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PubMed2005

[Periodontal disease among patients with acute coronary syndrome].

BACKGROUND: Epidemiological studies suggest an association between periodontal disease and coronary heart disease. It is possible that periodontal disease may contribute to plaque destabilization in patients with acute coronary syndrome. AIM: To assess the association between severity of periodontal disease, the number of acute plaques and extension of coronary artery disease in patients with acute coronary syndrome. PATIENTS AND METHODS: The severity of periodontal disease was assessed by skilled independent observers in patients with acute coronary syndrome subjected to coronary angiography. The periodental disease was classified as mild or severe. Acute plaques were defined on angiography as those with thrombi, ulcers or flow alterations. The extension of coronary disease was analyzed using the Sullivan score. RESULTS: Forty three patients (35 males) aged 41 to 83 years, were studied. Mild and severe periodontal disease was present in 18 (42%) and 25 (58%) patients respectively. Seventy six percent of those with severe disease had two or more acute plaques, compared with 17% of those with mild disease (p<0.001). Median Sullivan score was 80.6 and 57.2 in patients with severe or mild periodontal disease respectively (p=0.001). CONCLUSIONS: Severe periodontal disease was associated with a higher number of acute coronary plasques and a higher extension of coronary artery disease, in patients with acute coronary syndromes.

Acute Disease↗
PubMed2002

The effect of shared genetic and environmental factors on periodontal disease parameters in untreated adult siblings in Guatemala.

BACKGROUND: Increasing evidence supports the role of genetic factors in susceptibility to infectious diseases, including chronic periodontitis. The role of genetic factors in phenotypic expression can be estimated from the degree of resemblance between relatives, as compared with that of unrelated members of a population. Heritability is an estimate of the proportion of total phenotypic variation of a quantitative trait, which is attributable to genetic factors, and is based on the variance within versus between family members. The aim of this study was to determine whether there is a familial basis for periodontal disease status in an untreated population in Guatemala using heritability estimates as a measure of familial clustering of disease. METHODS: One-hundred and thirteen adult subjects (including both siblings and spouse pairs), age range 35 to 60 years, participated in this study. Full-mouth periodontal examinations were performed and heritability estimates were calculated for mean plaque score, mean gingival index (GI), probing depth (PD), and clinical attachment level (CAL). Intraclass correlation coefficients (ICCs) were calculated using the same parameters for spouses to determine whether a common family environment in adulthood plays a role in disease expression. RESULTS: Only in the case of mean plaque score and mean recession score were heritability estimates significantly above zero at alpha = 0.05. For spouse pairs, mean GI score, mean PD, and percentage of sites of PD > or = 5 mm showed a statistically significant ICC. CONCLUSIONS: These results lead us to reject the hypothesis that there is substantial heritability for periodontal disease expression in this population. This may be due to an underlying lack of genetic variation within this sample or may indicate that, compared with the role of environmental factors, the genetic contribution to periodontal disease phenotypes is relatively minor.

Adult↗
PubMedDate not supplied

[Prevalence and risk factors for periodontal disease among preschool children in Mexico City].

UNLABELLED: Periodontal disease is one of the most frequent oral cavity diseases. Its main characteristic among pediatric patients is gingivitis. The aim of the present study was to determine the prevalence and severity of periodontal disease among preschool children living in an eastern suburb of Mexico City. STUDY DESIGN: We carried out a descriptive/observational study of 382 school age children. The following indexes were administered: IHOS, IPMA and IP. Risk factors for periodontal disease were analyzed. RESULTS: 70% of the children studied had periodontal disease. The index averages were: IHOS of 1.38+0.51; IPMA of 0.62+0.72 and IP of 0.51+0.42. Cervical cavities, restorations with cervical interference and eruption-exfoliation processes were associated with periodontal disease. Mild chronic gingivitis was the most prevalent. We must strengthen preventive programs aimed at improving oral health, hygienic and dietary habits among preschool children in Mexico.

Child↗
PubMed2005

[Periodontal diseases, tobacco and pregnancy].

This review summarizes the impact of tobacco on the periodontium of pregnant women and the effects of periodontal diseases combined with tobacco on the pregnancy. Periodontal diseases (gingivitis and periodontitis) are gram-negative anaerobic infections. Smokers are 2-7 times more likely to develop periodontal disease than non-smokers. Tobacco, an environmental factor, undermines the host response and may facilitate the development and progression of periodontal disease. Recent epidemiological studies suggest that maternal periodontal diseases would be a risk factor of pre-term deliveries or pre-term low birth weight (PLBW). Cigarette smoking during pregnancy leads to peri-natal morbidity and mortality and it is associated with reduced birth-weight. Tobacco during pregnancy also amplifies the risk of PLBW directly and via periodontal diseases. This article highlights the etio-pathogenic interrelations between periodontal diseases and tobacco as risk factors of PLBW. The blood dissemination of periodontal bacteria and the effects of cytokines like TNF-alpha, Il-1, produced during periodontal infections could explain these obstetrical adverse events. The concept of diagnosing and treating a periodontal disease in a pregnant woman to minimizes the deleterious effects of this infection on systemic conditions represents an unprecedented challenge. Moreover, periodontist have the opportunity to take part in smoking cessation program for pregnant women.

Female↗
PubMedDate not supplied

Diagnosis of periodontal diseases--changing concepts. A challenge for the future.

Periodontal research conducted over the last ten years has dramatically changed concepts relating to the assessment and diagnosis of periodontal diseases. These concepts have challenged the clinician to discard long accepted theories regarding the diagnosis and progression of periodontal disease transforming this area into a critical and important aspect of current periodontal research. Currently accepted theories regarding the progression of human periodontal disease (gingivitis and adult periodontitis), will be briefly reviewed, and current and potential new techniques for diagnosing periodontal disease activity will be discussed.

Diagnosis, Oral↗
PubMed1989

Dental patients' knowledge and beliefs about periodontal disease.

The knowledge and beliefs about periodontal disease of 1093 regularly attending patients in 36 North Carolina general dental practices were examined. Patients had a strong positive orientation toward keeping their teeth. Correct information concerning the signs, causes, prevention, and treatment of periodontal disease was widely held. Older patients were more knowledgeable about treatment and signs of periodontal disease, while younger patients expressed more positive beliefs about keeping their teeth for a lifetime. Although patients' knowledge was not perfect, it included few misperceptions that could threaten oral health. Additional education was most needed with respect to the significance of bleeding gums.

Adult↗
PubMed2000

Periodontal disease in American Indians and Alaska Natives.

OBJECTIVE: The primary purpose of this paper is to provide information on the periodontal disease status of Native Americans using a variety of data sources. The impact of periodontal disease on the provision of dental care within the Indian Health Service (IHS) is also discussed. METHODS: Four data sources were used to evaluate the periodontal disease status of Native Americans: IHS periodontal disease monitoring system (1962-78), 1984 IHS Patient Oral Health Survey, 1990 WHO community-based survey (ICS-II), and the 1991 IHS Patient Oral Health Survey. RESULTS: There appears to be a trend toward a higher prevalence of incipient and overt periodontal disease among Native Americans over time. The prevalence of overt periodontal disease (periodontal pockets > 5.5 mm) is higher among Native American diabetic patients than nondiabetic patients (34% vs 19%). CONCLUSIONS: Due to the variety of indices used by the IHS during the last 20 years, it is difficult to make direct comparisons of the available periodontal disease data. However, it appears that the prevalence of periodontal disease among Native Americans is increasing. Type II diabetes accounts for significant increases in periodontal disease and tooth loss in Native American populations. Certain forms of early onset periodontal disease also may pose significant threats to the oral health of Native Americans.

Adult↗
PubMed1998

Awareness of periodontal disease--the role of industry.

Recently periodontal treatments have been performed intensively in daily clinical work and the definitive approach to periodontal therapy has been established in various types of periodontal diseases. It is no exaggeration to say that this is impossible without the co-operation of the dental industry. Furthermore, industry has also contributed greatly to the improvement of the 'quality of life', concerning masticatory function in the elderly. Both the progression of dental devices and the development of diagnostic methods have been considered to be the primary prerequisite for success in treatment and in the prevention of recurrence of the periodontal diseases. It is necessary that dental devices and medications for treatment should be developed corresponding to the advanced scientific evaluation of periodontal disease. This paper reviews our present knowledge about the role or contribution of industry to periodontology in terms of periodontal health care products, diagnostic kits, and therapeutic drugs.

Aged↗
PubMed2000

Dietary vitamin C and the risk for periodontal disease.

BACKGROUND: Vitamin C has long been a candidate for modulating periodontal disease. Studies of scorbutic gingivitis and the effects of vitamin C on extracellular matrix and immunologic and inflammatory responses provide a rationale for hypothesizing that vitamin C is a risk factor for periodontal disease. METHODS: We evaluated the role of dietary vitamin C as a contributing risk factor for periodontal disease utilizing the Third National Health and Nutrition Examination Survey (NHANES III) which is representative of the U.S. civilian, non-institutionalized population. RESULTS: A sample of 12,419 adults (20 to 90+ years of age), with dental measurements and assessment of dietary information as well as demographic and medical histories were included in the studies. Dietary vitamin C was estimated by a 24-hour dietary record. Individuals with periodontal disease were arbitrarily defined as those who had mean clinical attachment levels of > or =1.5 mm. Using multiple logistic regression analysis, we found a relationship between reduced dietary vitamin C and increased risk for periodontal disease for the overall population (odds ratio [OR] = 1.19; 95% CI: 1.05 to 1.33). Current and former tobacco users who were taking less dietary vitamin C showed an increased risk of periodontal disease with OR of 1.28, 95% CI: 1.04 to 1.59 for former smokers, and an OR of 1.21, 95% CI: 1.02 to 1.43 for current tobacco users. There was a dose-response relationship between the levels of dietary vitamin C and periodontal disease with an OR of 1.30 for those taking 0 to 29 mg of vitamin C per day, to 1.16 for those taking 100 to 179 mg of vitamin C per day as compared to those taking 180 mg or more of vitamin C per day. CONCLUSION: Dietary intake of vitamin C showed a weak, but statistically significant, relationship to periodontal disease in current and former smokers as measured by clinical attachment. Those taking the lowest levels of vitamin C, and who also smoke, are likely to show the greatest clinical effect on the periodontal tissues.

Adult↗
PubMed2003

The influence of diet consistence, drinking water and bedding on periodontal disease in Sprague-Dawley rats.

BACKGROUND: Although rats have been extensively used in periodontal research, pre-experimental periodontal inspection has not been given high priority in previous studies of experimental periodontal disease in rats. An inspection of 50 Sprague-Dawley rats, which were to be used in a model of experimental periodontal disease, revealed signs of periodontal disease in a considerable proportion of the animals. OBJECTIVES: The objectives of the present study were to describe disease progression, identify factors responsible for induction of periodontal disease and test a method for breeding of healthy rats. METHODS AND RESULTS: A longitudinal study revealed that 33% of rats, bred under the same conditions, showed signs of periodontal disease during, or shortly after, eruption of the molars. Regular diet caused significantly more horizontal bone loss (P = 0.0001) and significantly less periodontal bone support (P < 0.0001) than the same kind of diet with a smaller grain size. Wood chip bedding in the rats' cages significantly reduced periodontal bone support (P < 0.0001) compared to a wire mesh floor and a simultaneous use of regular diet and bedding decreased it even further (P = 0.0023). Finally, by using finely milled diet, a wire mesh floor and tap water, instead of conventional breeding methods of regular diet, bedding and acidic water, it was possible to breed rats with minimal signs of periodontal disease. CONCLUSIONS: The results of the present study emphasize the need for pre- experimental examination of rats. They also show that diet and bedding conditions have the potential of seriously influencing outcomes of studies of periodontal disease in rats.

Alveolar Bone Loss↗
PubMed2006

Antimicrobial mouthrinses and the management of periodontal diseases. Introduction to the supplement.

BACKGROUND: Periodontal diseases are complex disorders that have been associated with multiple risk factors. These disorders are triggered by the accumulation of dental plaque, and the clinical signs are caused by the resultant inflammatory and immune responses. Tissue destruction that defines periodontitis has been linked to excessive production of proinflammatory molecules including matrix metalloproteinases, interleukin-1 beta and prostaglandin E(2). Important risk factors for periodontitis can be grouped into four categories: microbial, systemic, behavioral and local. These risk factors can be considered modifiable or unmodifiable. Controlling risk factors is important in the management of chronic diseases and is a valid strategy for controlling periodontal diseases. Limiting the accumulation of dental plaque is an important part of controlling the development and progression of periodontal diseases. By adhering to a daily oral hygiene regimen that includes brushing, flossing and rinsing, patients play an essential role in disease management. CONCLUSION: Patients play an important role in controlling the oral microbial biofilm that is essential to the initiation, development and progression of periodontal diseases. A daily oral hygiene regimen that includes the use of an antimicrobial mouthrinse can modify patients' microbial risk of developing periodontal disease. CLINICAL IMPLICATIONS: Patients can help reduce their risk of developing periodontal disease by controlling the accumulation of plaque. This can be accomplished, in part, by adhering to a daily oral hygiene regimen that includes brushing, flossing and using an antimicrobial mouthrinse.

Antimitotic Agents↗
PubMed1997

Occurrence of invading bacteria in radicular dentin of periodontally diseased teeth: microbiological findings.

Bacterial invasion in roots of periodontally diseased teeth, which has been recently documented using cultural and microscopic techniques, may be important in the pathogenesis of periodontal disease. The purpose of this investigation was to determine the occurrence and the species of invading bacteria in radicular dentin of periodontally diseased teeth. Samples were taken from the middle layer of radicular dentin of 26 periodontally diseased teeth. 14 healthy teeth were used as controls. Dentin samples were cultured anaerobically. The chosen methodology allowed the determination of the numbers of bacteria present in both deeper and outer part of dentinal tubules, and the bacterial concentration in dentin samples, expressed as colony forming units per mg of tissue (CFU/mg). Invading bacteria was detected in 14 (53.8%) samples from periodontally diseased teeth. The bacterial concentration ranged from 831.84 to 11971.3 CFU/mg (mean+/-standard deviation: 3043.15+/-2763.13). Micro-organisms identified included putative periodontal pathogens such as Prevotella intermedia, Porphyromonas gingivalis, Fusobacterium nucleatum, Bacteroides forsythus, Peptostreptococcus micros and Streptococcus intermedius. These findings suggest that radicular dentin could act as bacterial reservoir from which periodontal pathogens can recolonize treated periodontal pockets, contributing to the failure of therapy and recurrence of disease.

Adult↗
PubMed2003

Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease. A systematic review.

BACKGROUND: Several recent studies provide evidence that the oral cavity may influence the initiation and/or the progression of lung diseases such as pneumonia and chronic obstructive pulmonary disease (COPD). RATIONALE: Studies have shown that poor oral hygiene and periodontal disease may foster colonization of the oropharyngeal region by respiratory pathogens, particularly in hospital or nursing home patients. If aspirated, these pathogens can cause pneumonia, one of the most common respiratory infections, especially in institutionalized subjects. Other cross-sectional epidemiologic studies point to an association between periodontal disease and COPD. This systematic review examines the literature to determine if interventions that improve oral hygiene reduce the rate of pneumonia in high-risk populations. FOCUSED QUESTION: Do periodontal diseases or other indicators of poor oral health influence the initiation/progression of pneumonia or other lung diseases? SEARCH PROTOCOL: MEDLINE, pre-MEDLINE, MEDLINE Daily Update, and the Cochrane Controlled Trials Register were searched to identify published studies that related variables associated with pneumonia and other lung disease to periodontal disease. Searches were performed for articles published in English from 1966 through March 2002. INCLUSION CRITERIA: Randomized controlled clinical trials (RCTs), longitudinal, cohort, and case-control studies were included. Study populations included patients with any form of pneumonia or chronic obstructive pulmonary disease (COPD) and periodontal disease, as measured by assessments of gingival inflammation, probing depth, clinical attachment level, and/or radiographic bone loss, or oral hygiene indices. EXCLUSION CRITERIA: Limited to studies of humans. DATA COLLECTION AND ANALYSIS: The summary statistics used to analyze the RCTs included weighted mean differences in rates of disease between control and intervention groups. For cohort studies that measured differences in rates of disease between groups with and without oral disease, weighted mean differences, relative risks, or odds ratios were compared. A meta-analysis was performed on the 5 intervention studies to determine the relationship between oral hygiene intervention and rate of pneumonia in institutionalized patients. MAIN RESULTS: Of the initial 1,688 studies identified, 36 satisfied all inclusion criteria and were read. Of these, 21 (11 case-control and cohort studies [study population 1,413] and 9 RCTs [study population 1,759]) were included in the analysis. 1. A variety of oral interventions improving oral hygiene through mechanical and/or topical chemical disinfection or antibiotics reduced the incidence of nosocomial pneumonia by an average of 40%. 2. Several studies demonstrated a potential association between periodontal disease and COPD. REVIEWERS' CONCLUSIONS: 1. Oral colonization by respiratory pathogens, fostered by poor oral hygiene and periodontal diseases, appears to be associated with nosocomial pneumonia. 2. Additional large-scale RCTs are warranted to provide the medical community with further evidence to institute effective oral hygiene procedures in high-risk patients to prevent nosocomial pneumonia. 3. The results associating periodontal disease and COPD are preliminary and large-scale longitudinal and epidemiologic and RCTs are needed.

Consensus↗
PubMed1978

[Diagnostic criteria of periodontal diseases].

The designation of a periodontal disease and its classification do not permit to draw conclusions as to its targeted therapy. Since the parameters needed for the diagnosis of periodontal diseases are very numerous, they should be reduced by a problem-oriented diagnosis which corresponds to the aims and objectives (treatment plan, course of the disease, assessment of the therapeutical success). The parameters to be determined should be of sufficient validity. Only such parameters should be included in a problem-oriented diagnostic chart. The parameters for indices should be selected according to this principle. The selection of the indices requires co-ordination, at which the respective objective of the examination must be considered.

Dental Records↗
PubMed1990

Type 2 diabetes mellitus and periodontal disease.

The relationship between type 2 diabetes mellitus and periodontal disease was evaluated in 2,878 Pima Indians of the southwestern United States. Two independent measures of periodontal disease, probing attachment loss and radiographic bone loss, were used to compare prevalence and severity of periodontal disease in diabetic and nondiabetic subjects. In all age groups studied, subjects with diabetes had a higher prevalence of periodontal disease, indicating that diabetes may be a risk factor for periodontal disease.

Adolescent↗
PubMed1986

Caries, oral hygiene and periodontal disease in handicapped adults.

Caries, periodontal disease, oral hygiene and treatment needs were assessed in a group of handicapped adults. The study group comprised 199 individuals aged 17-64 yr, most of whom were mentally subnormal. The mean DMFT values ranged from 17.4 in the 17-24-yr-old age group to 26.9 in the 55-64-yr-old age group. Tooth loss increased rapidly with advancing age. In all age groups the F component was less than 20% and high numbers of untreated carious lesions were found. Of the group studied, 90% needed some conservative treatment. Oral hygiene was poor and a high prevalence of periodontal disease was found. Of the dentulous persons, 49% needed scaling and 34% complex periodontal treatment. The percentage of study group patients requiring dental treatment was very high, so that it can be concluded that dental care for the handicapped is insufficient. This situation must be improved and a suitable system for the delivery of preventive measures must be devised for this group of the population.

Adolescent↗
PubMed2003

Maternal periodontal disease is associated with an increased risk for preeclampsia.

OBJECTIVE: To determine if maternal periodontal disease is associated with the development of preeclampsia. METHODS: A cohort of 1,115 healthy pregnant women were enrolled at less than 26 weeks' gestation and followed until delivery. Maternal demographic and medical data were collected. Periodontal examinations were performed at enrollment and within 48 hours of delivery to determine the presence of severe periodontal disease or periodontal disease progression. Preeclampsia was defined as blood pressure greater than 140/90 on two separate occasions, and at least 1+ proteinuria on catheterized urine specimen. The potential effects of maternal age, race, smoking, gestational age at delivery, and insurance status were analyzed, and adjusted odds ratios for preeclampsia were calculated using multivariable logistic regression. RESULTS: During the study period, 763 women delivered live infants and had data available for analysis. Thirty-nine women had preeclampsia. Women were at higher risk for preeclampsia if they had severe periodontal disease at delivery (adjusted odds ratio 2.4, 95% confidence interval 1.1, 5.3), or if they had periodontal disease progression during pregnancy (adjusted odds ratio 2.1, 95% confidence interval 1.0, 4.4). CONCLUSION: After adjusting for other risk factors, active maternal periodontal disease during pregnancy is associated with an increased risk for the development of preeclampsia.

Adolescent↗