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Results for “Splenic Neoplasms”

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PubMed1981

The results of angiographic studies of abdominal masses.

This study reveals the continuing great viability of angiography in the investigation of abdominal masses. It is a fundamentally important procedure within the context of presurgical evaluation. Certain points should be underlined. - The radiological definition of the histological nature of an abdominal mass during angiography remains difficult, practically impossible in certain regions. - Borrowed vascularizations still pose complex diagnostic problems at different levels. - The benefit of angiography should be compared with other modern radiodiagnostic methods, especially the less aggressive ones. - The importance of each of these points has led us to develop them separately: - The diagnostic reliability of angiography in abdominal masses (from anatomico-radiological correlations). To be published - The borrowed vascularisation of abdominal masses. To be published - The tomodensitometry of abdominal masses. To be published - Diagnostic strategy in case of an abdominal mass. To be published.

Abdominal Neoplasms↗
PubMed1984

Suppression of NK-mediated natural resistance by interferon treatment of murine lymphomas.

The observation that interferon (IFN) can suppress the NK lytic sensitivity of murine lymphomas in vitro led us to examine the consequences of this treatment on tumor behavior in vivo. Preincubation in IFN suppressed natural resistance to two lymphomas in syngeneic DBA/2 and semisyngeneic BDF1 mice in a dose-dependent manner, measured by the retention of (131I)dUrd-labeled tumor. Poly I:C enhancement of NK-mediated natural resistance in the lung, liver, and peritoneal cavity was also abolished by IFN pretreatment. IFN was, however, ineffective in altering the elimination of the IFN-resistant L1210R lymphoma when compared to its IFN-sensitive variant, L1210S. In DBA/2 mice that were made NK-deficient by treatment with cyclophosphamide or rabbit anti-asialo GM1 antiserum, or in congenitally NK-deficient bg/bg strain mice, IFN-treated tumor and control tumor were rejected equally well. This indicated that the effects of IFN were dependent on the presence of NK cells in these mice, and suggests that the IFN suppressed the sensitivity of the lymphomas to NK cell-mediated host resistance.

Animals↗
PubMed1984

Histiocytic malignancies. Morphologic, immunologic, and enzymatic heterogeneity.

We have studied 14 hematopoietic malignancies with histologic features of histiocytic differentiation, using frozen section immunologic stains, plastic section enzyme histochemistry, and paraffin section immunocytochemistry. There was morphologic, immunologic, and enzymatic heterogeneity, including findings in seven cases that suggested differentiation toward specialized subsets of histiocytes. Four cases expressed a mature monocyte/macrophage phenotype by frozen section monoclonal antibody staining and three of these had histologic patterns diagnostic of malignant histiocytosis; two other cases had ATPase and S100 protein reactivity and morphologic features consistent with interdigitating (reticulum) cell proliferations; and one case was alkaline phosphatase positive, suggestive of differentiation toward fibroblastic reticulum cells. Four cases had histologic findings consistent with malignant histiocytosis, but weak or unreactive staining patterns and were considered poorly differentiated histiocytic or primitive hematopoietic malignancies. Three other cases, also morphologically consistent with malignant histiocytosis, were identified as probably T-cell lymphomas. The morphologic and phenotypic characteristics of non-neoplastic histiocytes and dendritic cell types and their related neoplasms are discussed. Histiocytic malignancies comprise a diverse group that can be identified and subclassified by immunologic and enzymatic techniques.

Adolescent↗
PubMed1978

Splenic disease.

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Animals↗
PubMed1982

[Contribution to the true non-African Burkitt's lymphoma (author's transl)].

It is reported on a 6-year-old Middle European boy suffering from a nasopharynx tumor with involvement of a submandibular lymph node. The tumor was classified by morphologic, serologic and virologic data as a true or Epstein-Barr virus-associated Burkitt's lymphoma, resp., which has been, up to now, seldom seen outside Africa. The patient died 3 months after diagnosis. Autopsy has shown tumor involvement of nasopharynx and soft tissues in the left neck region, several lymph nodes, kidneys, liver, spleen, and bone marrow. Cytologic, light and electron microscopic data are reported and the structural change of the tumor is referred to.

Autopsy↗
PubMed1982

An autopsy case of primary hepatoma associated with an oral contraceptive.

Primary hepatoma was found in a 38-year-old female who had been using an oral contraceptive for 28 months. Histologically the hepatoma was a well-differentiated hepatocellular carcinoma. Alpha-fetoprotein was not increased and tests for HBS antigen was negative. Carcinoembryonic antigen was elevated remarkably before death. The findings of hepatic arteriography and peritoneoscopy suggested metastatic tumors of the liver rather than primary hepatoma. During the course of the disease, phlebothrombosis occurred and spread widely in the lower left limb. The observation of erythrocytosis indicated the presence of a tumor producing erythropoietin or an erythropoietin-like substance.

Adult↗
PubMed1984

[Surgical therapy of gastric carcinoma in an advanced stage (clinical cases)].

The Authors study the casuistry of the Verona Surgical Clinic concerning the interventions for gastric cancer; they particularly study 35 cases of plurivisceral demolition for neoplasm in advanced phase. After a discussion of the data supplied by the literature; the Authors, as a conclusion, suggest not to consider the overcoming of the gastric barrier in multivisceral sense as a rigid element for the exclusion of these patients from surgery, although they exclude widely demolitive interventions in seriously weakened patients, or in bearers of such spreadings as to involve tremendous operative risks, not rewarded with a satisfactory advantage.

Aged↗