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PubMed1977

Pituitary and ovarian response to acute stimulation with LH-RH in normal and anovulatory women.

The LH FSH estradiol and progesterone responses to acute stimulation with LH-RH were studied in 12 normal women with ovulatory cycles (4 in the initial follicular phase, 4 in the mid-follicular phase and 4 in the late follicular phase) and in two castrated women, two under hormonal contraception, two with ovarian amenorrhea, twelve with central amenorrhea of no detectable origin (6 with normal and 6 with low basal gonadotrophins), eleven anovulatory patients with pseudomenstruation, two with anorexia nervosa, and two with pituitary amenorrhea. Each woman received a rapid i.v. injection of 100 microgram synthetic LH-RH at 9:00 a.m. Serum levels of LH, FSH, estradiol and progesterone were determined by radioimmunoassay in samples collected before and 60, 120, 240 and 480 minutes after injection. The findings were : 1) A significant rise in estradiol and progesterone levels, in addition to LH and FSH elevation, in normal women; 2) A lack of ovarian steroid response in the castrated women and in ovarian amenorrheas, which suggests that the source of steroid response to stimulation is not extragonadal; 3) Significant differences in the responses of the four hormones to LH-RH in the women with central amenorrhea in comparison with the normal group with great variability of results; the steroid response in the presence of a positive LH response might correlate with the severity and/or prognosis of the disorder, a point deserving further study; 4) In anovulatory women with pseudomenstruation, LH responses for the most part normal, and particularly, progesterone responses.

Adult↗
PubMed1990

[The effect of Enzaprost-F (PGF2) cervical tablets on the corpus luteum in the human body].

Authors removed dextro-ovary of a patient having 7-9th week of gestation for ovarian cyst during abortion. Preoperative cervical dilation was performed by Enzaprost-F cervical tablet containing 20 mg PGF2 agent. Before and 2, 4 and 6 hours after treatment, serum-progesterone and 17-beta-estradiol level was determined. Drug cervical dilation enabled instrumental termination of pregnancy within 4 hours. Histological finding of yellow body showed initial signs of colloid-cystic degeneration, which was followed by minimal decrease of values of serum-steroid concentrations. Authors presume that change in histological picture of yellow body was caused by effect of cervical tablet containing PGF2 agent.

Abortion, Therapeutic↗
PubMed1978

Inhibition of ovulation in women by chronic treatment with a stimulatory LRH analogue--a new approach to birth control?

A stimulatory luteinizing hormone-releasing hormone (LRH) analogue D-Ser(TBU)6-EA10-LRH was administered subcutaneously once daily in a dose of 5 microgram to four regularly menstruating women. Treatment was instituted within the first three days of the menstrual bleeding and continued for 22--30 days. Ovulation was inhibited in all the women during the treatment cycle. The treatment resulted in disturbances in the pituitary gonadotropin secretion which presumably led to disordered follicular menuration and anovulation. The maximum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) responses to the LRH analogue were obtained during the first few days of treatment. The gonadotropin responses then rapidly decreased during the prolonged treatment. This change in the pituitary responsiveness probably prevented the release of a normal preovulatory LH surge. After the treatment, all the women resumed normal ovulatory menstrual cycles. The results suggest that it might be possible to use stimulatory LRH analogues for birth control.

Adult↗
PubMed1979

[Oestrogen therapy of osteoporosis (author's transl)].

Twenty women with physiological (11) or post-operative (9) lack of oestrogen and progesterone developed progressively painful decalcifying osteosis. Improvement was obtained (after eliminating all contra-indications) by treatment with an oestrogen (17-bêta oestradiol-14 times) associated with a progesterone (14 times ) and increased calcium and phosphates (11 times). Clinical improvement was still present after a period varying from 6 to 36 months, with disappearance of the pain symptoms in 7 cases, and very great improvement in 9 cases. After 6 months of treatment there was also a significant reduction in the biological signs of bone resorption (blood phosphorus levels, calcium-creatinine ratio in morning urine specimens taken after fasting, total calcium in a 24-hour urine specimen). The improvement noted, both clinically and biologically, confirms the effect of oestrogens in reducing bone resorption, underlines their preventive and also curative action, and makes them suitable for use in decalcifying osteosis due to hormone lack, after eliminating all contra-indications and under strict regular supervision (breasts and endometrium).

Adult↗
PubMed1979

Interactions between steroidreceptors.

Interactions between the estradiolreceptor and the progesteronereceptor are known to exist in the uterus. The "priming effect" of estradiol is likely to exist also in human and rat mammary tumors. In detecting also the progesteronereceptors along with the estrogenreceptors, one cannot only demonstrate the presence but also the activity of the estrogenreceptor. This finding should improve the response rate of hormonesensitivity to receptorpositivity. However preoperative irradiation possibly induces negative progesteronereceptortiters in human breast tumors.

Animals↗
PubMed1980

[Cellular heterogeneity of steroid reactivity in human endometrial carcinoma: an approach by an immunofluorescent steroid-antibody technique (author's transl)].

The dispersed cancer cells obtained from biopsy or surgical specimens of 12 patients with endometrial carcinoma were incubated with 5 x 10(-8) M estradiol-17 beta or progesterone in TC medium 199 containing 10% calf serum at 37 degrees C for 1 hr. The immunofluorescent steroid-antibody technique using FITC-labeled anti-rabbit IgG and steroid antibodies raised from rabbits immunized with estradiol-6-oxime-BSA and progesterone-3-oxime-BSA was applied to the smear specimens and freeze-dry sections that had been incubated with these steroids. In 6 cases, there was a mixed cell-population with or without nuclear fluorescence to estradiol and progesterone. The cellular heterogeneity with respect to nuclear fluorescence was confirmed by the immunofluorescent technique applied to the freeze-dry sections. Two cases showed weak cytoplasmic fluorescence to estradiol and progesterone, but nuclear fluorescence was negative. In 3 cases, there was no immunoreactivity to these steroids. One case exhibited the similar distributional patterns of cytoplasmic and nuclear fluorescence to those of normal endometrial cells. These results indicated that in endometrial cancer, there were some impairments of subcellular steroid dynamics in comparison with those of normal cells and that cellular heterogeneity of the steroid reactivity might exist in some cases.

Adult↗
PubMed1977

[Hormontal treatment of pre-tumorous diseases of the testis in rats].

Tumours and proliferates of the testes from spermatogenic epithelium were treated with estrogens, and those from the interstitial cells-with androgens and 17-hydrosyprogesterone caproate. Depression of the folliculo-stimulating function of the pituitary body with a simultaneous stimulation of the luteinizing hormones (LH) production under the effect of estrogen led to cessation of teratoma and seminoma growth, and to the resolution of the proliferates. When androgens or 17-hydroxyprogesterone caproate were used, depression of the LH led to cessation of the tumour growth, and to the resolution of proliferion of proliferates from the interstitial cells.

Animals↗
PubMed1978

[The hormonal basis of discontinuous progestational contraception (author's transl)].

This study reports the changes in the principal biological parameters seen during the human menstrual cycle (plasma FSH and LH gonadotrophins, oestradiol and progesterone) and provoked by the discontinuous administration of a progestational agent. Fourteen women aged from 25 to 40 years, volunteers, received this treatment. In 9 women, 10 mg of lynoestrenol were administered from the 10th to the 25th day of the cycle. In 5 others, the progestational agent was given at the same dose from the 5th to the 25th day of the cycle. In all cases, there was a rapid and durable fall in gonadotrophins and ovarian steroids in the plasma. These results suggest a marked antigondadotrophic effect of the progestational agent used, which would provide effective contraception. The possibilities offered in the area of human contraception by the dicontinuous administration of progestational agents are discussed in relation with the indications of these substances, in particular during the premenopausal phase and in cases of luteal progesterone insufficiency.

Adult↗
PubMed1977

The interaction of clomiphene, estradiol, and progesterone in the control of rat uterine glycogen metabolism.

Uterine glycogen accumulation was studied in ovariectomized rats treated with all combinations of clomiphene citrate (0.25 mg/kg) estradiol (1.0 micron g) and progesterone (5.0 mg). The rats were given three consecutive daily dosages and killed 24 hours after the final dosage. Based on biochemical data, either estradiol or clomiphene increased uterine glycogen concentration and total glycogen, but progesterone did not. Progesterone significantly suppressed both the estradiol and clomiphene-induced glycogen increases. Based on the histochemical results, progesterone also suppressed the estradiol and clomiphene-induced glycogen responses, but the tissue affected differed. Clomiphene markedly increased luminal epithelial glycogen whereas estradiol induced primarily myometrial glycogenesis. Progesterone completely suppressed the clomiphene-induced epithelial effect and partially suppressed the estradiol-induced myometrial effect. Clomiphene also suppressed the estradiol-induced myometrial response. The results indicate that progesterone does have a significant interaction with clomiphene in the control of uterine morphology and biochemistry. The results also stress the importance of correlated histochemical and biochemical studies in the study of clomiphene-induced uterine glycognesis.

Animals↗
PubMed1976

[A progesterone-dependent pheromone of the female mouse (author's transl)].

Female mice kept in groups exhibit less oestrous smears than females kept singly. Ovariectomized females have only slightly reduced number of oestrous smears, but ovariectomized females injected with progesterone act on other females like intact ones. It is concluded that a progesterone-dependent pheromone excreted by dioestrous females acts oestrus-depressing on other females.

Animals↗
PubMed1986

A biological marker, strongly associated with early oral contraceptive use, for the selection of a high risk group for premenopausal breast cancer.

In a population-based group of women, consecutively diagnosed, with premenopausal breast cancer there was a significant correlation between tumour size and plasma prolactin (r = 0.30; P less than 0.004). The concentration of estrogen receptor was negatively correlated to tumour size (r = 0.17; P less than 0.09). There were no substantial correlations between tumour size and progesterone receptor, plasma progesterone or estradiol. Adjustments for menstrual cycle day and age did not alter the above findings. The ratio of plasma prolactin and estrogen receptor was significantly greater (P less than 0.037) for the group of the patients that had started using oral contraceptives before the age of 20 as compared with the other patients. Consequently, the tumour size was significantly greater in the group of early users (P less than 0.003). The findings indicate that breast tumours developing in previous early users of oral contraceptives have a low estrogen receptor concentration, while these patients have higher plasma prolactin. The tumour size is greater in early users indicating a poorer prognosis than other women with breast cancer. As early use of oral contraceptives increases breast cancer risk and a high ratio of plasma prolactin and estrogen receptor concentration of the primary tumour characterize early oral contraceptive users the ratio may be a valuable marker for the breast cancer risk.

Adult↗
PubMed1977

Effects of progesterone on some enzymes of fat and carbohydrate metabolism in rat liver.

The known effect of progesterone on carbohydrate metabolism prompted a study of some of the hepatic "lipogenic" and "gluconeogenic" enzymes in rats treated with progesterone. Several enzymes providing lipid precursors (phosphofructokinase, malic enzyme, glucose-6-phosphate dehydrogenase, and citrate cleavage enzyme) showed increased specific activity. These changes may represent insulin effects. Specific activity of phosphoenolpyruvate carboxykinase, usually associated with control of gluconeogenesis, was also increased. The latter is compatible with increased capability for glycogenesis, which is recognized as a progesterone effect.

ATP Citrate (pro-S)-Lyase↗