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PubMed2002

Development of U.S.-Russian medical support procedures for long-duration spaceflight: the NASA-Mir experience.

As the Russian Space Agency and the U.S. National Aeronautics and Space Administration began in the mid-1990s to plan a preliminary cooperative flight program in anticipation of the International Space Station, programmatic and philosophical differences became apparent in the technical and medical approaches of the two agencies. This paper briefly describes some of these differences and the process by which the two sides resolved differences in their approaches to the medical selection and certification of NASA-Mir crewmembers. These negotiations formed the basis for developing policies on other aspects of the medical support function for international missions, including crew training, preflight and postflight data collection, and rehabilitation protocols. The experience gained through this cooperative effort has been invaluable for developing medical care capabilities for the International Space Station.

Certification↗
PubMed1995

Sleep-wake cycles in rhesus monkeys during Spacelab flight simulations.

Neurophysiological data has been obtained in orbital flight from various non-human Primates. Aboard Russian satellites during both Bion and Biocosmos missions, impairments in duration and organization of the states of vigilance were observed in rhesus monkeys during flight: increase in nocturnal awakening, decrease of Rapid Eye Movements-sleep (REM-sleep). It was assumed that weightlessness played a role in these changes. The former "Rhesus Project", a joint program between CNES and NASA, was devoted to physiological studies using the rhesus monkey as a human model aboard Spacelab, during 14 to 16 day orbital flights. In the first stage of this project, we investigated the effect of experimental conditions as well as specific restraint and confinement on the circadian sleep-wake rhythm in a group of rhesus monkeys. Prior to flight, our aim was to determine quantitatively and qualitatively sleep-wake cycles. These control data would thus be compared with inflight data in order to assess the influence of weightlessness.

Activity Cycles↗
PubMed1986

Survey of Earth orbital telescopes and their potential for exobiology.

A series of Workshops on Exobiology in Earth Orbit held at NASA Ames Research Center has recently concluded. The draft of the final report from these Workshops contains a prioritized list of telescopic observations (possible only from above the Earth's atmosphere) that relate to the origin and evolution of the biogenic elements and compounds from their nucleosynthetic creation within stars to their inclusion in living systems. These orbital observations and the ground based laboratory and theoretical research necessary to support them have been termed Observational Exobiology. The details available on spacecraft, platforms and instrumentation most likely to be launched in the near future by the U.S. and Europe were considered in the Workshops. The purpose was to determine what observational programs would be tractible and what area of interest to exobiology required hardware and/or mission capabilities not yet envisioned. This paper summarizes the exciting opportunities that exist for Observational Exobiology.

Astronomy↗
PubMed1990

Potato growth and yield using nutrient film technique (NFT).

Potato plants, cvs Denali and Norland, were grown in polyvinyl chloride (PVC) trays using a continuous flowing nutrient film technique (NFT) to study tuber yield for NASA's Controlled Ecological Life Support Systems (CELSS) program. Nutrient solution pH was controlled automatically using 0.39M (2.5% (v/v) nitric acid (HNO3), while water and nutrients were replenished manually each day and twice each week, respectively. Plants were spaced either one or two per tray, allotting 0.2 or 0.4 m2 per plant. All plants were harvested after 112 days. Denali plants yielded 2850 and 2800 g tuber fresh weight from the one- and two-plant trays, respectively, while Norland plants yielded 1800 and 2400 g tuber fresh weight from the one- and two-plant trays. Many tubers of both cultivars showed injury to the periderm tissue, possibly caused by salt accumulation from the nutrient solution on the surface. Total system water usage throughout the study for all the plants equaled 709 liters (L), or approximately 2 L m-2 d-1. Total system acid usage throughout the study (for nutrient solution pH control) equaled 6.60 L, or 18.4 ml m-2 d-1 (7.2 mmol m-2 d-1). The results demonstrate that continuous flowing nutrient film technique can be used for tuber production with acceptable yields for the CELSS program.

Culture Media↗
PubMedDate not supplied

Space radiation dose estimates on the surface of Mars.

A future goal of the U.S. space program is a commitment to the manned exploration and habitation of Mars. An important consideration of such missions is the exposure of crew members to the damaging effects of ionizing radiation from high-energy galactic cosmic ray fluxes and solar proton flares. The crew will encounter the most harmful radiation environment in transit to Mars from which they must be adequately protected. However, once on the planet's surface, the Martian environment should provide a significant amount of protection from free-space radiative fluxes. In current Mars scenario descriptions, the crew flight time to Mars is estimated to be anywhere from 7 months to over a year each way, with stay times on the surface ranging from 20 days to 2 years. To maintain dose levels below established astronaut limits, dose estimates need to be determined for the entire mission length. With extended crew durations on the surface anticipated, the characterization of the Mars radiation environment is important in assessing all radiation protection requirements. This synopsis focuses on the probable doses incurred by surface inhabitants from the transport of galactic cosmic rays and solar protons through the Mars atmosphere.

Astronauts↗
PubMed1992

Achieving and documenting closure in plant growth facilities.

As NASA proceeds with its effort to develop a Controlled Ecological Life Support System (CELSS) that will provide life support to crews during long duration space missions, it must address the question of facility and system closure. Here we discuss the concept of closure as it pertains to CELSS and describe engineering specifications, construction problems and monitoring procedures used in the development and operation of a closed plant growth facility for the CELSS program. A plant growth facility is one of several modules required for a CELSS. A prototype of this module at Kennedy Space Center is the large (7m tall x 3.5m diameter) Biomass Production Chamber (BPC), the central facility of the CELSS Breadboard Project. The BPC is atmospherically sealed to a leak rate of approximately 5% of its total volume per 24 hours. This paper will discuss the requirements for atmospheric closure in this facility, present CO2 and trace gas data from initial tests of the BPC with and without plants, and describe how the chamber was sealed atmospherically. Implications that research conducted in this type of facility will have for the CELSS program are discussed.

Atmosphere↗
PubMed1991

The BIMDA shuttle flight mission: a low cost microgravity payload.

This paper presents the design, operation and experiment protocol of the Bioserve sponsored flights of the ITA Materials Dispersion Apparatus Payload (BIMDA) flown on the Space Shuttle on STS-37. The BIMDA payload represents a joint effort between ITA (Instrumentation Technology Associates, Inc.) and Bioserve Space Technologies, a NASA Center for the Commercial Development of Space, to investigate the methods and commercial potential of biomedical and fluid science applications in the microgravity environment of space. The BIMDA payload, flown in a Refrigerator/Incubator Module (R/IM) in the Orbiter middeck, consists of three different devices designed to mix fluids in space; four Materials Dispersion Apparatus (MDA) Minilabs developed by ITA, six Cell Syringes, and six Bioprocessing Modules both developed by NASA JSC and Bioserve. The BIMDA design and operation reflect user needs for late access prior to launch (<24 h) and early access after landing (<2 h). The environment for the payload is temperature controlled by the R/IM. The astronaut crew operates the payload and documents its operation. The temperature of the payload is recorded automatically during flight. The flight of the BIMDA payload is the first of two development flights of the MDA on the Space Shuttle. Future commercial flights of ITA's Materials Dispersion Apparatus on the Shuttle will be sponsored by NASA's Office of Commercial Programs and will take place over the next three years. Experiments for the BIMDA payload include research into the following areas: protein crystal growth, thin film membrane casting, collagen formation, fibrin clot formation, seed germination, enzymatic catalysis, zeolite crystallization, studies of mixing effects of lymphocyte functions, and solute diffusion and transport.

Biotechnology↗
PubMed1986

Radiation protection standards in space.

Radiation protection standards for the individual exposed to ionizing radiation in his/her daily work have evolved over more than 50 years since the first recommendations on limits by the NCRP and the ICRP. Initial standards were based on the absence of observable harm, notably skin erythema, but have since been modified as other concerns, such as leukemia and genetic effects, became more important. More recently, the general carcinogenic effect of radiation has become the principal concern at low doses. Genetic effects are also of concern in the younger individual. Modern radiation protection practices take both of these risks into account. Quantification of these risks improves as new information emerges. The study of the Japanese survivors of the atomic bombs continues to yield new information and the recent revisions in the dosimetry are about to be completed. The special circumstances of space travel suggest approaches to limits not unlike those for radiation workers on the ground. One approach is to derive a career limit based on the risks of accident faced by many nonradiation workers in a lifetime. The career limit can be apportioned according to the type of mission. The NCRP is considering this and other approaches to the specification of radiation standards in space.

Adult↗
PubMed1989

Microlesions: theory and reality.

Efforts to assess radiation risk in space have been complicated by the considerable unknowns regarding the biological effects of the heavy ion component (HZE particles) of the cosmic rays. The attention has focused primarily on the assignation of a quality factor (Q) which would take into account the greater effectiveness of heavy ions vis-a-vis other forms of ionizing radiation. If however, as the so-called "Microlesion Theory" allows, the passage of HZE particles through living tissue produces unique biological damage, the traditional use of Q becomes meaningless. Therefore, it is critical to determine if microlesions, in fact, do exist. While the concept does not necessarily require detectable morphological damage, "tunnel-lesions" or holes in ocular tissues have been cited as evidence of microlesions. These data, however, are open to reinterpretation. On-going light, scanning and transmission electron microscopic studies of the corneas, lenses and retinas of rat eyes exposed to 450 MeV/amu 56Fe ions thus far have not revealed tunnel-lesion damage. The morphological effects of the heavy ions have been found to be qualitatively similar to the changes following other kinds of ionizing radiation.

Animals↗
PubMed1992

Chromosomal changes in cultured human epithelial cells transformed by low- and high-LET radiation.

For a better assessment of radiation risk in space, an understanding of the responses of human cells, especially the epithelial cells, to low- and high-LET radiation is essential. In our laboratory, we have successfully developed techniques to study the neoplastic transformation of two human epithelial cell systems by ionizing radiation. These cell systems are human mammary epithelial cells (H184B5) and human epidermal keratinocytes (HEK). Both cell lines are immortal, anchorage dependent for growth, and nontumorigenic in athymic nude mice. Neoplastic transformation was achieved by irradiating cells successively. Our results showed that radiogenic cell transformation is a multistep process and that a single exposure of ionizing radiation can cause only one step of transformation. It requires, therefore, multihits to make human epithelial cells fully tumorigenic. Using a simple karyotyping method, we did chromosome analysis with cells cloned at various stages of transformation. We found no consistent large terminal deletion of chromosomes in radiation-induced transformants. Some changes of total number of chromosomes, however, were observed in the transformed cells. These transformants provide an unique opportunity for further genetic studies at a molecular level.

Animals↗
PubMed1992

Measurements of LET spectra and comparison to models.

We present measurements of LET spectra for near earth orbits with various inclinations and altitudes. A comparison with calculated LET spectra shows that the contribution from direct ionizing galactic cosmic rays is well described by the models. An additional contribution to the spectra originates from stopping protons and from nuclear interactions of particles with material. In the case of an interaction a large amount of energy is deposited in a small volume by target recoils or target fragments. These events will be called short range (SR) events. For a low inclination orbit radiation belt protons are the main source of these events while galactic protons become more important when increasing the inclination to near polar orbits. We show that the contribution of SR events for orbits with low altitude (324 km) and 57 degrees inclination is comparable to that for an orbit with 28 degrees inclination at a high altitude (510 km).

Cosmic Radiation↗
PubMed1992

Late cataractogenesis in primates and lagomorphs after exposure to particulate radiations.

Rhesus monkeys that were exposed in 1969, at the age of approximately 2 years, to low doses of "mixed-energy" protons (10- and 110-MeV) are exhibiting progressive (degenerative) lenticular changes. We have conducted regular examinations of this group of monkeys for cataractogenic development since 1987, i.e., 18 years after irradiation, and the animals began to show enhanced degrees of lenticular opacification two years later. The lenses of age-matched controls (median lifespan in captivity approximately 24 years) continue to exhibit much lower levels of opacification (senile cataracts). Trends in the new data are consistent with the cataractogenic patterns observed for other groups of monkeys that were exposed at similar ages in 1964 and 1965 to protons of different energies, and which we began to monitor only 20-21 years later. Therefore, the new information from the mixed-energy group of monkeys provides insight into the development of late cataractogenic sequelae in the other groups of animals during the 2-3 years before we began to measure them. Comparisons are also made here among recent results from the different groups of primates and from New Zealand white (NZW) rabbits that were exposed when young to 56Fe ions and monitored continuously thereafter. This is done because analogous expression of radiation-induced degenerative cataractogenesis also occurs late in the lifespan of the lagomorphs (control median lifespan in captivity approximately 5-7 years), but in this case the cataractogenic profile has been documented through most of the post-irradiation lifespan.

Animals↗
PubMed1992

Fluence-related risk coefficients using the Harderian gland data as an example.

The risk of radiation-induced cancer to space travelers outside the earth's magnetosphere will be of concern on missions to the Moon and beyond to Mars. High energy galactic cosmic rays with high charge (HZE particles) will penetrate the spacecraft and the bodies of the astronauts, sometimes fragmenting into nuclear secondary species of lower charge but always ionizing densely, thus causing cellular damage which may lead to malignant transformation. To quantitate this risk, the concept of dose equivalent (in which a quality factor Q as a function of LET is assumed) may not be adequate, since different particles of the same LET may have different efficiencies for tumor induction. Also, RBE values on which quality factors are based depend on response to low-LET radiation at low doses, a very difficult region for which to obtain reliable experimental data. Thus, we introduce a new concept, a fluence-related risk coefficient (F), which is the risk of a cancer per unit particle fluence and which we call the risk cross section. The total risk is the sum of the risk from each particle type: sigma i integral Fi(Li) phi i(Li) dLi, where Li is the LET and phi i(Li) is the fluence-LET spectrum of the ith particle type. As an example, tumor prevalence data in mice are used to estimate the probability of mouse Harderian gland tumor induction per year on an extra-magnetospheric mission inside an idealized shielding configuration of a spherical aluminum shell 1 g/cm2 thick. The combined shielding code BRYNTRN/GCR is used to generate the LET spectra at the center of the sphere. Results indicate a yearly prevalence at solar minimum conditions of 0.06, with 60% of this arising from charge components with Z between 10 and 28, and two-thirds of the contribution arising from LET components between 10 and 200 keV/micrometers.

Animals↗
PubMed1994

Dose rate and repair effects on cell damage in Earth orbit.

Radiobiology experiments performed in space will encounter continuous exposures to the cosmic rays and fractionated exposures to trapped protons which accumulate to several hundred dose fractions in a few weeks. Using models of track structure and cellular kinetics combined with models of the radiation environment and radiation transport, we consider calculations of damage rates for cell cultures. Analysis of the role of repair mechanisms for space exposures for the endpoints of survival and transformation is emphasized.

Aluminum↗
PubMed1994

Neuritogenesis: a model for space radiation effects on the central nervous system.

Pivotal to the astronauts' functional integrity and survival during long space flights are the strategies to deal with space radiations. The majority of the cellular studies in this area emphasize simple endpoints such as growth related events which, although useful to understand the nature of primary cell injury, have poor predictive value for extrapolation to more complex tissues such as the central nervous system (CNS). In order to assess the radiation damage on neural cell populations, we developed an in vitro model in which neuronal differentiation, neurite extension, and synaptogenesis occur under controlled conditions. The model exploits chick embryo neural explants to study the effects of radiations on neuritogenesis. In addition, neurobiological problems associated with long-term space flights are discussed.

Animals↗
PubMed1994

Non-subjective cataract analysis and its application in space radiation risk assessment.

Experimental animal studies and human observations suggest that the question is not whether or not prolonged space missions will cause cataracts to appear prematurely in the astronauts, but when and to what degree. Historically the major impediment to radiation cataract follow-up has been the necessarily subjective nature of assessing the degree of lens transparency. This has spurred the development of instruments which produce video images amenable to digital analysis. One such system, the Zeiss Scheimpflug slit lamp measuring system (SLC), was incorporated into our ongoing studies of radiation cataractogenesis. It was found that the Zeiss SLC measuring system has high resolution and permits the acquisition of reproducible images of the anterior segment of the eye. Our results, based on about 650 images of the rats lens, and followed over a period of 91 weeks of radiation cataract development, showed that the integrated optical density (IOD) of the lens correlated well with conventional assessment with the added advantages of objectivity, permanent and transportable records and linearity as cataracts become more severe. This continuous data acquisition, commencing with cataract onset, can proceed through more advanced stages. The SLC exhibits much greater sensitivity reflected in a continuously progressive severity despite the artifactual plateaus in staging which occur using conventional scoring methods. Systems such as the Zeiss SLC should be used to monitor astronauts frequent visits to low earth orbit to obtain a longitudinal data-base on the influence of this activity on the lens.

Animals↗