Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “RADIO”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 361 records · Page 20Linked to original sources
PubMedDate not supplied

Increasing specificity of anti-tumor therapy: cytotoxic protein delivery by non-pathogenic clostridia under regulation of radio-induced promoters.

BACKGROUND: Pathogenic clostridia, genetically engineered to express therapeutic genes, will specifically target hypoxic regions in tumors. This specificity can be further improved if expression of these genes is controlled by a radio-induced promoter, leading to spatial and temporal control of gene expression. MATERIALS AND METHODS: Following administration of Clostridium spores to tumor bearing rats, normal tissue and tumoral specimens were compared for colonization. Clostridium was genetically modified to express tumor necrosis factor a or cytosine deaminase. Expression of these proteins was assayed. Northern blot hybridizations were used to detect genes which are radio-induced. RESULTS: Clostridium gave a selective colonization of tumors. The recombinant clostridia expressed in vitro and in vivo TNF alpha and cytosine deaminase. Clostridial SOS-repair genes were induced at a dose of 2 Gy. CONCLUSIONS: Pathogenic Clostridium can be used for tumor specific delivery of therapeutic genes. The specificity can be improved via radio-induced promoters. Overall, this new gene delivery system can lead to an increase of the therapeutic ratio in cancer treatment.

Animals↗
PubMed2001

Induction of radio-adaptive response in colony formation by low dose X-ray irradiation.

In this study, we examined the induction of a radio-adaptive response to cell death using a colony formation test in m5S, G401.2/6TG.1 and HeLa cells. When m5S cells were subjected to priming irradiation of 0.05 to approximately 0.15 Gy 4 hr before being irradiated with 4.5 Gy, the survival ratios increased significantly to 39 to approximately 42%. The priming irradiation effect was also observed when G401.2/6TG.1 cells were subjected to priming irradiation of 0.025 to approximately 0.1 Gy 4 hr before being irradiated with 0.8 Gy. This effect showed a two-phasic characteristic, where the first peak was reached at 0.025 Gy, and the second peak was reached at 0.075 Gy. The first peak showed a survival ratio of 56%, while the second peak was at 55%. However, in HeLa cells, this priming irradiation effect was not observed. These results indicated that induction of the radio-adaptive response did not depend on whether cells are normal or cancerous. One of the differences in these cells is that m5S and G401.2/6TG.1 cells have gap-junctional intercellular communication, but HeLa cells do not. Induction of the radio-adaptive response may be related to gap-junctional intercellular communication.

Adaptation, Physiological↗
PubMed2000

Prognostic factors and therapeutic efficacy of combined radio-chemotherapy in Waldeyer's ring non-Hodgkin lymphoma.

OBJECTIVE: To improve the prognosis and therapeutic efficacy of Waldeyer's ring non-Hodgkin lymphoma (NHL-WR), combined radio-chemotherapy was used to treat the patients with NHL-WR and prognostic factors were analyzed. METHODS: Ninety patients with stage I-IV NHL-WR were treated with combined radio-chemotherapy. 4000 cGy to 6000 cGy were given to Waldeyer's ring structure and involved cervical nodes. Uninvolved low cervical nodes received 3000 cGy to 4000 cGy. The combination chemotherapy consisted of COPP (cyclophosphamide [CTX], vincristine [VCR], procarbazine [PCZ], prednisone [PDN]) or CHOP (CTX, ADM, VCR and PDN). Univariate analysis was performed to determine the prognostic unfavorable factors. RESULTS: Five-year overall survival rate was 69.7% for the whole group, and 83.2% for patients with stage I, II. In univariate analyses, over survival (OS) rates of the patients with low and intermediate grade (76.1%), with stage I, II (83.2%), without fever (75.2%) and with performance status (PS) 0, 1 (85.7%) were significantly better than those of the patients with high grade (53.0%), with stage III, IV (24.7%) with fever (38.5%), with PS2 (41.7%), PS3, 4 (0.0%), respectively (P < 0.05). CONCLUSIONS: Combined radio-chemotherapy can improve the 5-year survival rate for the patients with NHL-WR, especially for stage I, II patients. PS > or = 2, stage III, IV, fever and high grade histology were associated with unfavorable prognosis.

Adolescent↗
PubMed2000

Radio-contrast imaging of the rectum prior to colostomy closure for rectal trauma--is routine use still justified?

This retrospective study was undertaken to assess the yield of radio-contrast imaging of the rectum before closure of colostomy following extraperitoneal rectal trauma. Sixty-nine patients (63 males) underwent colostomy closure in 36 months. All radio-contrast studies (colograms) performed before closure of colostomy were normal, and there were no deaths following closure. This study demonstrated that the yield from pre-closure radio-contrast imaging of the rectum after rectal trauma was negligible and did not influence colostomy closure. We conclude that while it may be appealing to suggest abandonment of its routine use, this investigation needs to be further evaluated prospectively with special attention given to injury to associated structures such as bone, bladder and vagina.

Adolescent↗
PubMed2002

[Non-traumatic osteoarthritis of the distal radio-ulnar joint: a consecutive series of 11 wrists with 42 months follow-up].

PURPOSE OF THE STUDY: Non-traumatic osteoarthritis of the distal radio-ulnar joint is generally observed in a context of chondrocalcinosis and can lead to rupture of the extensor tendons. We reviewed patients operated on in our unit between 1986 and 1988 for this condition in order to examine modalities of surgical care. MATERIAL AND METHODS: Eleven patients who underwent surgery for non-traumatic osteoarthritis of the distal radio-ulnar joint were included in the study. Demographic data, clinical signs, joint amplitudes, radiologically identified lesions, peroperative macroscopic features, and results of the microscopic examinations of the synovectomy specimen were recorded. Injury to the extensor tendons and surgical procedures used for repair were noted. Outcome was assessed clinically (pain, stability of the ulnar stump, active extension of the fingers, pronation-supination, flexion-extension) and radiologically. RESULTS: The series included 11 wrists in 8 women, mean age 73.2 years. The underlying cause was chondrocalcinosis in 9 cases and primary osteoarthritis in 2. All patients had painful pronation-supination and 9 of them had ruptured extensor tendons. There was a dorsal displacement of the ulnar head in all cases. Synovectomy-realignment-stabilization was performed using the Sauvé-Kapandji procedure in 10 wrists and resection of the ulnar head using the Darrach procedure in one. Extensor tendons were repaired by side-to-side anastomosis with neighboring tendons in 6 wrists and with grafts in 3. At a mean 42 months follow-up, 7 wrists were pain free and 4 continued to have climatic pain. The ulnar stump was stable in all cases. All the patients achieved active extension of the fingers and preserved wrist mobility. DISCUSSION: According to the literature, non-traumatic osteoarthritis of the distal radio-ulnar joint is uncommon and occurs principally in the elderly patient. The most common complication being rupture of the extensor tendons. Different treatments can be discussed, but we prefer synovectomy-realignment-stabilization using the Sauvé-Kapandji method which, in light of the results obtained in this series, can regularly provide good pain relief and good functional results when associated with tendon repair as needed and as early as possible.

Aged↗
PubMed2002

[Hazards of radio frequency magnetic field and their prevention and control].

The paper briefs the sources of radio frequency (RF) electromagnetic field, their hazards to human health and the hygienic standards of RF electro-magnetic field for occupational exposure and for general population exposure. Based on the physical properties of RF electromagnetic field, the author put forward the comprehensive measures for controlling the electromagnetic radiation to meet the hygienic standards. These measures are improvement of the technology to lower the intensity of RF electromagnetic radiation, shielding the RF radiation sources to reduce the radio frequency levels in accessible areas, increasing the distance between the sources and human, and using personal RF protecting devices in area of high radio frequency levels, etc.. In protecting the general population from exposing to RF radiation, measures keeping a safe distance between the sources and the public play very important role, in which good city planning and the effective control of new and existing RF sources are very important. Referring to the RF electromagnetic problems by using electrical devices in the household, different measures based on the above principles for controlling RF hazards are also cited.

Cataract↗
PubMed2002

[Lesions of the distal radio-ulnar joint associated with isolated fractures of the radial shaft].

The authors have performed a retrospective study of 49 Galeazzi fractures treated between 1990 and 1998. This lesion is considered rare because it is often misdiagnosed as an isolated fracture of the radius. The mean age of the patients was 31 years. There was a male predominance with a sex ratio of 4/1. Road traffic accidents were the main etiology (45%). Galeazzi fracture type III in Mansat's classification represented 53%, followed by type II (33%), type I (8%) and equivalents of Galeazzi fracture (6%). The treatment was surgical in all cases. The radial fracture was internally fixed with a plate. Reduction of the distal radio-ulnar instability, achieved by manipulation, was maintained with radio-ulnar pin fixation in 53% and with plaster cast immobilization 45%. The results, evaluated according to Mikic's criteria were excellent in 87%. The prognosis of Galeazzi's fracture depends mainly on the initial treatment of the lesions of the distal radio-ulnar joint, which require for their diagnosis a meticulous clinical evaluation and a good radiological analysis.

Adolescent↗
PubMedDate not supplied

[In-hospital Radio-Pharmacy Unit: creation and development].

Regarding the creation of an In-Hospital Radio-Pharmacy Unit within Clínica Puerta de Hierro University Hospital, as well as the compliance with Real Decreto 479/1993 on the regulation of radio-drugs for human use, the steps to be taken to bring it service are laid out and discussed. An overall review of the differential characteristics of radio-drugs is undertaken. The adequate distribution of spaces and the Unit's functioning regulations are presented, and the responsibilities of the person in charge of the ionisation chamber are clearly placed on record. The professional responsible of the Unit should define performance and quality control protocols for each test. The responsibility for coordinating the Unit's operation is assigned to the Heads of Nuclear Medicine and Pharmacy Departments, within the Pharmacy and Therapeutics Committee and the Nuclear Medicine Quality Committee.

Drug Compounding↗
PubMed2003

[Percutaneous hepatic puncture radio frequency ablation in the treatment of hepatocellular carcinoma].

OBJECTIVE: To observe the curative effect of percutaneous radio frequency ablation (PRFA) on hepatocellular carcinoma. METHODS: Under local or epidural anaesthesia, radio frequency electrodes were percutaneously introduced with ultrasound guide into the tumor in the liver for ablation. RESULTS: Among the 96 hepatic cancer lesions in 60 patients, 41 (42.7%) with diameter < 3.5 cm were ablated by one session. The effective rate (CR + PR) was 100% (41/41) with CR 92.6% (38/41) and PR 7.3% (3/41). During the 6 - 24 month follow up of these lesions, 36 (87.8%) of these 41 patients showed no recurrence by CT or MRI. Fifty-five (57.3%) lesions with diameter 3.5 cm < or = Phi < 12 cm were ablated by two or three sessions, with CR 3.6% (2/55), PR 67.3% (37/55) and CR + PR 70.9% (39/55) by CT or MRI in 1 to 3 months after the treatment. CONCLUSION: Percutaneous radio frequency ablation is effective on liver tumor with Phi < 3.5 cm. It is partly effective on lesions with 3.5 cm < or = Phi < 12 cm.

Adult↗
PubMed1992

Radio-ulnar dissociation. A review of twenty cases.

The results of treatment were reviewed for twenty patients who had sustained concomitant injuries of the lateral compartment of the radiohumeral joint and the ipsilateral distal radio-ulnar joint. The ages of the patients ranged from eight to seventy-four years (average, thirty-five years) and the duration of follow-up ranged from four months to twenty-seven years (average, 113 months). In fifteen patients, the injury of the wrist was diagnosed after a mean delay of seven years and eleven months (range, one month to twenty-six years). In all fifteen, the radial head injury was treated by excision, either initially or after some delay. After excision of the radial head, all fifteen patients complained of severe pain at the distal radio-ulnar joint. The results, on the basis of elbow and wrist scores of fair or better without complications, were satisfactory in only three patients. In the remaining five patients, in whom the injuries of both the elbow and the wrist had been identified at the initial evaluation, the radial head was either preserved or replaced. The results, on the basis of elbow and wrist scores of fair or better, were graded as satisfactory in four of these patients. Our data show that any injury to the lateral side of the elbow should prompt a careful evaluation of the ipsilateral distal radio-ulnar joint for associated instability.

Adolescent↗
PubMed2005

[Role of an exclusive concomitant radio-chemotherapy treatment in non operable esophageal cancer: results of a 10-year experience in Antoine-Lacassagne Center].

Treatment of non operable esophageal cancer still remains debatable. To date, radio-chemotherapy treatment could be considered as a standard, offers to the patients real hope and a new area of management in this unfavourable cancer. The aim of the present study was to report retrospectively a 10 year experience in concomitant radio-chemotherapy primary treatment in non operable esophageal cancer patients in Antoine Lacassagne anti cancer Center. Between January 1989 and June 1997, 63 consecutive, previously untreated patients with squamous cell carcinoma of the esophagus and who were inoperable for various reasons were majoritably treated with cisplatin (70 mg/m2) at J1 plus 5-fluorouracil (800 mg/m2/d) from J1 to J5 every 3 weeks (78% of patients) concomitantly with external beam radiotherapy (2 types). Two other chemotherapy regimens has been also used. Seventy-five percent (47/63) of the patients received the stipuled concomitant radio-chemotherapy dose. Neutropenia in the form of WHO grade 3-4 : 27% (17/63) was observed, grade 3-4 anemia and thrombopenia in 16 (26 %) and in 9 (15%) patients, respectively, grade 3-4 emesis in 6 % (4/63), grade 3-4 mucositis in 10 % (6/63). On 47 patients with accessible responder status, 18 of them presented a complete response, 20 a partial response, 6 a stable disease and 3 a progressive disease. The median follow up was 7 years. The median overall survival was 9.6 months with 11% estimated to be alive after 5 years. Combined treatment with cisplatin 5-fluorouracil and radiotherapy for inoperable cancer of the esophageal is relatively well tolerated and reasonably efficacious in a very selected group of patients.

Adult↗
PubMed2005

[Combined radioiodine (I131) treatment and radio-guided surgery for recurrent cervical well-differentiated thyroid cancer].

Local recurrence and cervical lymph node involvement are relatively common in patients with well-differentiated thyroid carcinoma. Since these patients are young and have a good prognosis, their treatment is challenging. Therapeutic doses of radioiodine (I131) are seldom curative and include a long period of discomfort--stopping the replacement therapy. Most patients will require surgery to eradicate the recurrent disease. However, when performed, excision of all involved tissue should be complete and accomplished in a single procedure since repeated cervical surgery is technically difficult, carries a high morbidity rate and yields bad cosmetic results. This study aims to combine radioiodine (I131) treatment and radio-guided surgery to improve the completeness of surgical excision without wide resections of cervical tissues. The combined treatment protocol was described previously and includes preparation of the patient for radioiodine (I131) treatment, administration of a therapeutic dose of 3.7 GBq of radioiodine (I131) in the hypothyroid state and using the radio-activity as a marker for identifying tumor aggregates intraoperatively using a hand held gamma probe. Both patients treated show complete removal of all neoplastic foci with radioiodine uptake. Moreover, in both patients the intraoperative probe identified additional metastatic foci that were not shown by the preoperative scan. Although our experience is limited (only two patients), and a larger series with a longer follow-up period is needed, we believe radio-guided surgery for recurrent or persistent cervical well-differentiated thyroid cancer offers an important therapeutic tool.

Adult↗
PubMed2005

Radio surgery in pilonidal sinus: a new approach for the old problem.

BACKGROUND: A wide variety of approaches are employed in dealing with sacro-coccygeal pilonidal sinus disease. They range from a conservative treatment to an extensive surgical excision. However, a method of lying open sinuses is still practiced in many parts of the world due to its simplicity and favourable outcome. MATERIAL AND METHODS: This study describes a modified approach to the above procedure where a radio surgical device has been used to carry out the complete process. Twenty-one patients with chronic pilonidal sinus were treated with this technique of radio surgery. There were 11 males and 10 females. RESULTS: The mean hospital stay was 8 hrs and mean time to return to work was 7 days. Mean healing time was recorded as 71 days. One patient had a delayed wound healing due to premature approximation of the external wound, needing refashioning of the edges. No recurrence was seen at a 2-year follow-up. CONCLUSION: An ideal surgical procedure for pilonidal sinus should be one, aiming at reducing hospital stay, minimizing tissue assault, promoting early work resumption and preventing recurrence. The technique of lying open of sinus tract using radio surgery technique resulted in achieving less tissue trauma, pain and inflammation. The patients returned to their routine within a short duration of time. The results do compare with the other extensive surgical procedures in vogue.

Adolescent↗
PubMedDate not supplied

Radio-iodination of monoclonal antibody using potassium [125I]-(4-isothiocyanatobenzylammonio)-iodo-decahydro-closo-dodecaborate (iodo-DABI).

BACKGROUND: Negatively-charged polyhedral boron clusters can be easily halogenated with highly stable boron-halogen bonds and are promising in radionuclide diagnostics and cancer therapy. MATERIALS AND METHODS: The radio-iodination conditions for the closo-dodecaborate anion and for the conjugation of its labeled isothiocyanatobenzylammonio derivative to the monoclonal antibody (mAb) were optimized. RESULTS: The labeling yield was about 90% and the overall conjugation yield was 55-60%. The in vitro stability of the radio-iodinated mAb was good under physiological and non-physiological conditions. The immunoreactivity of the labeled mAb (SK-BR-3 cells) was retained in the one-pot two-step labeling. CONCLUSION: Negatively-charged polyhedral boron clusters can be used for indirect radio-iodination of mAbs.

Antibodies, Monoclonal↗
PubMed2006

[Percutaneous radio frequency thermal ablation of non-resectable lung cancer: state of the art].

BACKGROUND: Unfortunately, as of yet, most lung cancers are not operable as soon as diagnosis is available; in these situations chemo- and radio-therapy still play a key role, albeit palliative, improving survival rate moderately, but are not lacking in toxic effects, especially in case of concurrent pathology, reduced cardio-respiratory functionality or being advanced in years. Therefore thermal ablation mini-invasive techniques, already employed as ancillary treatments of hepatic cancer or in place of surgery, have been performed for these pathologies. AIM: Aim of this work is to define the current state of the art for Radio-Frequency Ablation (RFA) to be performed on non-resectable lung cancer, also by means of a thorough review of international literature, from which to infer purposes, suggestions, methodologies, effectiveness, safety, complications and achievements, also in terms of the possible improvement of life quality and/or survival expectancy. PATIENTS AND METHODS: Patients have been carefully selected. Pulmonary nodules have been treated with TC or echo-guided percutaneous thermal ablation and, afterwards, evaluated by radiological and clinical (sometimes histopathological) follow-up. RESULTS: The size of the RFA-treated nodules is necessary in order to evaluate full or partial necrosis extent and, therefore, average survival rate. CONCLUSIONS: Availability of more extensive and homogeneous case histories, as well as standard follow-up (TC and/or histopathological sampling) methodologies, is required. Nevertheless several authors agree that RFA is a safe and effective technique within the framework of a substitutive or complementary treatment of non-operable lung cancer. The best results can be achieved for cancers less than 3 cm wide; RFA, performed before chemo- and/or radio-therapy, plays a neoadjuvant role for larger cancers, decreasing cancer volume and weakening the symptoms.

Catheter Ablation↗
PubMed2006

Diagnostic validity of radio-guided sentinel node mapping for gastric cancer: a review of current status and future direction.

Diagnostic validity of sentinel node (SN) mapping has been recently introduced into the field of various solid tumors, including gastrointestinal (GI) cancer. In gastric cancer, acceptable detection rates of SNs, as well as sensitivity in detecting micrometastasis based on SN status, was reported using the dye-guided method, as well as the radio-guided method. Gastric cancer is currently one of the suitable targets of SN navigation surgery among visceral tumors. Despite the multi-directional and complicated lymphatic flow from gastric mucosa, the anatomical situation of the stomach is relatively suitable for SN mapping in comparison with organs embedded in closed spaces, such as the esophagus and rectum. In particular, clinically T1N0 gastric cancer seems to be a good entity for which to try to modify the therapeutic approach. From the data reported in the literature, micro-metastases tend to be limited within the sentinel basins in cT1N0 gastric cancer. Sentinel basins are, therefore, good targets of selective lymphadenectomy for cT1N0 gastric cancer with the potential risk of micrometastasis. Furthermore, laparoscopic local resection is theoretically feasible for curative treatment of SN negative early gastric cancer. For laparoscopic application of SN mapping of gastric cancer, a radio-guided method is essential. Although recent single institutional studies support the validity of the SN concept, a multi-centric prospective validation study based on a standardized protocol is essential for further clinical application. Currently, two major well-designed clinical trials of SN mapping for gastric cancer open surgery have been initiated in Japan. Radio-guided SN mapping for gastric cancer has a great potential to provide a new paradigm shift for surgical management of an early gastric cancer.

Forecasting↗
PubMed1990

[The lower radio-ulnar joint in malunion of the lower end of the radius: therapeutic implications].

Malunion of the lower extremity of the radius is frequently accompanied by a lesion of the inferior radio-ulnar joint marked by inversion of the inferior radio-ulnar index. Surgical treatment must always take this parameter into account and should attempt to correct it. The authors' preference in the treatment of malunion consists of Duparc osteotomy, in which the size of the graft is calculated in order to restore the inferior radio-ulnar index. If the correction is insufficient or in the case of moderate malunion, the authors propose the Kapandji-Sauvé operation which allows better preservation of the wrist stability.

Adult↗
PubMed1991

[Clinical assessment of various methods of radio-modification in radiotherapy of advanced oropharyngeal cancer].

The purpose of the study was to evaluate the effectiveness of RF-hyperthermia and regional intraarterial hyperglycemia as adjuvant radiotherapy vs conventional radiotherapy of advanced head and neck cancers. Altogether 115 patients with advanced T3-T-4 carcinoma of the tongue, oral cavity and oropharynx underwent external radiotherapy (Co-60). An RF capacitative heating device operating at 40.68 MHz was employed twice a week, a total of 4 sessions per patient. Intratumor temperature was 41.5-43 degrees C. Hyperglycemia was performed via the branches of the carotid artery, a total of 3 sessions per patient. There were 4 groups (1-31 patients on conventional radiotherapy; 2-24 patients on thermoradiotherapy; 3-30 patients on radiotherapy plus regional hyperglycemia; 4-30 patients underwent combined radio-modification). A complete response was 29% for conventional radiotherapy, 67% for thermoradiotherapy, 60% for radiotherapy plus hyperglycemia, and 77% for combined radio-modification. A 2-year local control was found to be 13% for radiotherapy, 37% for thermoradiotherapy, 17% for radiotherapy plus hyperglycemia, and 35% for combined radio-modification. Only hyperthermia was found to improve a 2-year local control of advanced oropharyngeal cancer.

Adult↗