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Mammographic x-ray spectra measured by Compton spectroscopy using a high resolution Schottky CdTe detector.

Analysis of x-ray spectra is important for quality assurance (QA) and quality control (QC) of radiographic systems. This is especially true for mammographic x-ray imaging systems which require low-contrast detectability. Under clinical conditions, the measurement of diagnostic x-ray spectra is difficult because of pulse pile-up due to the high fluence rate of incident x-ray photons. However, it is difficult to set a long source-to-detector distance to reduce the number of photons detected per unit time for mammographic x-ray units. Compton spectroscopy is a suitable tool to deal with this problem. Detection of 90-degrees scattered photons only, energy correction and reconstruction are easy using the Klein-Nishina formula. However, x-ray spectra measured by this method have lower energy resolution, because of the geometrical irradiation angle or electron movement in the scatterer. Moreover, spectra measured with a compound semiconductor detector, such as a high resolution Schottky CdTe detector like we used, are distorted by the detector response, which is based on detecting x-ray photon interactions and charge carrier trapping in the semiconductor crystal. While the distortion of spectra caused by the response can be easily corrected by applying a stripping procedure, it is very difficult to reconstruct the broad spectra measured by Compton spectroscopy as sharp spectra such as obtained when directly measured. Some complicated reconstruction algorithms have been reported to fit the shape of spectra obtained by the Compton spectroscopy to sharp standard spectra. However, for QA / QC of the radiographic system, it is not necessary to correct the spectra sharply if the spectral broadening is at a tolerable level and the properties of the broad spectra acquired by the Compton spectroscopy agree with those of the sharp spectra measured directly; i.e. evaluations are necessary only for estimation of spectral shape. In this paper, we compared attenuation curves calculated using Hubbell's attenuation coefficients to estimate the coincidence or difference of spectra measured by the Compton spectroscopy and directly measured in the primary beam. Our results showed that the attenuation curves acquired from the reconstructed spectra measured by the Compton spectroscopy agreed with that acquired from corrected spectra that were directly measured. Moreover, the attenuation curves acquired from the spectra actually measured by adding aluminum attenuators agreed with theoretically calculated curves.

Mammography↗

Instantaneous parameter estimation in cardiovascular time series by harmonic and time-frequency analysis.

Time-frequency distributions, such as smoothed pseudo Wigner-Ville distribution (SPWVD), complex demodulation (CDM), and provide useful time-varying spectral parameter estimators. However, each of these methods has limitations that a joint utilization could largely reduce, due to their interesting complementary features. The aim of this paper is to validate the joint SPWVD-CDM method on synthetic and real cardiovascular time series with normal and reduced variability such as in autonomic blockade or autonomic deficiency. We propose two indexes related to the noise present in the signal and to the dispersion of the power spectrum in order to validate instantaneous parameter estimation. In the low-frequency band, the interpretation of the instantaneous frequency and phase of cardiovascular time-series should be discarded in many real-life situations. Conversely, in the high frequency band, under paced breathing, the reliability of the instantaneous parameters is demonstrated even in conditions of reduced cardiovascular variability.

Algorithms↗

Soft tissue absorption tomography with correction for scattering aberrations.

Among the many factors involved in ultrasound attenuation phenomena, scattering effects play a major role, even in the unexpected case of soft tissues. It is proposed in this study to quantitatively evaluate the scattering affecting the measurements before reconstructing the absorption parameter alone. The reconstruction procedure involves three steps: (1) Estimating the sound speed map using a transmission tomography algorithm. This estimation procedure provides a numerical phantom of the organ probed, cleared of all dissipative components. This absorption free phantom mimics the (viscoacoustic) tissues imaged except for the density and absorption characteristics: the density a priori equals 1000 kg/m3 and the absorption is not taken into account. The impedance fluctuations in the object are therefore approximated on the basis of the sound speed contrast. (2) Synthesing the field scattered by the absorption free phantom; the attenuation observed here results solely from the scattering phenomenon. The synthesis is carried out using a finite-element time domain code simulating the ultrasonic propagation through the phantom. It provides the scattering distortion reference introduced into the log spectral absorption estimator. (3) Reducing the scattering distortions affecting the integrated absorption measured along the ray paths using a log spectral procedure. The corrected integrated absorption is then processed using a tomographic reconstruction procedure that provides an estimate of the absorption distribution. Simple numerical simulations show the improvement obtained in the absorption estimates with this approach.

Absorption↗

Doppler power spectrum from a Gaussian sample volume.

A closed-form expression for the Doppler power spectrum due solely to the range of blood velocities passing through a Gaussian sample volume placed anywhere in a vessel under conditions of axisymmetric flow, uniform backscatter and negligible intrinsic spectral broadening has been derived. The formulation presented here allows the independent specification of the sample volume position and width, in the three dimensions, and enables simple estimations of spectral shape for pulsed wave Doppler systems. Simpler expressions were derived for the cases of symmetric sample volume projections onto the vessel cross-section and/or sample volumes centred in the vessel. Closed form expressions were derived for mean frequency and spectral width in the case of a symmetric sample volume projection centred in the vessel. The effects of sample volume size and position on the Doppler spectral width and mean frequency are shown for a range of velocity profiles.

Blood Flow Velocity↗

Fitting of deuterium quadrupole echo spectra with multiple motional models.

Dynamic information is generally extracted from deuterium quadrupole echo spectra by matching a spectrum calculated for a particular motional model to the experimental spectrum. In this work, a set of computer programs has been written to facilitate fitting of calculated spectra to experimental spectra that represent from one to five motional models. The fitting program requires pre-calculated libraries of spectra for the models of interest, and accomplishes the fitting either by a systematic method or by simulated annealing. The systematic method is convenient for fitting with one or two motional models, but the simulated annealing method is faster for two or more models, if the libraries are made up of hundreds of spectra. The parameter Q, with the standard deviation of the spectral points estimated as the standard deviation of the baseline noise, provides a stringent measure of goodness of fit. Acceptable fits of experimental data as judged by this criterion have not been found, even in the case of ring flip motion in phenylalanine-d(5) in which the fit may be judged acceptable by eye. An example of fitting with isotropic and methyl rotation motional models of alanine-d(3), which have distinct spectral patterns, shows that it is possible to obtain reasonably accurate estimates of the relative amounts of deuterium representing the different models, even from poorly fitted spectra.

Algorithms↗

Modelling oil droplet absorption spectra and spectral sensitivities of bird cone photoreceptors.

Birds have four spectrally distinct types of single cones that they use for colour vision. It is often desirable to be able to model the spectral sensitivities of the different cone types, which vary considerably between species. However, although there are several mathematical models available for describing the spectral absorption of visual pigments, there is no model describing the spectral absorption of the coloured oil droplets found in three of the four single cone types. In this paper, we describe such a model and illustrate its use in estimating the spectral sensitivities of single cones. Furthermore, we show that the spectral locations of the wavelengths of maximum absorbance (lambda(max)) of the short- (SWS), medium- (MWS) and long- (LWS) wavelength-sensitive visual pigments and the cut-off wavelengths (lambda(cut)) of their respective C-, Y- and R-type oil droplets can be predicted from the lambda(max) of the ultraviolet- (UVS)/violet- (VS) sensitive visual pigment.

Animals↗

Effects of swept scanning on velocity estimation.

The swept-scan technique adopted in high-frequency ultrasound involves mechanically scanning a single-element transducer to acquire image data. Unlike conventional step scanning, where the image data are acquired at discrete positions, the swept-scan technique acquires the image data while the transducer is continuously moving. Such a scanning method is particularly advantageous for Doppler flow estimation because its frame rate is higher than that for the step-scan technique. However, the effects of the transducer motion on the accuracy of velocity estimation have not been studied comprehensively. This study employed a k-space approach to experimentally investigate the effects of swept scanning on both conventional Doppler axial velocity estimation and spectral-broadening-based lateral velocity estimation using a 45-MHz transducer. The results indicate that such effects must be corrected in order to obtain an accurate estimation of flow velocities.

Blood Flow Velocity↗

Quantitative EEG analysis in children with hemiparetic cerebral palsy.

Clinical assessment and imaging studies of twenty-six children with hemiparetic cerebral palsy (HCP) were conducted. For each child 20 artifact-free EEG epochs, each of 2 s duration were selected for spectral analysis to calculate spectral power and coherence functions. A fast Fourier transformation alogorithm of signal processing was used to obtain the power spectrum of each lead. The objective of this study was to estimate EEG spectral power as well as the interhemispheric (ICoh) and intrahemispheric (Hcoh) coherence in children with hemiparetic cerebral palsy (HCP) as compared with healthy children. Significant differences between the HCP and control children were noted in the distribution of the alpha, theta and delta rhythms over the left and right hemispheres. In this study we found significant differences between the HCP and control children in the distribution of alpha, theta, delta and beta rhythm over the left and right hemispheres. Significant differences between the HCP and control children were in the distribution of the theta rhythm over the right and left hemispheres. The lower ICoh at the temporal, parietal and occipital derivations in the alpha band implies hypoconnectivity between the right and left hemispheres. The HCoh asymmetry, which implies relative hypoconnectivity within the right and left hemispheres, suggests the functional hemispheric differentiation may be diminished in comparison with the controls.

Alpha Particles↗

[Spectral analysis and EEG coherence in children with cerebral palsy: spastic diplegia].

Cerebral palsy (CP) occurs in 1.4-3.0 per 1000 live births children. Major clinical features of CP are: spasticity of extremities, extrapyramidale movements, dyskinesis and ataxia. Spastic diplegia is the most common type of CP. Spectral analysis and coherence EEG are noninvasive measures of the functional relationship between brain regions and are evaluated to determine electrophysiologic abnormalities of neurologic and psychiatric disorders. The objective of this study was to estimate EEG spectral power density and coherence in children with spastic diplegia. A group of 29 children (15 girls and 14 boys) with DS recruited from the Department and Clinic of the Pediatric Neurology Ward in Medical Academy in Białystok, were studied. Their ages ranged from 6-14 years, mean 8.79 +/- 3.23 years. EEG results were compared with a control group of 31 healthy children with normal EEG records. For every subject, 20 artifact-free EEG epochs, each 2 s duration were selected for spectral analysis and coherence functions. A standard (fast fourier transformation) algorithm of signal processing was used. Significant decrease of power alpha at occipital derivations demonstrated in children with DS. On the other hand, there was an increase of theta power and delta bands almost in all leads. An increase of beta power was no significant compared with controls. Significant decrease of interhemispheric coherence values in children with DS for the alpha and theta band frequencies and in a few cases decrease of delta and beta bands were observed. Differences of intrahemispheric coherence values were detected at central-temporal and temporal-occipital leads. The presented results support anatomic-neurophysiologic abnormalities demonstrated in children with DS.

Adolescent↗

[Study of the characteristics of diagnostic X-ray equipment. 2. Relationship of spectral distribution of braking radiation and its dosimetric characteristics].

The results obtained by the method outlined in the paper for calculating dosimetric characteristics of a braking radiation spectrum are in rather good agreement with those of experimental studies and may be used for practical calculations instead of expensive and labour-consuming experimental methods for estimating the spectral characteristics of braking spectra.

Humans↗

Flash-related synchronization and desynchronization revealed by a multiple band frequency analysis.

The fast Fourier transform (FFT) is a good method to estimate power spectral density (PSD), but the frequency resolution is limited to the sampling window, and thus the precise characteristics of PSD for short signals are not clear. To relax the limitation, a multiple band-pass filter was introduced to estimate the precise course of PSDs for flash visual evoked potentials (VEPs). Signals were recorded during -200 and 600 ms using balanced noncephalic electrodes, and sampled at 1,000 Hz in 12 bits. With 1 Hz and 10 ms resolutions, PSDs were estimated between 10 and 100 Hz. Background powers at the alpha- and beta-bands were high over the posterior scalp, and powers around 200 ms were evoked at the same bands over the same region, corresponding to P110 and N165 of VEPs. Normalized PSDs showed evoked powers around 200 ms and suppressed powers following the evoked powers over the posterior scalp. The evoked powers above the 20 Hz band were not statistically significant, however, the gamma band was significantly evoked intra-individually; details in the gamma bands were varied among the subjects. Details of PSDs were complicated even for a simple task such as watching flashes; both synchronization and desynchronization occurred with different distributions and different time courses.

Adult↗

Power spectra accuracy improvement by optimal signal epoch selection: an heuristic approach.

The problem of epoch selection in frequency analysis of biomedical signals often involves tradeoffs between the physiological system studied stationarity, the spectral resolution required, the need for dynamic investigations implying shorter epochs, etc. The accuracy of the spectra strongly depends on the epoch length. We propose a method for optimal epoch selection introducing the notion of 'quality of power spectra'. Two criteria for quantitative estimation of spectral quality are defined, considering a quality to be high when more power is concentrated in narrow frequency bands. A synthesized signal is used for describing the procedure developed and evaluating the accuracy. Noise sensitivity is assessed by adding intensive noise to the signal. Hundreds of synthesized signals are used for validation of the method and some initial experiments with heart rate variation data are presented.

Child↗

Raman study of aluminum speciation in simulated alkaline nuclear waste.

The chemistry of concentrated sodium aluminate solutions stored in many of the large, underground storage tanks containing high-level waste (HLW) at the Hanford and Savannah River Nuclear Reservations is an area of recent research interest. Not only is the presence of aluminate in solution important for continued safe storage of these wastes, the nature of both solid and solution aluminum oxyhydroxides is important for waste pretreatment. Moreover, for many tanks that have leaked high aluminum waste in the past, little is known about the speciation of Al in the soil. In this study, Raman spectroscopy has been used to investigate the speciation of the aqueous species in the Al2O3-Na2O-H2O system over a wide range of solution compositions and hydration. A ternary phase diagram has been used to correlate the observed changes in the spectra with the composition of the solution and with dimerization of aluminate that occurs at elevated aluminate concentrations (>1.5 M). Dimerization is evidenced by growth of new Al-O stretching bands at 535 and 695 cm(-1) at the expense of the aluminate monomer band at 620 cm(-1). The spectrum of water was strongly influenced by the high concentrations of Na+ and OH- (>17 M). Upon increasing the concentration of NaOH in solution, the delta-(H-O-H) bending band of water (v2 mode) increased in frequency to 1663 cm(-1), indicating that the water contained in the concentrated caustic solution was more strongly hydrogen bonded at the higher base content. In addition, the sharp, well-resolved band at 3610 cm(-1), assigned to the v(O-H) of free OH-, increased in intensity with increasing NaOH. Analysis of the v(O-H) bands in the 3800-2600 cm(-1) region supported the overall increase in hydrogen bonding as evidenced by the increase in relative intensity of a strongly hydrated water band at 3118 cm(-1). Taking into consideration the activity of water, the molar concentrations of the monomeric and dimeric aluminate species were estimated using the relative intensities of the Al-O stretching bands from the Raman spectra. A constant apparent log Kdimer value was obtained at aluminate concentrations >1.5 M with a value of 0.97+/-0.04 at approximately 25 degrees C. This study represents the first spectral-based estimation of a thermodynamic equilibrium constant for the Al2O3-Na2O-H2O system.

Aluminum↗

Theoretical estimates of the logarithmic phonon spectral moment for monatomic liquids.

We calculate the logarithmic moment of the phonon frequency spectrum at a single density for 29 monatomic liquids using two methods, both suggested by Wallace's theory of liquid dynamics: The first method relies on liquid entropy data and the second on neutron scattering data in the crystal phase. This theory predicts that for a class of elements called "normal melters," including all 29 of these materials, the two estimates should closely match, and we find that they agree to within a few percent. We also perform the same calculations for four "anomalous melters," for which we expect the two estimates to differ markedly; we find that they disagree by factors almost up to 3. From our results we conclude that the liquid entropy estimates of the logarithmic moment, applicable both to normal and anomalous melters, are trustworthy to a few percent, which makes them reliable for use in estimates of various liquid transport coefficients.

Journal Article↗

Baroreflex sensitivity determined by spectral method and heart rate variability, and two-years mortality in patients after myocardial infarction.

Sympathetic overactivity and low parasympathetic activity is an autonomic dysfunction (AD) which enhances cardiac mortality. In the present study, the impact of AD on the mortality in patients after myocardial infarction was evaluated. We examined 162 patients 7-21 days after myocardial infarction, 20 patients of whom died in the course of two years. Baroreflex sensitivity (BRS) was estimated by spectral analysis of spontaneous fluctuations of systolic blood pressure and cardiac intervals (Finapres, 5 min recording, controlled breathing 20/min). The heart rate variability was determined as SDNN index (mean of standard deviations of RR intervals for all 5-min segments of 24-hour ECG recordings). BRS < 3 ms/mm Hg and/or SDNN index < 30 ms were taken as markers of AD. The risk stratification was performed according to the number of the following standard risk factors of increased risk of cardiac mortality (SRF): ejection fraction < 40%, positive late potentials and the presence of ventricular extrasystoles > 10/h. No difference in mortality between patients with AD (4%) and without AD (4.5%) was found in 92 patients without SRF, the mortality in 6 patients with three SRF was 66.6%. Five of these patients had AD. Out of 64 patients with one or two SRF, 32 had AD. The mortality of patients without AD was 6.25% and 31.2% of those with AD (p<0.025). It is concluded that AD enhanced two-years mortality five fold in our patients with moderate risks.

Aged↗

Two-tone auditory spectral resolution.

Two component complex tones were synthesized so that each member of a complementary pair exhibited identical amplitude modulations; frequency modulations, however, were in opposite directions. Previous work has shown that the discriminability of the members of a complementary pair is related to the envelope-weighted differences in their instantaneous frequency functions. Listeners report that they base their discriminations upon differences in pitch between complementary two component signals. We assumed that the high discriminability found for moderate separations between the two component frequencies would not obtain if the components were resolved into separate critical bands. Thus we could define the just discriminable (75%) frequency separation as a direct estimate of spectral resolving power without recourse to assumptions about masking effectiveness, loudness summation, or other subjective changes thought to depend upon auditory spectral resolving power. Our findings indicate that resolution bandwidths resulting from the discriminability of complex tone pairs approximate the width of the traveling-wave envelope observed by von Békèsy. In light of our results, the implications for other critical bandwidth estimates are discussed.

Humans↗

Dynamic spectral analysis of event-related potentials.

This paper presents a new method for the identification of individual event related potential (ERP) components in both frequency and time domains. Using the similar basis function (SBF) algorithm the method provides a time to frequency transform, representing a frequency domain equivalent of the component waveform. Notable features of the SBF algorithm are that it allows for unevenly spaced sampled functions in both the time and frequency domains, and estimates of spectral densities are obtained by numerical computation of finite Fourier integrals. Application of this method to ERP data from 20 normal subjects demonstrated a similar shape of component amplitude frequency characteristics for traditional late component waveforms (N1, P2, N2 and P3). On this basis, a low-frequency band was found where the component amplitude frequency characteristic was described by a Gaussian function, while the component phase frequency characteristic was a linear function of frequency. These relationships are interpreted as frequency domain equivalents of the component. Transformed to the time domain, they provided an analytical description of the ERP as the sum of positive- and negative-going monopolar waves. The study points to similar mechanisms underlying these component waveforms, and analytically defines dynamic properties for the components both in the frequency and time domains.

Adult↗

Nutrient fluxes toward phytoplankton: is it useful to consider turbulence intermittency?

The Influence of turbulence on nutrient fluxes towards phytoplankton cells has been previously estimated, but those studies did not take into account the intermittent nature of turbulent processes. This has been investigated here comparing the nutrient fluxes obtained using both mean and instantaneous turbulent energy dissipation rates. This approach shows that the size of cell potentially influenced by turbulence is lower than previously indicated, and that the spectral average estimate of the turbulence effect overestimates the flux. The capacity of cell to use such intermittent flux is then discussed.

Models, Theoretical↗