothpaste "Propodent". The data about the indices studied in the experimental group--24 children and juveniles with DJD and chronica catarrhal gingivitis, aged from 8 to 16, were compared with the values of the indices studied in the control group of 10 children and juveniles without DJD and with clinically health periodontium of the same age. The comparison between the mean values of the quantity gingival fluid, pH, protein and erythrocytes of the experimental group, before and after the treatment, revealed: 78.6% reduction of the quantity of gingival fluid, 3.8% increase of pH, 93.74% reduction of protein and 95.98% reduction of erythrocytes. In this way, the indices studied in the experimental group after the treatment did not differ with statistical significance from those of the healthy children. The methods for determination of the quantity, pH, protein and erythrocytes, proposed by T. Dzemileva and P. Nenov, objectivized the clinically observed favourable changes in gingiva as a result from the hygienic-therapeutic course in the students with DJD and chronic catarrhal gingivitis.
A clear association between the use of cinnamaldehyde containing toothpaste and inflammation of the lips, labial mucosa, and gingivae is described in a 59-year-old man. The sensitivity reaction was verified by patch testing with cinnamaldehyde.
The effect of a toothpaste containing mineral fat (paraffin oil) on the accumulation of food debris was evaluated in 17 adults. Food debris indices were scored during 3 weeks. A significant lower food debris index was detected in the subject group brushing their teeth with the paste containing mineral fat as compared with the fat-free paste or water. From a clinical standpoint the results do not appear to be all that different from each other.
The free ionic concentration of fluoride of 16 toothpastes for adults, of 5 pastes for children, and of one fluoride gel were analysed straight after production and after 4 months of storage. The fresh products containing fluoride as inorganic salt of hydrofluoric acid or as organic fluoride salt contained more than 65% of the manufacturers declaration of ionic fluoride. In the pastes containing sodiummonofluorphosphate the assessed concentration of free fluoride ions was less than 20% of the declaration. After 4 months of storage more than 75% of the ionic fluoride found in the new products could still be detected. The pastes containing sodiummonofluorphosphate, however, showed an increase of the ionic concentration of fluoride.