Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Systemic Vasculitis”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 361 records · Page 20Linked to original sources
PubMed2003

Silica exposure and systemic vasculitis.

Work in Department of Energy (DOE) facilities has exposed workers to multiple toxic agents leading to acute and chronic diseases. Many exposures were common to numerous work sites. Exposure to crystalline silica was primarily restricted to a few facilities. I present the case of a 63-year-old male who worked in DOE facilities for 30 years as a weapons testing technician. In addition to silica, other workplace exposures included beryllium, various solvents and heavy metals, depleted uranium, and ionizing radiation. In 1989 a painful macular skin lesion was biopsied and diagnosed as leukocytoclastic vasculitis. By 1992 he developed gross hematuria and dyspnea. Blood laboratory results revealed a serum creatinine concentration of 2.1 mg/dL, ethrythrocyte sedimentation rate of 61 mm/hr, negative cANCA (antineutrophil cytoplasmic antibody cytoplasmic pattern), positive pANCA (ANCA perinuclear pattern), and antiglomerular basement membrane negative. Renal biopsy showed proliferative (crescentric) and necrotizing glomerulonephritis. The patient's diagnoses included microscopic polyangiitis, systemic necrotizing vasculitis, leukocytoclastic vasculitis, and glomerulonephritis. Environmental triggers are thought to play a role in the development of an idiopathic expression of systemic autoimmune disease. Crystalline silica exposure has been linked to rheumatoid arthritis, scleroderma, systemic lupus erythematosus, rapidly progressive glomerulonephritis and some of the small vessel vasculitides. DOE workers are currently able to apply for compensation under the federal Energy Employees Occupational Illness Compensation Program (EEOICP). However, the only diseases covered by EEOICP are cancers related to radiation exposure, chronic beryllium disease, and chronic silicosis.

Arthralgia↗
PubMed1998

An 18-year-old man with Goodpasture's syndrome and ANCA-negative central nervous system vasculitis.

An 18-year-old man with Goodpasture's syndrome developed a recurrent seizure disorder refractory to anticonvulsant therapy spanning a full course of plasmapheresis and cytotoxic therapy. Status epilepticus developed during a taper of cytotoxic agents, with magnetic resonance imaging (MRI) findings consistent with multiple lacunar infarcts. Although the diagnosis of vasculitis was considered, anti-neutrophilic cytoplasmic antibody serology was consistently negative. A meningeal biopsy showed vasculitis, which was successfully treated with the reintroduction of high-dose steroids and cytotoxic agents in conjunction with anticonvulsants. Nearly 1 year later, with Goodpasture's disease in remission, he received a living-related renal transplant from his mother. He is currently leading a normal lifestyle. From an extensive review of the literature, this is the first case of anti-neutrophil cytoplasmic antibody-negative central nervous system (CNS) vasculitis in a patient with Goodpasture's syndrome.

Adolescent↗
PubMed1990

Chronic bronchial suppuration and antineutrophil cytoplasmic antibody (ANCA) positive systemic vasculitis.

Two patients with long-standing chronic bronchial suppuration developed antineutrophil cytoplasmic antibody (ANCA) positive Wegener's granulomatosis and microscopic polyarteritis respectively. There is published evidence of an association between previous suppurative respiratory disease and Wegener's granulomatosis. We believe that our cases provide further evidence that chronic lung infection may play an aetiological role in the development of ANCA-positive systemic necrotizing vasculitis in some individuals.

Arteritis↗
PubMed2006

Therapy insight: The recognition and treatment of retinal manifestations of systemic vasculitis.

A variety of retinal signs can occur in patients who have systemic vasculitides, or who experience complications of these diseases or their treatment. Although treatment of these retinal manifestations is usually the treatment of the systemic disease, specific treatment is occasionally indicated to preserve vision. The more prevalent of the systemic vasculitides are giant cell arteritis, polyarteritis nodosa, Wegener's granulomatosis, Churg-Strauss syndrome, relapsing polychondritis and systemic lupus erythematosus. Less frequently occurring vasculitides include Takayasu's arteritis, Goodpasture's disease, microscopic polyangiitis and Henoch-Schönlein purpura, as well as vasculitis secondary to scleroderma and rheumatoid arthritis. This article describes the pathogenesis, clinical features and treatment of retinal manifestations of systemic vasculitides.

Clinical Trials as Topic↗
PubMed1994

Allergic disorders in systemic vasculitis: a case-controlled study.

A number of the systemic vasculitides (SV) may have an allergic component although specific allergens remain unknown. We evaluated the prevalence of several types of allergy in 60 consecutive patients with SV and their families. Two control groups were studied. One included 60 healthy people and the other 60 unselected patients attending a general rheumatology clinic who did not have SV. Forty-four of the 60 patients (73%) had a history of at least one type of allergy. This was significantly higher than in either control group (P = 0.0001 and P = 0.0002). There was also a significantly higher prevalence of allergies among the families of the SV patients compared to the controls. This data supports the idea that an allergic response to an external allergen may play an important part in the aetiology of these diseases.

Adult↗
PubMed2004

Pregnancy in rare autoimmune rheumatic diseases: UCTD, MCTD, myositis, systemic vasculitis and Beçhet disease.

The physiological adaptation of the immune system to pregnancy can potentially affect the course of all autoimmune rheumatic diseases (ARD), conversely the autoimmune processes characteristic of these conditions may compromise the foetal outcome. Unfortunately, very few reports on pregnancy outcome in patients with rare ARD are available. In this paper, we briefly review the data published until now on these disorders. Some general guidelines which were elaborated for more prevalent ARD seem to be valid also for such rare conditions: 1) patients should be correctly informed on the risk of becoming pregnant; 2) pregnancies should be planned when the disease is in remission since it increases the probability of successful maternal and foetal outcome; 3) patients should be regularly monitored during gestation and postpartum by a multidisciplinary team including rheumatologist, obstetrician, and neonatologist; 4) in the case of disease relapse an adequate treatment, even aggressive if necessary, should be recommended since active disease can be more detrimental for foetus than drugs; 5) pregnancies complicated by the onset of rare ARD have a particularly severe prognosis; in these cases a prompt treatment and very close clinical surveillance are indicated.

Autoimmune Diseases↗
PubMed1995

Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis.

Angiotropic large cell lymphoma (ALCL), the so-called malignant angioendotheliomatosis, is characterised by proliferation of tumorous cells within small vessels. Manifestations in the CNS and cutaneous lesions prevail in the clinical presentation, although any organ can be involved. The recent classification of this lymphoma as part of the large cell lymphomas has modified the therapeutic approaches employed. This should improve the prognosis of this usually fatal disease. An unusual case presenting with fever, mononeuritis multiplex, and cutaneous lesions is reported. Peripheral neuropathy without other neurological symptoms is uncommon, and, to our knowledge, such isolated mononeuritis multiplex with nerve lesions has not been previously reported in ALCL. The clinical diagnosis was a systemic necrotising vasculitis and it is considered that its differential diagnosis must include angiotropic large cell lymphoma.

Aged↗
PubMed1997

Diagnostic approach to central and peripheral nervous system vasculitis.

The diagnosis of vasculitis is first and foremost a clinical one. Correct diagnosis requires a high index of suspicion coupled with knowledge of the manifestations of other disorders that may masquerade as vasculitis. Treatment of vasculitis requires prolonged use of drugs with the potential for serious side effects. Whereas the prompt initiation of definitive treatment is a very high priority, there is also substantial risk of inappropriately treating self-limited and more benign disorders mimicking vasculitis. This has been a particular problem with primary angiitis of the central nervous system. Laboratory studies, particularly tissue biopsy, provide a crucial adjunct to clinical diagnosis.

Antibodies, Antineutrophil Cytoplasmic↗
PubMed1989

Systemic vasculitis in association with human immunodeficiency virus infection.

Fourteen cases of vasculitis associated with human immunodeficiency virus infection have thus far been described. Five of these cases may be classified as angiocentric immunoproliferative disorders, including benign lymphocytic angiitis, lymphomatoid granulomatosis, and angiocentric lymphoma. We report a case of benign lymphocytic angiitis of T cell lineage. Extensive studies found no evidence of viral antigens in the inflammatory infiltrates, and immunologic evaluation of the pathologic lesions revealed the infiltrating cells to be predominantly CD3+, CD8+, CD4-. A significant number of these lymphocytes demonstrated a deletion of T cell antigen receptor determinants. We believe that in certain cases of human immunodeficiency virus disease, there occurs a spectrum of lymphoproliferative disorders with angiocentric features that lead to the clinical picture of systemic necrotizing vasculitis. Clinicians should be aware of this association.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Autoantibodies in primary systemic vasculitis.

Strong evidence for the presence of autoantibodies in the primary systemic vasculitides now exists, and there is a particularly marked association between ANCA and Wegener's granulomatosis and microscopic polyarteritis. The presence of ANCA serves to place these disorders in a firm autoimmune setting. Although ANCAs are of undoubted diagnostic significance, their role in etiology and pathogenesis has still to be fully explored, so further developments in this area are awaited with interest.

Autoantibodies↗