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PubMed1963

Shunt bilirubin: evidence for two components.

Studies with C(14)-labeled glycine and delta-aminolevulinic acid as heme-bilirubin precursors in man indicate that the early labeled or shunt bilirubin consists of two fractions. Fraction 1 requires 1 to 24 hours for maximum synthesis, is not dependent on marrow erythropoietic heme synthesis, and is possibly of anabolic origin (formed by a direct pathway from heme precursors). Fraction 2 requires 3 to 4 days for maximum production, is dependent on heme synthesis, and probably has its origin in the bone marrow, as a degradation product of red-cell heme.

Amino Acids↗
PubMed1963

ACTION OF HAEMOPHILUS CULTURES ON DELTA-AMINOLEVULINIC ACID.

Biberstein, Ernst L. (University of California, Davis), Patricia D. Mini, and Marjorie G. Gills. Action of Haemophilus cultures on delta-aminolevulinic acid. J. Bacteriol. 86:814-819. 1963.-Utilization of delta-aminolevulinic acid (ALA) by strains of Haemophilus recovered from various sources was investigated. With the 37 cultures studied, there was perfect correlation between absence of hemin requirement and ability to convert ALA to porphyrin. A total of 29 strains, including representatives of H. parainfluenzae, H. parahaemolyticus, H. "parasuis," and H. gallinarum, fell into this group. The remaining eight isolates, which were incapable of porphyrin synthesis from ALA, were strains of H. influenzae, H. suis, and a Haemophilus culture of uncertain classification obtained from a splenic abscess in a deer. In the active preparations, the products of synthesis included a mixture of porphyrins, porphobilinogen (PBG), and a pigment which absorbed light strongly at 470 to 480 mmu. Paper chromatographic studies of fractions of supernatants and cells revealed the presence of porphyrins having R(F) values similar to those of uro- and protoporphyrins, as well as some intermediate rates of migration probably representing coproporphyrins. Porphyrins were found both intra- and extracellularly, and PBG and the pigment absorbing at 470 to 480 mmu were confined to the supernatant.

Aminolevulinic Acid↗