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Modern neurosurgery for psychiatric disorders.

OBJECTIVE: The evolution, rationale, and results of modern functional neurosurgery to treat psychiatric disorders are documented. The potential benefits of neurosurgical treatment for selected, critically ill, psychiatric patients are considered. METHODS: The history, anatomic features, and evolution of and contemporary indications for the four currently used procedures (cingulotomy, subcaudate tractotomy, limbic leukotomy, and capsulotomy) are reviewed. Available outcome, neuropsychological assessment, and functional imaging data are presented. RESULTS: Recently, there has been a renaissance of interest in the surgical treatment of psychiatric disease. Modern psychiatric neurosurgical procedures are quite safe, with extremely low surgical mortality rates and transient postoperative morbidity. In selected cases, patients with conditions that had previously been completely refractory to comprehensive medical and behavioral intervention demonstrated significant improvement. This improvement was usually observed in the absence of long-term adverse neuropsychological consequences. CONCLUSION: Recent outcome studies, together with advances in neurobiology, psychiatry, functional imaging, and stereotaxy, support the further investigation of modern functional neurosurgical procedures to treat psychiatric disorders and their application for a subset of psychiatric patients with conditions refractory to all other therapies.

Humans↗

Evolution of modern humans: evidence from nuclear DNA polymorphisms.

Previously we have described studies of the evolution of modern humans based upon data for classical genetic markers and for nuclear DNA polymorphisms. Such polymorphisms provide a different point of view regarding human evolution than do mitochondrial DNA sequences. Here we compare revised dates for major migrations of anatomically modern humans, estimated from archaeological data, with separations suggested by a genetic tree constructed from classical marker allele frequencies. Analyses of DNA polymorphisms have now been extended and compared with those of classical markers; genetic trees continue to support the hypothesis of an initial African and non-African divergence for modern humans. We have also begun testing non-human primates for a set of human DNA polymorphisms. For most polymorphisms tested so far, humans share a single allele with other primates; such shared alleles are likely to be ancestral. Populations living in humid tropical environments have significantly higher frequencies of ancestral alleles than do other populations, supporting the hypothesis that natural selection acts to maintain high frequencies of particular alleles in some environments.

Animals↗

African and Asian perspectives on the origins of modern humans.

The ways in which the cultural evidence - in its chronological context - can be used to imply behavioural patterning and to identify possible causes of change are discussed. Improved reliability in dating methods, suites of dates from different regional localities, and new, firmly dated fossil hominids from crucial regions such as northeast Africa, the Levant, India and China, are essential for clarification of the origin and spread of the modern genepool. Hominid ancestry in Africa is reviewed, as well as the claims for an independent origin in Asia. The cultural differences and changes within Africa, West and South Asia and the Far East in the later Middle and early Upper Pleistocene are examined and compared, and some behavioural implications are suggested, taking account of the evolutionary frameworks suggested by the 'multiregional evolution' and 'Noah's Ark' hypotheses of human evolution. A possible explanation is proposed for the cultural differences between Africa, West Asia and India on the one hand, and southeast Asia and the Far East on the other. The apparent hiatus between the appearance of the first anatomically modern humans, ca. 100 ka ago, and the appearance of the Upper Palaeolithic and other contemporaneous technological and behavioural changes around 40 ka ago, is discussed. It is suggested that the anatomical changes occurred first, and that neurological changes permitted the development of fully syntactic language some 50 ka later. The intellectual and behavioural revolution, best demonstrated by the 'Upper Palaeolithic' of Eurasia, seems to have been dependent on this linguistic development - within the modern genepool - and triggered the rapid migration of human populations throughout the Old World.

Africa↗

Models and realities in modern human origins: the African fossil evidence.

The recent application of such chronometric techniques as electron spin resonance (ESR), thermoluminescence (TL), and uranium series dating has had a significant impact on perceptions of modern human origins. Claims for the presence of anatomically modern humans in Africa prior to 100 ka and for the transition leading to modern Africans at an even earlier date have been made, partly based on results of these techniques. However, a careful examination of the pertinent record shows that these claims are not unequivocally supported by the available fossil and chronological evidence.

Africa↗

Modern human origins: progress and prospects.

The question of the mode of origin of modern humans (Homo sapiens) has dominated palaeoanthropological debate over the last decade. This review discusses the main models proposed to explain modern human origins, and examines relevant fossil evidence from Eurasia, Africa and Australasia. Archaeological and genetic data are also discussed, as well as problems with the concept of 'modernity' itself. It is concluded that a recent African origin can be supported for H. sapiens, morphologically, behaviourally and genetically, but that more evidence will be needed, both from Africa and elsewhere, before an absolute African origin for our species and its behavioural characteristics can be established and explained.

Africa↗

Medical modernization, scientific research fields and the epistemic politics of health social movements.

As health social movements (HSMs) and complementary and alternative medicine (CAM) professions increasingly mount challenges to the authority of medical knowledge, the tendency for the medical research community and medical profession to dismiss such epistemic challenges (termed here 'paternalistic progressivism') and the corresponding response from challengers that medicine is corrupt (termed here 'medical devolution') has given way to a process of incorporation of challenges under the rubric of evidence-based research (termed here the epistemic dimension of 'medical modernization'). Under conditions of medical modernization the distinction between lay/alternative knowledge and scientific knowledge, upon which the epistemic authority of medicine rested, is submerged in a more complex field of competing scientific networks and research programmes. Furthermore, the older policy of transmitting science to an illiterate public and suppressing dissidents is replaced by an emerging system of the 'public shaping of science', in which there is both greater agency of social movement/lay advocacy organisations and greater recognition of the legitimacy of that agency. Indirect and direct forms of the public shaping of science are discussed, as are emergent problems of co-optation. Understanding the emergent epistemic politics that are characterised here as medical modernization requires an ongoing theoretical integration of medical sociology and the sociology of science.

Attitude of Health Personnel↗

The modern matron: a hybrid management role with implications for continuous quality improvement.

This paper describes the second phase of a research study into the introduction of the 'modern matron' role in the National Health Service. It draws on information from a survey of modern matrons in 10 case study trusts and from semistructured interviews with purposively selected matrons and their key contacts. Three models of role implementation are identified, each typical of 'hybrid management' but with different emphases on matrons' professional (clinical) and corporate management responsibilities. There is evidence that matrons are starting to make an impact on different aspects of quality improvement in their trusts, but this is often limited by lack of forethought about where they should be located in the organization. It is suggested that, before making decisions about establishing modern matron posts, trusts need to have a clearer understanding both of the different contributions matrons can make to quality improvement and the challenges posed by this type of role.

Health Policy↗

Auditing the impact of implementing the Modern Matron role in an acute teaching trust.

AIM: This paper describes how an acute teaching trust established the role of Senior Nurses (Modern Matrons) and an audit that was undertaken 12 months after they were appointed to evaluate the role. BACKGROUND: The concept of the Modern Matron was introduced in 2000 and all trusts had to implement the role by April 2002. METHODS: The audit comprised: measurement of progress against agreed corporate objectives and questionnaires to all senior nurses and a range of trust staff staff. RESULTS: The following themes were identified: Senior Nurse post, patient care, infection control and leadership. Senior nurses were found to be satisfied with their role and the preparation for and understanding of their role seemed to be successful. There were many improvements such as a reduction in drug errors, complaints and MRSA bacteriaemias. CONCLUSIONS: Implementation of the Modern Matron role has been successful and made improvements in patient care.

Attitude of Health Personnel↗

Religion, modernity and foreign nurses in Iceland 1896-1930.

This paper describes the influence of foreign nurses upon the development of modern healthcare services and the nursing profession in Iceland in the first three decades of the twentieth century. It represents a case study of how new ideas, traditions and practices migrated between countries and cultures in the twentieth century. Icelandic society was, at that time, still premodern in many ways. Healthcare institutions were almost nonexistent and the means of production were undeveloped. It was into this context that the idea of nursing as a professional activity was introduced. Groups of nurses, the Catholic Sisters of St Joseph of Chambéry and secular nurses, mainly from Denmark, came to the country to organize and provide healthcare services, of which nursing was of central importance. These groups were diasporas, in that they brought traditions and practices from other cultures. The Sisters of St Joseph built, owned and ran the first modern hospital in the country. The Danish nurses introduced nursing as a specialized field of work, in leprosy and tuberculosis nursing and by initiating public health nursing services. They were instrumental in promoting education as an important condition to becoming a nurse, and the development of an Icelandic nursing profession. These nurses were generally respected by the Icelandic people for their contributions and were received with interest and appreciation. The healthcare services introduced by these different groups of nurses reflected modern ways of living and a commitment to professionalism, which involved providing assistance to patients based on the best knowledge available and a philosophy of respect and care.

Catholicism↗

Quality control issues in modern cataract surgery.

Modern extracapsular cataract surgery is considerably more complex than the previous intracapsular procedure. Intraocular manipulations are required, and solutions and products must be introduced into the eye. Due to the shift to ambulatory surgery, modern cataract surgery is also being performed in a difficult and more dangerous environment. In these circumstances, sterility and product quality may be compromised when a lack of appropriate surveillance techniques leads to the use of defective products in surgery. The modern cataract surgeon must, therefore, become knowledgeable about infection and quality control procedures in the operating room, and also about details of manufacture and industrial standards applicable to the products used in eye surgery.

Cataract Extraction↗

Use of traditional healers and modern medicine in Ghana.

PURPOSE: To gain understanding of the use of traditional and modern medicine among the people in Ghana, West Africa. METHODS: Data were collected from nine participants using a semi-structured questionnaire developed by the researchers based on review of the literature. FINDINGS: Data analysis was performed manually using reduction methodology to develop broad themes. Findings indicated that choices in healthcare modalities by literate Ghanaians included either traditional or modern medicine, or blending of both. Strong influences on these choices were the level of education and related themes, influence of family and friends, and spiritual/religious beliefs. IMPLICATIONS: Findings indicate that traditional and modern medicines will always be part of Ghanaian healthcare delivery and efforts should be made to integrate traditional practitioners into the national healthcare delivery system.

Adult↗

Morphological cerebral asymmetries of modern man, fossil man, and nonhuman primate.

Cerebral asymmetries are common in modern and fossil man and the great apes. Those occurring most often are listed here: 1. The left sylvian fissure in man is longer than the right and in both fetal and adult brains the posterior end of the right sylvian fissure is commonly higher than the left. Associated with these findings, the left planum temporale is usually longer than the right. 2. The left occipital pole is often wider and usually protrudes more posteriorly than the right. 3. The left lateral ventricle, and especially the occipital horn, is usually larger than the right. 4. If one frontal pole extends beyond the other it is usually the right. 5. On X-ray computerized axial tomograms (CT) of the brain the right frontal lobe and the central portion of the right hemisphere more often measure wider than the left. 6. The CT studies commonly show a Yakovlevian anticlockwise torque (taking the nose as 12 o'clock), with the left occipital pole longer and often extending across the midline toward the right and a wider right hemisphere in its central and frontal portions and frequent forward protrusion of the right frontal pole. This is found also in newborns. 7. The posterior end of the sagittal sinus usually lies to the right of the midline and the sinus flows more directly into the right transverse sinus than into the left. 8. The right transverse sinus is usually higher than the left. 9. In left-handed and ambidextrous individuals the posterior ends of the sylvian fissures are more often nearly equal in height and the occipital regions are more often equal in width or the right may be wider. 10. The torque of the pyramidal tract and the hemispheral torque cannot at present be related to right- or left-handedness. Statistics concerning left-handedness are somewhat confounded, because it is likely that not a few individuals are left-handed because of an early injury of the left hemisphere in a normally right-handed individual. 11. Cerebral asymmetries are found in fossil man similar to those in modern man. 12. Asymmetries of the sylvian fissures similar to those of modern man have been found in the great apes and are particularly common in the orangutan. 13. The most striking and consistently present cerebral asymmetries found in adult and fetal brains are in the region of the posterior end of the sylvian fissures-- the areas generally regarded as a major importance in language function.

Adolescent↗

A hominid from the lower Pleistocene of Atapuerca, Spain: possible ancestor to Neandertals and modern humans.

Human fossil remains recovered from the TD6 level (Aurora stratum) of the lower Pleistocene cave site of Gran Dolina, Sierra de Atapuerca, Spain, exhibit a unique combination of cranial, mandibular, and dental traits and are suggested as a new species of Homo-H. antecessor sp. nov. The fully modern midfacial morphology of the fossils antedates other evidence of this feature by about 650, 000 years. The midfacial and subnasal morphology of modern humans may be a retention of a juvenile pattern that was not yet present in H. ergaster. Homo antecessor may represent the last common ancestor for Neandertals and modern humans.

Adult↗

Modern sports eye injuries.

AIMS: To determine the severity and long term sequelae of eye injuries caused by modern sports that could be responsible for significant ocular trauma in the future. METHODS: Prospective observational study of 24 (25 eyes) athletes with sports related ocular injuries from health clubs, war games, adventure, radical and new types of soccer, presenting to an eye emergency department between 1992 and 2002 (10 years). RESULTS: Modern sports were responsible for 8.3% of the 288 total sports eye injuries reported. Squash (29.2%) was the most common cause, followed by paintball (20.8%) and motocross (16.6%). The most common diagnosis during the follow up period was retinal breaks (20%). 18 (75%) patients sustained a severe injury. The final visual acuity remained <20/100 in two paintball players. CONCLUSIONS: Ocular injuries resulting from modern sports are often severe. Adequate instruction of the participants in the games, proper use of eye protectors, and a routine complete ophthalmological examination after an eye trauma should be mandatory.

Adolescent↗

Principles of modern low vision rehabilitation.

Low vision rehabilitation is a new emerging subspecialty drawing from the traditional fields of ophthalmology, optometry, occupational therapy, and sociology, with an ever-increasing impact on our customary concepts of research, education, and services for the visually impaired patient. A multidisciplinary approach and coordinated effort are necessary to take advantage of new scientific advances and achieve optimal results for the patient. Accordingly, the intent of this paper is to outline the principles and details of a modern low vision rehabilitation service. All rehabilitation attempts must start with a first hand interview (the intake) for assessing functionality and priority tasks for rehabilitation, as well as assessing the patient's all-important cognitive skills. The assessment of residual visual functions follows the intake and offers a unique opportunity to measure, evaluate, and document accurately the extent of functional loss sustained by the patient from disease. An accurate assessment of residual visual functions includes assessment of visual acuity, contrast sensitivity, binocularity, refractive errors, perimetry, oculomotor functions, cortical visual integration, and light characteristics affecting visual functions. Functional vision assessment in low vision rehabilitation measures how well one uses residual visual functions to perform routine tasks, using different items under various conditions, throughout the day. Of the many functional vision skills known, reading skills is an obligatory item for all low vision rehabilitation assessments. Results of assessment guide rehabilitation professionals in developing rehabilitation plans for the individual and recommending appropriate low vision devices. The outcome from assessing residual visual functions is detection of visual functions that can be improved with the use of optical devices. Methods for prescribing devices such as image relocation with prisms to a preferred retinal locus, field displacement to primary gaze position, field expansion, and manipulation of light are practiced today in addition to, or instead of, magnification. Correction of refractive errors, occlusion therapy, enhancement of oculomotor skills, and field restitution are additional methods now available for prescribing devices leading to rehabilitation of visual functions. The outcome from assessing residual functional vision is detection of functional vision that can be improved with the use of vision therapy training. After restoration of optimal residual visual functions is achieved with optical devices, one can follow with training programs for restoration of lost vision-related skills. If an optical dispensary is available where prescribing of low vision devices routinely take place, this will help ensure familiarity and specialization of the dispensary and staff with low vision devices and their special dispensing requirements. The dispensing of low vision devices is an opportunity to introduce the device to the patient, train the patient in the correct use of the device for the task selected, and create a direct and continuous connection with the patient until the next encounter. Following assessment, prescribing, and dispensing of devices, a low vision practitioner, ophthalmologist or optometrist, is responsible for recommending and prescribing vision therapy training to improve residual functional vision. An attempt to present a template for a comprehensive modern low vision rehabilitation practice is made here by summarizing scientific developments in the field and stressing the multidisciplinary involvement required for this kind of practice. It is hoped that this paper and other initiatives from colleagues, the public, and government will promote and raise awareness of modern low vision rehabilitation for the benefit of all.

Humans↗

[Regulative therapy: treatment with nonspecific stimulants in dermatology in traditional and modern perspectives].

Stimulation or regulation therapies are old therapeutic procedures based on models reaching back to traditional medical faculties in ancient times and in the Middle Ages. Among this heterogeneous group are acupuncture, purgative procedures (especially the Aschner methods), autohemotherapy, fasting therapy, homeopathy, microbiological and physical therapies. The basic principle underlying all of these procedures is that stimulants applied in proper doses to the organism elicit counterregulation. The counterregulation stimulates 'self-healing processes' within the organism. The efficacy of stimulation therapies was originally deduced mostly from traditional explanatory models which have lost their relevance for modern medicine. However, it has been found in applications in dermatology that many of these stimulation therapies can lead to clinical improvement in selected indications and that modern explanatory models can be found for these effects. This presentation reports on exemplary applications of stimulation therapies in dermatology. Traditional and modern concepts of action are compared.

Complementary Therapies↗

Modern treatment of early gastric cancer: review of the Japanese experience.

BACKGROUND: Recently, detections of early gastric cancer (EGC) have been increasing, and the treatment strategies for gastric cancer have been changing. To demonstrate recent clinical experience of EGC in Japan and to assess modern strategies for the treatment of EGC, we investigated the English-language literature of the past 10 years through computer searches. METHODS: This article intends to provide gastric surgeons with recent Japanese experience of the treatment for EGC. In a search for modern treatments of EGC, we selected 100 papers published in well-known medical journals, and focused on the following items of EGC: (1) prognostic factors, (2) endoscopic treatment, (3) surgical procedures, and (4) Japanese guidelines. RESULTS: The most important factor influencing the survival of patients with EGC is the status of lymph node metastasis. The incidence of lymph node metastasis is 1-3% for mucosal cancers and 11-20% for submucosal cancers. Endoscopic mucosal resection (EMR) is a technique for the treatment of EGC, and the recent indication includes the tumors confined to the mucosa up to 3 cm in size or those invading the superficial submucosa. Surgical procedures include conventional Billroth I gastrectomy, limited resections, and laparoscopic surgery. Laparoscopic wedge resection using the lesion-lifting method and laparoscopy-assisted distal gastrectomy provide less pain, faster recovery and shorter hospital stay. Guidelines for the treatment of gastric cancer proposed by the Japanese Gastric Cancer Association show that patients with mucosal cancer can be managed by EMR or distal gastrectomy, whereas patients with submucosal cancer are candidates for distal gastrectomy with lymph node dissection. CONCLUSION: Although the prognosis of patients with EGC depends on the presence or absence of lymph node metastasis, most are successfully treated by modern endoscopic or surgical techniques. Laparoscopic surgery and limited resections will contribute to the better quality of life of patients with EGC.

Biopsy, Needle↗

Modern pacemaker and implantable cardioverter/defibrillator systems can be magnetic resonance imaging safe: in vitro and in vivo assessment of safety and function at 1.5 T.

BACKGROUND: MRI has unparalleled soft-tissue imaging capabilities. The presence of devices such as pacemakers and implantable cardioverter/defibrillators (ICDs), however, is historically considered a contraindication to MRI. These devices are now smaller, with less magnetic material and improved electromagnetic interference protection. Our aim was to determine whether these modern systems can be used in an MR environment. METHODS AND RESULTS: We tested in vitro and in vivo lead heating, device function, force acting on the device, and image distortion at 1.5 T. Clinical MR protocols and in vivo measurements yielded temperature changes <0.5 degrees C. Older (manufactured before 2000) ICDs were damaged by the MR scans. Newer ICD systems and most pacemakers, however, were not. The maximal force acting on newer devices was <100 g. Modern (manufactured after 2000) ICD systems were implanted in dogs (n=18), and after 4 weeks, 3- to 4-hour MR scans were performed (n=15). No device dysfunction occurred. The images were of high quality with distortion dependent on the scan sequence and plane. Pacing threshold and intracardiac electrogram amplitude were unchanged over the 8 weeks, except in 1 animal that, after MRI, had a transient (<12 hours) capture failure. Pathological data of the scanned animals revealed very limited necrosis or fibrosis at the tip of the lead area, which was not different from controls (n=3) not subjected to MRI. CONCLUSIONS: These data suggest that certain modern pacemaker and ICD systems may indeed be MRI safe. This may have major clinical implications for current imaging practices.

Animals↗