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Needle biopsy of the pleura in the diagnosis of pleural effusion.

Needle biopsy of the parietal pleura was undertaken in 64 patients with undiagnosed pleural effusion. An adequate specimen was obtained in 96% of procedures. This was diagnostic in 45% of those due to malignancy and in 50% of those due to tuberculosis. A second biopsy improved the combined diagnostic yield in these two diseases from 32% to 46%. Pleural fluid cytology was unhelpful in establishing the presence of a malignancy, and culture of the biopsy specimen was helpful in one case.

Adult↗

Radiology of the pleura.

Radiologic imaging of the pleura has undergone dramatic changes in the past 5 years. This can be primarily attributed to the availability and better understanding of computed tomography and, to a lesser extent, ultrasonography. When used in the proper clinical-radiologic environment, abnormalities of the pleural space can be quickly identified, localized, and often diagnosed in a rapid efficient manner.

Adult↗

Fine needle aspiration biopsy of the thoracic cage including the pleura--clinical value.

In a series comprising 122 patients with a lesion localized to the thoracic cage or pleura the value of fine needle aspiration biopsy has been analyzed. In 53 patients the cytological reports were decisive for further clinical evaluation and management. Two false negative reports were recorded. No complications occurred. Fine needle aspiration biopsy is recommended as first diagnostic step since it is well tolerated by the patients, without complication and has a fair diagnostic safety.

Biopsy, Needle↗

[Selection of a method and surgical tactics in late repeated operations on the lungs and pleura].

The experience with the surgical treatment of 97 patients subjected to late repeated operations on the lungs and pleura is generalized in this work. 68% of these patients had pleural empyema and bronchial fistulae. The authors prefer the radical surgery to pulmonectomy, pleuropulmonectomy, decortication, lung resection and repeated amputation of the main bronchus. Fatality in the late repeated operations was noted in 3.09% of cases and complications--in 10.3%.

Aged↗

Needle biopsy of the pleura in Nigeria.

The results of needle biopsy of the pleura carried out on 200 patients are presented. Biopsy was diagnostic in 60% of tuberculous pleural effusions and in 74% of cases of malignant effusions. The histological appearance of chronic fibrosis was seen in 34%, of which half were subsequently found to have tuberculosis.

Adolescent↗

[Construction of the microcirculatory bed of the parietal layers of the pleura and peritoneum in newborns].

Structural organization of the microcirculatory bed of the newborn parietal layers in pleura and peritoneum is described as a morphofunctional single whole. Pecularities in the bed construction revealed characterize it as a certain stage in the process of its formation and development. Elucidation of these peculiarities may help to better understanding of disturbances in microcirculatory hemodynamics and tissue metabolism in the newborns and fetuses.

Humans↗

[State of the vascular bed of the lungs and pleura in congenital heart defects with hypovolemia of the lesser circulation].

The status of the vessel bed of the lungs and pleura in congenital heart diseases with hypovolemia of the pulmonary circulation was studied. Morphological manifestations of adaptative changes in the vessels of microcirculation of these organs were found. The importance of the discovered changes in the maintenance of hemodynamic homeostasis under conditions of deficiency of blood inflow into the pulmonary artery is demonstrated.

Animals↗

Localized mesothelioma of the pleura: benign and malignant variants.

Mesothelioma, even of the pleura alone, is a ubiquitous pathological designation. The diffuse variety is associated with an ominous prognosis. The localized mesothelioma generally has been assumed to be benign. A review of tumors from 60 patients with localized pleural mesothelioma seems to justify separation into benign (52 patients) and malignant (eight patients) variants. Histologic criteria are used primarily to make this division. No single clinical feature allowed preoperative predictability concerning benignity or malignancy, although extrathoracic osteoarthropathy was seen only with benign lesions (20 percent), usually those greater than 7 cm. Follow-up periods of as long as 24 years revealed recurrent tumor in only two of the 58 patients with benign lesions and revealed a survival curve identical to that of the general population. All of the patients with the malignant variety had recurrence or metastasis, and all but one were dead within 2 years of the initial operation. One patient died of tumor complications after 9 years. More aggressive local resection is indicated for the malignant variant.

Adult↗

[Changes in the lungs and pleura during infection with Serratia marcescens].

Morphological changes predominantly in the lungs in two infants and a fetus when Serratia marcescens and simultaneously other gram-negative microorganisms were isolated from tissues are described. The localization of the process and the detection of the microorganisms are demonstrated. The presence of fields of hemolysed blood in alveoli, infiltration with predominance of plasma cells and macrophages in the periphery of the focus may be used as the basis for diagnosis. Contact microscopy detects microorganisms on the surface of the pleura more readily than in the lung tissues.

Enterobacteriaceae Infections↗

[Radiological technics in the study of the pleura and the chest wall].

Authors examine the most actual radiologic techniques for the investigation of pleura and chest wall. Advantages of decubitus views in the study of effusion are considered; diagnostic possibilities of echography and CT in the evaluation of abnormal findings in these regions are analyzed.

Bronchography↗

[Sarcoidosis of the parietal pleura--a contribution to the pathogenesis of intrathoracic sarcoidosis].

Sarcoidosis is a frequent systemic disease with various appearances and unknown etiology. The diagnosis of intrathoracical sarcoidosis can be made with considerable accuracy by means of X-rays and endoscopic and bioptic methods. In the international literature there exist very great differences concerning the pleural involvement in sarcoidosis. Potential causes and hypotheses of the modality of the involvement of the parietal pleura with noncaseating epitheloid granulomas are discussed.

Biopsy↗

Culture procedure of mesothelial cells from the rat parietal pleura.

Cultures were made of mesothelial cells obtained by scraping the parietal pleura of the adult rats. The growth was restricted to close polyhedric epithelial-like cells, forming a monolayer. The cellular proliferation continued until the 7th day, followed by a stationary phases. In subcultures the mesothelial cells kept their epithelial type. The cultures were stopped on the 20th day.

Animals↗

[Results of needle-biopsy of the pleura (author's transl)].

The technique of needle-biopsy of the pleura started with the Vim-Silvermann needle (often inadequate) and has now spread generally with the greater use of the Harefield-Abrams needle. The overall percentagetrue positive results (tuberculosis, cancer) has, over time, slowly fallen, because of the fall in the number of tuberculous cases and an increase in biopsies with insufficient material (T 1 1964 : 45%, T 2 1979 : 26,5%). In our third study (T 3), we studied in 150 cases selected at random out of the 628 cases studied in T 2. We compared our percentage true positive results with those obtained in T1 (number of biopsies positive for tuberculosis (TB) or cancer (CA) compared with the number of patients suffering from tuberculosis or cancer]. These figures, for percentage true positive results, was 90% for TB 62% for cancer in T 1, and fell to 87% for TB and 53% for cancer in T 3. There were no false positive results. The diagnosis of tuberculosis can, in general, be made with a single biopsy. Diagnosis of cancer requires repeated biopsies. Association of cytology increased the results to 70% (T 1 and T 3). Looking for the tuberculous bacillus from the biopsy material was rewarded in 33 % (T 3). Histological diagnoses of non-specific conditions was possible in 30 % of biopsies, which gave true non-specific results. The technical reliability in T 1 (95% with 4 individuals who carried out the biopsies) fell to 85% in T 3 (57 individuals). This fall was studied and could be explained by: 1) insufficiently repeated biopsies; 2) too great a number of individuals carrying out the biopsies (T 3 : 51 inexperienced individuals out of 57), with numerous cases of insufficient material; 3) the ratio "useful fragments/total fragments", was far too low. This relationship between useful fragments and total fragments is statistically (p less than 0.05) correlated with the experience of the doctor carrying out the procedure. The optimal number of fragments per biopsy is between 2 and 3 : a number greater than this does not improve the results. The later degradation in the diagnostic value of the biopsy by the histologist should be examined : the biopsy should be carried out by an experienced individual, and the biopsy should be read by an experienced histologist. The histologist should be exigent in his requirements, from the doctor carrying out the biopsy, and he should examine all the material brought up in the biopsy.

Adolescent↗

Complications associated with covering the bronchial stump with pleura.

Coverage of the bronchial stump with parietal pleura generally should be performed after pulmonary resection. We describe four patients who underwent coverage of the bronchial stump of the right upper lobe with a laterally based parietal pleural flap. The flap eventually caused distortion and collapse of the right intermediate bronchus, necessitating reoperation in three patients. This complication can be avoided.

Aged↗

[State of the microcirculatory bed of the visceral pleura in focal forms of pulmonary tuberculosis].

The microcirculatory bed (MCB) of visceral pleura (19 resected lungs) in focal forms of tuberculosis was studied. MCB changes were of systemic character and were more pronounced in the postcapillary-venular link. The causes of the development of the observed structural-functional changes in MCB include tuberculosis as an inflamation of the immune nature, the possibility of tissue manifestations of therapy pathology, and the influence of stress operation situation. Venulites are first described as a manifestation of immunopathological reaction in focal pulmonary tuberculosis. Irreversible MCB changes in focal forms of tuberculosis, despite the limited pulmonary process and clinical lack of functional changes in the respiratory and cardiovascular system of the patients, are an additional proof in favor of the necessity of early etiotropic therapy and may be used as a prognostic sign in morphological examinations of the operation material.

Adolescent↗

[Correlated multiple parameters in pleural effusion with pathology of pleurae for differential diagnosis of tuberculous and carcinomatous pleuritis].

The level of ADA, LZM, leukocyte count, lymphocyte in tuberculous effusion is higher than that of carcinomatous effusion (P < 0.05). All results showed that the change of multiple parameters is related to the pathological manifestation of pleurae. The false positive or negative result was influenced by pathological appearance and bloody character of pleural effusion. Using the ADA, LZM cut off value at 35U and 30mg, respectively, and pleural/serum ADA ratio > 1.4, LZM > 1.1, a sensitivity and specificity of 100 percent were achieved.

Adenosine Deaminase↗