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PubMed1986

Comparison of ultrasound and skinfold caliper measurement of subcutaneous fat tissue.

Subcutaneous fat thickness of 26 young males (aged 18-32 years) was measured at eight sites (biceps, triceps, subscapula, axillary, subcosta, paraumbilica, suprailiaca, quadriceps) using a commercial high-resolution B-scan ultrasound equipment with a 7.5-MHz transducer as well as a Holtain skinfold caliper. The aim of the study was to investigate the relationship between ultrasound and skinfold caliper measurements of subcutaneous fat and body density determined by the hydrostatic weighing technique. Correlations between ultrasound and caliper measurement were above 0.7. The variability of duplicate measurements with the skinfold caliper appeared to be somewhat lower than with ultrasound measurements. Using all possible subsets regression, for both techniques measuring subcutaneous fat thickness those multiple regression equations were chosen which predicted body density best. The best equations for the two techniques explained about 80 percent of the variance of body density in this group. These results indicate that in young men, body fat can be estimated with the same degree of accuracy using either the skinfold caliper or the ultrasound technique, but for estimates of actual subcutaneous fat thickness, ultrasound is to be preferred.

Adipose Tissue↗
PubMed2002

Distribution of orally administered trimethoprim and sulfadiazine into noninfected subcutaneous tissue chambers in adult ponies.

The distribution of trimethoprim (TMP) and sulfadiazine (SDZ) into subcutaneously implanted noninfected tissue chambers was studied in healthy adult ponies. Six ponies were given an oral TMP/SDZ paste formulation at a dose of 5 mg/kg TMP and 25 mg/kg SDZ at 12 h intervals for 2 days in order to reach steady-state concentrations. Plasma concentrations and tissue chamber fluid (TCF) concentrations of both drugs were measured at regular intervals during a period commencing 24 h after the last oral administration. The peak concentration of TMP (mean +/- SD) was 2.92 +/- 0.86 microg/mL for plasma and 1.09 +/- 0.25 microg/mL for TCF. For SDZ, the mean peak concentration was 40.20 +/- 14.74 microg/mL for plasma and 23.48 +/- 5.84 microg/mL for TCF. TMP peak concentrations in plasma were reached at 3.17 +/- 03.48 h and those in TCF at 7.33 +/- 03.72 h. SDZ peak concentrations in plasma were reached at 1.83 +/- 02.04 h and those in TCF at 8.00 +/- 03.10 h. Concentrations of TMP and SDZ in TCF remained above the generally accepted breakpoint for susceptibility (0.5/9.5 for the TMP/SDZ combination) for 12 h. Therefore, in ponies oral administration of TMP/SDZ at a dose rate of 30 mg/kg given twice daily in the form of a paste should be appropriate for effective treatment of infections caused by susceptible bacteria.

Administration, Oral↗