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PubMed2006

A high-resolution single photon emission computed tomography study of verbal recognition memory in Alzheimer's disease.

BACKGROUND: In view of the recent technological advances and its ease of availability, we used single photon emission computed tomography (SPECT) to examine the performance of early Alzheimer's disease (AD) subjects on a verbal recognition memory task. METHODS: Eighteen early AD and 10 matched healthy control subjects underwent split-dose (99m)Tc-HMPAO (Ceretec) SPECT using a verbal recognition memory and control task. SPECT images co-registered with MRI scans were used to determine relative regional cerebral blood flow (rCBF) changes in regions of interest. RESULTS: In healthy control subjects, verbal recognition increased rCBF in the right occipital region, thalamus, left prefrontal pole, posterior parietal region and cerebellum, and decreased rCBF in the right hippocampus. AD subjects showed bilateral prefrontal, posterior parietal and occipital increases, unilateral increase in the left posterior temporal region, and bilateral reductions in the hippocampus. Although activation was significantly different between the two groups in the right thalamus and left medial prefrontal region, the verbal recognition task did not enhance discrimination between groups. CONCLUSIONS: Compared with controls, AD subjects activate a similar but more extensive bilateral network during verbal recognition, possibly reflecting an attempt to compensate for impaired processing.

Aged↗
PubMed1990

Social facilitation effects in recognition memory.

This study investigates the effects of observer presence on recognition memory. The number of learning repetitions, the degree of association of category-instance word pairs, and the time interval between acquisition and testing were manipulated. While the basic recognition data conformed well to previous findings in the learning and memory literature, predictions, derived from the drive theory of social facilitation found little support. Instead, study results seem best explained by descriptions of the cognitive processes employed by subjects both during the initial acquisition and later recognition of the category-instance pairs.

Adult↗
PubMed1991

A bias in favor of the positive response to high-frequency words in recognition memory.

A relatively liberal response bias for high-frequency words and a violation of the mirror effect for hit and false-alarm rates were found in a yes-no recognition-memory test. Subjects more frequently responded "old" to high-frequency words than to low-frequency words. Four experiments were conducted to determine the causes of the different response biases and of the violation of the mirror effect. The word-frequency effect on hit rates did not appear, whereas the false-alarm rate for low-frequency words was lower than that for high-frequency words. When low- or high-frequency words were presented separately in distinct halves of a recognition-memory test, the relatively liberal response bias for high-frequency words was diminished. A model for recognition judgment is proposed that assumes the use of a common criterion for low- and high-frequency words.

Adult↗
PubMed1999

The effect of intention to learn novel, environmental sounds on the novelty P3 and old/new recognition memory.

Brain electrical activity was recorded while 32 young adults listened to frequent tones, infrequent target tones, and infrequent novel environmental sounds (some of which repeated). Subjects in the incidental group were not informed about the novel sounds, while subjects in the intentional group were informed and, in addition, were asked to memorize them for a subsequent memory test. Following the novelty oddball task, all subjects were given an old/new sound recognition memory task. The novelty P3 showed a more anterior scalp distribution and an effect of repetition in the incidental compared to the intentional group, suggesting that pre-categorizing the novel sounds influenced how they were processed. For the intentional group only, a subsequent memory effect was elicited by novel sounds that were subsequently recognized compared to those that were not, although both groups showed robust old/new ERP effects during the recognition task. The robust subsequent memory effects in the intentional group were associated with greater recognition accuracy of familiar environmental sounds relative to the incidental group. These data suggest that the encoding activity reflected in the ERP subsequent memory effect may have engendered an advantage in subsequent recognition memory performance.

Acoustic Stimulation↗
PubMed2005

Task-related activity in prefrontal cortex and its relation to recognition memory performance in young and old adults.

Older adults often have more widespread prefrontal cortex (PFC) activation during memory retrieval tasks, compared to young adults, particularly in the left hemisphere. Recruitment of additional frontal activity in older adults has been attributed by some researchers to compensation, perhaps for reduced activity elsewhere in the brain, whereas others have described it as a non-selective response that may be due to a failure to inhibit these PFC regions. To address further the impact of PFC activity on memory in older adults, we used PET to measure brain activity during recognition memory tasks. Both young and old adults showed increased activity during recognition, compared to a control task, in bilateral PFC. Young adults showed greater activation of left hippocampus and lateral temporal cortex during recognition, whereas older adults showed greater activity in the right inferior frontal gyrus. Age differences also were seen in correlations between brain activity and memory performance. There were positive correlations between activity in the right parahippocampal gyrus and recognition performance in young adults, whereas positive correlations between activity in PFC and performance were found only in older adults. These positive correlations included the right inferior PFC region where older adults had greater activation. Activity in this right PFC region was negatively correlated with medial temporal activity in both groups. These results provide further evidence for age-specific patterns of brain activity underlying memory performance and are consistent with the idea that PFC assumes a larger role in supporting successful recognition memory with increasing age. The negative correlation between activity in PFC and medial temporal regions, as well as the age differences in how these regions were related to behavior, suggest that those older individuals who recruit PFC to a greater degree may do so as a compensatory response to reductions in medial temporal regions.

Adult↗
PubMed1995

[Two types of facial impression judgments and recognition memory for faces].

The author investigated the semantic processing advantage effect on facial recognition memory using two types of personality traits and two types of recognition tests. In Experiment 1, based on the personality impression ratings for smiling and neutral faces made by 40 subjects, four expression-independent (i.e., intelligent, reliable, determined, and ambitious) and four expression-dependent (i.e. extroverted, friendly, affectionate, and likeable) personality trait words were selected. In Experiment 2, two groups of 22 subjects (expression-dependent trait group and expression-independent trait group) were asked to rate 32 faces in terms of physical features or personality traits. This was followed by an unexpected yes-no recognition test in which identical pictures of the target faces or the same person's expression-changed faces were randomly presented with distractor faces. In identical-picture recognition condition, the semantic processing advantage emerged in both expression-dependent and expression-independent trait groups, whereas in expression-changed recognition condition the advantage appeared only in expression-independent trait group. It was discussed that the semantic-codes explanation would be plausible to explain the results obtained.

Adult↗
PubMed2006

Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus.

Social isolation from weaning affects hippocampal structure and function in the rat. The intrinsic dynamic instability of the cytoskeletal microtubular system is essential for neuronal development and organization. Accordingly, the present paper investigated the effects of social isolation on hippocampal levels of alpha-tubulin isoforms associated with microtubule dynamics, the dendritic marker MAP-2 and alterations in locomotor activity and recognition memory. Male Lister Hooded rats (postnatal day 25-28) were housed either in groups or singly (isolated animals) for 30 days. Locomotor activity in a novel arena and novel object recognition were monitored in activity boxes. The hippocampus was dissected out 18 h after the novel object recognition task. Levels of alpha-tubulin isoforms and MAP-2 were analysed using Western blots. The experiments were conducted in duplicate, using two batches of rats obtained from different suppliers. Isolated animals were hyperactive and showed recognition memory deficits in the novel object recognition task. These behavioural alterations were accompanied by specific alterations in hippocampal alpha-tubulin isoforms and decreased MAP-2 expression. The results confirm that rearing rats in isolation produces hyperactivity and cognitive deficits. The behavioural alterations were accompanied by hippocampal cytoskeletal changes consistent with microtubule stabilization, and by decreased MAP-2 expression. These findings are indicative of an abnormal development of synaptic connections and/or reductions in neuronal cell number. The developmental structural abnormalities in the hippocampus may contribute to the cognitive impairments which result from isolation rearing in rats.

Analysis of Variance↗
PubMed1995

Cholinergic lesions by 192 IgG-saporin and short-term recognition memory: role of the septohippocampal projection.

Two experiments examined the effects of cholinergic basal forebrain lesions by intraventricular and intrahippocampal infusions of the immunotoxin 192 IgG-saporin on recognition memory in an operant delayed-non-matching-to-position task in rats. Intraventricular infusions produced extensive reductions in cortical and hippocampal choline acetyltransferase activity in the first experiment. Behaviourally, a mixed delay-dependent/independent accuracy deficit and increased biased responding was observed post-lesioning. Thus, both mnemonic as well as non-mnemonic processes were affected by the lesion. This performance deficit was indistinguishable from the impairment induced by acute intraventricular injections of the choline uptake inhibitor hemicholinium-3, which suggests that cholinergic damage induced by 192 IgG-saporin disrupted performance. In the second experiment more discrete intrahippocampal 192 IgG-saporin lesions were made, which reduced hippocampal choline acetyltransferase activity about 57%, although this reduction was not as extensive as following intraventricular injections. Although intrahippocampal lesions also impaired non-matching accuracy, this effect failed to reach significance during most stages of the experiment. Scopolamine just failed to significantly impair (P = 0.053) performance in hippocampal lesioned rats more than in controls. The nicotinic antagonist mecamylamine did not affect the lesion-induced changes in performance. These results suggest that the cholinergic basal forebrain, including the septohippocampal system, is important for the mediation of recognition memory, and muscarinic receptor-mediated mechanisms may be of greater importance than alterations of nicotinic receptor-mediated processes in the septohippocampal system.

Acetylcholinesterase↗
PubMed2003

Molsidomine antagonizes L-NAME-induced acquisition deficits in a recognition memory task in the rat.

The present study was designed to investigate the role of nitric oxide (NO) on the acquisition of a recognition memory task in the rat. For this purpose, the effects on memory exerted by pre-training administration of the NO synthase inhibitor L-NAME (N(omega)-nitro-L-arginine methyl ester) and the NO donor molsidomine (N-[ethoxycarbonyl]-3-[4-morpholinosydnomine]) were assessed by using the object recognition task, a working memory paradigm based on the differential exploration of a new and familiar object. In a first dose-response study, it was found that L-NAME (10, 30, and 60 mg kg(-1), i.p.) at 30 but not at 10 mg kg(-1) disrupted animals performance, whereas the dose of 60 mg kg(-1) induced side effects. Molsidomine (2 and 4 mg kg(-1), i.p.) at 4 but not at 2 mg kg(-1), antagonized the L-NAME-induced performance deficits. These results indicate that NO is involved in the acquisition of a recognition memory task.

Analysis of Variance↗
PubMed2000

Short duration power changes in the EEG during recognition memory for words and faces.

Although memory has been widely studied using event-related potentials, memory-related changes in the electroencephalogram (EEG) have been relatively neglected. The aim of this study was to determine whether evidence could be found for memory-related changes in the EEG. EEG was recorded from a sample of healthy volunteers while they performed word and face recognition memory tasks. Data were analyzed using the method of event-related desynchronization. In the theta frequency range there was a short-duration increase in power that occurred in the first 250 ms that was maximal at temporal sites (T5/T6). For words, but not faces, there was a repetition effect in theta such that new words elicited greater synchronization than old words at the midline frontal electrode (Fz). In the alpha frequency range there was a lateralized repetition effect, which occurred from 750 ms. In upper alpha this effect was lateralized in the expected way with greater desynchronization at temporo-parietal sites on the left for words and on the right for faces. For lower alpha, the lateralization was reversed. The meanings of these findings are interpreted in the light of existing models of recognition memory.

Adult↗
PubMed1991

Object recognition memory in the rat: the role of the hippocampus.

Object recognition memory of rats with fimbria-fornix or ventral temporal lesions was evaluated with a behavioral protocol (delayed non-matching-to-sample task with trial-unique stimuli) similar to that used to test recognition functions in primates. Animals with damage to the hippocampal system showed no evidence of lasting impairment on the object recognition task with retention intervals up to 30 s. In contrast, rats with fimbria-fornix lesions displayed severe and enduring deficits on a test of spatial memory, i.e. rewarded alternation, with but 5 s delays. These results provide further evidence that a dissociation exists between the types of memory that are and are not lost following damage to the hippocampus. Whereas the hippocampus is necessary for some types of mnemonic processes, other types of recognition functions (e.g. perceptual recognition) may be fully mediated in regions of sensory and/or association neocortex without the involvement of the hippocampus.

Animals↗
PubMed1991

Comparison of the effects of scopolamine administered before and after acquisition in a test of visual recognition memory in monkeys.

The effect of scopolamine on visual recognition memory in rhesus monkeys was assessed with a delayed nonmatching-to-sample task employing trial-unique stimuli. During the acquisition phase, 40 sample stimuli were presented sequentially. During the test phase, these same stimuli were presented in the reverse order, each paired with a novel stimulus. The animal was rewarded for choosing the novel stimulus in each pair. Two versions of this design were used. In Task 1, scopolamine (10.0 or 17.8 micrograms/kg) was administered 20 min prior to acquisition, which was followed immediately by the test phase. In Task 2, the drug was administered immediately after acquisition, which was followed 20 min later by the test phase. Performance was impaired in a dose-related manner in Task 1, but not at all in Task 2, indicating that the effects of scopolamine on performance cannot be attributed to an impairment either in the retrieval of stored information or in the attentive or perceptual discriminative processes needed for such retrieval, or, by implication, for storage. In addition, the forgetting curves for scopolamine in Task 1 were parallel to those of the control sessions; i.e., the curves did not diverge with increasing delay intervals, indicating that scopolamine did not increase the rate of forgetting. Taken together, the results suggest that scopolamine interferes selectively with the initial storage of the information to be remembered.

Animals↗
PubMedDate not supplied

Recognition memory for complex visual discriminations is influenced by stimulus interference in rodents with perirhinal cortex damage.

Rats with perirhinal cortex (PRC), hippocampal, or sham lesions were trained on a successive discrimination go/no-go task to examine recognition memory for an array of visual objects with varying interference among the objects in the array. Rats were trained to recognize a target array consisting of four particular objects that could be presented in any one of four possible configurations to cover baited food wells. If the four target objects were presented, the rat should displace each object to receive food. However, if a novel object replaced any one or more of the target objects, then the rat should withhold its response. The number of novel objects presented on nonrewarded trials varied from one to four. The fewer the number of novel objects in the array, the more interference the array shared with the target array, therefore increasing task difficulty. An increased number of novel objects should result in less interference with the target array and decreased task difficulty. Although accuracy was slightly lower in rats with hippocampal lesions compared with controls, the learning of the groups was not statistically different. In contrast, rats with PRC lesions were significantly impaired in learning compared with both control and hippocampal-lesioned rats. The results suggest that recognition memory for complex visual discriminations is affected by stimulus interference in rodents with PRC damage.

Animals↗
PubMed1989

Children's recall of aggressive and withdrawn behaviors: recognition memory and likability judgments.

This study examined children's recognition memory for descriptions of maladjusted behaviors displayed by hypothetical peers. 144 first-, third-, fifth-, and seventh-grade children (mean ages 6.4, 8.4, 10.5, and 12.5 years, respectively) listened to descriptions of hypothetical aggressive, withdrawn, and nonmaladjusted peers, following which they were asked to identify these descriptions from among a second list of descriptions. The children were also asked about the desirability of these hypothetical peers as friends. Whereas children accurately identified the aggressive and nonmaladjusted descriptors at all grade levels, only at grades 5 and 7 were they equally accurate for withdrawal descriptors. Across grade, they also showed an increasing tendency to identify erroneously novel withdrawal and aggression items, but not nonmaladjusted items, as previously displayed by the hypothetical peer. Finally, whereas the aggressive character was low in likability at all grades, the withdrawn character was viewed as increasingly less likable as grade increased. The relevance of these findings to children's peer assessments of aggression and withdrawal is discussed.

Aggression↗
PubMed1988

Recall and recognition memory in patients with Alzheimer's and Parkinson's diseases.

Alzheimer's and Parkinson's diseases are associated with cognitive impairment, although the pattern of cognitive dysfunction is not identical. We investigated the recall and recognition memory of 18 patients with idiopathic Parkinson's disease (PD) and of 32 patients with probable Alzheimer's disease (AD). In the list-learning test using Buschke's selective reminding method, PD patients showed superior delayed recognition memory capability compared to AD patients, whereas immediate recall did not differ in the two groups. In the delayed story recall, PD patients were also able to benefit from rehearsal and probe more than AD patients. The results suggest that PD patients are able to bind information better into long-term storage than are AD patients. This may be due to better function in PD of the entorhinal cortex and hippocampus.

Aged↗
PubMed1993

Decomposition of recognition memory event-related potentials yields target, repetition, and retrieval effects.

Task manipulations and a subtractive analytic strategy were combined to decompose the positive-going amplitude shift of the event-related potential (ERP) that is elicited by previously studied words during recognition memory testing. Target stimuli elicited a robust posterior P3b subcomponent, but this effect is shown to be independent of the effects of prior study. Two study-related subcomponents were also identified. The earlier study effect reached peak amplitude about 400 msec after word onset and was elicited by repeated words regardless of whether the task required retrieval of information from secondary memory. This effect might reflect a repetition-related decline in the amplitude of the N400 component. The other study-related effect reached peak amplitude around 600 msec post-stimulus onset. This later effect overlapped temporally with the P3b, but it was not related to targetness. Rather, it was specifically related to task conditions that required retrieval from secondary memory. The identification of this third effect helps to clarify the functional significance of the ERPs observed during recognition memory testing.

Analysis of Variance↗
PubMed1994

Very short term recognition memory for odors.

An investigation of very short term olfactory recognition memory was made with odors of low familiarity to subjects. The experimental procedure was that currently used to make qualitative similarity judgments on odors delivered in paired succession. Subjects made similarity judgments in a yes/no recognition paradigm on odors that were either identical or different. The dependence of recognition performance upon the degree of qualitative similarity was assessed by using two sets of dissimilar odor pairs: slightly dissimilar pairs (S1) and very dissimilar pairs (S2). Performance in terms of correct judgments (hits, correct rejections) was rather good for identical pairs in both sets and was nearly perfect for very dissimilar pairs with a delay of 2-300 sec, suggesting no effect of time or similarity on performance. However, for slightly dissimilar pairs, false alarms increased in number, thereby indicating a dependence of the recognition score on the qualitative distance between odors. In addition, false alarms tended to increase with the lengthening of the retention interval. It was suggested that the subjects based their responses on their capability to detect differences between odors rather than recognizing their similarities. Correct identifications were thus preserved at the cost of increasing false alarms when the discrimination task was made more difficult by closer similarity between odors (S1) or by the fading of memory traces with time. Studying the congruence between the similarity judgments and the kind of evocations associated with paired odors gives some support to the view that recognition performances had some cognitive/semantic basis.

Adult↗
PubMed1999

The electrophysiology of incidental and intentional retrieval: ERP old/new effects in lexical decision and recognition memory.

Event-related brain potentials (ERPs), recorded from a 128-sensor array were used to differentiate brain processes associated with intentional vs incidental memory retrieval. Two experiments examined ERP differences between old (studied) and new (non-studied) words and pseudowords while subjects performed either a recognition memory task or lexical decision task. Previous research has related a P600 old/new effect to the recollection of details, and the present experiments show that this effect was not amplified by intentional retrieval. The P600 effect was larger for words than pseudowords. An earlier (300 to 500 ms), frontally maximal, N400-like old/new effect ('FN400') was similar for words and pseudowords. A third, previously unidentified, mid-frontal, old/new effect was associated with only pseudoword recognition from 300 to 500 ms. Results are discussed with respect to dual-process theories of recognition memory.

Adult↗